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Medical acute complications of intracerebral hemorrhage in young adults.

Stroke research and treatment

Koivunen RJ, Haapaniemi E, Satopää J, Niemelä M, Tatlisumak T, Putaala J.
PMID: 25722917
Stroke Res Treat. 2015;2015:357696. doi: 10.1155/2015/357696. Epub 2015 Feb 02.

Background. Frequency and impact of medical complications on short-term mortality in young patients with intracerebral hemorrhage (ICH) have gone unstudied. Methods. We reviewed data of all first-ever nontraumatic ICH patients between 16 and 49 years of age treated in...

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Koivunen RJ, Haapaniemi E, Satopää J, et al. Medical acute complications of intracerebral hemorrhage in young adults. Stroke Res Treat. 2015;2015:357696doi: 10.1155/2015/357696.
Koivunen, R. J., Haapaniemi, E., Satopää, J., Niemelä, M., Tatlisumak, T., & Putaala, J. (2015). Medical acute complications of intracerebral hemorrhage in young adults. Stroke research and treatment, 2015357696. https://doi.org/10.1155/2015/357696
Koivunen, Riku-Jaakko, et al. "Medical acute complications of intracerebral hemorrhage in young adults." Stroke research and treatment vol. 2015 (2015): 357696. doi: https://doi.org/10.1155/2015/357696
Koivunen RJ, Haapaniemi E, Satopää J, Niemelä M, Tatlisumak T, Putaala J. Medical acute complications of intracerebral hemorrhage in young adults. Stroke Res Treat. 2015;2015:357696. doi: 10.1155/2015/357696. Epub 2015 Feb 02. PMID: 25722917; PMCID: PMC4333279.
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Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1.

Dermatology (Basel, Switzerland)

Kallionpää RA, Ahramo K, Martikkala E, Fazeli E, Haapaniemi P, Rokka A, Leivo I, Harvima IT, Peltonen J, Peltonen S.
PMID: 34237737
Dermatology. 2021 Jul 08;1-11. doi: 10.1159/000517011. Epub 2021 Jul 08.

BACKGROUND: Cutaneous neurofibromas (cNFs) are hallmarks of neurofibromatosis 1 (NF1) and cause the main disease burden in adults with NF1. Mast cells are a known component of cNFs. However, no comprehensive characterization of mast cells in cNFs is available,...

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Kallionpää RA, Ahramo K, Martikkala E, et al. Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1. Dermatology. 2021;1-11doi: 10.1159/000517011.
Kallionpää, R. A., Ahramo, K., Martikkala, E., Fazeli, E., Haapaniemi, P., Rokka, A., Leivo, I., Harvima, I. T., Peltonen, J., & Peltonen, S. (2021). Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1. Dermatology (Basel, Switzerland), 1-11. https://doi.org/10.1159/000517011
Kallionpää, Roope A, et al. "Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1." Dermatology (Basel, Switzerland) vol. (2021): 1-11. doi: https://doi.org/10.1159/000517011
Kallionpää RA, Ahramo K, Martikkala E, Fazeli E, Haapaniemi P, Rokka A, Leivo I, Harvima IT, Peltonen J, Peltonen S. Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1. Dermatology. 2021 Jul 08;1-11. doi: 10.1159/000517011. Epub 2021 Jul 08. PMID: 34237737.
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Rapid genome editing by CRISPR-Cas9-POLD3 fusion.

eLife

Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E.
PMID: 34898428
Elife. 2021 Dec 13;10. doi: 10.7554/eLife.75415.

Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the sources of this variation are incompletely...

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Reint G, Li Z, Labun K, et al. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. Elife. 2021;10doi: 10.7554/eLife.75415.
Reint, G., Li, Z., Labun, K., Keskitalo, S., Soppa, I., Mamia, K., Tolo, E., Szymanska, M., Meza-Zepeda, L. A., Lorenz, S., Cieslar-Pobuda, A., Hu, X., Bordin, D. L., Staerk, J., Valen, E., Schmierer, B., Varjosalo, M., Taipale, J., & Haapaniemi, E. (2021). Rapid genome editing by CRISPR-Cas9-POLD3 fusion. eLife, 10. https://doi.org/10.7554/eLife.75415
Reint, Ganna, et al. "Rapid genome editing by CRISPR-Cas9-POLD3 fusion." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.75415
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. Elife. 2021 Dec 13;10. doi: 10.7554/eLife.75415. PMID: 34898428.
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Rapid genome editing by CRISPR-Cas9-POLD3 fusion.

eLife

Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E.
PMID: 34898428
Elife. 2021 Dec 13;10. doi: 10.7554/eLife.75415.

Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the sources of this variation are incompletely...

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Reint G, Li Z, Labun K, et al. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. Elife. 2021;10doi: 10.7554/eLife.75415.
Reint, G., Li, Z., Labun, K., Keskitalo, S., Soppa, I., Mamia, K., Tolo, E., Szymanska, M., Meza-Zepeda, L. A., Lorenz, S., Cieslar-Pobuda, A., Hu, X., Bordin, D. L., Staerk, J., Valen, E., Schmierer, B., Varjosalo, M., Taipale, J., & Haapaniemi, E. (2021). Rapid genome editing by CRISPR-Cas9-POLD3 fusion. eLife, 10. https://doi.org/10.7554/eLife.75415
Reint, Ganna, et al. "Rapid genome editing by CRISPR-Cas9-POLD3 fusion." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.75415
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. Elife. 2021 Dec 13;10. doi: 10.7554/eLife.75415. PMID: 34898428.
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Identifying concert halls from source presence vs room presence.

The Journal of the Acoustical Society of America

Haapaniemi A, Lokki T.
PMID: 24907839
J Acoust Soc Am. 2014 Jun;135(6):EL311-7. doi: 10.1121/1.4879671.

Identification of concert halls was studied to uncover whether the early or late part of the acoustic response is more salient in a hall's fingerprint. A listening test was conducted with auralizations of measured halls using full, hybrid, and...

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Haapaniemi A, Lokki T. Identifying concert halls from source presence vs room presence. J Acoust Soc Am. 2014;135(6):EL311-7doi: 10.1121/1.4879671.
Haapaniemi, A., & Lokki, T. (2014). Identifying concert halls from source presence vs room presence. The Journal of the Acoustical Society of America, 135(6), EL311-7. https://doi.org/10.1121/1.4879671
Haapaniemi, Aki, and Lokki, Tapio. "Identifying concert halls from source presence vs room presence." The Journal of the Acoustical Society of America vol. 135,6 (2014): EL311-7. doi: https://doi.org/10.1121/1.4879671
Haapaniemi A, Lokki T. Identifying concert halls from source presence vs room presence. J Acoust Soc Am. 2014 Jun;135(6):EL311-7. doi: 10.1121/1.4879671. PMID: 24907839.
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Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis.

Annals of neurology

Ken-Dror G, Cotlarciuc I, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot AB, Zedde M, Mancuso M, Ruigrok YM, Marjot T, Worrall B, Majersik JJ, Metso TM, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Mitchell BD, Kittner SJ, Lemmens R, Jern C, Pappalardo E, Costa P, Colombi M, de Sousa DA, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Debette S, Coutinho JM, Thijs V, Jood K, Pare G, Tatlisumak T, Ferro JM, Sharma P.
PMID: 34459509
Ann Neurol. 2021 Nov;90(5):777-788. doi: 10.1002/ana.26205. Epub 2021 Sep 29.

OBJECTIVE: Cerebral venous thrombosis (CVT) is an uncommon form of stroke affecting mostly young individuals. Although genetic factors are thought to play a role in this cerebrovascular condition, its genetic etiology is not well understood.METHODS: A genome-wide association study...

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Ken-Dror G, Cotlarciuc I, Martinelli I, et al. Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. Ann Neurol. 2021;90(5):777-788doi: 10.1002/ana.26205.
Ken-Dror, G., Cotlarciuc, I., Martinelli, I., Grandone, E., Hiltunen, S., Lindgren, E., Margaglione, M., Duchez, V. L. C., Triquenot, A. B., Zedde, M., Mancuso, M., Ruigrok, Y. M., Marjot, T., Worrall, B., Majersik, J. J., Metso, T. M., Putaala, J., Haapaniemi, E., Zuurbier, S. M., Brouwer, M. C., Passamonti, S. M., Abbattista, M., Bucciarelli, P., Mitchell, B. D., Kittner, S. J., Lemmens, R., Jern, C., Pappalardo, E., Costa, P., Colombi, M., de Sousa, D. A., Rodrigues, S., Canhão, P., Tkach, A., Santacroce, R., Favuzzi, G., Arauz, A., Colaizzo, D., Spengos, K., Hodge, A., Ditta, R., Pezzini, A., Debette, S., Coutinho, J. M., Thijs, V., Jood, K., Pare, G., Tatlisumak, T., Ferro, J. M., & Sharma, P. (2021). Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. Annals of neurology, 90(5), 777-788. https://doi.org/10.1002/ana.26205
Ken-Dror, Gie, et al. "Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis." Annals of neurology vol. 90,5 (2021): 777-788. doi: https://doi.org/10.1002/ana.26205
Ken-Dror G, Cotlarciuc I, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot AB, Zedde M, Mancuso M, Ruigrok YM, Marjot T, Worrall B, Majersik JJ, Metso TM, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Mitchell BD, Kittner SJ, Lemmens R, Jern C, Pappalardo E, Costa P, Colombi M, de Sousa DA, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Debette S, Coutinho JM, Thijs V, Jood K, Pare G, Tatlisumak T, Ferro JM, Sharma P. Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. Ann Neurol. 2021 Nov;90(5):777-788. doi: 10.1002/ana.26205. Epub 2021 Sep 29. PMID: 34459509; PMCID: PMC8666091.
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Substituent effect in 2-benzoylmethylenequinoline difluoroborates exhibiting through-space couplings. Multinuclear magnetic resonance, X-ray diffraction, and computational study.

The journal of physical chemistry. A

Zakrzewska A, Kolehmainen E, Valkonen A, Haapaniemi E, Rissanen K, Chęcińska L, Ośmiałowski B.
PMID: 23252343
J Phys Chem A. 2013 Jan 10;117(1):252-6. doi: 10.1021/jp311072q. Epub 2012 Dec 31.

The series of nine 2-benzoylmethylenequinoline difluoroborates have been synthesized and characterized by multinuclear magnetic resonance, X-ray diffraction (XRD), and computational methods. The through-space spin-spin couplings between (19)F and (1)H/(13)C nuclei have been observed in solution. The NMR chemical shifts...

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Zakrzewska A, Kolehmainen E, Valkonen A, et al. Substituent effect in 2-benzoylmethylenequinoline difluoroborates exhibiting through-space couplings. Multinuclear magnetic resonance, X-ray diffraction, and computational study. J Phys Chem A. 2012;117(1):252-6doi: 10.1021/jp311072q.
Zakrzewska, A., Kolehmainen, E., Valkonen, A., Haapaniemi, E., Rissanen, K., Chęcińska, L., & Ośmiałowski, B. (2013). Substituent effect in 2-benzoylmethylenequinoline difluoroborates exhibiting through-space couplings. Multinuclear magnetic resonance, X-ray diffraction, and computational study. The journal of physical chemistry. A, 117(1), 252-6. https://doi.org/10.1021/jp311072q
Zakrzewska, Anna, et al. "Substituent effect in 2-benzoylmethylenequinoline difluoroborates exhibiting through-space couplings. Multinuclear magnetic resonance, X-ray diffraction, and computational study." The journal of physical chemistry. A vol. 117,1 (2013): 252-6. doi: https://doi.org/10.1021/jp311072q
Zakrzewska A, Kolehmainen E, Valkonen A, Haapaniemi E, Rissanen K, Chęcińska L, Ośmiałowski B. Substituent effect in 2-benzoylmethylenequinoline difluoroborates exhibiting through-space couplings. Multinuclear magnetic resonance, X-ray diffraction, and computational study. J Phys Chem A. 2013 Jan 10;117(1):252-6. doi: 10.1021/jp311072q. Epub 2012 Dec 31. PMID: 23252343.
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MTDH genetic variants in colorectal cancer patients.

Scientific reports

Gnosa S, Ticha I, Haapaniemi S, Sun XF.
PMID: 26983693
Sci Rep. 2016 Mar 17;6:23163. doi: 10.1038/srep23163.

The colorectal carcinogenesis is a complex process encompassing genetic alterations. The oncoprotein AEG-1, encoded by the MTDH gene, was shown previously to be involved in colorectal cancer (CRC). The aim of this study was to determine the frequency and...

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Gnosa S, Ticha I, Haapaniemi S, et al. MTDH genetic variants in colorectal cancer patients. Sci Rep. 2016;6:23163doi: 10.1038/srep23163.
Gnosa, S., Ticha, I., Haapaniemi, S., & Sun, X. F. (2016). MTDH genetic variants in colorectal cancer patients. Scientific reports, 623163. https://doi.org/10.1038/srep23163
Gnosa, Sebastian, et al. "MTDH genetic variants in colorectal cancer patients." Scientific reports vol. 6 (2016): 23163. doi: https://doi.org/10.1038/srep23163
Gnosa S, Ticha I, Haapaniemi S, Sun XF. MTDH genetic variants in colorectal cancer patients. Sci Rep. 2016 Mar 17;6:23163. doi: 10.1038/srep23163. PMID: 26983693; PMCID: PMC4794727.
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Complete .

Magnetic resonance in chemistry : MRC

Haapaniemi E.
PMID: 28225171
Magn Reson Chem. 2017 Sep;55(9):804-812. doi: 10.1002/mrc.4590. Epub 2017 Mar 21.

The

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Haapaniemi E. Complete . Magn Reson Chem. 2017;55(9):804-812doi: 10.1002/mrc.4590.
Haapaniemi, E. (2017). Complete . Magnetic resonance in chemistry : MRC, 55(9), 804-812. https://doi.org/10.1002/mrc.4590
Haapaniemi, Esa. "Complete ." Magnetic resonance in chemistry : MRC vol. 55,9 (2017): 804-812. doi: https://doi.org/10.1002/mrc.4590
Haapaniemi E. Complete . Magn Reson Chem. 2017 Sep;55(9):804-812. doi: 10.1002/mrc.4590. Epub 2017 Mar 21. PMID: 28225171.
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Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.

NPJ genomic medicine

Keskitalo S, Haapaniemi EM, Glumoff V, Liu X, Lehtinen V, Fogarty C, Rajala H, Chiang SC, Mustjoki S, Kovanen P, Lohi J, Bryceson YT, Seppänen M, Kere J, Heiskanen K, Varjosalo M.
PMID: 31263572
NPJ Genom Med. 2019 Jun 27;4:14. doi: 10.1038/s41525-019-0088-5. eCollection 2019.

Mutations in several proteins functioning as endolysosomal components cause monogenic autoimmune diseases, of which pathogenesis is linked to increased endoplasmic reticulum stress, inefficient autophagy, and defective recycling of immune receptors. We report here a heterozygous

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Keskitalo S, Haapaniemi EM, Glumoff V, et al. Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease. NPJ Genom Med. 2019;4:14doi: 10.1038/s41525-019-0088-5.
Keskitalo, S., Haapaniemi, E. M., Glumoff, V., Liu, X., Lehtinen, V., Fogarty, C., Rajala, H., Chiang, S. C., Mustjoki, S., Kovanen, P., Lohi, J., Bryceson, Y. T., Seppänen, M., Kere, J., Heiskanen, K., & Varjosalo, M. (2019). Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease. NPJ genomic medicine, 414. https://doi.org/10.1038/s41525-019-0088-5
Keskitalo, Salla, et al. "Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease." NPJ genomic medicine vol. 4 (2019): 14. doi: https://doi.org/10.1038/s41525-019-0088-5
Keskitalo S, Haapaniemi EM, Glumoff V, Liu X, Lehtinen V, Fogarty C, Rajala H, Chiang SC, Mustjoki S, Kovanen P, Lohi J, Bryceson YT, Seppänen M, Kere J, Heiskanen K, Varjosalo M. Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease. NPJ Genom Med. 2019 Jun 27;4:14. doi: 10.1038/s41525-019-0088-5. eCollection 2019. PMID: 31263572; PMCID: PMC6597545.
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Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences.

Laryngoscope investigative otolaryngology

Lilja M, Viitasalo S, Hytönen M, Haapaniemi A, Hagström J, Mäkitie A.
PMID: 31890872
Laryngoscope Investig Otolaryngol. 2019 Sep 30;4(6):567-572. doi: 10.1002/lio2.308. eCollection 2019 Dec.

OBJECTIVE: Reports on sinonasal oncocytic papilloma (SNOP) are scarce. The aim of this retrospective study was to evaluate the clinical features of this rarest form of sinonasal papilloma with special emphasis on the pattern of recurrences and on the...

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Lilja M, Viitasalo S, Hytönen M, et al. Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences. Laryngoscope Investig Otolaryngol. 2019;4(6):567-572doi: 10.1002/lio2.308.
Lilja, M., Viitasalo, S., Hytönen, M., Haapaniemi, A., Hagström, J., & Mäkitie, A. (2019). Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences. Laryngoscope investigative otolaryngology, 4(6), 567-572. https://doi.org/10.1002/lio2.308
Lilja, Markus, et al. "Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences." Laryngoscope investigative otolaryngology vol. 4,6 (2019): 567-572. doi: https://doi.org/10.1002/lio2.308
Lilja M, Viitasalo S, Hytönen M, Haapaniemi A, Hagström J, Mäkitie A. Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences. Laryngoscope Investig Otolaryngol. 2019 Sep 30;4(6):567-572. doi: 10.1002/lio2.308. eCollection 2019 Dec. PMID: 31890872; PMCID: PMC6929580.
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Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease.

Inflammatory bowel diseases

Alkaissi LY, Winberg ME, Heil SDS, Haapaniemi S, Myrelid P, Stange EF, Söderholm JD, Keita ÅV.
PMID: 33336693
Inflamm Bowel Dis. 2021 Jun 15;27(7):1116-1127. doi: 10.1093/ibd/izaa315.

BACKGROUND: The first visible signs of Crohn's disease (CD) are microscopic erosions over the follicle-associated epithelium (FAE). The aim of the study was to investigate the effects of human α-defensin 5 (HD5) on adherent-invasive Escherichia coli LF82 translocation and...

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Alkaissi LY, Winberg ME, Heil SDS, et al. Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease. Inflamm Bowel Dis. 2021;27(7):1116-1127doi: 10.1093/ibd/izaa315.
Alkaissi, L. Y., Winberg, M. E., Heil, S. D. S., Haapaniemi, S., Myrelid, P., Stange, E. F., Söderholm, J. D., & Keita, �. �. V. (2021). Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease. Inflammatory bowel diseases, 27(7), 1116-1127. https://doi.org/10.1093/ibd/izaa315
Alkaissi, Lina Y, et al. "Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease." Inflammatory bowel diseases vol. 27,7 (2021): 1116-1127. doi: https://doi.org/10.1093/ibd/izaa315
Alkaissi LY, Winberg ME, Heil SDS, Haapaniemi S, Myrelid P, Stange EF, Söderholm JD, Keita ÅV. Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease. Inflamm Bowel Dis. 2021 Jun 15;27(7):1116-1127. doi: 10.1093/ibd/izaa315. PMID: 33336693; PMCID: PMC8205628.
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