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Showing 1 to 12 of 108 entries
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Paroxysmal Nonepileptic Events in Glut1 Deficiency.

Movement disorders clinical practice

Klepper J, Leiendecker B, Eltze C, Heussinger N.
PMID: 28042592
Mov Disord Clin Pract. 2016 Nov-Dec;3(6):607-610. doi: 10.1002/mdc3.12387. Epub 2016 Jul 08.

View Supplementary Video Movement disorders are a major feature of Glut1 deficiency. As recently identified in adults with paroxysmal exercise-induced dystonia, similar events were reported in pediatric Glut1 deficiency. In a case series, parent videos of regular motor state...

Shear thickening in granular suspensions: interparticle friction and dynamically correlated clusters.

Physical review. E, Statistical, nonlinear, and soft matter physics

Heussinger C.
PMID: 24329197
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Nov;88(5):050201. doi: 10.1103/PhysRevE.88.050201. Epub 2013 Nov 14.

We consider the shear rheology of concentrated suspensions of non-Brownian frictional particles. The key result of our study is the emergence of a pronounced shear-thickening regime, where frictionless particles would normally undergo shear thinning. We can clarify that shear...

Transient Elastography for the Detection of Liver Damage in Patients with HIV.

Infectious diseases and therapy

Sagir A, Glaubach B, Sahin K, Graf D, Erhardt A, Oette M, Häussinger D.
PMID: 26143457
Infect Dis Ther. 2015 Sep;4(3):355-64. doi: 10.1007/s40121-015-0073-y. Epub 2015 Jul 05.

INTRODUCTION: Highly active antiretroviral therapy (HAART) is effective and well tolerated, but hepatotoxicity is relatively common. Different non-invasive methods are available for detecting liver fibrosis in patients with chronic liver disease.METHODS: Patients who were HIV positive and who had...

(Ir)reversibility in dense granular systems driven by oscillating forces.

Soft matter

Möbius R, Heussinger C.
PMID: 24838939
Soft Matter. 2014 Jul 21;10(27):4806-12. doi: 10.1039/c4sm00178h. Epub 2014 May 16.

We use computer simulations to study highly dense systems of granular particles that are driven by oscillating forces. We implement different dissipation mechanisms that are used to extract the injected energy. In particular, the action of a simple local...

Independent ion migration in suspensions of strongly interacting charged colloidal spheres.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics

Hessinger D, Evers M, Palberg T.
PMID: 11031602
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 May;61(5):5493-506. doi: 10.1103/physreve.61.5493.

We report on systematic measurements of the low-frequency conductivity sigma in aqueous suspensions of highly charged colloidal spheres. Sample preparation in a closed tubing system results in precisely controlled number densities of 10(16) m-3 < or = n <...

Force distributions and force chains in random stiff fiber networks.

The European physical journal. E, Soft matter

Heussinger C, Frey E.
PMID: 17763970
Eur Phys J E Soft Matter. 2007 Sep;24(1):47-53. doi: 10.1140/epje/i2007-10209-1. Epub 2007 Sep 03.

We study the elasticity of random stiff fiber networks. The elastic response of the fibers is characterized by a central force stretching stiffness as well as a bending stiffness that acts transverse to the fiber contour. Previous studies have...

Chiral boron-bridged bisoxazoline (borabox) ligands: structures and reactivities of Pd and Cu complexes.

Chemistry (Weinheim an der Bergstrasse, Germany)

Köhler V, Mazet C, Toussaint A, Kulicke K, Häussinger D, Neuburger M, Schaffner S, Kaiser S, Pfaltz A.
PMID: 18688831
Chemistry. 2008;14(28):8530-9. doi: 10.1002/chem.200800822.

Anionic boron-bridged bisoxazolines (borabox ligands) have been synthesized and characterized in their protonated forms. The ligands are tuneable over a wide range, allowing either alkyl or aryl substituents at the oxazoline rings and the central bridging boron atom. The...

Hepatic Encephalopathy and Astrocyte Senescence.

Journal of clinical and experimental hepatology

Görg B, Karababa A, Häussinger D.
PMID: 30302047
J Clin Exp Hepatol. 2018 Sep;8(3):294-300. doi: 10.1016/j.jceh.2018.05.003. Epub 2018 May 18.

Hepatic Encephalopathy (HE) is a severe complication of acute or chronic liver diseases with a broad spectrum of neurological symptoms including motor disturbances and cognitive impairment of different severity. Contrary to former beliefs, a growing number of studies suggest...

Molecular Ansa-Basket: Synthesis of Inherently Chiral All-Carbon [12](1,6)Pyrenophane.

The Journal of organic chemistry

Mannancherry R, Devereux M, Häussinger D, Mayor M.
PMID: 30945543
J Org Chem. 2019 May 03;84(9):5271-5276. doi: 10.1021/acs.joc.9b00255. Epub 2019 Apr 19.

The synthesis of inherently chiral all-carbon C2-symmetric [12](1,6)pyrenophane 1 is reported. The cyclophane 1 was obtained via a ring-closing alkyne metathesis reaction using Mortreux's catalyst molybdenum hexacarbonyl and 2-fluorophenol as a phenol additive. The M and P enantiomers of...

Activation of Primary and Secondary Benzylic and Tertiary Alkyl (sp .

Frontiers in chemistry

Köster JM, Häussinger D, Tiefenbacher K.
PMID: 30662892
Front Chem. 2019 Jan 04;6:639. doi: 10.3389/fchem.2018.00639. eCollection 2018.

Alkyl fluorides are generally regarded as chemically inert. However, several literature examples describe the activation of alkyl (sp3)C-F bonds via strong Brønsted or Lewis acids under harsh conditions. We here report that catalytic amounts of the self-assembled resorcinarene capsule...

Dimethylcethrene: A Chiroptical Diradicaloid Photoswitch.

Journal of the American Chemical Society

Ravat P, Šolomek T, Häussinger D, Blacque O, Juríček M.
PMID: 30067898
J Am Chem Soc. 2018 Aug 29;140(34):10839-10847. doi: 10.1021/jacs.8b05465. Epub 2018 Aug 17.

We describe the synthesis and properties of 13,14-dimethylcethrene, a prototype of a chiral diradicaloid photochemical switch that can be transformed reversibly via conrotatory electrocyclization to its more stable closed form by light (630 nm) or heat and back to...

Model-free extraction of spin label position distributions from pseudocontact shift data.

Chemical science

Suturina EA, Häussinger D, Zimmermann K, Garbuio L, Yulikov M, Jeschke G, Kuprov I.
PMID: 28553510
Chem Sci. 2017 Apr 01;8(4):2751-2757. doi: 10.1039/c6sc03736d. Epub 2017 Jan 20.

A significant problem with paramagnetic tags attached to proteins and nucleic acids is their conformational mobility. Each tag is statistically distributed within a volume between 5 and 10 Angstroms across; structural biology conclusions from NMR and EPR work are...

Showing 1 to 12 of 108 entries