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Showing 1 to 10 of 10 entries
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The Secretome of Hydrogel-Coembedded Endothelial Progenitor Cells and Mesenchymal Stem Cells Instructs Macrophage Polarization in Endotoxemia.

Stem cells translational medicine

Zullo JA, Nadel EP, Rabadi MM, Baskind MJ, Rajdev MA, Demaree CM, Vasko R, Chugh SS, Lamba R, Goligorsky MS, Ratliff BB.
PMID: 25947337
Stem Cells Transl Med. 2015 Jul;4(7):852-61. doi: 10.5966/sctm.2014-0111. Epub 2015 May 06.

UNLABELLED: : We previously reported the delivery of endothelial progenitor cells (EPCs) embedded in hyaluronic acid-based (HA)-hydrogels protects renal function during acute kidney injury (AKI) and promotes angiogenesis. We attempted to further ameliorate renal dysfunction by coembedding EPCs with...

Urinary proteomic analysis of chronic allograft nephropathy.

Proteomics. Clinical applications

O'Riordan E, Orlova TN, Mendelev N, Patschan D, Kemp R, Chander PN, Hu R, Hao G, Gross SS, Iozzo RV, Delaney V, Goligorsky MS.
PMID: 21136903
Proteomics Clin Appl. 2008 Jul;2(7):1025-35. doi: 10.1002/prca.200780137.

The pathogenesis of progressive renal allograft injury, which is termed chronic allograft nephropathy (CAN), remains obscure and is currently defined by histology. Prospective protocol-biopsy trials have demonstrated that clinical and standard laboratory tests are insufficiently sensitive indicators of the...

Perioperative implication of the endothelial glycocalyx.

Korean journal of anesthesiology

Song JW, Goligorsky MS.
PMID: 29619781
Korean J Anesthesiol. 2018 Apr;71(2):92-102. doi: 10.4097/kjae.2018.71.2.92. Epub 2018 Apr 02.

The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recently, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial...

PREMATURE VASCULAR SENESCENCE IN METABOLIC SYNDROME: COULD IT BE PREVENTED AND REVERSED BY A SELENORGANIC ANTIOXIDANT AND PEROXYNITRITE SCAVENGER EBSELEN?.

Drug discovery today. Therapeutic strategies

Chen J, Park HC, Patschan S, Brodsky SV, Gealikman O, Kuo MC, Li H, Addabbo F, Zhang F, Nasjletti A, Gross SS, Goligorsky MS.
PMID: 18496595
Drug Discov Today Ther Strateg. 2007;4(1):93-99. doi: 10.1016/j.ddstr.2007.10.006.

No abstract available.

Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat.

Frontiers in physiology

Lipphardt M, Dihazi H, Müller GA, Goligorsky MS.
PMID: 30298020
Front Physiol. 2018 Sep 21;9:1325. doi: 10.3389/fphys.2018.01325. eCollection 2018.

Sirtuins (SIRT) are ubiquitous histone and protein deacetylases and a member of this family, SIRT1, is the best-studied one. Its functions in endothelial cells encompass branching angiogenesis, activation of endothelial nitric oxide synthase, regulation of proapoptotic and proinflammatory pathways,...

Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool.

Aging

Yasuda K, Khandare A, Burianovskyy L, Maruyama S, Zhang F, Nasjletti A, Goligorsky MS.
PMID: 21705809
Aging (Albany NY). 2011 Jun;3(6):597-608. doi: 10.18632/aging.100341.

Although therapeutic effect of adoptive transfer of endothelial progenitor cells (EPC) has been well-substantiated, the actual engraftment is relatively low compared to a robust functional improvement of vasculopathy. Cellular mechanisms governing this action remain elusive. A recently discovered cell-cell...

Biomechanical properties of endothelial glycocalyx: An imperfect pendulum.

Matrix biology plus

Jiang XZ, Goligorsky MS.
PMID: 34820618
Matrix Biol Plus. 2021 Oct 21;12:100087. doi: 10.1016/j.mbplus.2021.100087. eCollection 2021 Dec.

Endothelial glycocalyx plays a crucial role in hemodynamics in health and disease, yet studying it is met by multiple technical hindrances. We attempted to outline our views on some biomechanical properties of endothelial glycocalyx, which are potentially amenable to...

Charting the course of renal cryoinjury.

Physiological reports

Abdulmahdi W, Zullo J, Nesi L, Goligorksy MS, Ratliff BB.
PMID: 25896979
Physiol Rep. 2015 Apr;3(4). doi: 10.14814/phy2.12357.

We sought to characterize a minor renal cryoinjury that allows investigation into renal damage processes and subsequent endogenous repair mechanisms. To achieve this, we induced a small cryoinjury to mice, in which the transient superficial application of a liquid...

The ins and outs of endothelial dysfunction: much ado about NO-thing.

Drug news & perspectives

Goligorsky MS, Gross SS.
PMID: 12819819
Drug News Perspect. 2001 Apr;14(3):133-42.

This article presents data linking eNOS function and nitric oxide (NO) generation or availability to vascular remodeling and signaling, hyperlipidemias, advanced glycated end products and hyperglycemia. These data should be viewed within the broader framework of endothelial cell dysfunction...

Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold.

Kidney research and clinical practice

Goligorsky MS.
PMID: 26484026
Kidney Res Clin Pract. 2015 Jun;34(2):76-82. doi: 10.1016/j.krcp.2015.05.003. Epub 2015 Jun 04.

Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview of ECD in CKD scans two decades...

Showing 1 to 10 of 10 entries