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Showing 1 to 12 of 17 entries
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Bacchus by Caravaggio as the Visual Diagnosis of Alcohol Use Disorder from the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

Frontiers in psychiatry

Haass-Koffler CL, Kenna GA.
PMID: 23964247
Front Psychiatry. 2013 Aug 08;4:86. doi: 10.3389/fpsyt.2013.00086. eCollection 2013.

No abstract available.

Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.

The American journal of drug and alcohol abuse

Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL.
PMID: 34582281
Am J Drug Alcohol Abuse. 2021 Nov 02;47(6):760-768. doi: 10.1080/00952990.2021.1961799. Epub 2021 Sep 28.

BACKGROUND: Participants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.OBJECTIVES: The objectives of this secondary analysis were...

Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study.

The international journal of neuropsychopharmacology

Farokhnia M, Abshire KM, Hammer A, Deschaine SL, Saravanakumar A, Cobbina E, You ZB, Haass-Koffler CL, Lee MR, Akhlaghi F, Leggio L.
PMID: 33560411
Int J Neuropsychopharmacol. 2021 Jul 14;24(6):464-476. doi: 10.1093/ijnp/pyab004.

BACKGROUND: Accumulating evidence has established a role for the orexigenic hormone ghrelin in alcohol-seeking behaviors. Accordingly, the ghrelin system may represent a potential pharmacotherapeutic target for alcohol use disorder. Ghrelin modulates several neuroendocrine pathways, such as appetitive, metabolic, and...

Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.

The American journal of drug and alcohol abuse

Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL.
PMID: 34582281
Am J Drug Alcohol Abuse. 2021 Nov 02;47(6):760-768. doi: 10.1080/00952990.2021.1961799. Epub 2021 Sep 28.

BACKGROUND: Participants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.OBJECTIVES: The objectives of this secondary analysis were...

Dataset for Phase I randomized clinical trial for safety and tolerability of GET 73 in single and repeated ascending doses including preliminary pharmacokinetic parameters.

Data in brief

Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L.
PMID: 29214202
Data Brief. 2017 Sep 17;15:407-413. doi: 10.1016/j.dib.2017.09.018. eCollection 2017 Dec.

The data in this article outline the methods used for the administration of GET 73 in the first time-in-human manuscript entitled "Phase I randomized clinical trial for the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator...

Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.

The American journal of drug and alcohol abuse

Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL.
PMID: 34582281
Am J Drug Alcohol Abuse. 2021 Nov 02;47(6):760-768. doi: 10.1080/00952990.2021.1961799. Epub 2021 Sep 28.

BACKGROUND: Participants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.OBJECTIVES: The objectives of this secondary analysis were...

Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research.

Frontiers in behavioral neuroscience

Curley DE, Webb AE, Sheffler DJ, Haass-Koffler CL.
PMID: 34912198
Front Behav Neurosci. 2021 Nov 29;15:786855. doi: 10.3389/fnbeh.2021.786855. eCollection 2021.

Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative...

Corrigendum: Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study.

Alcohol and alcoholism (Oxford, Oxfordshire)

Haass-Koffler CL, Goodyear K, Zywiak WH, Leggio L, Kenna GA, Swift RM.
PMID: 29718153
Alcohol Alcohol. 2018 Jul 01;53(4):500. doi: 10.1093/alcalc/agy030.

No abstract available.

Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.

The American journal of drug and alcohol abuse

Goodyear K, Vasaturo-Kolodner TR, Kenna GA, Swift RM, Leggio L, Haass-Koffler CL.
PMID: 34582281
Am J Drug Alcohol Abuse. 2021 Sep 28;1-9. doi: 10.1080/00952990.2021.1961799. Epub 2021 Sep 28.

BACKGROUND: Participants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.OBJECTIVES: The objectives of this secondary analysis were...

An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in individuals with alcohol use disorder.

Psychopharmacology

Haass-Koffler CL, Perciballi R, Magill M, Loche A, Cacciaglia R, Leggio L, Swift RM.
PMID: 34731268
Psychopharmacology (Berl). 2021 Nov 03; doi: 10.1007/s00213-021-06008-1. Epub 2021 Nov 03.

RATIONALE: Previous work suggests that GET 73, a novel compound with putative activity on the metabotropic glutamate receptor subtype 5 (mGluR5), may represent a novel pharmacological treatment for alcohol use disorder (AUD).OBJECTIVE: In this study, we investigated the safety,...

Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research.

Frontiers in behavioral neuroscience

Curley DE, Webb AE, Sheffler DJ, Haass-Koffler CL.
PMID: 34912198
Front Behav Neurosci. 2021 Nov 29;15:786855. doi: 10.3389/fnbeh.2021.786855. eCollection 2021.

Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative...

Protein Tyrosine Phosphatase β/ζ and Alcohol Use Disorder: A Commentary.

Alcoholism, clinical and experimental research

Haass-Koffler CL.
PMID: 32343842
Alcohol Clin Exp Res. 2020 Jun;44(6):1189-1191. doi: 10.1111/acer.14346. Epub 2020 May 18.

No abstract available.

Showing 1 to 12 of 17 entries