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Showing 1 to 12 of 35 entries
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Medical resource utilization and costs associated with autosomal dominant polycystic kidney disease in the USA: a retrospective matched cohort analysis of private insurer data.

ClinicoEconomics and outcomes research : CEOR

Knight T, Schaefer C, Krasa H, Oberdhan D, Chapman A, Perrone RD.
PMID: 25759590
Clinicoecon Outcomes Res. 2015 Feb 20;7:123-32. doi: 10.2147/CEOR.S75523. eCollection 2015.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) results in kidney cyst development and enlargement, resulting in chronic kidney disease (CKD) leading to renal failure. This study sought to determine if ADPKD patients in the early stages of CKD contribute...

Can BMI-1 be a biomarker of poor prognosis?.

Epigenomics

Itahana K, Dimri GP.
PMID: 22122046
Epigenomics. 2010 Oct;2(5):609-10. doi: 10.2217/epi.10.52.

No abstract available.

Severe pulmonary artery hypertension following intracardiac repair of tetralogy of Fallot: An unusual finding.

Pulmonary circulation

Kumar B, Puri GD, Manoj R, Gupta K, Shyam KS.
PMID: 22034598
Pulm Circ. 2011 Jan-Mar;1(1):115-8. doi: 10.4103/2045-8932.78099.

Although mild increase in pulmonary vascular resistance following intracardiac repair of tetralogy of Fallot is often seen in the early postoperative period, it usually subsides without any sequel. Persistent severe pulmonary artery hypertension after total correction is rare. We...

Review of Clinical Outcome Assessments in Pediatric Attention-Deficit/Hyperactivity Disorder.

Neuropsychiatric disease and treatment

Markowitz JT, Oberdhan D, Ciesluk A, Rams A, Wigal SB.
PMID: 32669845
Neuropsychiatr Dis Treat. 2020 Jul 01;16:1619-1643. doi: 10.2147/NDT.S248685. eCollection 2020.

PURPOSE: Various clinical outcome assessments (COAs) are used in clinical research to assess and monitor treatment efficacy in pediatric attention-deficit/hyperactivity disorder (ADHD) trials. It is unclear whether the concepts assessed are those that are important to patients and their...

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.

Nature communications

Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA.
PMID: 34795295
Nat Commun. 2021 Nov 18;12(1):6666. doi: 10.1038/s41467-021-27056-3.

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels...

Disconnect in Assessments of Autosomal Dominant Polycystic Kidney Disease Burden Between Patients and Physicians: A Survey Study.

International journal of nephrology and renovascular disease

Sanon Aigbogun M, Oberdhan D, Doane MJ, Rooney J, Inyart BC, Pao CS, Denny AH.
PMID: 33880055
Int J Nephrol Renovasc Dis. 2021 Apr 13;14:105-115. doi: 10.2147/IJNRD.S297491. eCollection 2021.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a rare inherited kidney disorder with considerable symptom burden and negative effects even in early-stage disease. Patients' reporting of ADPKD symptom burden may differ from physicians' impressions. In this quantitative, cross-section...

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.

Nature communications

Dar GH, Mendes CC, Kuan WL, Speciale AA, Conceição M, Görgens A, Uliyakina I, Lobo MJ, Lim WF, El Andaloussi S, Mäger I, Roberts TC, Barker RA, Goberdhan DCI, Wilson C, Wood MJA.
PMID: 34795295
Nat Commun. 2021 Nov 18;12(1):6666. doi: 10.1038/s41467-021-27056-3.

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels...

A Randomized Trial of Modified-Release Versus Immediate-Release Tolvaptan in ADPKD.

Kidney international reports

Perrone RD, Chapman AB, Oberdhan D, Czerwiec FS, Sergeyeva O, Ouyang J, Shoaf SE.
PMID: 32518861
Kidney Int Rep. 2020 Mar 17;5(6):790-800. doi: 10.1016/j.ekir.2020.03.013. eCollection 2020 Jun.

INTRODUCTION: Tolvaptan, for treatment of autosomal dominant polycystic kidney disease (ADPKD), is provided as immediate-release (IR) tablets administered twice daily in split-dose regimens to suppress urine osmolality to 

The NOCTURNE Randomized Trial Comparing 2 Tolvaptan Formulations.

Kidney international reports

Perrone RD, Chapman AB, Oberdhan D, Czerwiec FS, Sergeyeva O, Ouyang J, Shoaf SE.
PMID: 32518862
Kidney Int Rep. 2020 Apr 27;5(6):801-812. doi: 10.1016/j.ekir.2020.03.011. eCollection 2020 Jun.

INTRODUCTION: Tolvaptan, a treatment for autosomal dominant polycystic kidney disease (ADPKD), inhibits vasopressin V2 receptor signaling, which causes aquaretic adverse events (AAEs). The short-term efficacy and tolerability of a once-daily, modified-release (MR) formulation was assessed relative to the twice-daily,...

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles.

Journal of extracellular vesicles

Witwer KW, Goberdhan DC, O'Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, Ochiya T, Rome S, Sahoo S, Zheng L.
PMID: 34953156
J Extracell Vesicles. 2021 Dec;10(14):e12182. doi: 10.1002/jev2.12182.

The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and...

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles.

Journal of extracellular vesicles

Witwer KW, Goberdhan DC, O'Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, Ochiya T, Rome S, Sahoo S, Zheng L.
PMID: 34953156
J Extracell Vesicles. 2021 Dec;10(14):e12182. doi: 10.1002/jev2.12182.

The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and...

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles.

Journal of extracellular vesicles

Witwer KW, Goberdhan DC, O'Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, Ochiya T, Rome S, Sahoo S, Zheng L.
PMID: 34953156
J Extracell Vesicles. 2021 Dec;10(14):e12182. doi: 10.1002/jev2.12182.

The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and...

Showing 1 to 12 of 35 entries