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Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

ACS medicinal chemistry letters

Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT.
PMID: 25589925
ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 08.

Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM) fragment hit was identified, which bound to the hinge region with an atypical binding mode, and this was optimized using structure-based...

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Johnson CN, Berdini V, Beke L, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014;6(1):25-30doi: 10.1021/ml5001245.
Johnson, C. N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J. E., Day, P. J., Frederickson, M., Freyne, E. J., Gilissen, R. A., Hamlett, C. C., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D. C., Sharff, A., Sommen, F., Wu, T., & Linders, J. T. (2015). Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS medicinal chemistry letters, 6(1), 25-30. https://doi.org/10.1021/ml5001245
Johnson, Christopher N, et al. "Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase." ACS medicinal chemistry letters vol. 6,1 (2015): 25-30. doi: https://doi.org/10.1021/ml5001245
Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 08. PMID: 25589925; PMCID: PMC4291735.
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[Not Available].

MMW Fortschritte der Medizin

Gillissen A.
PMID: 27372332
MMW Fortschr Med. 2010 Mar;152(11):33-4. doi: 10.1007/BF03371000.

No abstract available.

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Gillissen A. Asthmakontrolle entscheidet ôber die Art der Dauertherapie : Schweregrad jetzt nachrangig. [Not Available]. MMW Fortschr Med. 2010;152(11):33-4doi: 10.1007/BF03371000.
Gillissen, A. (2010). Asthmakontrolle entscheidet ôber die Art der Dauertherapie : Schweregrad jetzt nachrangig. [Not Available]. MMW Fortschritte der Medizin, 152(11), 33-4. https://doi.org/10.1007/BF03371000
Gillissen, A. "Asthmakontrolle entscheidet ôber die Art der Dauertherapie : Schweregrad jetzt nachrangig." [Not Available]. MMW Fortschritte der Medizin vol. 152,11 (2010): 33-4. doi: https://doi.org/10.1007/BF03371000
Gillissen A. Asthmakontrolle entscheidet ôber die Art der Dauertherapie : Schweregrad jetzt nachrangig. [Not Available]. MMW Fortschr Med. 2010 Mar;152(11):33-4. doi: 10.1007/BF03371000. German. PMID: 27372332.
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[Not Available].

MMW Fortschritte der Medizin

Gillissen A.
PMID: 27369417
MMW Fortschr Med. 2011 Jun;153(23):29. doi: 10.1007/BF03368520.

No abstract available.

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Gillissen A. Asthmarisiko für Frühgeborene erhöht. [Not Available]. MMW Fortschr Med. 2011;153(23):29doi: 10.1007/BF03368520.
Gillissen, A. (2011). Asthmarisiko für Frühgeborene erhöht. [Not Available]. MMW Fortschritte der Medizin, 153(23), 29. https://doi.org/10.1007/BF03368520
Gillissen, A. "Asthmarisiko für Frühgeborene erhöht." [Not Available]. MMW Fortschritte der Medizin vol. 153,23 (2011): 29. doi: https://doi.org/10.1007/BF03368520
Gillissen A. Asthmarisiko für Frühgeborene erhöht. [Not Available]. MMW Fortschr Med. 2011 Jun;153(23):29. doi: 10.1007/BF03368520. German. PMID: 27369417.
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Profiling of Nutritional and Health-Related Compounds in Oat Varieties.

Foods (Basel, Switzerland)

van den Broeck HC, Londono DM, Timmer R, Smulders MJ, Gilissen LJ, van der Meer IM.
PMID: 28231097
Foods. 2015 Dec 25;5(1). doi: 10.3390/foods5010002.

The use of oats in the human diet has decreased over the past 70 years. This is an unfortunate development from the perspective of human health because oats have a high nutritional value and contain many compounds, including β-glucan,...

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van den Broeck HC, Londono DM, Timmer R, et al. Profiling of Nutritional and Health-Related Compounds in Oat Varieties. Foods. 2015;5(1)doi: 10.3390/foods5010002.
van den Broeck, H. C., Londono, D. M., Timmer, R., Smulders, M. J., Gilissen, L. J., & van der Meer, I. M. (2015). Profiling of Nutritional and Health-Related Compounds in Oat Varieties. Foods (Basel, Switzerland), 5(1), . https://doi.org/10.3390/foods5010002
van den Broeck, Hetty C, et al. "Profiling of Nutritional and Health-Related Compounds in Oat Varieties." Foods (Basel, Switzerland) vol. 5,1 (2015). doi: https://doi.org/10.3390/foods5010002
van den Broeck HC, Londono DM, Timmer R, Smulders MJ, Gilissen LJ, van der Meer IM. Profiling of Nutritional and Health-Related Compounds in Oat Varieties. Foods. 2015 Dec 25;5(1). doi: 10.3390/foods5010002. PMID: 28231097; PMCID: PMC5224580.
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[Early diagnosis of pulmonary diseases].

MMW Fortschritte der Medizin

Gillissen A.
PMID: 24930349
MMW Fortschr Med. 2014 Mar 27;156(1):56-60; quiz 61-2.

No abstract available.

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Gillissen A. Früherkennung von Lungenerkrankungen. Verbessern Sie die Prognose Ihrer Lungenpatienten! [Early diagnosis of pulmonary diseases]. MMW Fortschr Med. 2014;156(1):56-60; quiz 61-2
Gillissen, A. (2014). Früherkennung von Lungenerkrankungen. Verbessern Sie die Prognose Ihrer Lungenpatienten! [Early diagnosis of pulmonary diseases]. MMW Fortschritte der Medizin, 156(1), 56-60; quiz 61-2.
Gillissen, Adrian. "Früherkennung von Lungenerkrankungen. Verbessern Sie die Prognose Ihrer Lungenpatienten!" [Early diagnosis of pulmonary diseases]. MMW Fortschritte der Medizin vol. 156,1 (2014): 56-60; quiz 61-2.
Gillissen A. Früherkennung von Lungenerkrankungen. Verbessern Sie die Prognose Ihrer Lungenpatienten! [Early diagnosis of pulmonary diseases]. MMW Fortschr Med. 2014 Mar 27;156(1):56-60; quiz 61-2. German. PMID: 24930349.
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Competence for Regeneration during Tobacco Internodal Development (Involvement of Plant Age, Cell Elongation Stage, and Degree of Polysomaty).

Plant physiology

Gilissen L, Van Staveren MJ, Hakkert JC, Smulders M.
PMID: 12226359
Plant Physiol. 1996 Aug;111(4):1243-1250. doi: 10.1104/pp.111.4.1243.

This study deals with internodal development in vegetative plants of Nicotiana tabacum cv Samsun NN and its reflection in changes of the cellular competence for regeneration. During elongation of the internodes, the cells of the epidermis, subepidermis, and cortex...

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Gilissen L, Van Staveren MJ, Hakkert JC, et al. Competence for Regeneration during Tobacco Internodal Development (Involvement of Plant Age, Cell Elongation Stage, and Degree of Polysomaty). Plant Physiol. 1996;111(4):1243-1250doi: 10.1104/pp.111.4.1243.
Gilissen, L., Van Staveren, M. J., Hakkert, J. C., & Smulders, M. (1996). Competence for Regeneration during Tobacco Internodal Development (Involvement of Plant Age, Cell Elongation Stage, and Degree of Polysomaty). Plant physiology, 111(4), 1243-1250. https://doi.org/10.1104/pp.111.4.1243
Gilissen, LJW., et al. "Competence for Regeneration during Tobacco Internodal Development (Involvement of Plant Age, Cell Elongation Stage, and Degree of Polysomaty)." Plant physiology vol. 111,4 (1996): 1243-1250. doi: https://doi.org/10.1104/pp.111.4.1243
Gilissen L, Van Staveren MJ, Hakkert JC, Smulders M. Competence for Regeneration during Tobacco Internodal Development (Involvement of Plant Age, Cell Elongation Stage, and Degree of Polysomaty). Plant Physiol. 1996 Aug;111(4):1243-1250. doi: 10.1104/pp.111.4.1243. PMID: 12226359; PMCID: PMC161002.
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Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.

Rapid communications in mass spectrometry : RCM

Kantharaj E, Tuytelaars A, Proost PE, Ongel Z, Van Assouw HP, Gilissen RA.
PMID: 14648905
Rapid Commun Mass Spectrom. 2003;17(23):2661-8. doi: 10.1002/rcm.1228.

The use of in vitro drug metabolism data in the understanding of in vivo pharmacokinetic, safety and toxicity data has become a large area of scientific interest. This has stemmed from a trend in the pharmaceutical industry to use...

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Kantharaj E, Tuytelaars A, Proost PE, et al. Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry. Rapid Commun Mass Spectrom. 2003;17(23):2661-8doi: 10.1002/rcm.1228.
Kantharaj, E., Tuytelaars, A., Proost, P. E., Ongel, Z., Van Assouw, H. P., & Gilissen, R. A. (2003). Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry. Rapid communications in mass spectrometry : RCM, 17(23), 2661-8. https://doi.org/10.1002/rcm.1228
Kantharaj, E, et al. "Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry." Rapid communications in mass spectrometry : RCM vol. 17,23 (2003): 2661-8. doi: https://doi.org/10.1002/rcm.1228
Kantharaj E, Tuytelaars A, Proost PE, Ongel Z, Van Assouw HP, Gilissen RA. Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry. Rapid Commun Mass Spectrom. 2003;17(23):2661-8. doi: 10.1002/rcm.1228. PMID: 14648905.
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Pollination-Induced Corolla Wilting in Petunia hybrida Rapid Transfer through the Style of a Wilting-Inducing Substance.

Plant physiology

Gilissen LJ, Hoekstra FA.
PMID: 16663651
Plant Physiol. 1984 Jun;75(2):496-8. doi: 10.1104/pp.75.2.496.

Pollination or wounding of the stigma of Petunia hybrida flowers led to the generation of a wilting factor and its transfer to the corolla within 4 hours. This was concluded from the effects of time course removal of whole...

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Gilissen LJ, Hoekstra FA. Pollination-Induced Corolla Wilting in Petunia hybrida Rapid Transfer through the Style of a Wilting-Inducing Substance. Plant Physiol. 1984;75(2):496-8doi: 10.1104/pp.75.2.496.
Gilissen, L. J., & Hoekstra, F. A. (1984). Pollination-Induced Corolla Wilting in Petunia hybrida Rapid Transfer through the Style of a Wilting-Inducing Substance. Plant physiology, 75(2), 496-8. https://doi.org/10.1104/pp.75.2.496
Gilissen, L J, and Hoekstra, F A. "Pollination-Induced Corolla Wilting in Petunia hybrida Rapid Transfer through the Style of a Wilting-Inducing Substance." Plant physiology vol. 75,2 (1984): 496-8. doi: https://doi.org/10.1104/pp.75.2.496
Gilissen LJ, Hoekstra FA. Pollination-Induced Corolla Wilting in Petunia hybrida Rapid Transfer through the Style of a Wilting-Inducing Substance. Plant Physiol. 1984 Jun;75(2):496-8. doi: 10.1104/pp.75.2.496. PMID: 16663651; PMCID: PMC1066937.
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Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring.

Journal of Crohn's & colitis

Mares WG, Wong DR, Gilissen LP, Masclee AA, Hooymans PM, Engels LG.
PMID: 21172256
J Crohns Colitis. 2009 Jun;3(2):128-30. doi: 10.1016/j.crohns.2009.02.002. Epub 2009 Mar 16.

The immunosuppressive thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP), have proven efficacy in steroid-dependant or refractory inflammatory bowel disease (IBD). In case of TPMT deficiency serious myelosuppression may occur. 6-thioguanine (6-TG), has been suggested in case of AZA and 6-MP...

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Mares WG, Wong DR, Gilissen LP, et al. Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring. J Crohns Colitis. 2009;3(2):128-30doi: 10.1016/j.crohns.2009.02.002.
Mares, W. G., Wong, D. R., Gilissen, L. P., Masclee, A. A., Hooymans, P. M., & Engels, L. G. (2009). Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring. Journal of Crohn's & colitis, 3(2), 128-30. https://doi.org/10.1016/j.crohns.2009.02.002
Mares, W G N, et al. "Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring." Journal of Crohn's & colitis vol. 3,2 (2009): 128-30. doi: https://doi.org/10.1016/j.crohns.2009.02.002
Mares WG, Wong DR, Gilissen LP, Masclee AA, Hooymans PM, Engels LG. Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring. J Crohns Colitis. 2009 Jun;3(2):128-30. doi: 10.1016/j.crohns.2009.02.002. Epub 2009 Mar 16. PMID: 21172256.
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[Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology].

Pneumologie (Stuttgart, Germany)

Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupoldt A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A.
PMID: 30406626
Pneumologie. 2017 Dec;71(12):e3. doi: 10.1055/a-0790-0021. Epub 2018 Nov 07.

No abstract available.

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Buhl R, Bals R, Baur X, et al. S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma. [Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology]. Pneumologie. 2018;71(12):e3doi: 10.1055/a-0790-0021.
Buhl, R., Bals, R., Baur, X., Berdel, D., Criée, C. P., Gappa, M., Gillissen, A., Greulich, T., Haidl, P., Hamelmann, E., Kardos, P., Kenn, K., Klimek, L., Korn, S., Lommatzsch, M., Magnussen, H., Nicolai, T., Nowak, D., Pfaar, O., Rabe, K. F., Riedler, J., Ritz, T., Schultz, K., Schuster, A., Spindler, T., Taube, C., Taube, K., Vogelmeier, C., von Leupoldt, A., Wantke, F., Weise, S., Wildhaber, J., Worth, H., & Zacharasiewicz, A. (2017). S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma. [Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology]. Pneumologie (Stuttgart, Germany), 71(12), e3. https://doi.org/10.1055/a-0790-0021
Buhl, R, et al. "S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma." [Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology]. Pneumologie (Stuttgart, Germany) vol. 71,12 (2017): e3. doi: https://doi.org/10.1055/a-0790-0021
Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupoldt A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A. S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma. [Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology]. Pneumologie. 2017 Dec;71(12):e3. doi: 10.1055/a-0790-0021. Epub 2018 Nov 07. German. PMID: 30406626.
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Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of .

Journal of natural products

Maeda G, Gilissen PJ, Rudenko A, van der Wal J, Bourgard C, Gupta AK, Sunnerhagen P, Munissi JJE, Nyandoro SS, Erdélyi M.
PMID: 34802242
J Nat Prod. 2021 Nov 21; doi: 10.1021/acs.jnatprod.1c00811. Epub 2021 Nov 21.

Five new cyclohexene derivatives, dipandensin A and B (

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Maeda G, Gilissen PJ, Rudenko A, et al. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of . J Nat Prod. 2021;doi: 10.1021/acs.jnatprod.1c00811.
Maeda, G., Gilissen, P. J., Rudenko, A., van der Wal, J., Bourgard, C., Gupta, A. K., Sunnerhagen, P., Munissi, J. J. E., Nyandoro, S. S., & Erdélyi, M. (2021). Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of . Journal of natural products, . https://doi.org/10.1021/acs.jnatprod.1c00811
Maeda, Gasper, et al. "Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of ." Journal of natural products vol. (2021). doi: https://doi.org/10.1021/acs.jnatprod.1c00811
Maeda G, Gilissen PJ, Rudenko A, van der Wal J, Bourgard C, Gupta AK, Sunnerhagen P, Munissi JJE, Nyandoro SS, Erdélyi M. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of . J Nat Prod. 2021 Nov 21; doi: 10.1021/acs.jnatprod.1c00811. Epub 2021 Nov 21. PMID: 34802242.
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Extending the allelic spectrum at noncoding risk loci of orofacial clefting.

Human mutation

Thieme F, Henschel L, Hammond NL, Ishorst N, Hausen J, Adamson AD, Biedermann A, Bowes J, Zieger HK, Maj C, Kruse T, Buness A, Hoischen A, Gilissen C, Kreusch T, Jäger A, Gölz L, Braumann B, Aldhorae K, Rojas-Martinez A, Krawitz PM, Mangold E, Dixon MJ, Ludwig KU.
PMID: 34004033
Hum Mutat. 2021 Aug;42(8):1066-1078. doi: 10.1002/humu.24219. Epub 2021 Jun 03.

Genome-wide association studies (GWAS) have generated unprecedented insights into the genetic etiology of orofacial clefting (OFC). The moderate effect sizes of associated noncoding risk variants and limited access to disease-relevant tissue represent considerable challenges for biological interpretation of genetic...

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Thieme F, Henschel L, Hammond NL, et al. Extending the allelic spectrum at noncoding risk loci of orofacial clefting. Hum Mutat. 2021;42(8):1066-1078doi: 10.1002/humu.24219.
Thieme, F., Henschel, L., Hammond, N. L., Ishorst, N., Hausen, J., Adamson, A. D., Biedermann, A., Bowes, J., Zieger, H. K., Maj, C., Kruse, T., Buness, A., Hoischen, A., Gilissen, C., Kreusch, T., Jäger, A., Gölz, L., Braumann, B., Aldhorae, K., Rojas-Martinez, A., Krawitz, P. M., Mangold, E., Dixon, M. J., & Ludwig, K. U. (2021). Extending the allelic spectrum at noncoding risk loci of orofacial clefting. Human mutation, 42(8), 1066-1078. https://doi.org/10.1002/humu.24219
Thieme, Frederic, et al. "Extending the allelic spectrum at noncoding risk loci of orofacial clefting." Human mutation vol. 42,8 (2021): 1066-1078. doi: https://doi.org/10.1002/humu.24219
Thieme F, Henschel L, Hammond NL, Ishorst N, Hausen J, Adamson AD, Biedermann A, Bowes J, Zieger HK, Maj C, Kruse T, Buness A, Hoischen A, Gilissen C, Kreusch T, Jäger A, Gölz L, Braumann B, Aldhorae K, Rojas-Martinez A, Krawitz PM, Mangold E, Dixon MJ, Ludwig KU. Extending the allelic spectrum at noncoding risk loci of orofacial clefting. Hum Mutat. 2021 Aug;42(8):1066-1078. doi: 10.1002/humu.24219. Epub 2021 Jun 03. PMID: 34004033.
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Showing 1 to 12 of 127 entries