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Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS.

Drug testing and analysis

Salomonsson ML, Bondesson U, Hedeland M.
PMID: 28945329
Drug Test Anal. 2017 Sep;9(9):1472. doi: 10.1002/dta.2265. Epub 2017 Aug 30.

No abstract available.

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Salomonsson ML, Bondesson U, Hedeland M. Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS. Drug Test Anal. 2017;9(9):1472doi: 10.1002/dta.2265.
Salomonsson, M. L., Bondesson, U., & Hedeland, M. (2017). Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS. Drug testing and analysis, 9(9), 1472. https://doi.org/10.1002/dta.2265
Salomonsson, Matilda L, et al. "Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS." Drug testing and analysis vol. 9,9 (2017): 1472. doi: https://doi.org/10.1002/dta.2265
Salomonsson ML, Bondesson U, Hedeland M. Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS. Drug Test Anal. 2017 Sep;9(9):1472. doi: 10.1002/dta.2265. Epub 2017 Aug 30. PMID: 28945329.
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Prednisolone in Dogs-Plasma Exposure and White Blood Cell Response.

Frontiers in veterinary science

Ekstrand C, Pettersson H, Gehring R, Hedeland M, Adolfsson S, Lilliehöök I.
PMID: 34179161
Front Vet Sci. 2021 Jun 09;8:666219. doi: 10.3389/fvets.2021.666219. eCollection 2021.

Glucocorticoids such as prednisolone are commonly used in dogs but there is sparse quantitative pharmacokinetic and pharmacodynamic information of this drug in this species. The objective of this study was to quantitatively characterize the concentration-effect relationship for prednisolone in...

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Ekstrand C, Pettersson H, Gehring R, et al. Prednisolone in Dogs-Plasma Exposure and White Blood Cell Response. Front Vet Sci. 2021;8:666219doi: 10.3389/fvets.2021.666219.
Ekstrand, C., Pettersson, H., Gehring, R., Hedeland, M., Adolfsson, S., & Lilliehöök, I. (2021). Prednisolone in Dogs-Plasma Exposure and White Blood Cell Response. Frontiers in veterinary science, 8666219. https://doi.org/10.3389/fvets.2021.666219
Ekstrand, Carl, et al. "Prednisolone in Dogs-Plasma Exposure and White Blood Cell Response." Frontiers in veterinary science vol. 8 (2021): 666219. doi: https://doi.org/10.3389/fvets.2021.666219
Ekstrand C, Pettersson H, Gehring R, Hedeland M, Adolfsson S, Lilliehöök I. Prednisolone in Dogs-Plasma Exposure and White Blood Cell Response. Front Vet Sci. 2021 Jun 09;8:666219. doi: 10.3389/fvets.2021.666219. eCollection 2021. PMID: 34179161; PMCID: PMC8219870.
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Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.

BMC veterinary research

Askar R, Fredriksson E, Manell E, Hedeland M, Bondesson U, Bate S, Olsén L, Hedenqvist P.
PMID: 33863335
BMC Vet Res. 2021 Apr 16;17(1):169. doi: 10.1186/s12917-021-02858-1.

No abstract available.

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Askar R, Fredriksson E, Manell E, et al. Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits. BMC Vet Res. 2021;17(1):169doi: 10.1186/s12917-021-02858-1.
Askar, R., Fredriksson, E., Manell, E., Hedeland, M., Bondesson, U., Bate, S., Olsén, L., & Hedenqvist, P. (2021). Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits. BMC veterinary research, 17(1), 169. https://doi.org/10.1186/s12917-021-02858-1
Askar, Raad, et al. "Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits." BMC veterinary research vol. 17,1 (2021): 169. doi: https://doi.org/10.1186/s12917-021-02858-1
Askar R, Fredriksson E, Manell E, Hedeland M, Bondesson U, Bate S, Olsén L, Hedenqvist P. Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits. BMC Vet Res. 2021 Apr 16;17(1):169. doi: 10.1186/s12917-021-02858-1. PMID: 33863335; PMCID: PMC8052722.
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Etherglycerophospholipids and ferroptosis: structure, regulation, and location.

Trends in endocrinology and metabolism: TEM

Balgoma D, Hedeland M.
PMID: 34481732
Trends Endocrinol Metab. 2021 Dec;32(12):960-962. doi: 10.1016/j.tem.2021.08.005. Epub 2021 Sep 01.

Two pioneering studies by Zou et al. and Cui et al. have reported that the synthesis of etherglycerophospholipids (etherPLs) sensitizes cells to ferroptosis. The location and regulation of etherPLs suggest that: (i) lipid peroxidation in the inner leaflet of...

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Balgoma D, Hedeland M. Etherglycerophospholipids and ferroptosis: structure, regulation, and location. Trends Endocrinol Metab. 2021;32(12):960-962doi: 10.1016/j.tem.2021.08.005.
Balgoma, D., & Hedeland, M. (2021). Etherglycerophospholipids and ferroptosis: structure, regulation, and location. Trends in endocrinology and metabolism: TEM, 32(12), 960-962. https://doi.org/10.1016/j.tem.2021.08.005
Balgoma, David, and Hedeland, Mikael. "Etherglycerophospholipids and ferroptosis: structure, regulation, and location." Trends in endocrinology and metabolism: TEM vol. 32,12 (2021): 960-962. doi: https://doi.org/10.1016/j.tem.2021.08.005
Balgoma D, Hedeland M. Etherglycerophospholipids and ferroptosis: structure, regulation, and location. Trends Endocrinol Metab. 2021 Dec;32(12):960-962. doi: 10.1016/j.tem.2021.08.005. Epub 2021 Sep 01. PMID: 34481732.
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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat.

Pharmaceutics

Dahlgren D, Cano-Cebrián MJ, Olander T, Hedeland M, Sjöblom M, Lennernäs H.
PMID: 32182653
Pharmaceutics. 2020 Mar 08;12(3). doi: 10.3390/pharmaceutics12030242.

Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model. This model can determine intestinal...

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Dahlgren D, Cano-Cebrián MJ, Olander T, et al. Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat. Pharmaceutics. 2020;12(3)doi: 10.3390/pharmaceutics12030242.
Dahlgren, D., Cano-Cebrián, M. J., Olander, T., Hedeland, M., Sjöblom, M., & Lennernäs, H. (2020). Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat. Pharmaceutics, 12(3), . https://doi.org/10.3390/pharmaceutics12030242
Dahlgren, David, et al. "Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat." Pharmaceutics vol. 12,3 (2020). doi: https://doi.org/10.3390/pharmaceutics12030242
Dahlgren D, Cano-Cebrián MJ, Olander T, Hedeland M, Sjöblom M, Lennernäs H. Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat. Pharmaceutics. 2020 Mar 08;12(3). doi: 10.3390/pharmaceutics12030242. PMID: 32182653; PMCID: PMC7150977.
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The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge .

Frontiers in chemistry

Erngren I, Smit E, Pettersson C, Cárdenas P, Hedeland M.
PMID: 34041223
Front Chem. 2021 May 10;9:662659. doi: 10.3389/fchem.2021.662659. eCollection 2021.

No abstract available.

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Erngren I, Smit E, Pettersson C, et al. The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge . Front Chem. 2021;9:662659doi: 10.3389/fchem.2021.662659.
Erngren, I., Smit, E., Pettersson, C., Cárdenas, P., & Hedeland, M. (2021). The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge . Frontiers in chemistry, 9662659. https://doi.org/10.3389/fchem.2021.662659
Erngren, Ida, et al. "The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge ." Frontiers in chemistry vol. 9 (2021): 662659. doi: https://doi.org/10.3389/fchem.2021.662659
Erngren I, Smit E, Pettersson C, Cárdenas P, Hedeland M. The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge . Front Chem. 2021 May 10;9:662659. doi: 10.3389/fchem.2021.662659. eCollection 2021. PMID: 34041223; PMCID: PMC8141568.
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Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children.

Global pediatric health

Hedeland RL, Christensen VB, Jørgensen MH, Teilmann G, Iskandar A, Andersen J.
PMID: 27335908
Glob Pediatr Health. 2014 Oct 14;1:2333794X14552897. doi: 10.1177/2333794X14552897. eCollection 2014.

Objective. To characterize early risk factors of moderate/severe hepatotoxicity in a pediatric population with acetaminophen overdose, due to suicide attempt, admitted to a general secondary-level pediatric department. Methods. A retrospective case study of 107 patients, 11 to 15 years...

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Hedeland RL, Christensen VB, Jørgensen MH, et al. Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children. Glob Pediatr Health. 2014;1:2333794X14552897doi: 10.1177/2333794X14552897.
Hedeland, R. L., Christensen, V. B., Jørgensen, M. H., Teilmann, G., Iskandar, A., & Andersen, J. (2014). Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children. Global pediatric health, 12333794X14552897. https://doi.org/10.1177/2333794X14552897
Hedeland, Rikke Lindgaard, et al. "Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children." Global pediatric health vol. 1 (2014): 2333794X14552897. doi: https://doi.org/10.1177/2333794X14552897
Hedeland RL, Christensen VB, Jørgensen MH, Teilmann G, Iskandar A, Andersen J. Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children. Glob Pediatr Health. 2014 Oct 14;1:2333794X14552897. doi: 10.1177/2333794X14552897. eCollection 2014. PMID: 27335908; PMCID: PMC4804691.
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Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics.

Metabolites

Pirttilä K, Laurell G, Pettersson C, Hedeland M.
PMID: 34063084
Metabolites. 2021 May 05;11(5). doi: 10.3390/metabo11050295.

In order to increase metabolite coverage in LC-MS-based untargeted metabolomics, HILIC- and RPLC-mode separations are often combined. Unfortunately, these two techniques pose opposite requirements on sample composition, necessitating either dual sample preparations, increasing needed sample volume, or manipulation of...

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Pirttilä K, Laurell G, Pettersson C, et al. Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics. Metabolites. 2021;11(5)doi: 10.3390/metabo11050295.
Pirttilä, K., Laurell, G., Pettersson, C., & Hedeland, M. (2021). Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics. Metabolites, 11(5), . https://doi.org/10.3390/metabo11050295
Pirttilä, Kristian, et al. "Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics." Metabolites vol. 11,5 (2021). doi: https://doi.org/10.3390/metabo11050295
Pirttilä K, Laurell G, Pettersson C, Hedeland M. Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics. Metabolites. 2021 May 05;11(5). doi: 10.3390/metabo11050295. PMID: 34063084; PMCID: PMC8147996.
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Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples.

Metabolites

Erngren I, Nestor M, Pettersson C, Hedeland M.
PMID: 33804267
Metabolites. 2021 Mar 15;11(3). doi: 10.3390/metabo11030170.

Inorganic ions, such as sodium and potassium, are present in all biological matrices and are sometimes also added during sample preparation. However, these inorganic ions are known to hamper electrospray ionization -mass spectrometry (ESI-MS) applications, especially in hydrophilic interaction...

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Erngren I, Nestor M, Pettersson C, et al. Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples. Metabolites. 2021;11(3)doi: 10.3390/metabo11030170.
Erngren, I., Nestor, M., Pettersson, C., & Hedeland, M. (2021). Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples. Metabolites, 11(3), . https://doi.org/10.3390/metabo11030170
Erngren, Ida, et al. "Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples." Metabolites vol. 11,3 (2021). doi: https://doi.org/10.3390/metabo11030170
Erngren I, Nestor M, Pettersson C, Hedeland M. Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples. Metabolites. 2021 Mar 15;11(3). doi: 10.3390/metabo11030170. PMID: 33804267; PMCID: PMC7999259.
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin.

Pharmaceutics

Dahlgren D, Sjöblom M, Hedeland M, Lennernäs H.
PMID: 31991924
Pharmaceutics. 2020 Jan 26;12(2). doi: 10.3390/pharmaceutics12020099.

Permeation enhancers like sodium dodecyl sulfate (SDS) and caprate increase the intestinal permeability of small model peptide compounds, such as enalaprilat (349 Da). However, their effects remain to be investigated for larger low-permeability peptide drugs, such as hexarelin (887...

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Dahlgren D, Sjöblom M, Hedeland M, et al. The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin. Pharmaceutics. 2020;12(2)doi: 10.3390/pharmaceutics12020099.
Dahlgren, D., Sjöblom, M., Hedeland, M., & Lennernäs, H. (2020). The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin. Pharmaceutics, 12(2), . https://doi.org/10.3390/pharmaceutics12020099
Dahlgren, David, et al. "The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin." Pharmaceutics vol. 12,2 (2020). doi: https://doi.org/10.3390/pharmaceutics12020099
Dahlgren D, Sjöblom M, Hedeland M, Lennernäs H. The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin. Pharmaceutics. 2020 Jan 26;12(2). doi: 10.3390/pharmaceutics12020099. PMID: 31991924; PMCID: PMC7076382.
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats.

Acta pharmaceutica Sinica. B

Dahlgren D, Olander T, Sjöblom M, Hedeland M, Lennernäs H.
PMID: 34221875
Acta Pharm Sin B. 2021 Jun;11(6):1667-1675. doi: 10.1016/j.apsb.2020.12.019. Epub 2021 Jan 05.

Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the intestinal permeation of...

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Dahlgren D, Olander T, Sjöblom M, et al. Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta Pharm Sin B. 2021;11(6):1667-1675doi: 10.1016/j.apsb.2020.12.019.
Dahlgren, D., Olander, T., Sjöblom, M., Hedeland, M., & Lennernäs, H. (2021). Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta pharmaceutica Sinica. B, 11(6), 1667-1675. https://doi.org/10.1016/j.apsb.2020.12.019
Dahlgren, David, et al. "Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats." Acta pharmaceutica Sinica. B vol. 11,6 (2021): 1667-1675. doi: https://doi.org/10.1016/j.apsb.2020.12.019
Dahlgren D, Olander T, Sjöblom M, Hedeland M, Lennernäs H. Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta Pharm Sin B. 2021 Jun;11(6):1667-1675. doi: 10.1016/j.apsb.2020.12.019. Epub 2021 Jan 05. PMID: 34221875; PMCID: PMC8245904.
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Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling.

Frontiers in oncology

Lindell Jonsson E, Erngren I, Engskog M, Haglöf J, Arvidsson T, Hedeland M, Petterson C, Laurell G, Nestor M.
PMID: 31544064
Front Oncol. 2019 Aug 30;9:825. doi: 10.3389/fonc.2019.00825. eCollection 2019.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer worldwide. Radiotherapy, with or without surgery, represents the major approach to curative treatment. However, not all tumors are equally sensitive to irradiation. It is...

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Lindell Jonsson E, Erngren I, Engskog M, et al. Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling. Front Oncol. 2019;9:825doi: 10.3389/fonc.2019.00825.
Lindell Jonsson, E., Erngren, I., Engskog, M., Haglöf, J., Arvidsson, T., Hedeland, M., Petterson, C., Laurell, G., & Nestor, M. (2019). Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling. Frontiers in oncology, 9825. https://doi.org/10.3389/fonc.2019.00825
Lindell Jonsson, Eva, et al. "Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling." Frontiers in oncology vol. 9 (2019): 825. doi: https://doi.org/10.3389/fonc.2019.00825
Lindell Jonsson E, Erngren I, Engskog M, Haglöf J, Arvidsson T, Hedeland M, Petterson C, Laurell G, Nestor M. Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling. Front Oncol. 2019 Aug 30;9:825. doi: 10.3389/fonc.2019.00825. eCollection 2019. PMID: 31544064; PMCID: PMC6728927.
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Showing 1 to 12 of 15 entries