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Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.

Journal of drug delivery science and technology

Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra S, Mohapatra S, Haraszti RA, Khvorova A, Aronin N, Sava V.
PMID: 29805475
J Drug Deliv Sci Technol. 2018 Feb;43:453-460. doi: 10.1016/j.jddst.2017.11.013. Epub 2017 Nov 21.

The overall objective of the present research was to develop a nanocarrier system for non-invasive delivery to brain of molecules useful for gene therapy. Manganese-containing nanoparticles (mNPs) carrying

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Sanchez-Ramos J, Song S, Kong X, et al. Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. J Drug Deliv Sci Technol. 2017;43:453-460doi: 10.1016/j.jddst.2017.11.013.
Sanchez-Ramos, J., Song, S., Kong, X., Foroutan, P., Martinez, G., Dominguez-Viqueria, W., Mohapatra, S., Mohapatra, S., Haraszti, R. A., Khvorova, A., Aronin, N., & Sava, V. (2018). Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. Journal of drug delivery science and technology, 43453-460. https://doi.org/10.1016/j.jddst.2017.11.013
Sanchez-Ramos, Juan, et al. "Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain." Journal of drug delivery science and technology vol. 43 (2018): 453-460. doi: https://doi.org/10.1016/j.jddst.2017.11.013
Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra S, Mohapatra S, Haraszti RA, Khvorova A, Aronin N, Sava V. Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. J Drug Deliv Sci Technol. 2018 Feb;43:453-460. doi: 10.1016/j.jddst.2017.11.013. Epub 2017 Nov 21. PMID: 29805475; PMCID: PMC5967853.
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Dissipative disassembly of colloidal microgel crystals driven by a coupled cyclic reaction network.

Soft matter

Go D, Rommel D, Liao Y, Haraszti T, Sprakel J, Kuehne AJC.
PMID: 29379929
Soft Matter. 2018 Feb 14;14(6):910-915. doi: 10.1039/c7sm02061a. Epub 2018 Jan 30.

A plethora of natural systems rely on the consumption of chemical fuel or input of external energy to control the assembly and disassembly of functional structures on demand. While dissipative assembly has been demonstrated, the control of structural breakdown...

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Go D, Rommel D, Liao Y, et al. Dissipative disassembly of colloidal microgel crystals driven by a coupled cyclic reaction network. Soft Matter. 2018;14(6):910-915doi: 10.1039/c7sm02061a.
Go, D., Rommel, D., Liao, Y., Haraszti, T., Sprakel, J., & Kuehne, A. J. C. (2018). Dissipative disassembly of colloidal microgel crystals driven by a coupled cyclic reaction network. Soft matter, 14(6), 910-915. https://doi.org/10.1039/c7sm02061a
Go, Dennis, et al. "Dissipative disassembly of colloidal microgel crystals driven by a coupled cyclic reaction network." Soft matter vol. 14,6 (2018): 910-915. doi: https://doi.org/10.1039/c7sm02061a
Go D, Rommel D, Liao Y, Haraszti T, Sprakel J, Kuehne AJC. Dissipative disassembly of colloidal microgel crystals driven by a coupled cyclic reaction network. Soft Matter. 2018 Feb 14;14(6):910-915. doi: 10.1039/c7sm02061a. Epub 2018 Jan 30. PMID: 29379929.
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Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration.

Cells

Blizard S, Park D, O'Toole N, Norooz S, Dela Torre M, Son Y, Holstein A, Austin S, Harman J, Haraszti S, Fared D, Xu M.
PMID: 34685634
Cells. 2021 Oct 05;10(10). doi: 10.3390/cells10102654.

Insulin-like growth factor II mRNA-binding protein (IMP) 2 is one of the three homologues (IMP1-3) that belong to a conserved family of mRNA-binding proteins. Its alternative splice product is aberrantly expressed in human hepatocellular carcinoma, and it is therefore...

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Blizard S, Park D, O'Toole N, et al. Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration. Cells. 2021;10(10)doi: 10.3390/cells10102654.
Blizard, S., Park, D., O'Toole, N., Norooz, S., Dela Torre, M., Son, Y., Holstein, A., Austin, S., Harman, J., Haraszti, S., Fared, D., & Xu, M. (2021). Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration. Cells, 10(10), . https://doi.org/10.3390/cells10102654
Blizard, Sarah, et al. "Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration." Cells vol. 10,10 (2021). doi: https://doi.org/10.3390/cells10102654
Blizard S, Park D, O'Toole N, Norooz S, Dela Torre M, Son Y, Holstein A, Austin S, Harman J, Haraszti S, Fared D, Xu M. Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration. Cells. 2021 Oct 05;10(10). doi: 10.3390/cells10102654. PMID: 34685634; PMCID: PMC8534607.
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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.

JCI insight

Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A.
PMID: 34935646
JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.152203.

siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains upon direct...

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Ferguson CM, Godinho BM, Alterman JF, et al. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021;6(24)doi: 10.1172/jci.insight.152203.
Ferguson, C. M., Godinho, B. M., Alterman, J. F., Coles, A. H., Hassler, M., Echeverria, D., Gilbert, J. W., Knox, E. G., Caiazzi, J., Haraszti, R. A., King, R. M., Taghian, T., Puri, A., Moser, R. P., Gounis, M. J., Aronin, N., Gray-Edwards, H., & Khvorova, A. (2021). Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI insight, 6(24), . https://doi.org/10.1172/jci.insight.152203
Ferguson, Chantal M, et al. "Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep." JCI insight vol. 6,24 (2021). doi: https://doi.org/10.1172/jci.insight.152203
Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.152203. PMID: 34935646.
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Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rommel D, Mork M, Vedaraman S, Bastard C, Guerzoni LPB, Kittel Y, Vinokur R, Born N, Haraszti T, De Laporte L.
PMID: 35032119
Adv Sci (Weinh). 2022 Jan 14;e2103554. doi: 10.1002/advs.202103554. Epub 2022 Jan 14.

In this work, a two component microgel assembly using soft anisometric microgels that interlink to create a 3D macroporous construct for cell growth is reported. Reactive microgel rods with variable aspect ratio are produced via microfluidics in a continuous...

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Rommel D, Mork M, Vedaraman S, et al. Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture. Adv Sci (Weinh). 2022;e2103554doi: 10.1002/advs.202103554.
Rommel, D., Mork, M., Vedaraman, S., Bastard, C., Guerzoni, L. P. B., Kittel, Y., Vinokur, R., Born, N., Haraszti, T., & De Laporte, L. (2022). Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2103554. https://doi.org/10.1002/advs.202103554
Rommel, Dirk, et al. "Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. (2022): e2103554. doi: https://doi.org/10.1002/advs.202103554
Rommel D, Mork M, Vedaraman S, Bastard C, Guerzoni LPB, Kittel Y, Vinokur R, Born N, Haraszti T, De Laporte L. Functionalized Microgel Rods Interlinked into Soft Macroporous Structures for 3D Cell Culture. Adv Sci (Weinh). 2022 Jan 14;e2103554. doi: 10.1002/advs.202103554. Epub 2022 Jan 14. PMID: 35032119.
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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.

JCI insight

Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A.
PMID: 34935646
JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.152203.

siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains upon direct...

Cite
Ferguson CM, Godinho BM, Alterman JF, et al. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021;6(24)doi: 10.1172/jci.insight.152203.
Ferguson, C. M., Godinho, B. M., Alterman, J. F., Coles, A. H., Hassler, M., Echeverria, D., Gilbert, J. W., Knox, E. G., Caiazzi, J., Haraszti, R. A., King, R. M., Taghian, T., Puri, A., Moser, R. P., Gounis, M. J., Aronin, N., Gray-Edwards, H., & Khvorova, A. (2021). Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI insight, 6(24), . https://doi.org/10.1172/jci.insight.152203
Ferguson, Chantal M, et al. "Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep." JCI insight vol. 6,24 (2021). doi: https://doi.org/10.1172/jci.insight.152203
Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.152203. PMID: 34935646.
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Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings.

Macromolecular bioscience

Söder D, Garay-Sarmiento M, Rahimi K, Obstals F, Dedisch S, Haraszti T, Davari MD, Jakob F, Heß C, Schwaneberg U, Rodriguez-Emmenegger C.
PMID: 34145970
Macromol Biosci. 2021 Sep;21(9):e2100158. doi: 10.1002/mabi.202100158. Epub 2021 Jun 18.

The ability of proteins to adsorb irreversibly onto surfaces opens new possibilities to functionalize biological interfaces. Herein, the mechanism and kinetics of adsorption of protein-polymer macromolecules with the ability to equip surfaces with antifouling properties are investigated. These macromolecules...

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Söder D, Garay-Sarmiento M, Rahimi K, et al. Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings. Macromol Biosci. 2021;21(9):e2100158doi: 10.1002/mabi.202100158.
Söder, D., Garay-Sarmiento, M., Rahimi, K., Obstals, F., Dedisch, S., Haraszti, T., Davari, M. D., Jakob, F., Heß, C., Schwaneberg, U., & Rodriguez-Emmenegger, C. (2021). Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings. Macromolecular bioscience, 21(9), e2100158. https://doi.org/10.1002/mabi.202100158
Söder, Dominik, et al. "Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings." Macromolecular bioscience vol. 21,9 (2021): e2100158. doi: https://doi.org/10.1002/mabi.202100158
Söder D, Garay-Sarmiento M, Rahimi K, Obstals F, Dedisch S, Haraszti T, Davari MD, Jakob F, Heß C, Schwaneberg U, Rodriguez-Emmenegger C. Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings. Macromol Biosci. 2021 Sep;21(9):e2100158. doi: 10.1002/mabi.202100158. Epub 2021 Jun 18. PMID: 34145970.
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Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa.

JAAD case reports

Haraszti S, Ezaldein H, Delost GR.
PMID: 30555879
JAAD Case Rep. 2018 Dec 04;5(1):21-23. doi: 10.1016/j.jdcr.2018.10.005. eCollection 2019 Jan.

No abstract available.

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Haraszti S, Ezaldein H, Delost GR. Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa. JAAD Case Rep. 2018;5(1):21-23doi: 10.1016/j.jdcr.2018.10.005.
Haraszti, S., Ezaldein, H., & Delost, G. R. (2019). Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa. JAAD case reports, 5(1), 21-23. https://doi.org/10.1016/j.jdcr.2018.10.005
Haraszti, Samantha, et al. "Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa." JAAD case reports vol. 5,1 (2019): 21-23. doi: https://doi.org/10.1016/j.jdcr.2018.10.005
Haraszti S, Ezaldein H, Delost GR. Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa. JAAD Case Rep. 2018 Dec 04;5(1):21-23. doi: 10.1016/j.jdcr.2018.10.005. eCollection 2019 Jan. PMID: 30555879; PMCID: PMC6280631.
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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.

iScience

Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A.
PMID: 31195240
iScience. 2019 Jun 28;16:230-241. doi: 10.1016/j.isci.2019.05.029. Epub 2019 May 27.

Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of exosomes to optimize exosome-mediated delivery of small interfering RNAs...

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Haraszti RA, Miller R, Dubuke ML, et al. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. iScience. 2019;16:230-241doi: 10.1016/j.isci.2019.05.029.
Haraszti, R. A., Miller, R., Dubuke, M. L., Rockwell, H. E., Coles, A. H., Sapp, E., Didiot, M. C., Echeverria, D., Stoppato, M., Sere, Y. Y., Leszyk, J., Alterman, J. F., Godinho, B. M. D. C., Hassler, M. R., McDaniel, J., Narain, N. R., Wollacott, R., Wang, Y., Shaffer, S. A., Kiebish, M. A., DiFiglia, M., Aronin, N., & Khvorova, A. (2019). Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. iScience, 16230-241. https://doi.org/10.1016/j.isci.2019.05.029
Haraszti, Reka Agnes, et al. "Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition." iScience vol. 16 (2019): 230-241. doi: https://doi.org/10.1016/j.isci.2019.05.029
Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A. Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. iScience. 2019 Jun 28;16:230-241. doi: 10.1016/j.isci.2019.05.029. Epub 2019 May 27. PMID: 31195240; PMCID: PMC6562145.
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The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus.

Biomedicines

Larasati RA, Harbuwono DS, Rahajeng E, Pradipta S, Nuraeni HS, Susilowati A, Wibowo H.
PMID: 31554278
Biomedicines. 2019 Sep 24;7(4). doi: 10.3390/biomedicines7040074.

Type 2 Diabetes Mellitus (T2DM) is a very serious global problem. In Indonesia, this disease attacks at the most productive age; consequently, it can reduce economic status and life expectancy. The pathogenesis of T2DM is very closely related to...

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Larasati RA, Harbuwono DS, Rahajeng E, et al. The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus. Biomedicines. 2019;7(4)doi: 10.3390/biomedicines7040074.
Larasati, R. A., Harbuwono, D. S., Rahajeng, E., Pradipta, S., Nuraeni, H. S., Susilowati, A., & Wibowo, H. (2019). The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus. Biomedicines, 7(4), . https://doi.org/10.3390/biomedicines7040074
Larasati, Rahma Ayu, et al. "The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus." Biomedicines vol. 7,4 (2019). doi: https://doi.org/10.3390/biomedicines7040074
Larasati RA, Harbuwono DS, Rahajeng E, Pradipta S, Nuraeni HS, Susilowati A, Wibowo H. The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus. Biomedicines. 2019 Sep 24;7(4). doi: 10.3390/biomedicines7040074. PMID: 31554278; PMCID: PMC6966637.
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STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data.

Chemistry Central journal

Haraszti T, Grunze M, Anderson MG.
PMID: 20525317
Chem Cent J. 2010 Jun 04;4:11. doi: 10.1186/1752-153X-4-11.

BACKGROUND: Soft X-ray spectromicroscopy based absorption near-edge structure analysis, is a spectroscopic technique useful for investigating sample composition at a nanoscale of resolution. While the technique holds great promise for analysis of biological samples, current methodologies are challenged by...

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Haraszti T, Grunze M, Anderson MG. STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data. Chem Cent J. 2010;4:11doi: 10.1186/1752-153X-4-11.
Haraszti, T., Grunze, M., & Anderson, M. G. (2010). STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data. Chemistry Central journal, 411. https://doi.org/10.1186/1752-153X-4-11
Haraszti, Tamás, et al. "STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data." Chemistry Central journal vol. 4 (2010): 11. doi: https://doi.org/10.1186/1752-153X-4-11
Haraszti T, Grunze M, Anderson MG. STXMPy: a new software package for automated region of interest selection and statistical analysis of XANES data. Chem Cent J. 2010 Jun 04;4:11. doi: 10.1186/1752-153X-4-11. PMID: 20525317; PMCID: PMC2891742.
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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.

Molecular therapy. Nucleic acids

Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A.
PMID: 27504598
Mol Ther Nucleic Acids. 2016 Aug 09;5(8):e344. doi: 10.1038/mtna.2016.50.

The use of siRNA-based therapies for the treatment of neurodegenerative disease requires efficient, nontoxic distribution to the affected brain parenchyma, notably the striatum and cortex. Here, we describe the synthesis and activity of a fully chemically modified siRNA that...

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Nikan M, Osborn MF, Coles AH, et al. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016;5(8):e344doi: 10.1038/mtna.2016.50.
Nikan, M., Osborn, M. F., Coles, A. H., Godinho, B. M., Hall, L. M., Haraszti, R. A., Hassler, M. R., Echeverria, D., Aronin, N., & Khvorova, A. (2016). Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Molecular therapy. Nucleic acids, 5(8), e344. https://doi.org/10.1038/mtna.2016.50
Nikan, Mehran, et al. "Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain." Molecular therapy. Nucleic acids vol. 5,8 (2016): e344. doi: https://doi.org/10.1038/mtna.2016.50
Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids. 2016 Aug 09;5(8):e344. doi: 10.1038/mtna.2016.50. PMID: 27504598; PMCID: PMC5023396.
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Showing 1 to 12 of 27 entries