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Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response.

Current chemical genomics

Symons KT, Massari ME, Dozier SJ, Nguyen PM, Jenkins D, Herbert M, Gahman TC, Noble SA, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.
PMID: 20161838
Curr Chem Genomics. 2008 Sep 27;2:1-9. doi: 10.2174/1875397300802010001.

The transcription of inducible nitric oxide synthase (iNOS) is activated by a network of proinflammatory signaling pathways. Here we describe the identification of a small molecule that downregulates the expression of iNOS mRNA and protein in cytokine-activated cells and...

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Symons KT, Massari ME, Dozier SJ, et al. Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response. Curr Chem Genomics. 2008;2:1-9doi: 10.2174/1875397300802010001.
Symons, K. T., Massari, M. E., Dozier, S. J., Nguyen, P. M., Jenkins, D., Herbert, M., Gahman, T. C., Noble, S. A., Rozenkrants, N., Zhang, Y., Rao, T. S., Shiau, A. K., & Hassig, C. A. (2008). Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response. Current chemical genomics, 21-9. https://doi.org/10.2174/1875397300802010001
Symons, Kent T, et al. "Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response." Current chemical genomics vol. 2 (2008): 1-9. doi: https://doi.org/10.2174/1875397300802010001
Symons KT, Massari ME, Dozier SJ, Nguyen PM, Jenkins D, Herbert M, Gahman TC, Noble SA, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA. Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response. Curr Chem Genomics. 2008 Sep 27;2:1-9. doi: 10.2174/1875397300802010001. PMID: 20161838; PMCID: PMC2803434.
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Phytochrome-controlled extension growth of Avena sativa L. seedlings : II. Fluence rate response relationships and action spectra of mesocotyl and coleoptile responses.

Planta

Schäfer E, Lassig TU, Schopfer P.
PMID: 24276066
Planta. 1982 May;154(3):231-40. doi: 10.1007/BF00387869.

Fluence rate response curves for light-induced inhibition of mesocotyl growth and promotion of coleoptile growth in etiolated Avena sativa L. (cv. Victory) were developed. The irradiation time was 24 h. Fluence rates between 10(-6) and 10(5) nmol m(-2)s(-1) and...

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Schäfer E, Lassig TU, Schopfer P. Phytochrome-controlled extension growth of Avena sativa L. seedlings : II. Fluence rate response relationships and action spectra of mesocotyl and coleoptile responses. Planta. 1982;154(3):231-40doi: 10.1007/BF00387869.
Schäfer, E., Lassig, T. U., & Schopfer, P. (1982). Phytochrome-controlled extension growth of Avena sativa L. seedlings : II. Fluence rate response relationships and action spectra of mesocotyl and coleoptile responses. Planta, 154(3), 231-40. https://doi.org/10.1007/BF00387869
Schäfer, E, et al. "Phytochrome-controlled extension growth of Avena sativa L. seedlings : II. Fluence rate response relationships and action spectra of mesocotyl and coleoptile responses." Planta vol. 154,3 (1982): 231-40. doi: https://doi.org/10.1007/BF00387869
Schäfer E, Lassig TU, Schopfer P. Phytochrome-controlled extension growth of Avena sativa L. seedlings : II. Fluence rate response relationships and action spectra of mesocotyl and coleoptile responses. Planta. 1982 May;154(3):231-40. doi: 10.1007/BF00387869. PMID: 24276066.
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Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock.

Research & reviews. Journal of hospital and clinical pharmacy

Nappi JM, Sieg A, Hassig TB, Wahlquist AE.
PMID: 28804796
Res Rev J Hosp Clin Pharm. 2016 May;2(2):87-91. Epub 2016 May 12.

PURPOSE: With the previous norepinephrine shortage, alternative agents were required to treat patients with septic shock. This retrospective study evaluated whether the shortage of norepinephrine had an adverse effect on patients admitted to the intensive care unit with a...

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Nappi JM, Sieg A, Hassig TB, et al. Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock. Res Rev J Hosp Clin Pharm. 2016;2(2):87-91
Nappi, J. M., Sieg, A., Hassig, T. B., & Wahlquist, A. E. (2016). Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock. Research & reviews. Journal of hospital and clinical pharmacy, 2(2), 87-91.
Nappi, Jean M, et al. "Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock." Research & reviews. Journal of hospital and clinical pharmacy vol. 2,2 (2016): 87-91.
Nappi JM, Sieg A, Hassig TB, Wahlquist AE. Impact of Norepinephrine Shortage on Outcomes in Patients with Septic Shock. Res Rev J Hosp Clin Pharm. 2016 May;2(2):87-91. Epub 2016 May 12. PMID: 28804796; PMCID: PMC5553972.
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About pseudotuberculosis in humans.

Schweizerische medizinische Wochenschrift

HASSIG A, KARRER J, PUSTERLA F.
PMID: 18143767
Schweiz Med Wochenschr. 1949 Oct 15;79(41):971-3.

No abstract available.

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HASSIG A, KARRER J, PUSTERLA F. Ueber Pseudotuberkulose beim Menschen. About pseudotuberculosis in humans. Schweiz Med Wochenschr. 1949;79(41):971-3
HASSIG, A., KARRER, J., & PUSTERLA, F. (1949). Ueber Pseudotuberkulose beim Menschen. About pseudotuberculosis in humans. Schweizerische medizinische Wochenschrift, 79(41), 971-3.
HASSIG, A, et al. "Ueber Pseudotuberkulose beim Menschen." About pseudotuberculosis in humans. Schweizerische medizinische Wochenschrift vol. 79,41 (1949): 971-3.
HASSIG A, KARRER J, PUSTERLA F. Ueber Pseudotuberkulose beim Menschen. About pseudotuberculosis in humans. Schweiz Med Wochenschr. 1949 Oct 15;79(41):971-3. German. PMID: 18143767.
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Species-based comparison of disease severity and risk factors for disseminated Candida infections in pediatric patients.

Infection and drug resistance

Hawkshead JJ, Van Dyke RB, Hassig SE, Webber LS, Begue RE.
PMID: 27143942
Infect Drug Resist. 2016 Apr 18;9:59-70. doi: 10.2147/IDR.S102490. eCollection 2016.

BACKGROUND: Pediatric Candida infections are associated with worse clinical outcomes and increased costs. Yet, it is not definitively known if particular species are associated with more severe illness. Differential risk factor exposures among the species group may also exist....

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Hawkshead JJ, Van Dyke RB, Hassig SE, et al. Species-based comparison of disease severity and risk factors for disseminated Candida infections in pediatric patients. Infect Drug Resist. 2016;9:59-70doi: 10.2147/IDR.S102490.
Hawkshead, J. J., Van Dyke, R. B., Hassig, S. E., Webber, L. S., & Begue, R. E. (2016). Species-based comparison of disease severity and risk factors for disseminated Candida infections in pediatric patients. Infection and drug resistance, 959-70. https://doi.org/10.2147/IDR.S102490
Hawkshead, John J, et al. "Species-based comparison of disease severity and risk factors for disseminated Candida infections in pediatric patients." Infection and drug resistance vol. 9 (2016): 59-70. doi: https://doi.org/10.2147/IDR.S102490
Hawkshead JJ, Van Dyke RB, Hassig SE, Webber LS, Begue RE. Species-based comparison of disease severity and risk factors for disseminated Candida infections in pediatric patients. Infect Drug Resist. 2016 Apr 18;9:59-70. doi: 10.2147/IDR.S102490. eCollection 2016. PMID: 27143942; PMCID: PMC4846055.
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Dynamic potential and surface morphology study of sertraline membrane sensors.

Journal of advanced research

Khater MM, Issa YM, Hassib HB, Mohammed SH.
PMID: 26257944
J Adv Res. 2015 May;6(3):459-69. doi: 10.1016/j.jare.2014.11.005. Epub 2014 Dec 01.

New rapid, sensitive and simple electrometric method was developed to determine sertraline hydrochloride (Ser-Cl) in its pure raw material and pharmaceutical formulations. Membrane sensors based on heteropolyacids as ion associating material were prepared. Silicomolybdic acid (SMA), silicotungstic acid (STA)...

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Khater MM, Issa YM, Hassib HB, et al. Dynamic potential and surface morphology study of sertraline membrane sensors. J Adv Res. 2014;6(3):459-69doi: 10.1016/j.jare.2014.11.005.
Khater, M. M., Issa, Y. M., Hassib, H. B., & Mohammed, S. H. (2015). Dynamic potential and surface morphology study of sertraline membrane sensors. Journal of advanced research, 6(3), 459-69. https://doi.org/10.1016/j.jare.2014.11.005
Khater, M M, et al. "Dynamic potential and surface morphology study of sertraline membrane sensors." Journal of advanced research vol. 6,3 (2015): 459-69. doi: https://doi.org/10.1016/j.jare.2014.11.005
Khater MM, Issa YM, Hassib HB, Mohammed SH. Dynamic potential and surface morphology study of sertraline membrane sensors. J Adv Res. 2015 May;6(3):459-69. doi: 10.1016/j.jare.2014.11.005. Epub 2014 Dec 01. PMID: 26257944; PMCID: PMC4522588.
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Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.

Data in brief

Cheng Z, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C, Shi K, Yang B, Qian Z, Boyle P, Zheng T.
PMID: 33937452
Data Brief. 2021 Mar 27;36:107014. doi: 10.1016/j.dib.2021.107014. eCollection 2021 Jun.

In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were...

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Cheng Z, Zhang X, Bassig B, et al. Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types. Data Brief. 2021;36:107014doi: 10.1016/j.dib.2021.107014.
Cheng, Z., Zhang, X., Bassig, B., Hauser, R., Holford, T. R., Zheng, E., Shi, D., Zhu, Y., Schwartz, S. M., Chen, C., Shi, K., Yang, B., Qian, Z., Boyle, P., & Zheng, T. (2021). Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types. Data in brief, 36107014. https://doi.org/10.1016/j.dib.2021.107014
Cheng, Zhiyuan, et al. "Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types." Data in brief vol. 36 (2021): 107014. doi: https://doi.org/10.1016/j.dib.2021.107014
Cheng Z, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C, Shi K, Yang B, Qian Z, Boyle P, Zheng T. Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types. Data Brief. 2021 Mar 27;36:107014. doi: 10.1016/j.dib.2021.107014. eCollection 2021 Jun. PMID: 33937452; PMCID: PMC8076715.
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A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU.

Pharmacotherapy

Boyd C, Hassig T, MacLaren R.
PMID: 34478588
Pharmacotherapy. 2021 Oct;41(10):820-827. doi: 10.1002/phar.2621. Epub 2021 Sep 12.

OBJECTIVE: Approximately 1%-5% of critically ill patients experience clinically important gastrointestinal bleeding (CIGB). This study assessed the effectiveness and safety of proton pump inhibitors (PPIs) compared to histamine type 2 receptor antagonists (H2RAs) for prevention of CIGB in mechanically...

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Boyd C, Hassig T, MacLaren R. A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU. Pharmacotherapy. 2021;41(10):820-827doi: 10.1002/phar.2621.
Boyd, C., Hassig, T., & MacLaren, R. (2021). A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU. Pharmacotherapy, 41(10), 820-827. https://doi.org/10.1002/phar.2621
Boyd, Carly, et al. "A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU." Pharmacotherapy vol. 41,10 (2021): 820-827. doi: https://doi.org/10.1002/phar.2621
Boyd C, Hassig T, MacLaren R. A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU. Pharmacotherapy. 2021 Oct;41(10):820-827. doi: 10.1002/phar.2621. Epub 2021 Sep 12. PMID: 34478588.
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The establishment of the Household Air Pollution Consortium (HAPCO).

Atmosphere

Hosgood HD, Klugman M, Matsuo K, White AJ, Sadakane A, Shu XO, Lopez-Ridaura R, Shin A, Tsuji I, Malekzadeh R, Noisel N, Bhatti P, Yang G, Saito E, Rahman S, Hu W, Bassig B, Downward G, Vermeulen R, Xue X, Rohan T, Abe SK, Broët P, Grant EJ, Dummer TJB, Rothman N, Inoue M, Lajous M, Yoo KY, Ito H, Sandler DP, Ashan H, Zheng W, Boffetta P, Lan Q.
PMID: 32064123
Atmosphere (Basel). 2019 Jul;10(7). doi: 10.3390/atmos10070422. Epub 2019 Jul 23.

Household air pollution (HAP) is of public health concern with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from...

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Hosgood HD, Klugman M, Matsuo K, et al. The establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere (Basel). 2019;10(7)doi: 10.3390/atmos10070422.
Hosgood, H. D., Klugman, M., Matsuo, K., White, A. J., Sadakane, A., Shu, X. O., Lopez-Ridaura, R., Shin, A., Tsuji, I., Malekzadeh, R., Noisel, N., Bhatti, P., Yang, G., Saito, E., Rahman, S., Hu, W., Bassig, B., Downward, G., Vermeulen, R., Xue, X., Rohan, T., Abe, S. K., Broët, P., Grant, E. J., Dummer, T. J. B., Rothman, N., Inoue, M., Lajous, M., Yoo, K. Y., Ito, H., Sandler, D. P., Ashan, H., Zheng, W., Boffetta, P., & Lan, Q. (2019). The establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere, 10(7), . https://doi.org/10.3390/atmos10070422
Hosgood, H Dean, et al. "The establishment of the Household Air Pollution Consortium (HAPCO)." Atmosphere vol. 10,7 (2019). doi: https://doi.org/10.3390/atmos10070422
Hosgood HD, Klugman M, Matsuo K, White AJ, Sadakane A, Shu XO, Lopez-Ridaura R, Shin A, Tsuji I, Malekzadeh R, Noisel N, Bhatti P, Yang G, Saito E, Rahman S, Hu W, Bassig B, Downward G, Vermeulen R, Xue X, Rohan T, Abe SK, Broët P, Grant EJ, Dummer TJB, Rothman N, Inoue M, Lajous M, Yoo KY, Ito H, Sandler DP, Ashan H, Zheng W, Boffetta P, Lan Q. The establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere (Basel). 2019 Jul;10(7). doi: 10.3390/atmos10070422. Epub 2019 Jul 23. PMID: 32064123; PMCID: PMC7021252.
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Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts.

Environmental pollution (Barking, Essex : 1987)

Cheng Z, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C, Shi K, Yang B, Qian Z, Boyle P, Zheng T.
PMID: 33482463
Environ Pollut. 2021 Jan 11;273:116458. doi: 10.1016/j.envpol.2021.116458. Epub 2021 Jan 11.

The incidence rate of testicular germ cell tumors (TGCT) has continuously increased in Western countries over the last several decades. Some epidemiologic studies have reported that the endocrine disrupting polychlorinated biphenyls (PCBs) in serum may be associated with TGCT...

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Cheng Z, Zhang X, Bassig B, et al. Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts. Environ Pollut. 2021;273:116458doi: 10.1016/j.envpol.2021.116458.
Cheng, Z., Zhang, X., Bassig, B., Hauser, R., Holford, T. R., Zheng, E., Shi, D., Zhu, Y., Schwartz, S. M., Chen, C., Shi, K., Yang, B., Qian, Z., Boyle, P., & Zheng, T. (2021). Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts. Environmental pollution (Barking, Essex : 1987), 273116458. https://doi.org/10.1016/j.envpol.2021.116458
Cheng, Zhiyuan, et al. "Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts." Environmental pollution (Barking, Essex : 1987) vol. 273 (2021): 116458. doi: https://doi.org/10.1016/j.envpol.2021.116458
Cheng Z, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C, Shi K, Yang B, Qian Z, Boyle P, Zheng T. Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts. Environ Pollut. 2021 Jan 11;273:116458. doi: 10.1016/j.envpol.2021.116458. Epub 2021 Jan 11. PMID: 33482463.
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Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma.

Scientific reports

Liu Z, Sarathkumara YD, Chan JKC, Kwong YL, Lam TH, Ip DKM, Chiu BC, Xu J, Su YC, Proietti C, Cooper MM, Yu KJ, Bassig B, Liang R, Hu W, Ji BT, Coghill AE, Pfeiffer RM, Hildesheim A, Rothman N, Doolan DL, Lan Q.
PMID: 34880297
Sci Rep. 2021 Dec 08;11(1):23664. doi: 10.1038/s41598-021-02788-w.

Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy that has been etiologically linked to Epstein-Barr virus (EBV) infection, with EBV gene transcripts identified in almost all cases. However, the humoral immune response to EBV in NKTCL patients has...

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Liu Z, Sarathkumara YD, Chan JKC, et al. Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Sci Rep. 2021;11(1):23664doi: 10.1038/s41598-021-02788-w.
Liu, Z., Sarathkumara, Y. D., Chan, J. K. C., Kwong, Y. L., Lam, T. H., Ip, D. K. M., Chiu, B. C., Xu, J., Su, Y. C., Proietti, C., Cooper, M. M., Yu, K. J., Bassig, B., Liang, R., Hu, W., Ji, B. T., Coghill, A. E., Pfeiffer, R. M., Hildesheim, A., Rothman, N., Doolan, D. L., & Lan, Q. (2021). Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Scientific reports, 11(1), 23664. https://doi.org/10.1038/s41598-021-02788-w
Liu, Zhiwei, et al. "Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma." Scientific reports vol. 11,1 (2021): 23664. doi: https://doi.org/10.1038/s41598-021-02788-w
Liu Z, Sarathkumara YD, Chan JKC, Kwong YL, Lam TH, Ip DKM, Chiu BC, Xu J, Su YC, Proietti C, Cooper MM, Yu KJ, Bassig B, Liang R, Hu W, Ji BT, Coghill AE, Pfeiffer RM, Hildesheim A, Rothman N, Doolan DL, Lan Q. Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Sci Rep. 2021 Dec 08;11(1):23664. doi: 10.1038/s41598-021-02788-w. PMID: 34880297; PMCID: PMC8655014.
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Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report.

Archives of medical science : AMS

Hassid B, Azmoon S, Aronow WS, Palaniswamy C, Cohen M, Gass A.
PMID: 22427775
Arch Med Sci. 2010 Dec;6(6):971-5. doi: 10.5114/aoms.2010.19311. Epub 2010 Dec 29.

Tako-tsubo cardiomyopathy is characterized by chest pain, electrocardiographic abnormalities mimicking acute myocardial infarction, akinesis or dyskinesis of apical or mid left ventricular segments, and the absence of obstructive coronary artery disease. Tako-tsubo cardiomyopathy is usually a potentially reversible form...

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Hassid B, Azmoon S, Aronow WS, et al. Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report. Arch Med Sci. 2010;6(6):971-5doi: 10.5114/aoms.2010.19311.
Hassid, B., Azmoon, S., Aronow, W. S., Palaniswamy, C., Cohen, M., & Gass, A. (2010). Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report. Archives of medical science : AMS, 6(6), 971-5. https://doi.org/10.5114/aoms.2010.19311
Hassid, Babak, et al. "Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report." Archives of medical science : AMS vol. 6,6 (2010): 971-5. doi: https://doi.org/10.5114/aoms.2010.19311
Hassid B, Azmoon S, Aronow WS, Palaniswamy C, Cohen M, Gass A. Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report. Arch Med Sci. 2010 Dec;6(6):971-5. doi: 10.5114/aoms.2010.19311. Epub 2010 Dec 29. PMID: 22427775; PMCID: PMC3302713.
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