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Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats.

The Ceylon medical journal

Thammitiyagodage MG, Gunatillaka MM, Ekanayaka N, Rathnayake C, Horadagoda NU, Jayathissa R, Gunaratne UK, Kumara WG, Abeynayake P.
PMID: 28390327
Ceylon Med J. 2017 Mar 31;62(1):20-24. doi: 10.4038/cmj.v62i1.8428.

INTRODUCTION: Chronic kidney disease of unknown aetiology (CKDu) is prevalent in the North Central Province (NCP) of Sri Lanka and ingestion of dug well water is considered a potential causative factor. Three CKDu prevalent villages were selected from the...

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Thammitiyagodage MG, Gunatillaka MM, Ekanayaka N, et al. Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats. Ceylon Med J. 2017;62(1):20-24doi: 10.4038/cmj.v62i1.8428.
Thammitiyagodage, M. G., Gunatillaka, M. M., Ekanayaka, N., Rathnayake, C., Horadagoda, N. U., Jayathissa, R., Gunaratne, U. K., Kumara, W. G., & Abeynayake, P. (2017). Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats. The Ceylon medical journal, 62(1), 20-24. https://doi.org/10.4038/cmj.v62i1.8428
Thammitiyagodage, M G, et al. "Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats." The Ceylon medical journal vol. 62,1 (2017): 20-24. doi: https://doi.org/10.4038/cmj.v62i1.8428
Thammitiyagodage MG, Gunatillaka MM, Ekanayaka N, Rathnayake C, Horadagoda NU, Jayathissa R, Gunaratne UK, Kumara WG, Abeynayake P. Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats. Ceylon Med J. 2017 Mar 31;62(1):20-24. doi: 10.4038/cmj.v62i1.8428. PMID: 28390327.
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Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model.

Pharmacognosy research

Ranasinghe P, Perera S, Gunatilake M, Abeywardene E, Gunapala N, Premakumara S, Perera K, Lokuhetty D, Katulanda P.
PMID: 22518078
Pharmacognosy Res. 2012 Apr;4(2):73-9. doi: 10.4103/0974-8490.94719.

PHASE I: There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05). Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P <...

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Ranasinghe P, Perera S, Gunatilake M, et al. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy Res. 2012;4(2):73-9doi: 10.4103/0974-8490.94719.
Ranasinghe, P., Perera, S., Gunatilake, M., Abeywardene, E., Gunapala, N., Premakumara, S., Perera, K., Lokuhetty, D., & Katulanda, P. (2012). Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy research, 4(2), 73-9. https://doi.org/10.4103/0974-8490.94719
Ranasinghe, Priyanga, et al. "Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model." Pharmacognosy research vol. 4,2 (2012): 73-9. doi: https://doi.org/10.4103/0974-8490.94719
Ranasinghe P, Perera S, Gunatilake M, Abeywardene E, Gunapala N, Premakumara S, Perera K, Lokuhetty D, Katulanda P. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy Res. 2012 Apr;4(2):73-9. doi: 10.4103/0974-8490.94719. PMID: 22518078; PMCID: PMC3326760.
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History and development of laboratory animal science in Sri Lanka.

Animal models and experimental medicine

Gunatilake M.
PMID: 30891541
Animal Model Exp Med. 2018 Apr 19;1(1):3-6. doi: 10.1002/ame2.12003. eCollection 2018 Mar.

The Faculty of Medicine, University of Colombo (UCFM), is the forerunner in the laboratory animal science (LAS) field in Sri Lanka. Here laboratory animals such as rats, frogs and rabbits were used in medical education to demonstrate physiological principles...

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Gunatilake M. History and development of laboratory animal science in Sri Lanka. Animal Model Exp Med. 2018;1(1):3-6doi: 10.1002/ame2.12003.
Gunatilake, M. (2018). History and development of laboratory animal science in Sri Lanka. Animal models and experimental medicine, 1(1), 3-6. https://doi.org/10.1002/ame2.12003
Gunatilake, Mangala. "History and development of laboratory animal science in Sri Lanka." Animal models and experimental medicine vol. 1,1 (2018): 3-6. doi: https://doi.org/10.1002/ame2.12003
Gunatilake M. History and development of laboratory animal science in Sri Lanka. Animal Model Exp Med. 2018 Apr 19;1(1):3-6. doi: 10.1002/ame2.12003. eCollection 2018 Mar. PMID: 30891541; PMCID: PMC6354312.
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Preliminary survey on animal research statistics in Sri Lanka from 2010 onwards.

Animal models and experimental medicine

Ishak Sahabdeen C, Gunatilake M.
PMID: 30891551
Animal Model Exp Med. 2018 Jul 28;1(2):79-81. doi: 10.1002/ame2.12014. eCollection 2018 Jun.

BACKGROUND: Animal research is conducted in many countries across the world. However, concepts of recording and reporting the numbers of animals used vary. In the context of animal studies, inadequate reporting raises both ethical and scientific concerns. Sri Lanka...

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Ishak Sahabdeen C, Gunatilake M. Preliminary survey on animal research statistics in Sri Lanka from 2010 onwards. Animal Model Exp Med. 2018;1(2):79-81doi: 10.1002/ame2.12014.
Ishak Sahabdeen, C., & Gunatilake, M. (2018). Preliminary survey on animal research statistics in Sri Lanka from 2010 onwards. Animal models and experimental medicine, 1(2), 79-81. https://doi.org/10.1002/ame2.12014
Ishak Sahabdeen, Chedliya, and Gunatilake, Mangala. "Preliminary survey on animal research statistics in Sri Lanka from 2010 onwards." Animal models and experimental medicine vol. 1,2 (2018): 79-81. doi: https://doi.org/10.1002/ame2.12014
Ishak Sahabdeen C, Gunatilake M. Preliminary survey on animal research statistics in Sri Lanka from 2010 onwards. Animal Model Exp Med. 2018 Jul 28;1(2):79-81. doi: 10.1002/ame2.12014. eCollection 2018 Jun. PMID: 30891551; PMCID: PMC6388058.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

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Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

Cite
Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310; PMCID: PMC8692107.
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Bacterial and fungal pathogens isolated from corneal ulcerations in domesticated elephants (Elephas maximus maximus) in Sri Lanka.

Veterinary ophthalmology

Kodikara DS, De Silva N, Makuloluwa CA, De Silva N, Gunatilake M.
PMID: 11397264
Vet Ophthalmol. 1999;2(3):191-192. doi: 10.1046/j.1463-5224.1999.00072.x.

Infective corneal diseases are common among the domesticated elephants in Sri Lanka, causing morbidity including blindness leading to loss of revenue to their owners. From 140 elephants of different ages and both sexes, 36 animals (25.7%) had evidence of...

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Kodikara DS, De Silva N, Makuloluwa CA, et al. Bacterial and fungal pathogens isolated from corneal ulcerations in domesticated elephants (Elephas maximus maximus) in Sri Lanka. Vet Ophthalmol. 1999;2(3):191-192doi: 10.1046/j.1463-5224.1999.00072.x.
Kodikara, D. S., De Silva, N., Makuloluwa, C. A., De Silva, N., & Gunatilake, M. (1999). Bacterial and fungal pathogens isolated from corneal ulcerations in domesticated elephants (Elephas maximus maximus) in Sri Lanka. Veterinary ophthalmology, 2(3), 191-192. https://doi.org/10.1046/j.1463-5224.1999.00072.x
Kodikara, D.S., et al. "Bacterial and fungal pathogens isolated from corneal ulcerations in domesticated elephants (Elephas maximus maximus) in Sri Lanka." Veterinary ophthalmology vol. 2,3 (1999): 191-192. doi: https://doi.org/10.1046/j.1463-5224.1999.00072.x
Kodikara DS, De Silva N, Makuloluwa CA, De Silva N, Gunatilake M. Bacterial and fungal pathogens isolated from corneal ulcerations in domesticated elephants (Elephas maximus maximus) in Sri Lanka. Vet Ophthalmol. 1999;2(3):191-192. doi: 10.1046/j.1463-5224.1999.00072.x. PMID: 11397264.
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Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract.

Pharmacognosy research

Gunatilake M, Lokuhetty MD, Bartholameuz NA, Edirisuriye DT, Kularatne MU, Date A.
PMID: 23225960
Pharmacognosy Res. 2012 Oct;4(4):181-8. doi: 10.4103/0974-8490.102259.

CONTEXT: Aerva lanata is not prescribed for long-term use in Ayurveda as it is believed to produce structural changes in the urinary tract of the patients leading to renal failure.AIM: To investigate the toxic effects of Aerva lanata on...

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Gunatilake M, Lokuhetty MD, Bartholameuz NA, et al. Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract. Pharmacognosy Res. 2012;4(4):181-8doi: 10.4103/0974-8490.102259.
Gunatilake, M., Lokuhetty, M. D., Bartholameuz, N. A., Edirisuriye, D. T., Kularatne, M. U., & Date, A. (2012). Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract. Pharmacognosy research, 4(4), 181-8. https://doi.org/10.4103/0974-8490.102259
Gunatilake, Mangala, et al. "Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract." Pharmacognosy research vol. 4,4 (2012): 181-8. doi: https://doi.org/10.4103/0974-8490.102259
Gunatilake M, Lokuhetty MD, Bartholameuz NA, Edirisuriye DT, Kularatne MU, Date A. Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract. Pharmacognosy Res. 2012 Oct;4(4):181-8. doi: 10.4103/0974-8490.102259. PMID: 23225960; PMCID: PMC3510869.
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Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure.

Chest

Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ.
PMID: 34157310
Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19.

BACKGROUND: In pediatrics, tracheomalacia is an airway condition that causes tracheal lumen collapse during breathing and may lead to the patient requiring respiratory support. Adult patients can narrow their glottis to self-generate positive end-expiratory pressure (PEEP) to raise the...

Cite
Gunatilaka CC, Hysinger EB, Schuh A, et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021;160(6):2168-2177doi: 10.1016/j.chest.2021.06.021.
Gunatilaka, C. C., Hysinger, E. B., Schuh, A., Gandhi, D. B., Higano, N. S., Xiao, Q., Hahn, A. D., Fain, S. B., Fleck, R. J., Woods, J. C., & Bates, A. J. (2021). Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest, 160(6), 2168-2177. https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka, Chamindu C, et al. "Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure." Chest vol. 160,6 (2021): 2168-2177. doi: https://doi.org/10.1016/j.chest.2021.06.021
Gunatilaka CC, Hysinger EB, Schuh A, Gandhi DB, Higano NS, Xiao Q, Hahn AD, Fain SB, Fleck RJ, Woods JC, Bates AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021 Dec;160(6):2168-2177. doi: 10.1016/j.chest.2021.06.021. Epub 2021 Jun 19. PMID: 34157310; PMCID: PMC8692107.
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A new 1,2-deoxytaxane diterpenoid from Taxus chinensis.

Planta medica

Liang JY, Huang KS, Gunatilaka AA.
PMID: 17253235
Planta Med. 1998 Mar;64(2):187-8. doi: 10.1055/s-2006-957403.

The bark of Taxus chinensis yielded a new taxane diterpenoid, 2-deacetoxy-7,9-dideacetyltaxinine J ( 1) together with several known taxoids. (1)H- and (13)C-NMR data of 1 are reported.

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Liang JY, Huang KS, Gunatilaka AA. A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta Med. 1998;64(2):187-8doi: 10.1055/s-2006-957403.
Liang, J. Y., Huang, K. S., & Gunatilaka, A. A. (1998). A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta medica, 64(2), 187-8. https://doi.org/10.1055/s-2006-957403
Liang, J Y, et al. "A new 1,2-deoxytaxane diterpenoid from Taxus chinensis." Planta medica vol. 64,2 (1998): 187-8. doi: https://doi.org/10.1055/s-2006-957403
Liang JY, Huang KS, Gunatilaka AA. A new 1,2-deoxytaxane diterpenoid from Taxus chinensis. Planta Med. 1998 Mar;64(2):187-8. doi: 10.1055/s-2006-957403. PMID: 17253235.
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Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal House, Faculty of Medicine, University of Colombo, Sri Lanka.

Animal models and experimental medicine

Delwatta SL, Gunatilake M, Baumans V, Seneviratne MD, Dissanayaka MLB, Batagoda SS, Udagedara AH, Walpola PB.
PMID: 30891574
Animal Model Exp Med. 2018 Nov 21;1(4):250-254. doi: 10.1002/ame2.12041. eCollection 2018 Dec.

BACKGROUND: Lack of available reference values in a research setting under local conditions can be a drawback for beginners, as the accuracy of data from control samples cannot be checked at the beginning of a research project. This affects...

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Delwatta SL, Gunatilake M, Baumans V, et al. Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal House, Faculty of Medicine, University of Colombo, Sri Lanka. Animal Model Exp Med. 2018;1(4):250-254doi: 10.1002/ame2.12041.
Delwatta, S. L., Gunatilake, M., Baumans, V., Seneviratne, M. D., Dissanayaka, M. L. B., Batagoda, S. S., Udagedara, A. H., & Walpola, P. B. (2018). Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal House, Faculty of Medicine, University of Colombo, Sri Lanka. Animal models and experimental medicine, 1(4), 250-254. https://doi.org/10.1002/ame2.12041
Delwatta, Shehani L, et al. "Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal House, Faculty of Medicine, University of Colombo, Sri Lanka." Animal models and experimental medicine vol. 1,4 (2018): 250-254. doi: https://doi.org/10.1002/ame2.12041
Delwatta SL, Gunatilake M, Baumans V, Seneviratne MD, Dissanayaka MLB, Batagoda SS, Udagedara AH, Walpola PB. Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal House, Faculty of Medicine, University of Colombo, Sri Lanka. Animal Model Exp Med. 2018 Nov 21;1(4):250-254. doi: 10.1002/ame2.12041. eCollection 2018 Dec. PMID: 30891574; PMCID: PMC6388088.
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Maternal RSV vaccine development. Where to from here?.

Human vaccines & immunotherapeutics

Gunatilaka A, Giles ML.
PMID: 34499565
Hum Vaccin Immunother. 2021 Sep 09;1-7. doi: 10.1080/21645515.2021.1955608. Epub 2021 Sep 09.

Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection and is responsible for a large proportion of infant morbidity and mortality worldwide. Most RSV-related deaths occur in children under six months, and the majority...

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Gunatilaka A, Giles ML. Maternal RSV vaccine development. Where to from here?. Hum Vaccin Immunother. 2021;1-7doi: 10.1080/21645515.2021.1955608.
Gunatilaka, A., & Giles, M. L. (2021). Maternal RSV vaccine development. Where to from here?. Human vaccines & immunotherapeutics, 1-7. https://doi.org/10.1080/21645515.2021.1955608
Gunatilaka, Ahinsa, and Giles, Michelle L. "Maternal RSV vaccine development. Where to from here?." Human vaccines & immunotherapeutics vol. (2021): 1-7. doi: https://doi.org/10.1080/21645515.2021.1955608
Gunatilaka A, Giles ML. Maternal RSV vaccine development. Where to from here?. Hum Vaccin Immunother. 2021 Sep 09;1-7. doi: 10.1080/21645515.2021.1955608. Epub 2021 Sep 09. PMID: 34499565.
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