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Showing 1 to 12 of 44 entries
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Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.

Frontiers in oncology

Pfeiffer MM, Burow H, Schleicher S, Handgretinger R, Lang P.
PMID: 23641363
Front Oncol. 2013 Apr 29;3:99. doi: 10.3389/fonc.2013.00099. eCollection 2013.

Epigenetic drugs like histone deacetylase inhibitors (HDACi) and DNA-methyltransferase inhibitors (DNMTi) have been shown to be effective against a variety of tumor entities. Among different molecular anticancer activities of epigenetic active substances, up-regulation of natural killer (NK) cell ligands...

Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study.

Stem cells international

Hartleif S, Schumm M, Döring M, Mezger M, Lang P, Dahlke MH, Riethmüller J, Königsrainer A, Handgretinger R, Nadalin S, Sturm E.
PMID: 28740511
Stem Cells Int. 2017;2017:2352954. doi: 10.1155/2017/2352954. Epub 2017 Jun 27.

BACKGROUND: Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. Mesenchymal stem (stromal) cells (MSC) have potent immunomodulatory properties,...

Immunotargeting relapsed or refractory precursor B-cell acute lymphoblastic leukemia - role of blinatumomab.

OncoTargets and therapy

Queudeville M, Handgretinger R, Ebinger M.
PMID: 28790849
Onco Targets Ther. 2017 Jul 19;10:3567-3578. doi: 10.2147/OTT.S103470. eCollection 2017.

Patients with refractory or relapsed (R/R) acute lymphoblastic leukemia (ALL) have a dismal prognosis of around 5% long-term survival when treated with cytotoxic chemotherapy and allogenic stem cell transplantation. T-cell immunobased strategies open up new therapeutic perspectives. Blinatumomab is...

Serving his patients with passion and dedication-Obituary to Prof. Dr. Dr. h.c. Dietrich Niethammer.

Bone marrow transplantation

Bader P, Handgretinger R, Klingebiel T.
PMID: 32094416
Bone Marrow Transplant. 2020 Jun;55(6):1209-1210. doi: 10.1038/s41409-020-0840-6. Epub 2020 Feb 24.

No abstract available.

Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.

Nature communications

Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L.
PMID: 34853305
Nat Commun. 2021 Dec 01;12(1):7005. doi: 10.1038/s41467-021-27303-7.

Immune-checkpoint inhibitors (ICI) have transformed oncological therapy. Up to 20% of all non-small cell lung cancers (NSCLCs) show durable responses upon treatment with ICI, however, robust markers to predict therapy response are missing. Here we show that blood platelets...

Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study.

Biomolecules

Zirjacks L, Stransky N, Klumpp L, Prause L, Eckert F, Zips D, Schleicher S, Handgretinger R, Huber SM, Ganser K.
PMID: 34827559
Biomolecules. 2021 Oct 21;11(11). doi: 10.3390/biom11111561.

Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for therapy resistance and tumor spreading in the brain, reportedly upregulate aldehyde dehydrogenase isoform-1A3 (ALDH1A3) which can be inhibited by disulfiram (DSF), an FDA-approved drug formerly prescribed...

Blinatumomab In pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis.

Blood advances

Locatelli F, Zugmaier G, Mergen N, Bader P, Jeha S, Schlegel PG, Bourquin JP, Handgretinger R, Brethon B, Rössig C, Kormany WN, Viswagnachar P, Chen-Santel C.
PMID: 34979020
Blood Adv. 2022 Jan 03; doi: 10.1182/bloodadvances.2021005579. Epub 2022 Jan 03.

The safety and efficacy of blinatumomab, a CD3/CD19-directed bispecific T-cell engager molecule, for treatment of pediatric relapsed/refractory B-cell precursor acute lymphoblastic leukemia (R/R B-ALL) were examined in an open-label, single-arm, expanded access study (RIALTO). Children (>28 days,

Long-Term Follow-Up After the Application of Mesenchymal Stromal Cells in Children and Adolescents with Steroid-Refractory Graft-Versus-Host Disease.

Stem cells and development

Döring M, Cabanillas Stanchi KM, Lenglinger K, Treuner C, Gieseke F, Erbacher A, Mezger M, Vaegler M, Schlegel PG, Greil J, Bettoni da Cunha Riehm C, Faul C, Schumm M, Lang P, Handgretinger R, Müller I.
PMID: 33446053
Stem Cells Dev. 2021 Mar;30(5):234-246. doi: 10.1089/scd.2020.0191. Epub 2021 Feb 19.

Steroid-refractory graft-versus-host disease (GvHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). Alternative treatment options are often insufficient. Several studies have proven the efficacy of mesenchymal stromal cells (MSCs) in the treatment of therapy-refractory acute GvHD...

RNA ImmunoGenic Assay: A Method to Detect Immunogenicity of .

Bio-protocol

Haque AA, Weinmann P, Biswas S, Handgretinger R, Mezger M, Kormann MSD, Antony JS.
PMID: 33855105
Bio Protoc. 2020 Dec 20;10(24):e3850. doi: 10.21769/BioProtoc.3850. eCollection 2020 Dec 20.

The mRNA therapeutics is a new class of medicine to treat many various diseases. However,

Correction to: Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.

BMC pediatrics

Schober S, Schilbach K, Doering M, Cabanillas Stanchi KM, Holzer U, Kasteleiner P, Schittenhelm J, Schaefer JF, Mueller I, Lang P, Handgretinger R.
PMID: 31791281
BMC Pediatr. 2019 Dec 02;19(1):470. doi: 10.1186/s12887-019-1851-6.

After publication of the original article (1), it was brought to our attention that references 24 and 31 are inappropriately cited in the article.

Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.

Nature communications

Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L.
PMID: 34853305
Nat Commun. 2021 Dec 01;12(1):7005. doi: 10.1038/s41467-021-27303-7.

Immune-checkpoint inhibitors (ICI) have transformed oncological therapy. Up to 20% of all non-small cell lung cancers (NSCLCs) show durable responses upon treatment with ICI, however, robust markers to predict therapy response are missing. Here we show that blood platelets...

Arginase 1.

Experimental dermatology

Neri D, Carevic-Neri M, Brück J, Holstein J, Schäfer I, Solimani F, Handgretinger R, Hartl D, Ghoreschi K.
PMID: 33528891
Exp Dermatol. 2021 Jun;30(6):782-791. doi: 10.1111/exd.14298. Epub 2021 Feb 23.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells, which are characterized by their capability to suppress T-cell responses. While MDSCs have been traditionally associated with cancer diseases, their role as regulators of autoimmune diseases is...

Showing 1 to 12 of 44 entries