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Showing 1 to 12 of 48 entries
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Alterations of nutritional status in the main gastrointestinal pathologies.

Minerva gastroenterologica e dietologica

Capristo E, Valentini G, Scarfone A, Addolorato G, Giancaterini A, Ghittoni G, Mingrone G, Greco AV, Gasbarrini G.
PMID: 16498323
Minerva Gastroenterol Dietol. 1999 Jun;45(2):137-51.

An impairment of nutritional status up to real malnutrition can frequently be associated to gastrointestinal diseases. The diseases of the gastrointestinal tract can be divided into five groups: those hampering the nutrient physiological transit (especially neoplastic diseases); those affecting...

Main physiopathologic mechanisms involved in hepatic drug reactions.

Minerva gastroenterologica e dietologica

Valentini G, Capristo E, Scarfone A, Mingrone G, Greco AV, Gasbarrini G.
PMID: 16489299
Minerva Gastroenterol Dietol. 2002 Jun;48(2):81-8.

The liver has a pivotal role in drug metabolism and hepatic drug reactions are frequent events, accounting for 5% of cases of jaundice or acute hepatitis in the community. The importance of hepatic drug reactions lies not only in...

A brief overview of currently used atherosclerosis treatment approaches targeting lipid metabolism alterations.

American journal of cardiovascular disease

Poznyak AV, Zhang D, Orekhova V, Grechko AV, Wetzker R, Orekhov AN.
PMID: 32685264
Am J Cardiovasc Dis. 2020 Jun 15;10(2):62-71. eCollection 2020.

Non-contagious diseases such as atherosclerosis, diabetes, cardiovascular disease, cancer, chronic respiratory diseases, and mental disorders hold responsibility for major health losses worldwide. Atherosclerosis was found to be the leading cause of deaths due to the major consequences, such as...

Vibrational Coupling between Organic and Inorganic Sublattices of Hybrid Perovskites.

Angewandte Chemie (International ed. in English)

Grechko M, Bretschneider SA, Vietze L, Kim H, Bonn M.
PMID: 30109912
Angew Chem Int Ed Engl. 2018 Oct 08;57(41):13657-13661. doi: 10.1002/anie.201806676. Epub 2018 Sep 19.

The interplay of electronic and nuclear degrees of freedom in semiconductor hybrid organic-inorganic perovskites determines many of their fundamental photophysical properties. For instance, charge carriers are dressed with phonons, that is, form polarons, and combination modes composed of strongly...

ATHENA (GOG-3020/ENGOT-ov45): a randomized, phase III trial to evaluate rucaparib as monotherapy (ATHENA-MONO) and rucaparib in combination with nivolumab (ATHENA-COMBO) as maintenance treatment following frontline platinum-based chemotherapy in ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Monk BJ, Coleman RL, Fujiwara K, Wilson MK, Oza AM, Oaknin A, O'Malley DM, Lorusso D, Westin SN, Safra T, Herzog TJ, Marmé F, N Eskander R, Lin KK, Shih D, Goble S, Grechko N, Hume S, Maloney L, McNeish IA, Kristeleit RS.
PMID: 34593565
Int J Gynecol Cancer. 2021 Dec;31(12):1589-1594. doi: 10.1136/ijgc-2021-002933. Epub 2021 Sep 30.

BACKGROUND: The optimal treatment strategy for women with newly diagnosed ovarian cancer has yet to be determined. Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated substantial improvement in progression-free survival as monotherapy maintenance treatment in the frontline setting versus active surveillance....

Vasculoprotective Role of Olive Oil Compounds via Modulation of Oxidative Stress in Atherosclerosis.

Frontiers in cardiovascular medicine

Summerhill V, Karagodin V, Grechko A, Myasoedova V, Orekhov A.
PMID: 30622950
Front Cardiovasc Med. 2018 Dec 21;5:188. doi: 10.3389/fcvm.2018.00188. eCollection 2018.

Existing evidence supports the significant role of oxidative stress in the endothelial injury, and there is a direct link between increased oxidative stress, and the development of endothelial dysfunction. Endothelial dysfunction precedes the development of atherosclerosis and subsequent cardiovascular...

ATHENA (GOG-3020/ENGOT-ov45): a randomized, phase III trial to evaluate rucaparib as monotherapy (ATHENA-MONO) and rucaparib in combination with nivolumab (ATHENA-COMBO) as maintenance treatment following frontline platinum-based chemotherapy in ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Monk BJ, Coleman RL, Fujiwara K, Wilson MK, Oza AM, Oaknin A, O'Malley DM, Lorusso D, Westin SN, Safra T, Herzog TJ, Marmé F, N Eskander R, Lin KK, Shih D, Goble S, Grechko N, Hume S, Maloney L, McNeish IA, Kristeleit RS.
PMID: 34593565
Int J Gynecol Cancer. 2021 Dec;31(12):1589-1594. doi: 10.1136/ijgc-2021-002933. Epub 2021 Sep 30.

BACKGROUND: The optimal treatment strategy for women with newly diagnosed ovarian cancer has yet to be determined. Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated substantial improvement in progression-free survival as monotherapy maintenance treatment in the frontline setting versus active surveillance....

Generation of GW radiation pulses from a VUV free-electron laser operating in the femtosecond regime.

Physical review letters

Ayvazyan V, Baboi N, Bohnet I, Brinkmann R, Castellano M, Castro P, Catani L, Choroba S, Cianchi A, Dohlus M, Edwards HT, Faatz B, Fateev AA, Feldhaus J, Flöttmann K, Gamp A, Garvey T, Genz H, Gerth Ch, Gretchko V, Grigoryan B, Hahn U, Hessler C, Honkavaara K, Hüning M, Ischebeck R, Jablonka M, Kamps T, Körfer M, Krassilnikov M, Krzywinski J, Liepe M, Liero A, Limberg T, Loos H, Luong M, Magne C, Menzel J, Michelato P, Minty M, Müller UC, Nölle D, Novokhatski A, Pagani C, Peters F, Pflüger J, Piot P, Plucinski L, Rehlich K, Reyzl I, Richter A, Rossbach J, Saldin EL, Sandner W, Schlarb H, Schmidt G, Schmüser P, Schneider JR, Schneidmiller EA, Schreiber HJ, Schreiber S, Sertore D, Setzer S, Simrock S, Sobierajski R, Sonntag B, Steeg B, Stephan F, Sytchev KP, Tiedtke K, Tonutti M, Treusch R, Trines D, Türke D, Verzilov V, Wanzenberg R, Weiland T, Weise H, Wendt M, Will I, Wolff S, Wittenburg K, Yurkov MV, Zapfe K.
PMID: 11909361
Phys Rev Lett. 2002 Mar 11;88(10):104802. doi: 10.1103/PhysRevLett.88.104802. Epub 2002 Feb 25.

Experimental results are presented from vacuum-ultraviolet free-electron laser (FEL) operating in the self-amplified spontaneous emission (SASE) mode. The generation of ultrashort radiation pulses became possible due to specific tailoring of the bunch charge distribution. A complete characterization of the...

Normalization of Insulin Sensitivity in the Obese Patient after Stable Weight Reduction with Biliopancreatic Diversion.

Obesity surgery

Castagneto M, De Gaetano A, Mingrone G, Tacchino R, Nanni G, Capristo E, Benedetti G, Tataranni PA, Greco AV.
PMID: 10742775
Obes Surg. 1994 May;4(2):161-168. doi: 10.1381/096089294765558755.

Insulin resistance is a common feature in obese patients. To evaluate the modifications in insulin sensitivity after a bariatric operation such as Bilio-pancreatic diversion (BPD), three groups of subjects (14 normal controls (N); seven ex-obese patients (X) with at...

Sialidase Activity in Human Blood Serum Has a Distinct Seasonal Pattern: A Pilot Study.

Biology

Glanz VY, Kashirskikh DA, Grechko AV, Yet SF, Sobenin IA, Orekhov AN.
PMID: 32708035
Biology (Basel). 2020 Jul 22;9(8). doi: 10.3390/biology9080184.

Desialylation-loss of terminal sialic acid residues from glycoconjugates catalyzed by sialidases-is involved in many human diseases and is considered a key molecular event of atherosclerosis onset. Desialylated low-density lipoproteins with atherogenic properties have been detected in human blood previously....

Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations.

Frontiers in pharmacology

Markin AM, Sobenin IA, Grechko AV, Zhang D, Orekhov AN.
PMID: 32528276
Front Pharmacol. 2020 May 14;11:642. doi: 10.3389/fphar.2020.00642. eCollection 2020.

Atherosclerosis is one of the most common diseases of the cardiovascular system that leads to the development of life-threatening conditions, such as heart attack and stroke. Arthrosclerosis affects various arteries in the human body, but is especially dangerous in...

Oxidative Stress and Antioxidants in Atherosclerosis Development and Treatment.

Biology

Poznyak AV, Grechko AV, Orekhova VA, Chegodaev YS, Wu WK, Orekhov AN.
PMID: 32245238
Biology (Basel). 2020 Mar 21;9(3). doi: 10.3390/biology9030060.

Atherosclerosis can be regarded as chronic inflammatory disease affecting the arterial wall. Despite the recent progress in studying the pathogenesis of atherosclerosis, some of the pathogenic mechanisms remain to be fully understood. Among these mechanisms is oxidative stress, which...

Showing 1 to 12 of 48 entries