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Showing 1 to 12 of 32 entries
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Tachykinins and kinins in airway allergy.

Expert opinion on investigational drugs

Geppetti P, Tognetto M, Trevisani M, Amadesi S, Bertrand C.
PMID: 15992096
Expert Opin Investig Drugs. 1999 Jul;8(7):947-56. doi: 10.1517/13543784.8.7.947.

Using models of airway diseases, our understanding of the role of tachykinins and kinins in airway pathophysiology has been greatly enhanced by the recent development of a large series of peptide, peptoid and non-peptide antagonists for tachykinin and kinin...

The role of TRP ion channels in migraine and headache.

Neuroscience letters

Iannone LF, De Logu F, Geppetti P, De Cesaris F.
PMID: 34861342
Neurosci Lett. 2022 Jan 18;768:136380. doi: 10.1016/j.neulet.2021.136380. Epub 2021 Nov 30.

Migraine afflicts more than 10% of the general population. Although its mechanism is poorly understood, recent preclinical and clinical evidence has identified calcitonin gene related peptide (CGRP) as a major mediator of migraine pain. CGRP, which is predominantly expressed...

Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain.

Cancer research

De Logu F, Marini M, Landini L, Souza Monteiro de Araujo D, Bartalucci N, Trevisan G, Bruno G, Marangoni M, Schmidt BL, Bunnett NW, Geppetti P, Nassini R.
PMID: 33771895
Cancer Res. 2021 Jun 15;81(12):3387-3401. doi: 10.1158/0008-5472.CAN-20-3326. Epub 2021 Mar 26.

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their contribution to cancer pain has not been established. Here we report that depletion of sciatic nerve resident MΦs (rMΦ) in mice attenuates mechanical/cold hypersensitivity and...

Galcanezumab effectiveness on comorbid cluster headache and chronic migraine: a prospective case series.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Iannone LF, Fattori D, Geppetti P, De Cesaris F.
PMID: 34586542
Neurol Sci. 2022 Jan;43(1):697-703. doi: 10.1007/s10072-021-05624-1. Epub 2021 Sep 29.

BACKGROUND: Cluster headache (CH) and migraine are recurrent painful primary cephalalgies, typically with different clinical appearance and some shared features, such as unilateral pain, common triggers and response to triptans and/or monoclonal antibodies against the calcitonin gene-related peptide (CGRP)...

The role of TRP ion channels in migraine and headache.

Neuroscience letters

Iannone LF, De Logu F, Geppetti P, De Cesaris F.
PMID: 34861342
Neurosci Lett. 2022 Jan 18;768:136380. doi: 10.1016/j.neulet.2021.136380. Epub 2021 Nov 30.

Migraine afflicts more than 10% of the general population. Although its mechanism is poorly understood, recent preclinical and clinical evidence has identified calcitonin gene related peptide (CGRP) as a major mediator of migraine pain. CGRP, which is predominantly expressed...

Antihypertensive therapy among newly treated patients: An analysis of adherence and cost of treatment over years.

ClinicoEconomics and outcomes research : CEOR

Degli Esposti L, Saragoni S, Batacchi P, Geppetti P, Buda S, Degli Esposti E.
PMID: 21935320
Clinicoecon Outcomes Res. 2010;2:113-20. doi: 10.2147/ceor.s11933. Epub 2010 Jul 28.

OBJECTIVE: To perform a time-trend analysis of adherence and cost of antihypertensive treatment over four years.METHODS: A population-based retrospective cohort study was conducted. We included subjects ≥18 years, and newly treated for hypertension with diuretics, beta-blockers, calcium channel blockers,...

Investigating the Effects of COVID-19 Quarantine in Migraine: An Observational Cross-Sectional Study From the Italian National Headache Registry (RICe).

Frontiers in neurology

Delussi M, Gentile E, Coppola G, Prudenzano AMP, Rainero I, Sances G, Abagnale C, Caponnetto V, De Cesaris F, Frattale I, Guaschino E, Marcinnò A, Ornello R, Pistoia F, Putortì A, Roca ME, Roveta F, Lupi C, Trojano M, Pierelli F, Geppetti P, Sacco S, de Tommaso M.
PMID: 33240213
Front Neurol. 2020 Nov 10;11:597881. doi: 10.3389/fneur.2020.597881. eCollection 2020.

No abstract available.

Diffusive-like redistribution in state-changing collisions between Rydberg atoms and ground state atoms.

Nature communications

Geppert P, Althön M, Fichtner D, Ott H.
PMID: 34162846
Nat Commun. 2021 Jun 23;12(1):3900. doi: 10.1038/s41467-021-24146-0.

Exploring the dynamics of inelastic and reactive collisions on the quantum level is a fundamental goal in quantum chemistry. Such collisions are of particular importance in connection with Rydberg atoms in dense environments since they may considerably influence both...

The role of TRP ion channels in migraine and headache.

Neuroscience letters

Iannone LF, De Logu F, Geppetti P, De Cesaris F.
PMID: 34861342
Neurosci Lett. 2021 Nov 30;768:136380. doi: 10.1016/j.neulet.2021.136380. Epub 2021 Nov 30.

Migraine afflicts more than 10% of the general population. Although its mechanism is poorly understood, recent preclinical and clinical evidence has identified calcitonin gene related peptide (CGRP) as a major mediator of migraine pain. CGRP, which is predominantly expressed...

The role of TRP ion channels in migraine and headache.

Neuroscience letters

Iannone LF, De Logu F, Geppetti P, De Cesaris F.
PMID: 34861342
Neurosci Lett. 2021 Nov 30;768:136380. doi: 10.1016/j.neulet.2021.136380. Epub 2021 Nov 30.

Migraine afflicts more than 10% of the general population. Although its mechanism is poorly understood, recent preclinical and clinical evidence has identified calcitonin gene related peptide (CGRP) as a major mediator of migraine pain. CGRP, which is predominantly expressed...

The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma.

Cells

De Logu F, Souza Monteiro de Araujo D, Ugolini F, Iannone LF, Vannucchi M, Portelli F, Landini L, Titiz M, De Giorgi V, Geppetti P, Massi D, Nassini R.
PMID: 34831352
Cells. 2021 Nov 11;10(11). doi: 10.3390/cells10113131.

Macrophages (MΦs) and reactive oxygen species (ROS) are implicated in carcinogenesis. The oxidative stress sensor, transient receptor potential ankyrin 1 (TRPA1), activated by ROS, appears to contribute to lung and breast cancer progression. Although TRPA1 expression has been reported...

Migraine during COVID-19: Data from Second Wave Pandemic in an Italian Cohort.

Brain sciences

Gentile E, Delussi M, Abagnale C, Caponnetto V, De Cesaris F, Frattale I, Guaschino E, Marcinnò A, Ornello R, Pistoia F, Putortì A, Candida G, Roveta F, Lupi C, Coppola G, Prudenzano AMP, Rainero I, Sances G, Roca ME, Trojano M, Pierelli F, Geppetti P, Sacco S, de Tommaso M.
PMID: 33920175
Brain Sci. 2021 Apr 10;11(4). doi: 10.3390/brainsci11040482.

OBJECTIVES: The study aims to assess the impact of the second COVID-19 pandemic wave on migraine characteristics.METHODS: This is an observational cross-sectional study conducted on migraine patients previously interviewed during the first Italian pandemic outbreak. A second structured telephone...

Showing 1 to 12 of 32 entries