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Isothiazolo[4,3-.

MedChemComm

Li J, Kovackova S, Pu S, Rozenski J, De Jonghe S, Einav S, Herdewijn P.
PMID: 26925208
Medchemcomm. 2015 Sep 01;6(9):1666-1672. doi: 10.1039/c5md00229j. Epub 2015 Aug 07.

Isothiazolo[4,3-

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Li J, Kovackova S, Pu S, et al. Isothiazolo[4,3-. Medchemcomm. 2015;6(9):1666-1672doi: 10.1039/c5md00229j.
Li, J., Kovackova, S., Pu, S., Rozenski, J., De Jonghe, S., Einav, S., & Herdewijn, P. (2015). Isothiazolo[4,3-. MedChemComm, 6(9), 1666-1672. https://doi.org/10.1039/c5md00229j
Li, Jiahong, et al. "Isothiazolo[4,3-." MedChemComm vol. 6,9 (2015): 1666-1672. doi: https://doi.org/10.1039/c5md00229j
Li J, Kovackova S, Pu S, Rozenski J, De Jonghe S, Einav S, Herdewijn P. Isothiazolo[4,3-. Medchemcomm. 2015 Sep 01;6(9):1666-1672. doi: 10.1039/c5md00229j. Epub 2015 Aug 07. PMID: 26925208; PMCID: PMC4763718.
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Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization.

Organic letters

Nie P, Groaz E, De Jonghe S, Lescrinier E, Herdewijn P.
PMID: 29388776
Org Lett. 2018 Feb 16;20(4):1203-1206. doi: 10.1021/acs.orglett.8b00123. Epub 2018 Feb 01.

The efficient synthesis of a [2'S] C-nucleoside phosphonate and its corresponding prodrug has been realized. A phosphonomethoxy group was stereoselectively introduced at the anomeric 5'-carbon atom through glycosylation of a benzoyl protected [5'R]-acetoxy-[2'R]-9-deazaadenine. An unexpected epimerization at the 2'-position...

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Nie P, Groaz E, De Jonghe S, et al. Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization. Org Lett. 2018;20(4):1203-1206doi: 10.1021/acs.orglett.8b00123.
Nie, P., Groaz, E., De Jonghe, S., Lescrinier, E., & Herdewijn, P. (2018). Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization. Organic letters, 20(4), 1203-1206. https://doi.org/10.1021/acs.orglett.8b00123
Nie, Peng, et al. "Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization." Organic letters vol. 20,4 (2018): 1203-1206. doi: https://doi.org/10.1021/acs.orglett.8b00123
Nie P, Groaz E, De Jonghe S, Lescrinier E, Herdewijn P. Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization. Org Lett. 2018 Feb 16;20(4):1203-1206. doi: 10.1021/acs.orglett.8b00123. Epub 2018 Feb 01. PMID: 29388776.
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TNA as a Potential Alternative to Natural Nucleic Acids.

Angewandte Chemie (International ed. in English)

Herdewijn P.
PMID: 11433484
Angew Chem Int Ed Engl. 2001 Jun 18;40(12):2249-2251. doi: 10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i.

No abstract available.

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Herdewijn P. TNA as a Potential Alternative to Natural Nucleic Acids. Angew Chem Int Ed Engl. 2001;40(12):2249-2251doi: 10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i.
Herdewijn, P. (2001). TNA as a Potential Alternative to Natural Nucleic Acids. Angewandte Chemie (International ed. in English), 40(12), 2249-2251. https://doi.org/10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i
Herdewijn, Piet. "TNA as a Potential Alternative to Natural Nucleic Acids." Angewandte Chemie (International ed. in English) vol. 40,12 (2001): 2249-2251. doi: https://doi.org/10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i
Herdewijn P. TNA as a Potential Alternative to Natural Nucleic Acids. Angew Chem Int Ed Engl. 2001 Jun 18;40(12):2249-2251. doi: 10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i. PMID: 11433484.
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Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines.

The Journal of organic chemistry

Maurinsh Y, Schraml J, De Winter H, Blaton N, Peeters O, Lescrinier E, Rozenski J, Van Aerschot A, De Clercq E, Busson R, Herdewijn P.
PMID: 11671649
J Org Chem. 1997 May 02;62(9):2861-2871. doi: 10.1021/jo962204x.

The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl 1,3-cyclohexadiene-1-carboxylate and hydroboration of the cyclohexenyl precursor. The lack of antiviral activity of the compounds...

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Maurinsh Y, Schraml J, De Winter H, et al. Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. J Org Chem. 1997;62(9):2861-2871doi: 10.1021/jo962204x.
Maurinsh, Y., Schraml, J., De Winter, H., Blaton, N., Peeters, O., Lescrinier, E., Rozenski, J., Van Aerschot, A., De Clercq, E., Busson, R., & Herdewijn, P. (1997). Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. The Journal of organic chemistry, 62(9), 2861-2871. https://doi.org/10.1021/jo962204x
Maurinsh, Yuris, et al. "Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines." The Journal of organic chemistry vol. 62,9 (1997): 2861-2871. doi: https://doi.org/10.1021/jo962204x
Maurinsh Y, Schraml J, De Winter H, Blaton N, Peeters O, Lescrinier E, Rozenski J, Van Aerschot A, De Clercq E, Busson R, Herdewijn P. Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. J Org Chem. 1997 May 02;62(9):2861-2871. doi: 10.1021/jo962204x. PMID: 11671649.
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Recall and recognition of in-game advertising: the role of game control.

Frontiers in psychology

Herrewijn L, Poels K.
PMID: 24478736
Front Psychol. 2014 Jan 24;4:1023. doi: 10.3389/fpsyg.2013.01023. eCollection 2013.

Digital gaming has become one of the largest entertainment sectors worldwide, increasingly turning the medium into a promising vehicle for advertisers. As a result, the inclusion of advertising messages in digital games or in-game advertising (IGA) is expected to...

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Herrewijn L, Poels K. Recall and recognition of in-game advertising: the role of game control. Front Psychol. 2014;4:1023doi: 10.3389/fpsyg.2013.01023.
Herrewijn, L., & Poels, K. (2013). Recall and recognition of in-game advertising: the role of game control. Frontiers in psychology, 41023. https://doi.org/10.3389/fpsyg.2013.01023
Herrewijn, Laura, and Poels, Karolien. "Recall and recognition of in-game advertising: the role of game control." Frontiers in psychology vol. 4 (2013): 1023. doi: https://doi.org/10.3389/fpsyg.2013.01023
Herrewijn L, Poels K. Recall and recognition of in-game advertising: the role of game control. Front Psychol. 2014 Jan 24;4:1023. doi: 10.3389/fpsyg.2013.01023. eCollection 2013. PMID: 24478736; PMCID: PMC3901361.
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Base pairing involving artificial bases .

Chemical science

Bande O, Braddick D, Agnello S, Jang M, Pezo V, Schepers G, Rozenski J, Lescrinier E, Marlière P, Herdewijn P.
PMID: 29896368
Chem Sci. 2016 Feb 01;7(2):995-1010. doi: 10.1039/c5sc03474d. Epub 2015 Nov 10.

Herein we report the synthesis of

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Bande O, Braddick D, Agnello S, et al. Base pairing involving artificial bases . Chem Sci. 2015;7(2):995-1010doi: 10.1039/c5sc03474d.
Bande, O., Braddick, D., Agnello, S., Jang, M., Pezo, V., Schepers, G., Rozenski, J., Lescrinier, E., Marlière, P., & Herdewijn, P. (2016). Base pairing involving artificial bases . Chemical science, 7(2), 995-1010. https://doi.org/10.1039/c5sc03474d
Bande, Omprakash, et al. "Base pairing involving artificial bases ." Chemical science vol. 7,2 (2016): 995-1010. doi: https://doi.org/10.1039/c5sc03474d
Bande O, Braddick D, Agnello S, Jang M, Pezo V, Schepers G, Rozenski J, Lescrinier E, Marlière P, Herdewijn P. Base pairing involving artificial bases . Chem Sci. 2016 Feb 01;7(2):995-1010. doi: 10.1039/c5sc03474d. Epub 2015 Nov 10. PMID: 29896368; PMCID: PMC5954848.
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Amidate Prodrugs of Cyclic 9-(.

ACS medicinal chemistry letters

Luo M, Groaz E, De Jonghe S, Snoeck R, Andrei G, Herdewijn P.
PMID: 29670705
ACS Med Chem Lett. 2018 Mar 16;9(4):381-385. doi: 10.1021/acsmedchemlett.8b00079. eCollection 2018 Apr 12.

A series of amidate prodrugs of cyclic 9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (cHPMPA) featuring different amino acid motifs were synthesized. All phosphonamidates derived from (

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Luo M, Groaz E, De Jonghe S, et al. Amidate Prodrugs of Cyclic 9-(. ACS Med Chem Lett. 2018;9(4):381-385doi: 10.1021/acsmedchemlett.8b00079.
Luo, M., Groaz, E., De Jonghe, S., Snoeck, R., Andrei, G., & Herdewijn, P. (2018). Amidate Prodrugs of Cyclic 9-(. ACS medicinal chemistry letters, 9(4), 381-385. https://doi.org/10.1021/acsmedchemlett.8b00079
Luo, Min, et al. "Amidate Prodrugs of Cyclic 9-(." ACS medicinal chemistry letters vol. 9,4 (2018): 381-385. doi: https://doi.org/10.1021/acsmedchemlett.8b00079
Luo M, Groaz E, De Jonghe S, Snoeck R, Andrei G, Herdewijn P. Amidate Prodrugs of Cyclic 9-(. ACS Med Chem Lett. 2018 Mar 16;9(4):381-385. doi: 10.1021/acsmedchemlett.8b00079. eCollection 2018 Apr 12. PMID: 29670705; PMCID: PMC5900341.
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Anno 2021: Which antivirals for the coming decade?.

Annual reports in medicinal chemistry

Groaz E, De Clercq E, Herdewijn P.
PMID: 34744210
Annu Rep Med Chem. 2021;57:49-107. doi: 10.1016/bs.armc.2021.09.004. Epub 2021 Nov 03.

Despite considerable progress in the development of antiviral drugs, among which anti-immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be considered real success stories, many viral infections remain without an effective treatment. This not only applies to...

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Groaz E, De Clercq E, Herdewijn P. Anno 2021: Which antivirals for the coming decade?. Annu Rep Med Chem. 2021;57:49-107doi: 10.1016/bs.armc.2021.09.004.
Groaz, E., De Clercq, E., & Herdewijn, P. (2021). Anno 2021: Which antivirals for the coming decade?. Annual reports in medicinal chemistry, 5749-107. https://doi.org/10.1016/bs.armc.2021.09.004
Groaz, Elisabetta, et al. "Anno 2021: Which antivirals for the coming decade?." Annual reports in medicinal chemistry vol. 57 (2021): 49-107. doi: https://doi.org/10.1016/bs.armc.2021.09.004
Groaz E, De Clercq E, Herdewijn P. Anno 2021: Which antivirals for the coming decade?. Annu Rep Med Chem. 2021;57:49-107. doi: 10.1016/bs.armc.2021.09.004. Epub 2021 Nov 03. PMID: 34744210; PMCID: PMC8563371.
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Biologically Active Nucleosides.

Current protocols in nucleic acid chemistry

Herdewijn P.
PMID: 33299517
Curr Protoc Nucleic Acid Chem. 2006 Mar;24(1):1401-1406. doi: 10.1002/0471142700.nc1400s24. Epub 2006 Apr 15.

No abstract available.

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Herdewijn P. Biologically Active Nucleosides. Curr Protoc Nucleic Acid Chem. 2006;24(1):1401-1406doi: 10.1002/0471142700.nc1400s24.
Herdewijn, P. (2006). Biologically Active Nucleosides. Current protocols in nucleic acid chemistry, 24(1), 1401-1406. https://doi.org/10.1002/0471142700.nc1400s24
Herdewijn, Piet. "Biologically Active Nucleosides." Current protocols in nucleic acid chemistry vol. 24,1 (2006): 1401-1406. doi: https://doi.org/10.1002/0471142700.nc1400s24
Herdewijn P. Biologically Active Nucleosides. Curr Protoc Nucleic Acid Chem. 2006 Mar;24(1):1401-1406. doi: 10.1002/0471142700.nc1400s24. Epub 2006 Apr 15. PMID: 33299517; PMCID: PMC7162386.
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Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.

ACS medicinal chemistry letters

Zheng Z, Groaz E, Snoeck R, De Jonghe S, Herdewijn P, Andrei G.
PMID: 33479570
ACS Med Chem Lett. 2020 Dec 09;12(1):88-92. doi: 10.1021/acsmedchemlett.0c00485. eCollection 2021 Jan 14.

In addition to its therapeutic value as a chemotherapy drug, gemcitabine is of ongoing interest to the scientific community for its broad-spectrum antiviral activity. Herein the synthesis of 4'-methoxy- and 4'-fluoro-substituted gemcitabine analogues along with their phosphoramidate prodrugs is...

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Zheng Z, Groaz E, Snoeck R, et al. Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2. ACS Med Chem Lett. 2020;12(1):88-92doi: 10.1021/acsmedchemlett.0c00485.
Zheng, Z., Groaz, E., Snoeck, R., De Jonghe, S., Herdewijn, P., & Andrei, G. (2021). Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2. ACS medicinal chemistry letters, 12(1), 88-92. https://doi.org/10.1021/acsmedchemlett.0c00485
Zheng, Zihua, et al. "Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2." ACS medicinal chemistry letters vol. 12,1 (2021): 88-92. doi: https://doi.org/10.1021/acsmedchemlett.0c00485
Zheng Z, Groaz E, Snoeck R, De Jonghe S, Herdewijn P, Andrei G. Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2. ACS Med Chem Lett. 2020 Dec 09;12(1):88-92. doi: 10.1021/acsmedchemlett.0c00485. eCollection 2021 Jan 14. PMID: 33479570; PMCID: PMC7737538.
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Synthesis of a Nucleobase-Modified ProTide Library.

Organic letters

Gao LJ, Jonghe S, Herdewijn P.
PMID: 27791384
Org Lett. 2016 Nov 18;18(22):5816-5819. doi: 10.1021/acs.orglett.6b02764. Epub 2016 Oct 28.

A new method for the construction of (aryloxy)phosphoramidate nucleoside prodrugs is presented. An (aryloxy)phosphoramidate ribose derivative as key building block was used for coupling with a number of nucleobases under Vorbrüggen reaction conditions yielding the protected ProTides in excellent...

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Gao LJ, Jonghe S, Herdewijn P. Synthesis of a Nucleobase-Modified ProTide Library. Org Lett. 2016;18(22):5816-5819doi: 10.1021/acs.orglett.6b02764.
Gao, L. J., Jonghe, S., & Herdewijn, P. (2016). Synthesis of a Nucleobase-Modified ProTide Library. Organic letters, 18(22), 5816-5819. https://doi.org/10.1021/acs.orglett.6b02764
Gao, Ling-Jie, et al. "Synthesis of a Nucleobase-Modified ProTide Library." Organic letters vol. 18,22 (2016): 5816-5819. doi: https://doi.org/10.1021/acs.orglett.6b02764
Gao LJ, Jonghe S, Herdewijn P. Synthesis of a Nucleobase-Modified ProTide Library. Org Lett. 2016 Nov 18;18(22):5816-5819. doi: 10.1021/acs.orglett.6b02764. Epub 2016 Oct 28. PMID: 27791384.
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[No title available]

The Journal of organic chemistry

Leonczak P, Srivastava P, Bande O, Schepers G, Lescrinier E, Herdewijn P.
PMID: 31617362
J Org Chem. 2019 Nov 01;84(21):13394-13409. doi: 10.1021/acs.joc.9b01576. Epub 2019 Oct 16.

In this report, we present the synthesis of

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Leonczak P, Srivastava P, Bande O, et al. . J Org Chem. 2019;84(21):13394-13409doi: 10.1021/acs.joc.9b01576.
Leonczak, P., Srivastava, P., Bande, O., Schepers, G., Lescrinier, E., & Herdewijn, P. (2019). . The Journal of organic chemistry, 84(21), 13394-13409. https://doi.org/10.1021/acs.joc.9b01576
Leonczak, Piotr, et al. "." The Journal of organic chemistry vol. 84,21 (2019): 13394-13409. doi: https://doi.org/10.1021/acs.joc.9b01576
Leonczak P, Srivastava P, Bande O, Schepers G, Lescrinier E, Herdewijn P. . J Org Chem. 2019 Nov 01;84(21):13394-13409. doi: 10.1021/acs.joc.9b01576. Epub 2019 Oct 16. PMID: 31617362.
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Showing 1 to 12 of 43 entries