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Retention characteristics of porous graphitic carbon in reversed-phase liquid chromatography with methanol-water mobile phases.

The Analyst

Lepont C, Gunatillaka AD, Poole CF.
PMID: 11534599
Analyst. 2001 Aug;126(8):1318-25. doi: 10.1039/b102719k.

The solvation parameter model is used to study the retention mechanism of neutral organic compounds on porous graphitic carbon with methanol-water mobile phases containing from 0-100% (v/v) methanol. The dominant contribution to retention is the cavity formation-dispersion interaction term,...

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Lepont C, Gunatillaka AD, Poole CF. Retention characteristics of porous graphitic carbon in reversed-phase liquid chromatography with methanol-water mobile phases. Analyst. 2001;126(8):1318-25doi: 10.1039/b102719k.
Lepont, C., Gunatillaka, A. D., & Poole, C. F. (2001). Retention characteristics of porous graphitic carbon in reversed-phase liquid chromatography with methanol-water mobile phases. The Analyst, 126(8), 1318-25. https://doi.org/10.1039/b102719k
Lepont, C, et al. "Retention characteristics of porous graphitic carbon in reversed-phase liquid chromatography with methanol-water mobile phases." The Analyst vol. 126,8 (2001): 1318-25. doi: https://doi.org/10.1039/b102719k
Lepont C, Gunatillaka AD, Poole CF. Retention characteristics of porous graphitic carbon in reversed-phase liquid chromatography with methanol-water mobile phases. Analyst. 2001 Aug;126(8):1318-25. doi: 10.1039/b102719k. PMID: 11534599.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

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Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

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Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310; PMCID: PMC8692107.
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Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins.

Cancer research

Tewary P, Brooks AD, Xu YM, Wijeratne EMK, Babyak AL, Back TC, Chari R, Evans CN, Henrich CJ, Meyer TJ, Edmondson EF, de Aquino MTP, Kanagasabai T, Shanker A, Gunatilaka AAL, Sayers TJ.
PMID: 33837043
Cancer Res. 2021 Jun 15;81(12):3374-3386. doi: 10.1158/0008-5472.CAN-20-2634. Epub 2021 Apr 09.

Screening for sensitizers of cancer cells to TRAIL-mediated apoptosis identified a natural product of the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), as a promising hit. In this study, we show that PCC was also able to sensitize melanoma and...

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Tewary P, Brooks AD, Xu YM, et al. Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins. Cancer Res. 2021;81(12):3374-3386doi: 10.1158/0008-5472.CAN-20-2634.
Tewary, P., Brooks, A. D., Xu, Y. M., Wijeratne, E. M. K., Babyak, A. L., Back, T. C., Chari, R., Evans, C. N., Henrich, C. J., Meyer, T. J., Edmondson, E. F., de Aquino, M. T. P., Kanagasabai, T., Shanker, A., Gunatilaka, A. A. L., & Sayers, T. J. (2021). Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins. Cancer research, 81(12), 3374-3386. https://doi.org/10.1158/0008-5472.CAN-20-2634
Tewary, Poonam, et al. "Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins." Cancer research vol. 81,12 (2021): 3374-3386. doi: https://doi.org/10.1158/0008-5472.CAN-20-2634
Tewary P, Brooks AD, Xu YM, Wijeratne EMK, Babyak AL, Back TC, Chari R, Evans CN, Henrich CJ, Meyer TJ, Edmondson EF, de Aquino MTP, Kanagasabai T, Shanker A, Gunatilaka AAL, Sayers TJ. Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins. Cancer Res. 2021 Jun 15;81(12):3374-3386. doi: 10.1158/0008-5472.CAN-20-2634. Epub 2021 Apr 09. PMID: 33837043.
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Modulation of polyketide biosynthetic pathway of the endophytic fungus, .

Phytochemistry letters

Mafezoli J, Xu YM, Hilário F, Freidhof B, Espinosa-Artiles P, Dos Santos LC, de Oliveira MCF, Gunatilaka AAL.
PMID: 31354886
Phytochem Lett. 2018 Dec;28:157-163. doi: 10.1016/j.phytol.2018.10.011. Epub 2018 Oct 25.

In an attempt to explore the biosynthetic potential of endosymbiotic fungi, the secondary metabolite profiles of the endophytic fungus,

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Mafezoli J, Xu YM, Hilário F, et al. Modulation of polyketide biosynthetic pathway of the endophytic fungus, . Phytochem Lett. 2018;28:157-163doi: 10.1016/j.phytol.2018.10.011.
Mafezoli, J., Xu, Y. M., Hilário, F., Freidhof, B., Espinosa-Artiles, P., Dos Santos, L. C., de Oliveira, M. C. F., & Gunatilaka, A. A. L. (2018). Modulation of polyketide biosynthetic pathway of the endophytic fungus, . Phytochemistry letters, 28157-163. https://doi.org/10.1016/j.phytol.2018.10.011
Mafezoli, Jair, et al. "Modulation of polyketide biosynthetic pathway of the endophytic fungus, ." Phytochemistry letters vol. 28 (2018): 157-163. doi: https://doi.org/10.1016/j.phytol.2018.10.011
Mafezoli J, Xu YM, Hilário F, Freidhof B, Espinosa-Artiles P, Dos Santos LC, de Oliveira MCF, Gunatilaka AAL. Modulation of polyketide biosynthetic pathway of the endophytic fungus, . Phytochem Lett. 2018 Dec;28:157-163. doi: 10.1016/j.phytol.2018.10.011. Epub 2018 Oct 25. PMID: 31354886; PMCID: PMC6660184.
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Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells.

Frontiers in pharmacology

Issa ME, Wijeratne EMK, Gunatilaka AAL, Cuendet M.
PMID: 28943850
Front Pharmacol. 2017 Sep 08;8:610. doi: 10.3389/fphar.2017.00610. eCollection 2017.

In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the...

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Issa ME, Wijeratne EMK, Gunatilaka AAL, et al. Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells. Front Pharmacol. 2017;8:610doi: 10.3389/fphar.2017.00610.
Issa, M. E., Wijeratne, E. M. K., Gunatilaka, A. A. L., & Cuendet, M. (2017). Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells. Frontiers in pharmacology, 8610. https://doi.org/10.3389/fphar.2017.00610
Issa, Mark E, et al. "Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells." Frontiers in pharmacology vol. 8 (2017): 610. doi: https://doi.org/10.3389/fphar.2017.00610
Issa ME, Wijeratne EMK, Gunatilaka AAL, Cuendet M. Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells. Front Pharmacol. 2017 Sep 08;8:610. doi: 10.3389/fphar.2017.00610. eCollection 2017. PMID: 28943850; PMCID: PMC5596074.
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Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model.

Journal of natural products

Freitas Misakyan MF, Wijeratne EMK, Issa ME, Xu YM, Monteillier A, Gunatilaka AAL, Cuendet M.
PMID: 34445874
J Nat Prod. 2021 Aug 27;84(8):2321-2335. doi: 10.1021/acs.jnatprod.1c00446. Epub 2021 Aug 17.

Multiple myeloma (MM) is a hematological cancer in which relapse and resistance are highly frequent. Therefore, alternatives to conventional treatments are necessary. Withaferin A, a withanolide isolated from

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Freitas Misakyan MF, Wijeratne EMK, Issa ME, et al. Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model. J Nat Prod. 2021;84(8):2321-2335doi: 10.1021/acs.jnatprod.1c00446.
Freitas Misakyan, M. F., Wijeratne, E. M. K., Issa, M. E., Xu, Y. M., Monteillier, A., Gunatilaka, A. A. L., & Cuendet, M. (2021). Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model. Journal of natural products, 84(8), 2321-2335. https://doi.org/10.1021/acs.jnatprod.1c00446
Freitas Misakyan, Micaela F, et al. "Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model." Journal of natural products vol. 84,8 (2021): 2321-2335. doi: https://doi.org/10.1021/acs.jnatprod.1c00446
Freitas Misakyan MF, Wijeratne EMK, Issa ME, Xu YM, Monteillier A, Gunatilaka AAL, Cuendet M. Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model. J Nat Prod. 2021 Aug 27;84(8):2321-2335. doi: 10.1021/acs.jnatprod.1c00446. Epub 2021 Aug 17. PMID: 34445874.
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Cycloartane- and Lanostane-Type Triterpenoids from the Resin of .

ACS omega

Xu YM, Madasu C, Liu MX, Wijeratne EMK, Dierig D, White B, Molnár I, Gunatilaka AAL.
PMID: 34151127
ACS Omega. 2021 Jun 04;6(23):15486-15498. doi: 10.1021/acsomega.1c01714. eCollection 2021 Jun 15.

A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (

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Xu YM, Madasu C, Liu MX, et al. Cycloartane- and Lanostane-Type Triterpenoids from the Resin of . ACS Omega. 2021;6(23):15486-15498doi: 10.1021/acsomega.1c01714.
Xu, Y. M., Madasu, C., Liu, M. X., Wijeratne, E. M. K., Dierig, D., White, B., Molnár, I., & Gunatilaka, A. A. L. (2021). Cycloartane- and Lanostane-Type Triterpenoids from the Resin of . ACS omega, 6(23), 15486-15498. https://doi.org/10.1021/acsomega.1c01714
Xu, Ya-Ming, et al. "Cycloartane- and Lanostane-Type Triterpenoids from the Resin of ." ACS omega vol. 6,23 (2021): 15486-15498. doi: https://doi.org/10.1021/acsomega.1c01714
Xu YM, Madasu C, Liu MX, Wijeratne EMK, Dierig D, White B, Molnár I, Gunatilaka AAL. Cycloartane- and Lanostane-Type Triterpenoids from the Resin of . ACS Omega. 2021 Jun 04;6(23):15486-15498. doi: 10.1021/acsomega.1c01714. eCollection 2021 Jun 15. PMID: 34151127; PMCID: PMC8210430.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

Cite
Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310; PMCID: PMC8692107.
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An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in .

Tetrahedron

de Amorim MR, Wijeratne EMK, Zhou S, Arnold AE, Batista ANL, Batista JM, Dos Santos LC, Gunatilaka AAL.
PMID: 33716326
Tetrahedron. 2020 Oct 23;76(43). doi: 10.1016/j.tet.2020.131525. Epub 2020 Aug 22.

Incorporation of the epigenetic modifier suberoylanilide hydroxamic acid (SAHA) into a potato dextrose broth culture of the endophytic fungus

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de Amorim MR, Wijeratne EMK, Zhou S, et al. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in . Tetrahedron. 2020;76(43)doi: 10.1016/j.tet.2020.131525.
de Amorim, M. R., Wijeratne, E. M. K., Zhou, S., Arnold, A. E., Batista, A. N. L., Batista, J. M., Dos Santos, L. C., & Gunatilaka, A. A. L. (2020). An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in . Tetrahedron, 76(43), . https://doi.org/10.1016/j.tet.2020.131525
de Amorim, Marcelo R, et al. "An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in ." Tetrahedron vol. 76,43 (2020). doi: https://doi.org/10.1016/j.tet.2020.131525
de Amorim MR, Wijeratne EMK, Zhou S, Arnold AE, Batista ANL, Batista JM, Dos Santos LC, Gunatilaka AAL. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in . Tetrahedron. 2020 Oct 23;76(43). doi: 10.1016/j.tet.2020.131525. Epub 2020 Aug 22. PMID: 33716326; PMCID: PMC7945046.
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A new 1,2-deoxytaxane diterpenoid from Taxus chinensis.

Planta medica

Liang JY, Huang KS, Gunatilaka AA.
PMID: 17253235
Planta Med. 1998 Mar;64(2):187-8. doi: 10.1055/s-2006-957403.

The bark of Taxus chinensis yielded a new taxane diterpenoid, 2-deacetoxy-7,9-dideacetyltaxinine J ( 1) together with several known taxoids. (1)H- and (13)C-NMR data of 1 are reported.

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Liang JY, Huang KS, Gunatilaka AA. A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta Med. 1998;64(2):187-8doi: 10.1055/s-2006-957403.
Liang, J. Y., Huang, K. S., & Gunatilaka, A. A. (1998). A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta medica, 64(2), 187-8. https://doi.org/10.1055/s-2006-957403
Liang, J Y, et al. "A new 1,2-deoxytaxane diterpenoid from Taxus chinensis." Planta medica vol. 64,2 (1998): 187-8. doi: https://doi.org/10.1055/s-2006-957403
Liang JY, Huang KS, Gunatilaka AA. A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta Med. 1998 Mar;64(2):187-8. doi: 10.1055/s-2006-957403. PMID: 17253235.
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Maternal RSV vaccine development. Where to from here?.

Human vaccines & immunotherapeutics

Gunatilaka A, Giles ML.
PMID: 34499565
Hum Vaccin Immunother. 2021 Sep 09;1-7. doi: 10.1080/21645515.2021.1955608. Epub 2021 Sep 09.

Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection and is responsible for a large proportion of infant morbidity and mortality worldwide. Most RSV-related deaths occur in children under six months, and the majority...

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Gunatilaka A, Giles ML. Maternal RSV vaccine development. Where to from here?. Hum Vaccin Immunother. 2021;1-7doi: 10.1080/21645515.2021.1955608.
Gunatilaka, A., & Giles, M. L. (2021). Maternal RSV vaccine development. Where to from here?. Human vaccines & immunotherapeutics, 1-7. https://doi.org/10.1080/21645515.2021.1955608
Gunatilaka, Ahinsa, and Giles, Michelle L. "Maternal RSV vaccine development. Where to from here?." Human vaccines & immunotherapeutics vol. (2021): 1-7. doi: https://doi.org/10.1080/21645515.2021.1955608
Gunatilaka A, Giles ML. Maternal RSV vaccine development. Where to from here?. Hum Vaccin Immunother. 2021 Sep 09;1-7. doi: 10.1080/21645515.2021.1955608. Epub 2021 Sep 09. PMID: 34499565.
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