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Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.

Pharmaceutics

Löhr JM, Haas SL, Kröger JC, Friess HM, Höft R, Goretzki PE, Peschel C, Schweigert M, Salmons B, Gunzburg WH.
PMID: 25116885
Pharmaceutics. 2014 Aug 11;6(3):447-66. doi: 10.3390/pharmaceutics6030447.

Despite progress in the treatment of pancreatic cancer, there is still a need for improved therapies. In this manuscript, we report clinical experience with a new therapy for the treatment of pancreatic cancer involving the implantation of encapsulated cells...

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Löhr JM, Haas SL, Kröger JC, et al. Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer. Pharmaceutics. 2014;6(3):447-66doi: 10.3390/pharmaceutics6030447.
Löhr, J. M., Haas, S. L., Kröger, J. C., Friess, H. M., Höft, R., Goretzki, P. E., Peschel, C., Schweigert, M., Salmons, B., & Gunzburg, W. H. (2014). Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer. Pharmaceutics, 6(3), 447-66. https://doi.org/10.3390/pharmaceutics6030447
Löhr, J Matthias, et al. "Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer." Pharmaceutics vol. 6,3 (2014): 447-66. doi: https://doi.org/10.3390/pharmaceutics6030447
Löhr JM, Haas SL, Kröger JC, Friess HM, Höft R, Goretzki PE, Peschel C, Schweigert M, Salmons B, Gunzburg WH. Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer. Pharmaceutics. 2014 Aug 11;6(3):447-66. doi: 10.3390/pharmaceutics6030447. PMID: 25116885; PMCID: PMC4190529.
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Photochemical hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr(VI).

Langmuir : the ACS journal of surfaces and colloids

Boiadjiev VI, Brown GM, Pinnaduwage LA, Goretzki G, Bonnesen PV, Thundat T.
PMID: 15697249
Langmuir. 2005 Feb 15;21(4):1139-42. doi: 10.1021/la047852n.

We report a novel approach to the design and development of microcantilever sensors in which photochemical hydrosilylation is used to modify the microcantilever surface. This process enables individual microcantilevers in multicantilever array chips to be modified separately by focusing...

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Boiadjiev VI, Brown GM, Pinnaduwage LA, et al. Photochemical hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr(VI). Langmuir. 2005;21(4):1139-42doi: 10.1021/la047852n.
Boiadjiev, V. I., Brown, G. M., Pinnaduwage, L. A., Goretzki, G., Bonnesen, P. V., & Thundat, T. (2005). Photochemical hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr(VI). Langmuir : the ACS journal of surfaces and colloids, 21(4), 1139-42. https://doi.org/10.1021/la047852n
Boiadjiev, V I, et al. "Photochemical hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr(VI)." Langmuir : the ACS journal of surfaces and colloids vol. 21,4 (2005): 1139-42. doi: https://doi.org/10.1021/la047852n
Boiadjiev VI, Brown GM, Pinnaduwage LA, Goretzki G, Bonnesen PV, Thundat T. Photochemical hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr(VI). Langmuir. 2005 Feb 15;21(4):1139-42. doi: 10.1021/la047852n. PMID: 15697249.
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An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture.

Toxicology in vitro : an international journal published in association with BIBRA

Hildebrand H, Schmidt U, Kempka G, Jacob R, Ahr HJ, Ebener C, Goretzki PE, Bader A.
PMID: 20654484
Toxicol In Vitro. 1999 Apr;13(2):265-73. doi: 10.1016/s0887-2333(98)00078-2.

Peroxisome proliferators comprise a group of structurally diverse chemicals which share as a common biologic effect the induction of peroxisomal fatty acid degrading enzymes. Concomitantly, the number and size of peroxisomes within hepatocytes increases. Following chronic administration some peroxisome...

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Hildebrand H, Schmidt U, Kempka G, et al. An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicol In Vitro. 1999;13(2):265-73doi: 10.1016/s0887-2333(98)00078-2.
Hildebrand, H., Schmidt, U., Kempka, G., Jacob, R., Ahr, H. J., Ebener, C., Goretzki, P. E., & Bader, A. (1999). An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicology in vitro : an international journal published in association with BIBRA, 13(2), 265-73. https://doi.org/10.1016/s0887-2333(98)00078-2
Hildebrand, H, et al. "An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture." Toxicology in vitro : an international journal published in association with BIBRA vol. 13,2 (1999): 265-73. doi: https://doi.org/10.1016/s0887-2333(98)00078-2
Hildebrand H, Schmidt U, Kempka G, Jacob R, Ahr HJ, Ebener C, Goretzki PE, Bader A. An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicol In Vitro. 1999 Apr;13(2):265-73. doi: 10.1016/s0887-2333(98)00078-2. PMID: 20654484.
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The Impact of Gender on Diagnosis and Treatment in Endocrine Surgery.

Visceral medicine

Goretzki PE.
PMID: 32110649
Visc Med. 2020 Feb;36(1):2. doi: 10.1159/000505502. Epub 2020 Jan 14.

No abstract available.

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Goretzki PE. The Impact of Gender on Diagnosis and Treatment in Endocrine Surgery. Visc Med. 2020;36(1):2doi: 10.1159/000505502.
Goretzki, P. E. (2020). The Impact of Gender on Diagnosis and Treatment in Endocrine Surgery. Visceral medicine, 36(1), 2. https://doi.org/10.1159/000505502
Goretzki, Peter E. "The Impact of Gender on Diagnosis and Treatment in Endocrine Surgery." Visceral medicine vol. 36,1 (2020): 2. doi: https://doi.org/10.1159/000505502
Goretzki PE. The Impact of Gender on Diagnosis and Treatment in Endocrine Surgery. Visc Med. 2020 Feb;36(1):2. doi: 10.1159/000505502. Epub 2020 Jan 14. PMID: 32110649; PMCID: PMC7036585.
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Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors.

Physical review. B, Condensed matter

Chiarello G, Goretzki H, Parmigiani F, Ripamonti N, Roll U.
PMID: 9942447
Phys Rev B Condens Matter. 1987 Nov 01;36(13):7148-7150. doi: 10.1103/physrevb.36.7148.

No abstract available.

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Chiarello G, Goretzki H, Parmigiani F, et al. Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors. Phys Rev B Condens Matter. 1987;36(13):7148-7150doi: 10.1103/physrevb.36.7148.
Chiarello, G., Goretzki, H., Parmigiani, F., Ripamonti, N., & Roll, U. (1987). Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors. Physical review. B, Condensed matter, 36(13), 7148-7150. https://doi.org/10.1103/physrevb.36.7148
Chiarello, et al. "Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors." Physical review. B, Condensed matter vol. 36,13 (1987): 7148-7150. doi: https://doi.org/10.1103/physrevb.36.7148
Chiarello G, Goretzki H, Parmigiani F, Ripamonti N, Roll U. Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors. Phys Rev B Condens Matter. 1987 Nov 01;36(13):7148-7150. doi: 10.1103/physrevb.36.7148. PMID: 9942447.
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Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases.

Frontiers in immunology

Lin YJ, Goretzki A, Schülke S.
PMID: 34925372
Front Immunol. 2021 Dec 01;12:790658. doi: 10.3389/fimmu.2021.790658. eCollection 2021.

Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and...

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Lin YJ, Goretzki A, Schülke S. Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Front Immunol. 2021;12:790658doi: 10.3389/fimmu.2021.790658.
Lin, Y. J., Goretzki, A., & Schülke, S. (2021). Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Frontiers in immunology, 12790658. https://doi.org/10.3389/fimmu.2021.790658
Lin, Yen-Ju, et al. "Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases." Frontiers in immunology vol. 12 (2021): 790658. doi: https://doi.org/10.3389/fimmu.2021.790658
Lin YJ, Goretzki A, Schülke S. Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Front Immunol. 2021 Dec 01;12:790658. doi: 10.3389/fimmu.2021.790658. eCollection 2021. PMID: 34925372; PMCID: PMC8671807.
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The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE.

Cells

Lin YJ, Flaczyk A, Wolfheimer S, Goretzki A, Jamin A, Wangorsch A, Vieths S, Scheurer S, Schülke S.
PMID: 34943923
Cells. 2021 Dec 04;10(12). doi: 10.3390/cells10123415.

Developing new adjuvants/vaccines and better understanding their mode-of-action is an important task. To specifically improve birch pollen allergy treatment, we designed a fusion protein consisting of major birch pollen allergen Betv1 conjugated to the TLR5-ligand flagellin (rFlaA:Betv1). This study...

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Lin YJ, Flaczyk A, Wolfheimer S, et al. The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE. Cells. 2021;10(12)doi: 10.3390/cells10123415.
Lin, Y. J., Flaczyk, A., Wolfheimer, S., Goretzki, A., Jamin, A., Wangorsch, A., Vieths, S., Scheurer, S., & Schülke, S. (2021). The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE. Cells, 10(12), . https://doi.org/10.3390/cells10123415
Lin, Yen-Ju, et al. "The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE." Cells vol. 10,12 (2021). doi: https://doi.org/10.3390/cells10123415
Lin YJ, Flaczyk A, Wolfheimer S, Goretzki A, Jamin A, Wangorsch A, Vieths S, Scheurer S, Schülke S. The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE. Cells. 2021 Dec 04;10(12). doi: 10.3390/cells10123415. PMID: 34943923; PMCID: PMC8700022.
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Supramolecular assemblies formed on an epitaxial graphene superstructure.

Angewandte Chemie (International ed. in English)

Pollard AJ, Perkins EW, Smith NA, Saywell A, Goretzki G, Phillips AG, Argent SP, Sachdev H, Müller F, Hüfner S, Gsell S, Fischer M, Schreck M, Osterwalder J, Greber T, Berner S, Champness NR, Beton PH.
PMID: 20135656
Angew Chem Int Ed Engl. 2010 Mar 01;49(10):1794-9. doi: 10.1002/anie.200905503.

No abstract available.

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Pollard AJ, Perkins EW, Smith NA, et al. Supramolecular assemblies formed on an epitaxial graphene superstructure. Angew Chem Int Ed Engl. 2010;49(10):1794-9doi: 10.1002/anie.200905503.
Pollard, A. J., Perkins, E. W., Smith, N. A., Saywell, A., Goretzki, G., Phillips, A. G., Argent, S. P., Sachdev, H., Müller, F., Hüfner, S., Gsell, S., Fischer, M., Schreck, M., Osterwalder, J., Greber, T., Berner, S., Champness, N. R., & Beton, P. H. (2010). Supramolecular assemblies formed on an epitaxial graphene superstructure. Angewandte Chemie (International ed. in English), 49(10), 1794-9. https://doi.org/10.1002/anie.200905503
Pollard, Andrew J, et al. "Supramolecular assemblies formed on an epitaxial graphene superstructure." Angewandte Chemie (International ed. in English) vol. 49,10 (2010): 1794-9. doi: https://doi.org/10.1002/anie.200905503
Pollard AJ, Perkins EW, Smith NA, Saywell A, Goretzki G, Phillips AG, Argent SP, Sachdev H, Müller F, Hüfner S, Gsell S, Fischer M, Schreck M, Osterwalder J, Greber T, Berner S, Champness NR, Beton PH. Supramolecular assemblies formed on an epitaxial graphene superstructure. Angew Chem Int Ed Engl. 2010 Mar 01;49(10):1794-9. doi: 10.1002/anie.200905503. PMID: 20135656.
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Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases.

Frontiers in immunology

Lin YJ, Goretzki A, Schülke S.
PMID: 34925372
Front Immunol. 2021 Dec 01;12:790658. doi: 10.3389/fimmu.2021.790658. eCollection 2021.

Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and...

Cite
Lin YJ, Goretzki A, Schülke S. Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Front Immunol. 2021;12:790658doi: 10.3389/fimmu.2021.790658.
Lin, Y. J., Goretzki, A., & Schülke, S. (2021). Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Frontiers in immunology, 12790658. https://doi.org/10.3389/fimmu.2021.790658
Lin, Yen-Ju, et al. "Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases." Frontiers in immunology vol. 12 (2021): 790658. doi: https://doi.org/10.3389/fimmu.2021.790658
Lin YJ, Goretzki A, Schülke S. Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases. Front Immunol. 2021 Dec 01;12:790658. doi: 10.3389/fimmu.2021.790658. eCollection 2021. PMID: 34925372; PMCID: PMC8671807.
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The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages.

Cells

Lin YJ, Papp G, Miskey C, Fiedler A, Goretzki A, Wolfheimer S, Zimmermann J, Crauwels P, Ivics Z, van Zandbergen G, Vieths S, Scheurer S, Schülke S.
PMID: 34685593
Cells. 2021 Oct 01;10(10). doi: 10.3390/cells10102614.

TLR5 ligand flagellin-containing fusion proteins are potential vaccine candidates for many diseases. A recombinant fusion protein of flagellin A and the major birch pollen allergen Bet v 1 (rFlaA:Betv1) modulates immune responses in vitro and in vivo. We studied...

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Lin YJ, Papp G, Miskey C, et al. The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages. Cells. 2021;10(10)doi: 10.3390/cells10102614.
Lin, Y. J., Papp, G., Miskey, C., Fiedler, A., Goretzki, A., Wolfheimer, S., Zimmermann, J., Crauwels, P., Ivics, Z., van Zandbergen, G., Vieths, S., Scheurer, S., & Schülke, S. (2021). The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages. Cells, 10(10), . https://doi.org/10.3390/cells10102614
Lin, Yen-Ju, et al. "The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages." Cells vol. 10,10 (2021). doi: https://doi.org/10.3390/cells10102614
Lin YJ, Papp G, Miskey C, Fiedler A, Goretzki A, Wolfheimer S, Zimmermann J, Crauwels P, Ivics Z, van Zandbergen G, Vieths S, Scheurer S, Schülke S. The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages. Cells. 2021 Oct 01;10(10). doi: 10.3390/cells10102614. PMID: 34685593; PMCID: PMC8534024.
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Insulinoma in pregnancy (a case presentation and systematic review of the literature).

Rare tumors

Dobrindt EM, Mogl M, Goretzki PE, Pratschke J, Dukaczewska AK.
PMID: 33613925
Rare Tumors. 2021 Feb 07;13:2036361320986647. doi: 10.1177/2036361320986647. eCollection 2021.

Insulinomas are rare, benign and functional tumors that coincidentally may become overt during pregnancy or in the post-partum period. As the general symptoms of a pregnancy might cover the clinical presentation, diagnosing remains challenging. We present one additional case...

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Dobrindt EM, Mogl M, Goretzki PE, et al. Insulinoma in pregnancy (a case presentation and systematic review of the literature). Rare Tumors. 2021;13:2036361320986647doi: 10.1177/2036361320986647.
Dobrindt, E. M., Mogl, M., Goretzki, P. E., Pratschke, J., & Dukaczewska, A. K. (2021). Insulinoma in pregnancy (a case presentation and systematic review of the literature). Rare tumors, 132036361320986647. https://doi.org/10.1177/2036361320986647
Dobrindt, Eva M, et al. "Insulinoma in pregnancy (a case presentation and systematic review of the literature)." Rare tumors vol. 13 (2021): 2036361320986647. doi: https://doi.org/10.1177/2036361320986647
Dobrindt EM, Mogl M, Goretzki PE, Pratschke J, Dukaczewska AK. Insulinoma in pregnancy (a case presentation and systematic review of the literature). Rare Tumors. 2021 Feb 07;13:2036361320986647. doi: 10.1177/2036361320986647. eCollection 2021. PMID: 33613925; PMCID: PMC7874339.
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A rare case of a patient with a high grade neuroendocrine tumor developing neutropenic sepsis after receiving PRRT combined with Capecitabine or Temozolomide: A case report.

Molecular and clinical oncology

Özdirik B, Amthauer H, Schatka I, Goretzki PE, Mogl MT, Fehrenbach U, Tacke F, Jann H, Roderburg C.
PMID: 33363730
Mol Clin Oncol. 2021 Jan;14(1):20. doi: 10.3892/mco.2020.2182. Epub 2020 Nov 27.

Neuroendocrine tumors (NET) are rare and demonstrate variable clinical behavior depending on the degree of tumor differentiation. Patients with poorly differentiated tumors (NET G3) have a poor prognosis. Systemic treatment with cytotoxic chemotherapy is considered to be the treatment...

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Özdirik B, Amthauer H, Schatka I, et al. A rare case of a patient with a high grade neuroendocrine tumor developing neutropenic sepsis after receiving PRRT combined with Capecitabine or Temozolomide: A case report. Mol Clin Oncol. 2020;14(1):20doi: 10.3892/mco.2020.2182.
Özdirik, B., Amthauer, H., Schatka, I., Goretzki, P. E., Mogl, M. T., Fehrenbach, U., Tacke, F., Jann, H., & Roderburg, C. (2021). A rare case of a patient with a high grade neuroendocrine tumor developing neutropenic sepsis after receiving PRRT combined with Capecitabine or Temozolomide: A case report. Molecular and clinical oncology, 14(1), 20. https://doi.org/10.3892/mco.2020.2182
Özdirik, Burcin, et al. "A rare case of a patient with a high grade neuroendocrine tumor developing neutropenic sepsis after receiving PRRT combined with Capecitabine or Temozolomide: A case report." Molecular and clinical oncology vol. 14,1 (2021): 20. doi: https://doi.org/10.3892/mco.2020.2182
Özdirik B, Amthauer H, Schatka I, Goretzki PE, Mogl MT, Fehrenbach U, Tacke F, Jann H, Roderburg C. A rare case of a patient with a high grade neuroendocrine tumor developing neutropenic sepsis after receiving PRRT combined with Capecitabine or Temozolomide: A case report. Mol Clin Oncol. 2021 Jan;14(1):20. doi: 10.3892/mco.2020.2182. Epub 2020 Nov 27. PMID: 33363730; PMCID: PMC7725216.
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Showing 1 to 12 of 20 entries