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DNA base adducts in urine andwhite blood cells of cancer patients receiving combination chemotherapies which include N-methyl-N-nitrosourea.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Prevost V, Likhachev AJ, Loktionova NA, Bartsch H, Wild CP, Kazanova OI, Arkhipov AI, Gershanovich ML, Shuker DE.
PMID: 23888991
Biomarkers. 1996;1(4):244-51. doi: 10.3109/13547509609079364.

Abstract Urinary 3-methyladenine (3-MeAde) excretion andlymphocyte DNA adduct formation was studied in 15 patients receiving methylnitrosourea (MNU) at several dose levels (250 mg, 300 mg and600 mg total dose, 143-385 mg m(-2)) as part of various combination chemotherapies for...

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