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European collaboration on relative effectiveness will move into the next phase.

Journal of comparative effectiveness research

Goettsch W.
PMID: 24236514
J Comp Eff Res. 2013 Jan;2(1):5-6. doi: 10.2217/cer.12.70.

No abstract available.

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Goettsch W. European collaboration on relative effectiveness will move into the next phase. J Comp Eff Res. 2013;2(1):5-6doi: 10.2217/cer.12.70.
Goettsch, W. (2013). European collaboration on relative effectiveness will move into the next phase. Journal of comparative effectiveness research, 2(1), 5-6. https://doi.org/10.2217/cer.12.70
Goettsch, Wim. "European collaboration on relative effectiveness will move into the next phase." Journal of comparative effectiveness research vol. 2,1 (2013): 5-6. doi: https://doi.org/10.2217/cer.12.70
Goettsch W. European collaboration on relative effectiveness will move into the next phase. J Comp Eff Res. 2013 Jan;2(1):5-6. doi: 10.2217/cer.12.70. PMID: 24236514.
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Adsorption energy, growth mode, and sticking probability of Ca on poly(methyl methacrylate) surfaces with and without electron damage.

Journal of the American Chemical Society

Zhu J, Goetsch P, Ruzycki N, Campbell CT.
PMID: 17465543
J Am Chem Soc. 2007 May 23;129(20):6432-41. doi: 10.1021/ja067437c. Epub 2007 Apr 28.

The adsorption of Ca atoms on pristine and electron-irradiated poly(methyl methacrylate) (PMMA) surfaces at 300 K has been studied by adsorption microcalorimetry, atomic beam/surface scattering, and low-energy He+ ion scattering spectroscopy (ISS). On pristine PMMA, the initial sticking probability...

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Zhu J, Goetsch P, Ruzycki N, et al. Adsorption energy, growth mode, and sticking probability of Ca on poly(methyl methacrylate) surfaces with and without electron damage. J Am Chem Soc. 2007;129(20):6432-41doi: 10.1021/ja067437c.
Zhu, J., Goetsch, P., Ruzycki, N., & Campbell, C. T. (2007). Adsorption energy, growth mode, and sticking probability of Ca on poly(methyl methacrylate) surfaces with and without electron damage. Journal of the American Chemical Society, 129(20), 6432-41. https://doi.org/10.1021/ja067437c
Zhu, Junfa, et al. "Adsorption energy, growth mode, and sticking probability of Ca on poly(methyl methacrylate) surfaces with and without electron damage." Journal of the American Chemical Society vol. 129,20 (2007): 6432-41. doi: https://doi.org/10.1021/ja067437c
Zhu J, Goetsch P, Ruzycki N, Campbell CT. Adsorption energy, growth mode, and sticking probability of Ca on poly(methyl methacrylate) surfaces with and without electron damage. J Am Chem Soc. 2007 May 23;129(20):6432-41. doi: 10.1021/ja067437c. Epub 2007 Apr 28. PMID: 17465543.
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Mortality in Goitre Operations: An Analysis of a Series of 1,755 Operations During the Ten-Year Period, 1920-1929 Inc.

Annals of surgery

Goetsch E.
PMID: 17866610
Ann Surg. 1931 Aug;94(2):167-78. doi: 10.1097/00000658-193108000-00002.

No abstract available.

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Goetsch E. Mortality in Goitre Operations: An Analysis of a Series of 1,755 Operations During the Ten-Year Period, 1920-1929 Inc. Ann Surg. 1931;94(2):167-78doi: 10.1097/00000658-193108000-00002.
Goetsch, E. (1931). Mortality in Goitre Operations: An Analysis of a Series of 1,755 Operations During the Ten-Year Period, 1920-1929 Inc. Annals of surgery, 94(2), 167-78. https://doi.org/10.1097/00000658-193108000-00002
Goetsch, E. "Mortality in Goitre Operations: An Analysis of a Series of 1,755 Operations During the Ten-Year Period, 1920-1929 Inc." Annals of surgery vol. 94,2 (1931): 167-78. doi: https://doi.org/10.1097/00000658-193108000-00002
Goetsch E. Mortality in Goitre Operations: An Analysis of a Series of 1,755 Operations During the Ten-Year Period, 1920-1929 Inc. Ann Surg. 1931 Aug;94(2):167-78. doi: 10.1097/00000658-193108000-00002. PMID: 17866610; PMCID: PMC1391481.
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NERVE ENDINGS IN NUTRITIONAL MUSCULAR DYSTROPHY IN GUINEA PIGS.

The Journal of experimental medicine

Rogers WM, Pappenheimer AM, Goettsch M.
PMID: 19869906
J Exp Med. 1931 Jul 31;54(2):167-9. doi: 10.1084/jem.54.2.167.

The nutritional muscle dystrophy of guinea pigs and rabbits is primarily a degeneration of the muscle fibers and is not associated with visible alterations of the peripheral nerves or their motor terminals.

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Rogers WM, Pappenheimer AM, Goettsch M. NERVE ENDINGS IN NUTRITIONAL MUSCULAR DYSTROPHY IN GUINEA PIGS. J Exp Med. 1931;54(2):167-9doi: 10.1084/jem.54.2.167.
Rogers, W. M., Pappenheimer, A. M., & Goettsch, M. (1931). NERVE ENDINGS IN NUTRITIONAL MUSCULAR DYSTROPHY IN GUINEA PIGS. The Journal of experimental medicine, 54(2), 167-9. https://doi.org/10.1084/jem.54.2.167
Rogers, W M, et al. "NERVE ENDINGS IN NUTRITIONAL MUSCULAR DYSTROPHY IN GUINEA PIGS." The Journal of experimental medicine vol. 54,2 (1931): 167-9. doi: https://doi.org/10.1084/jem.54.2.167
Rogers WM, Pappenheimer AM, Goettsch M. NERVE ENDINGS IN NUTRITIONAL MUSCULAR DYSTROPHY IN GUINEA PIGS. J Exp Med. 1931 Jul 31;54(2):167-9. doi: 10.1084/jem.54.2.167. PMID: 19869906; PMCID: PMC2131954.
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NUTRITIONAL MYOPATHY IN DUCKLINGS.

The Journal of experimental medicine

Pappenheimer AM, Goettsch M.
PMID: 19870229
J Exp Med. 1934 Jan 01;59(1):35-42. doi: 10.1084/jem.59.1.35.

Ducklings fed on a diet of skimmed milk powder, casein, corn-starch, lard, cod liver oil, yeast, salts and paper pulp rapidly develop a disease characterized by extreme and progressive myasthenia, ending in death within a few days. Pathological changes...

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Pappenheimer AM, Goettsch M. NUTRITIONAL MYOPATHY IN DUCKLINGS. J Exp Med. 1934;59(1):35-42doi: 10.1084/jem.59.1.35.
Pappenheimer, A. M., Goettsch, M. (1934). NUTRITIONAL MYOPATHY IN DUCKLINGS. The Journal of experimental medicine, 59(1), 35-42. https://doi.org/10.1084/jem.59.1.35
Pappenheimer, A M, et al. "NUTRITIONAL MYOPATHY IN DUCKLINGS." The Journal of experimental medicine vol. 59,1 (1934): 35-42. doi: https://doi.org/10.1084/jem.59.1.35
Pappenheimer AM, Goettsch M. NUTRITIONAL MYOPATHY IN DUCKLINGS. J Exp Med. 1934 Jan 01;59(1):35-42. doi: 10.1084/jem.59.1.35. PMID: 19870229; PMCID: PMC2132341.
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The new SFB/TRR219 Research Centre.

European heart journal

Noels H, Boor P, Goettsch C, Hohl M, Jahnen-Dechent W, Jankowski V, Kindermann I, Kramann R, Lehrke M, Linz D, Maack C, Niemeyer B, Roma LP, Schuett K, Speer T, Wagenpfeil S, Werner C, Zewinger S, Böhm M, Marx N, Floege J, Fliser D, Jankowski J.
PMID: 29579229
Eur Heart J. 2018 Mar 21;39(12):975-977. doi: 10.1093/eurheartj/ehy083.

No abstract available.

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Noels H, Boor P, Goettsch C, et al. The new SFB/TRR219 Research Centre. Eur Heart J. 2018;39(12):975-977doi: 10.1093/eurheartj/ehy083.
Noels, H., Boor, P., Goettsch, C., Hohl, M., Jahnen-Dechent, W., Jankowski, V., Kindermann, I., Kramann, R., Lehrke, M., Linz, D., Maack, C., Niemeyer, B., Roma, L. P., Schuett, K., Speer, T., Wagenpfeil, S., Werner, C., Zewinger, S., Böhm, M., Marx, N., Floege, J., Fliser, D., & Jankowski, J. (2018). The new SFB/TRR219 Research Centre. European heart journal, 39(12), 975-977. https://doi.org/10.1093/eurheartj/ehy083
Noels, Heidi, et al. "The new SFB/TRR219 Research Centre." European heart journal vol. 39,12 (2018): 975-977. doi: https://doi.org/10.1093/eurheartj/ehy083
Noels H, Boor P, Goettsch C, Hohl M, Jahnen-Dechent W, Jankowski V, Kindermann I, Kramann R, Lehrke M, Linz D, Maack C, Niemeyer B, Roma LP, Schuett K, Speer T, Wagenpfeil S, Werner C, Zewinger S, Böhm M, Marx N, Floege J, Fliser D, Jankowski J. The new SFB/TRR219 Research Centre. Eur Heart J. 2018 Mar 21;39(12):975-977. doi: 10.1093/eurheartj/ehy083. PMID: 29579229.
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Psychosocial stress promotes food intake and enhances the neuroenergetic level in men.

Stress (Amsterdam, Netherlands)

Kistenmacher A, Goetsch J, Ullmann D, Wardzinski EK, Melchert UH, Jauch-Chara K, Oltmanns KM.
PMID: 29969341
Stress. 2018 Nov;21(6):538-547. doi: 10.1080/10253890.2018.1485645. Epub 2018 Jul 03.

Psychosocial stress may lead to increased food consumption and overweight. In turn, obesity is related to reduced brain energy content. We hypothesized that psychosocial stress influencing food intake may alter the neuroenergetic status in the human brain. We tested...

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Kistenmacher A, Goetsch J, Ullmann D, et al. Psychosocial stress promotes food intake and enhances the neuroenergetic level in men. Stress. 2018;21(6):538-547doi: 10.1080/10253890.2018.1485645.
Kistenmacher, A., Goetsch, J., Ullmann, D., Wardzinski, E. K., Melchert, U. H., Jauch-Chara, K., & Oltmanns, K. M. (2018). Psychosocial stress promotes food intake and enhances the neuroenergetic level in men. Stress (Amsterdam, Netherlands), 21(6), 538-547. https://doi.org/10.1080/10253890.2018.1485645
Kistenmacher, Alina, et al. "Psychosocial stress promotes food intake and enhances the neuroenergetic level in men." Stress (Amsterdam, Netherlands) vol. 21,6 (2018): 538-547. doi: https://doi.org/10.1080/10253890.2018.1485645
Kistenmacher A, Goetsch J, Ullmann D, Wardzinski EK, Melchert UH, Jauch-Chara K, Oltmanns KM. Psychosocial stress promotes food intake and enhances the neuroenergetic level in men. Stress. 2018 Nov;21(6):538-547. doi: 10.1080/10253890.2018.1485645. Epub 2018 Jul 03. PMID: 29969341.
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Exploring the opportunities for alignment of regulatory postauthorization requirements and data required for performance-based managed entry agreements.

International journal of technology assessment in health care

Eichler HG, Adams R, Andreassen E, Arlett P, van de Casteele M, Chapman SJ, Goettsch WG, Martinsson JL, Llinares-Garcia J, Nachtnebel A, Pean E, Rasi G, Reksten TR, Timmers L, Vreman RA, van de Vijver I, Wenzl M.
PMID: 34424152
Int J Technol Assess Health Care. 2021 Aug 23;37(1):e83. doi: 10.1017/S026646232100057X.

Performance-based managed entry agreements (PB-MEAs) might allow patient access to new medicines, but practical hurdles make competent authorities for pricing and reimbursement (CAPR) reluctant to implement PB-MEAs. We explored if the feasibility of PB-MEAs might improve by better aligning...

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Eichler HG, Adams R, Andreassen E, et al. Exploring the opportunities for alignment of regulatory postauthorization requirements and data required for performance-based managed entry agreements. Int J Technol Assess Health Care. 2021;37(1):e83doi: 10.1017/S026646232100057X.
Eichler, H. G., Adams, R., Andreassen, E., Arlett, P., van de Casteele, M., Chapman, S. J., Goettsch, W. G., Martinsson, J. L., Llinares-Garcia, J., Nachtnebel, A., Pean, E., Rasi, G., Reksten, T. R., Timmers, L., Vreman, R. A., van de Vijver, I., & Wenzl, M. (2021). Exploring the opportunities for alignment of regulatory postauthorization requirements and data required for performance-based managed entry agreements. International journal of technology assessment in health care, 37(1), e83. https://doi.org/10.1017/S026646232100057X
Eichler, Hans-Georg, et al. "Exploring the opportunities for alignment of regulatory postauthorization requirements and data required for performance-based managed entry agreements." International journal of technology assessment in health care vol. 37,1 (2021): e83. doi: https://doi.org/10.1017/S026646232100057X
Eichler HG, Adams R, Andreassen E, Arlett P, van de Casteele M, Chapman SJ, Goettsch WG, Martinsson JL, Llinares-Garcia J, Nachtnebel A, Pean E, Rasi G, Reksten TR, Timmers L, Vreman RA, van de Vijver I, Wenzl M. Exploring the opportunities for alignment of regulatory postauthorization requirements and data required for performance-based managed entry agreements. Int J Technol Assess Health Care. 2021 Aug 23;37(1):e83. doi: 10.1017/S026646232100057X. PMID: 34424152.
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NDMA analytics in metformin products: Comparison of methods and pitfalls.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Fritzsche M, Blom G, Keitel J, Goettsche A, Seegel M, Leicht S, Guessregen B, Hickert S, Reifenberg P, Cimelli A, Baranowski R, Desmartin E, Barrau E, Harrison M, Bristow T, O'Neill N, Kirsch A, Krueger P, Saal C, Mouton B, Schlingemann J.
PMID: 34597792
Eur J Pharm Sci. 2021 Sep 29;168:106026. doi: 10.1016/j.ejps.2021.106026. Epub 2021 Sep 29.

BACKGROUND: For nearly three years, the concerns regarding trace levels of N-nitrosamines in pharmaceuticals and the associated cancer risk have significantly expanded and are a major issue facing the global pharmaceutical industry. N-nitrosodimethylamine (NDMA) found in formulations of the...

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Fritzsche M, Blom G, Keitel J, et al. NDMA analytics in metformin products: Comparison of methods and pitfalls. Eur J Pharm Sci. 2021;168:106026doi: 10.1016/j.ejps.2021.106026.
Fritzsche, M., Blom, G., Keitel, J., Goettsche, A., Seegel, M., Leicht, S., Guessregen, B., Hickert, S., Reifenberg, P., Cimelli, A., Baranowski, R., Desmartin, E., Barrau, E., Harrison, M., Bristow, T., O'Neill, N., Kirsch, A., Krueger, P., Saal, C., Mouton, B., & Schlingemann, J. (2021). NDMA analytics in metformin products: Comparison of methods and pitfalls. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 168106026. https://doi.org/10.1016/j.ejps.2021.106026
Fritzsche, Matthias, et al. "NDMA analytics in metformin products: Comparison of methods and pitfalls." European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences vol. 168 (2021): 106026. doi: https://doi.org/10.1016/j.ejps.2021.106026
Fritzsche M, Blom G, Keitel J, Goettsche A, Seegel M, Leicht S, Guessregen B, Hickert S, Reifenberg P, Cimelli A, Baranowski R, Desmartin E, Barrau E, Harrison M, Bristow T, O'Neill N, Kirsch A, Krueger P, Saal C, Mouton B, Schlingemann J. NDMA analytics in metformin products: Comparison of methods and pitfalls. Eur J Pharm Sci. 2021 Sep 29;168:106026. doi: 10.1016/j.ejps.2021.106026. Epub 2021 Sep 29. PMID: 34597792.
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Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies.

Drug discovery today

Wang T, McAuslane N, Gardarsdottir H, Goettsch WG, Leufkens HGM.
PMID: 34597755
Drug Discov Today. 2022 Jan;27(1):347-353. doi: 10.1016/j.drudis.2021.09.014. Epub 2021 Sep 28.

There is a growing trend for pharmaceutical companies to seek scientific advice on drug development from a Health Technology Assessment (HTA) perspective, to improve the efficiency of their studies, enable better trial design, and support the goals of positive...

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Wang T, McAuslane N, Gardarsdottir H, et al. Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies. Drug Discov Today. 2021;27(1):347-353doi: 10.1016/j.drudis.2021.09.014.
Wang, T., McAuslane, N., Gardarsdottir, H., Goettsch, W. G., & Leufkens, H. G. M. (2022). Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies. Drug discovery today, 27(1), 347-353. https://doi.org/10.1016/j.drudis.2021.09.014
Wang, Ting, et al. "Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies." Drug discovery today vol. 27,1 (2022): 347-353. doi: https://doi.org/10.1016/j.drudis.2021.09.014
Wang T, McAuslane N, Gardarsdottir H, Goettsch WG, Leufkens HGM. Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies. Drug Discov Today. 2022 Jan;27(1):347-353. doi: 10.1016/j.drudis.2021.09.014. Epub 2021 Sep 28. PMID: 34597755.
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A 96-Channel Electrophysiology Catheter with Integrated Read-Out ASIC and Optical Link.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Frank A, Kootte B, Gottsche T, Jutte P, Schleipen J, Henneken V, van der Mark M, Bihler E, Dijkstra P, Anders J, Burghartz J.
PMID: 34891531
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1336-1340. doi: 10.1109/EMBC46164.2021.9629996.

This paper describes a realization of an electrophysiology (EP) catheter with 96 electrodes which requires no electrical wiring to the outside by relying on an optical link for both power supply and data communication. The catheter tip is constructed...

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Frank A, Kootte B, Gottsche T, et al. A 96-Channel Electrophysiology Catheter with Integrated Read-Out ASIC and Optical Link. Annu Int Conf IEEE Eng Med Biol Soc. 2021;2021:1336-1340doi: 10.1109/EMBC46164.2021.9629996.
Frank, A., Kootte, B., Gottsche, T., Jutte, P., Schleipen, J., Henneken, V., van der Mark, M., Bihler, E., Dijkstra, P., Anders, J., & Burghartz, J. (2021). A 96-Channel Electrophysiology Catheter with Integrated Read-Out ASIC and Optical Link. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 20211336-1340. https://doi.org/10.1109/EMBC46164.2021.9629996
Frank, Alexander, et al. "A 96-Channel Electrophysiology Catheter with Integrated Read-Out ASIC and Optical Link." Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference vol. 2021 (2021): 1336-1340. doi: https://doi.org/10.1109/EMBC46164.2021.9629996
Frank A, Kootte B, Gottsche T, Jutte P, Schleipen J, Henneken V, van der Mark M, Bihler E, Dijkstra P, Anders J, Burghartz J. A 96-Channel Electrophysiology Catheter with Integrated Read-Out ASIC and Optical Link. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1336-1340. doi: 10.1109/EMBC46164.2021.9629996. PMID: 34891531.
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Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7.

Microorganisms

Widera M, Mühlemann B, Corman VM, Toptan T, Beheim-Schwarzbach J, Kohmer N, Schneider J, Berger A, Veith T, Pallas C, Bleicker T, Goetsch U, Tesch J, Gottschalk R, Jones TC, Ciesek S, Drosten C.
PMID: 33918332
Microorganisms. 2021 Apr 02;9(4). doi: 10.3390/microorganisms9040748.

BACKGROUND: International travel is a major driver of the introduction and spread of SARS-CoV-2.AIM: To investigate SARS-CoV-2 genetic diversity in the region of a major transport hub in Germany, we characterized the viral sequence diversity of the SARS-CoV-2 variants...

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Widera M, Mühlemann B, Corman VM, et al. Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7. Microorganisms. 2021;9(4)doi: 10.3390/microorganisms9040748.
Widera, M., Mühlemann, B., Corman, V. M., Toptan, T., Beheim-Schwarzbach, J., Kohmer, N., Schneider, J., Berger, A., Veith, T., Pallas, C., Bleicker, T., Goetsch, U., Tesch, J., Gottschalk, R., Jones, T. C., Ciesek, S., & Drosten, C. (2021). Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7. Microorganisms, 9(4), . https://doi.org/10.3390/microorganisms9040748
Widera, Marek, et al. "Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7." Microorganisms vol. 9,4 (2021). doi: https://doi.org/10.3390/microorganisms9040748
Widera M, Mühlemann B, Corman VM, Toptan T, Beheim-Schwarzbach J, Kohmer N, Schneider J, Berger A, Veith T, Pallas C, Bleicker T, Goetsch U, Tesch J, Gottschalk R, Jones TC, Ciesek S, Drosten C. Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7. Microorganisms. 2021 Apr 02;9(4). doi: 10.3390/microorganisms9040748. PMID: 33918332; PMCID: PMC8065810.
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