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"Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy.

Journal of the peripheral nervous system : JPNS

Conceição I, González-Duarte A, Obici L, Schmidt HH, Simoneau D, Ong ML, Amass L.
PMID: 26663427
J Peripher Nerv Syst. 2016 Mar;21(1):5-9. doi: 10.1111/jns.12153.

Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare, progressive, life-threatening, hereditary disorder caused by mutations in the transthyretin gene and characterized by extracellular deposition of transthyretin-derived amyloid fibrils in peripheral and autonomic nerves, heart, and other organs. TTR-FAP is...

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Conceição I, González-Duarte A, Obici L, et al. "Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016;21(1):5-9doi: 10.1111/jns.12153.
Conceição, I., González-Duarte, A., Obici, L., Schmidt, H. H., Simoneau, D., Ong, M. L., & Amass, L. (2016). "Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy. Journal of the peripheral nervous system : JPNS, 21(1), 5-9. https://doi.org/10.1111/jns.12153
Conceição, Isabel, et al. ""Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy." Journal of the peripheral nervous system : JPNS vol. 21,1 (2016): 5-9. doi: https://doi.org/10.1111/jns.12153
Conceição I, González-Duarte A, Obici L, Schmidt HH, Simoneau D, Ong ML, Amass L. "Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016 Mar;21(1):5-9. doi: 10.1111/jns.12153. PMID: 26663427; PMCID: PMC4788142.
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Solid-State (109)Ag NMR: A Sensitive Environmental Probe for Silver Thiolates.

Inorganic chemistry

Fijolek HG, Oriskovich TA, Benesi AJ, González-Duarte P, Natan MJ.
PMID: 11666245
Inorg Chem. 1996 Feb 14;35(4):797-799. doi: 10.1021/ic950824v.

No abstract available.

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Fijolek HG, Oriskovich TA, Benesi AJ, et al. Solid-State (109)Ag NMR: A Sensitive Environmental Probe for Silver Thiolates. Inorg Chem. 1996;35(4):797-799doi: 10.1021/ic950824v.
Fijolek, H. G., Oriskovich, T. A., Benesi, A. J., González-Duarte, P., & Natan, M. J. (1996). Solid-State (109)Ag NMR: A Sensitive Environmental Probe for Silver Thiolates. Inorganic chemistry, 35(4), 797-799. https://doi.org/10.1021/ic950824v
Fijolek, Hilary G., et al. "Solid-State (109)Ag NMR: A Sensitive Environmental Probe for Silver Thiolates." Inorganic chemistry vol. 35,4 (1996): 797-799. doi: https://doi.org/10.1021/ic950824v
Fijolek HG, Oriskovich TA, Benesi AJ, González-Duarte P, Natan MJ. Solid-State (109)Ag NMR: A Sensitive Environmental Probe for Silver Thiolates. Inorg Chem. 1996 Feb 14;35(4):797-799. doi: 10.1021/ic950824v. PMID: 11666245.
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Diverse evolution of [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 2, 3) metalloligands in CH(2)Cl(2).

Inorganic chemistry

Mas-Ballesté R, Capdevila M, Champkin PA, Clegg W, Coxall RA, Lledós A, Mégret C, González-Duarte P.
PMID: 12055001
Inorg Chem. 2002 Jun 17;41(12):3218-29. doi: 10.1021/ic0107173.

The nucleophilicity of the [Pt(2)S(2)] core in [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 3, dppp (1); n = 2, dppe (2)) metalloligands toward the CH(2)Cl(2) solvent has been thoroughly studied. Complex 1, which has been obtained and characterized by X-ray diffraction, is...

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Mas-Ballesté R, Capdevila M, Champkin PA, et al. Diverse evolution of [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 2, 3) metalloligands in CH(2)Cl(2). Inorg Chem. 2002;41(12):3218-29doi: 10.1021/ic0107173.
Mas-Ballesté, R., Capdevila, M., Champkin, P. A., Clegg, W., Coxall, R. A., Lledós, A., Mégret, C., & González-Duarte, P. (2002). Diverse evolution of [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 2, 3) metalloligands in CH(2)Cl(2). Inorganic chemistry, 41(12), 3218-29. https://doi.org/10.1021/ic0107173
Mas-Ballesté, Rubén, et al. "Diverse evolution of [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 2, 3) metalloligands in CH(2)Cl(2)." Inorganic chemistry vol. 41,12 (2002): 3218-29. doi: https://doi.org/10.1021/ic0107173
Mas-Ballesté R, Capdevila M, Champkin PA, Clegg W, Coxall RA, Lledós A, Mégret C, González-Duarte P. Diverse evolution of [[Ph(2)P(CH(2))(n)PPh(2)]Pt(mu-S)(2)Pt[Ph(2)P(CH(2))(n)PPh(2)]] (n = 2, 3) metalloligands in CH(2)Cl(2). Inorg Chem. 2002 Jun 17;41(12):3218-29. doi: 10.1021/ic0107173. PMID: 12055001.
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Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn(7)-complex by capillary zone electrophoresis with electrospray MS detection.

Talanta

Połeć Pawlak K, Palacios O, Capdevila M, González-Duarte P, Lobiński R.
PMID: 18968706
Talanta. 2002 Jul 03;57(5):1011-7.

A solution of a Zn-complex of recombinant mouse MT-1 isoform (Zn(7)-MT-1) was prepared and titrated with Cd(2+) ions. A method based on the coupling of capillary zone electrophoresis (CZE) with electrospray MS detection was developed for the analysis of...

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Połeć Pawlak K, Palacios O, Capdevila M, et al. Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn(7)-complex by capillary zone electrophoresis with electrospray MS detection. Talanta. 2002;57(5):1011-7
Połeć Pawlak, K., Palacios, O., Capdevila, M., González-Duarte, P., & Lobiński, R. (2002). Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn(7)-complex by capillary zone electrophoresis with electrospray MS detection. Talanta, 57(5), 1011-7.
Połeć Pawlak, Kasia, et al. "Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn(7)-complex by capillary zone electrophoresis with electrospray MS detection." Talanta vol. 57,5 (2002): 1011-7.
Połeć Pawlak K, Palacios O, Capdevila M, González-Duarte P, Lobiński R. Monitoring of the metal displacement from the recombinant mouse liver metallothionein Zn(7)-complex by capillary zone electrophoresis with electrospray MS detection. Talanta. 2002 Jul 03;57(5):1011-7. PMID: 18968706.
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The evolution of [[Ph2P(CH2)nPPh2]Pt(mu-S)2Pt[Ph2P(CH2)nPPh2]] (n=2, 3) metalloligands in protic acids: a cascade of sequential reactions.

Chemistry (Weinheim an der Bergstrasse, Germany)

Mas-Ballesté R, Aullón G, Champkin PA, Clegg W, Mégret C, González-Duarte P, Lledós A.
PMID: 14562320
Chemistry. 2003 Oct 17;9(20):5023-35. doi: 10.1002/chem.200304983.

Given the nucleophilicity of the [Pt(2)S(2)] ring, the evolution of [Pt(2)(mu-S)(2)(P intersection P)(2)] (P intersection P=1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp)) metalloligands in the presence of the simplest electrophilic species, the proton, has been studied. Combined use of experimental and theoretical...

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Mas-Ballesté R, Aullón G, Champkin PA, et al. The evolution of [[Ph2P(CH2)nPPh2]Pt(mu-S)2Pt[Ph2P(CH2)nPPh2]] (n=2, 3) metalloligands in protic acids: a cascade of sequential reactions. Chemistry. 2003;9(20):5023-35doi: 10.1002/chem.200304983.
Mas-Ballesté, R., Aullón, G., Champkin, P. A., Clegg, W., Mégret, C., González-Duarte, P., & Lledós, A. (2003). The evolution of [[Ph2P(CH2)nPPh2]Pt(mu-S)2Pt[Ph2P(CH2)nPPh2]] (n=2, 3) metalloligands in protic acids: a cascade of sequential reactions. Chemistry (Weinheim an der Bergstrasse, Germany), 9(20), 5023-35. https://doi.org/10.1002/chem.200304983
Mas-Ballesté, Rubén, et al. "The evolution of [[Ph2P(CH2)nPPh2]Pt(mu-S)2Pt[Ph2P(CH2)nPPh2]] (n=2, 3) metalloligands in protic acids: a cascade of sequential reactions." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 9,20 (2003): 5023-35. doi: https://doi.org/10.1002/chem.200304983
Mas-Ballesté R, Aullón G, Champkin PA, Clegg W, Mégret C, González-Duarte P, Lledós A. The evolution of [[Ph2P(CH2)nPPh2]Pt(mu-S)2Pt[Ph2P(CH2)nPPh2]] (n=2, 3) metalloligands in protic acids: a cascade of sequential reactions. Chemistry. 2003 Oct 17;9(20):5023-35. doi: 10.1002/chem.200304983. PMID: 14562320.
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Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions.

Chemical communications (Cambridge, England)

Nova A, Mas-Ballesté R, Ujaque G, González-Duarte P, Lledós A.
PMID: 18594718
Chem Commun (Camb). 2008 Jul 21;(27):3130-2. doi: 10.1039/b801889h. Epub 2008 Apr 29.

The high nucleophilicity of the sulfur atoms in [Pt(2)(dppp)(2)(micro-S)(2)] triggers a C-F activation process in 1,3-difluoro-2-propanol that leads to the [Pt(2)(dppp)(2)(micro-S)(micro-SCH(2)CH(OH)CH(2)F]F product through a S(N)2 mechanism, where the O-HF hydrogen bond established from the alcohol group of the organic...

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Nova A, Mas-Ballesté R, Ujaque G, et al. Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions. Chem Commun (Camb). 2008;(27):3130-2doi: 10.1039/b801889h.
Nova, A., Mas-Ballesté, R., Ujaque, G., González-Duarte, P., & Lledós, A. (2008). Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions. Chemical communications (Cambridge, England), (27), 3130-2. https://doi.org/10.1039/b801889h
Nova, Ainara, et al. "Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions." Chemical communications (Cambridge, England) vol. ,27 (2008): 3130-2. doi: https://doi.org/10.1039/b801889h
Nova A, Mas-Ballesté R, Ujaque G, González-Duarte P, Lledós A. Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions. Chem Commun (Camb). 2008 Jul 21;(27):3130-2. doi: 10.1039/b801889h. Epub 2008 Apr 29. PMID: 18594718.
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Aromatic C-F activation by complexes containing the {Pt2S2} core via nucleophilic substitution: a combined experimental and theoretical study.

Dalton transactions (Cambridge, England : 2003)

Nova A, Mas-Ballesté R, Ujaque G, González-Duarte P, Lledós A.
PMID: 19623398
Dalton Trans. 2009 Aug 14;(30):5980-8. doi: 10.1039/b901697j. Epub 2009 May 27.

The C-F bond activation of perfluorobenzene and perfluoropyridine have been achieved by means of the complex [Pt(2)(mu-S)(2)(dppp)(2)], where dppp denotes 1,3-bis(diphenylphosphino)propane. The reaction with the first substrate requires a long time (five days) and high temperature (reflux in toluene)...

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Nova A, Mas-Ballesté R, Ujaque G, et al. Aromatic C-F activation by complexes containing the {Pt2S2} core via nucleophilic substitution: a combined experimental and theoretical study. Dalton Trans. 2009;(30):5980-8doi: 10.1039/b901697j.
Nova, A., Mas-Ballesté, R., Ujaque, G., González-Duarte, P., & Lledós, A. (2009). Aromatic C-F activation by complexes containing the {Pt2S2} core via nucleophilic substitution: a combined experimental and theoretical study. Dalton transactions (Cambridge, England : 2003), (30), 5980-8. https://doi.org/10.1039/b901697j
Nova, Ainara, et al. "Aromatic C-F activation by complexes containing the {Pt2S2} core via nucleophilic substitution: a combined experimental and theoretical study." Dalton transactions (Cambridge, England : 2003) vol. ,30 (2009): 5980-8. doi: https://doi.org/10.1039/b901697j
Nova A, Mas-Ballesté R, Ujaque G, González-Duarte P, Lledós A. Aromatic C-F activation by complexes containing the {Pt2S2} core via nucleophilic substitution: a combined experimental and theoretical study. Dalton Trans. 2009 Aug 14;(30):5980-8. doi: 10.1039/b901697j. Epub 2009 May 27. PMID: 19623398.
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Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient.

Enfermedades infecciosas y microbiologia clinica (English ed.)

Tristán-Samaniego DP, García-Grimshaw M, Jiménez-Ruiz A, González-Duarte A.
PMID: 33353773
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Dec 19; doi: 10.1016/j.eimc.2020.10.008. Epub 2020 Dec 19.

No abstract available.

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Tristán-Samaniego DP, García-Grimshaw M, Jiménez-Ruiz A, et al. Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient. Enferm Infecc Microbiol Clin (Engl Ed). 2020;doi: 10.1016/j.eimc.2020.10.008.
Tristán-Samaniego, D. P., García-Grimshaw, M., Jiménez-Ruiz, A., & González-Duarte, A. (2020). Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient. Enfermedades infecciosas y microbiologia clinica (English ed.), . https://doi.org/10.1016/j.eimc.2020.10.008
Tristán-Samaniego, Dioselina Panamá, et al. "Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient." Enfermedades infecciosas y microbiologia clinica (English ed.) vol. (2020). doi: https://doi.org/10.1016/j.eimc.2020.10.008
Tristán-Samaniego DP, García-Grimshaw M, Jiménez-Ruiz A, González-Duarte A. Brain and spinal cord abscesses caused by Mycobacterium mucogenicum in an immunocompetent patient. Enferm Infecc Microbiol Clin (Engl Ed). 2020 Dec 19; doi: 10.1016/j.eimc.2020.10.008. Epub 2020 Dec 19. Spanish. PMID: 33353773.
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Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis.

Cureus

Garcia-Grimshaw MA, Gutierrez-Manjarrez FA, Gonzalez-Duarte A.
PMID: 30159215
Cureus. 2018 Jun 27;10(6):e2889. doi: 10.7759/cureus.2889.

Conduction aphasia being the arcuate fasciculus of the site of structural injury is a speech disorder characterized by fluent, spontaneous speech and paraphasias, intact auditory comprehension, and limited repetition. One of the causes of stroke in young adults is...

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Garcia-Grimshaw MA, Gutierrez-Manjarrez FA, Gonzalez-Duarte A. Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. Cureus. 2018;10(6):e2889doi: 10.7759/cureus.2889.
Garcia-Grimshaw, M. A., Gutierrez-Manjarrez, F. A., & Gonzalez-Duarte, A. (2018). Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. Cureus, 10(6), e2889. https://doi.org/10.7759/cureus.2889
Garcia-Grimshaw, Miguel A, et al. "Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis." Cureus vol. 10,6 (2018): e2889. doi: https://doi.org/10.7759/cureus.2889
Garcia-Grimshaw MA, Gutierrez-Manjarrez FA, Gonzalez-Duarte A. Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. Cureus. 2018 Jun 27;10(6):e2889. doi: 10.7759/cureus.2889. PMID: 30159215; PMCID: PMC6110626.
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Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy.

Neurology and therapy

González-Duarte A, Conceição I, Amass L, Botteman MF, Carter JA, Stewart M.
PMID: 32232748
Neurol Ther. 2020 Jun;9(1):135-149. doi: 10.1007/s40120-020-00183-7. Epub 2020 Mar 31.

INTRODUCTION: Hereditary (variant) transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTR-PN) is a rare genetic disorder that causes progressive autonomic and sensorimotor neuropathy, severe disability, and death within 10 years of onset. Previous studies have primarily focused on how baseline cardiac...

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González-Duarte A, Conceição I, Amass L, et al. Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy. Neurol Ther. 2020;9(1):135-149doi: 10.1007/s40120-020-00183-7.
González-Duarte, A., Conceição, I., Amass, L., Botteman, M. F., Carter, J. A., & Stewart, M. (2020). Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy. Neurology and therapy, 9(1), 135-149. https://doi.org/10.1007/s40120-020-00183-7
González-Duarte, Alejandra, et al. "Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy." Neurology and therapy vol. 9,1 (2020): 135-149. doi: https://doi.org/10.1007/s40120-020-00183-7
González-Duarte A, Conceição I, Amass L, Botteman MF, Carter JA, Stewart M. Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy. Neurol Ther. 2020 Jun;9(1):135-149. doi: 10.1007/s40120-020-00183-7. Epub 2020 Mar 31. PMID: 32232748; PMCID: PMC7229108.
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TRANSTHYRETIN AMYLOIDOSIS THERAPIES: GUIDING THE FUTURE.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

González-Duarte A.
PMID: 34609369
Rev Invest Clin. 2021;73(5):310-315. doi: 10.24875/RIC.21000323.

Transthyretin (TTR) amyloidosis (ATTR) is a progressive condition characterized by multiorgan accumulation of amyloid deposits composed of transthyretin (TTR) fibrils. Over the past decades, despite being a rare disease, ATTR amyloidosis has enabled top-tier therapeutics. In the 90s, organ...

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González-Duarte A. TRANSTHYRETIN AMYLOIDOSIS THERAPIES: GUIDING THE FUTURE. Rev Invest Clin. 2021;73(5):310-315doi: 10.24875/RIC.21000323.
González-Duarte, A. (2021). TRANSTHYRETIN AMYLOIDOSIS THERAPIES: GUIDING THE FUTURE. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 73(5), 310-315. https://doi.org/10.24875/RIC.21000323
González-Duarte, Alejandra. "TRANSTHYRETIN AMYLOIDOSIS THERAPIES: GUIDING THE FUTURE." Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion vol. 73,5 (2021): 310-315. doi: https://doi.org/10.24875/RIC.21000323
González-Duarte A. TRANSTHYRETIN AMYLOIDOSIS THERAPIES: GUIDING THE FUTURE. Rev Invest Clin. 2021;73(5):310-315. doi: 10.24875/RIC.21000323. PMID: 34609369.
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Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

González-Duarte A, Kaufer-Horwitz M, Aguilar-Salinas CA.
PMID: 33053578
Rev Invest Clin. 2020 May 07;72(5):265-270. doi: 10.24875/RIC.20000258. Epub 2020 May 07.

As all other aspects in times of the coronavirus disease (COVID)-19 pandemic, carrying-out quality clinical research has been challenging. Many well-established paradigms have shifted as a consequence of the rapid demand for new knowledge. New treatments are fast-moving, informed...

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González-Duarte A, Kaufer-Horwitz M, Aguilar-Salinas CA. Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies. Rev Invest Clin. 2020;72(5):265-270doi: 10.24875/RIC.20000258.
González-Duarte, A., Kaufer-Horwitz, M., & Aguilar-Salinas, C. A. (2020). Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 72(5), 265-270. https://doi.org/10.24875/RIC.20000258
González-Duarte, Alejandra, et al. "Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies." Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion vol. 72,5 (2020): 265-270. doi: https://doi.org/10.24875/RIC.20000258
González-Duarte A, Kaufer-Horwitz M, Aguilar-Salinas CA. Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies. Rev Invest Clin. 2020 May 07;72(5):265-270. doi: 10.24875/RIC.20000258. Epub 2020 May 07. PMID: 33053578.
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