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Knowledge of the modality comes from rigorous research.

Journal of physiotherapy

Nunes GS, de Noronha M, Vargas VZ, Wageck B, Haupenthal DP, da Luz CM.
PMID: 26951891
J Physiother. 2016 Apr;62(2):118-9. doi: 10.1016/j.jphys.2016.02.001. Epub 2016 Mar 04.

No abstract available.

Training Loads and RSA and Aerobic Performance Changes During the Preseason in Youth Soccer Squads.

Journal of human kinetics

Cetolin T, Teixeira AS, Netto AS, Haupenthal A, Nakamura FY, Guglielmo LGA, da Silva JF.
PMID: 30687435
J Hum Kinet. 2018 Dec 31;65:235-248. doi: 10.2478/hukin-2018-0032. eCollection 2018 Dec.

The aims of this study were to compare the internal training load (ITL) in soccer players of two competitive age groups (under-15 [U-15] and under-19 [U-19]) during an 8-week preseason training period and compare the associated changes in physical...

α-Asarone, β-asarone, and γ-asarone: Current status of toxicological evaluation.

Journal of applied toxicology : JAT

Uebel T, Hermes L, Haupenthal S, Müller L, Esselen M.
PMID: 33236787
J Appl Toxicol. 2021 Aug;41(8):1166-1179. doi: 10.1002/jat.4112. Epub 2020 Nov 25.

Asarone isomers are naturally occurring in Acorus calamus Linné, Guatteria gaumeri Greenman, and Aniba hostmanniana Nees. These secondary plant metabolites belong to the class of phenylpropenes (phenylpropanoids or alkenylbenzenes). They are further chemically classified into the propenylic trans- and...

Disability-Adjusted Life-Years Associated With Intracerebral Hemorrhage and Secondary Injury.

JAMA network open

Haupenthal D, Kuramatsu JB, Volbers B, Sembill JA, Mrochen A, Balk S, Hoelter P, Lücking H, Engelhorn T, Dörfler A, Schwab S, Huttner HB, Sprügel MI.
PMID: 34279649
JAMA Netw Open. 2021 Jul 01;4(7):e2115859. doi: 10.1001/jamanetworkopen.2021.15859.

IMPORTANCE: Intracerebral hemorrhage (ICH) contributes significantly to the global burden of disease.OBJECTIVE: To examine the association of ICH and secondary injury with disability-adjusted life-years (DALYs) for the individual patient.DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted using data...

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds.

ACS central science

Elangovan S, Afanasenko A, Haupenthal J, Sun Z, Liu Y, Hirsch AKH, Barta K.
PMID: 31660439
ACS Cent Sci. 2019 Oct 23;5(10):1707-1716. doi: 10.1021/acscentsci.9b00781. Epub 2019 Oct 11.

Inherently complex, lignin-derived aromatic monomers comprising valuable structural moieties present in many pharmaceuticals would serve as ideal substrates for the construction of biologically active molecules. Here, we describe a strategy that incorporates all intrinsic functional groups present in platform...

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.

ACS medicinal chemistry letters

Hille UE, Zimmer C, Haupenthal J, Hartmann RW.
PMID: 24900349
ACS Med Chem Lett. 2011 Jun 03;2(8):559-64. doi: 10.1021/ml100283h. eCollection 2011 Aug 11.

CYP11B1 is the key enzyme in cortisol biosynthesis, and its inhibition with selective compounds is a promising strategy for the treatment of diseases associated with elevated cortisol levels, such as Cushing's syndrome or metabolic disease. Expanding on a previous...

RSC medicinal chemistry

Yahiaoui S, Voos K, Haupenthal J, Wichelhaus TA, Frank D, Weizel L, Rotter M, Brunst S, Kramer JS, Proschak E, Ducho C, Hirsch AKH.
PMID: 34778771
RSC Med Chem. 2021 Jul 29;12(10):1698-1708. doi: 10.1039/d1md00187f. eCollection 2021 Oct 20.

Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth....

Pharmacophore Modeling and .

Frontiers in chemistry

Akram M, Waratchareeyakul W, Haupenthal J, Hartmann RW, Schuster D.
PMID: 29312923
Front Chem. 2017 Dec 19;5:104. doi: 10.3389/fchem.2017.00104. eCollection 2017.

Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing's syndrome, metabolic diseases, and delayed wound...

Tissue heating in different short wave diathermy methods: A systematic review and narrative synthesis.

Journal of bodywork and movement therapies

Benincá IL, de Estéfani D, Pereira de Souza S, Weisshahn NK, Haupenthal A.
PMID: 34776156
J Bodyw Mov Ther. 2021 Oct;28:298-310. doi: 10.1016/j.jbmt.2021.07.031. Epub 2021 Aug 08.

OBJECTIVE: To assess the change in temperature caused by different short wave diathermy (SWD) methods of application in different healthy tissues.DATA SOURCES: The Cochrane Central Register of Controlled Trials, MEDLINE, Science Direct, CINAHL, SciELO, PEDro, ClinicalTrials.gov, Brazilian Registry of...

Substrate-inspired fragment merging and growing affords efficacious LasB inhibitors.

Angewandte Chemie (International ed. in English)

Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinović J, Kany AM, Haupenthal J, Köhnke J, Hartmann RW, Hirsch AKH.
PMID: 34762767
Angew Chem Int Ed Engl. 2021 Nov 11; doi: 10.1002/anie.202112295. Epub 2021 Nov 11.

Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram-negative pathogen Pseudomonas aeruginosa secretes the virulence factor elastase B (LasB), which plays an important role in the infection process. Here, we report a...

Toward scientific dissemination of undergraduate thesis in physical therapy programs - a cross-sectional study.

BMC medical education

Nunes GS, Adami SL, Pellenz MM, Rigo D, Estivalet RA, Diel AP, Benincá IL, Haupenthal A.
PMID: 35016663
BMC Med Educ. 2022 Jan 11;22(1):32. doi: 10.1186/s12909-021-03087-8.

BACKGROUND: The execution of undergraduate thesis is a period in which students have an opportunity to develop their scientific knowledge. However, many barriers could prevent the learning process. This cross-sectional study aimed to analyze the scientific dissemination of results...

RSC medicinal chemistry

Yahiaoui S, Voos K, Haupenthal J, Wichelhaus TA, Frank D, Weizel L, Rotter M, Brunst S, Kramer JS, Proschak E, Ducho C, Hirsch AKH.
PMID: 34778771
RSC Med Chem. 2021 Jul 29;12(10):1698-1708. doi: 10.1039/d1md00187f. eCollection 2021 Oct 20.

Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth....

Showing 1 to 12 of 32 entries