Mycologia

Calderoni M, Sieber TN, Holdenrieder O.
PMID: 21156609
Mycologia. 2003 Mar-Apr;95(2):232-8.

Monobasidiospore isolates were prepared from basidiocarps of Stereum sanguinolentum. Five isolates per basidiome were paired with each other and with isolates from the trama. Interbasidiome pairings of the trama isolates and of a selection of single-spore isolates also were...

Plant disease

Queloz V, Wey T, Holdenrieder O.
PMID: 30703904
Plant Dis. 2014 Dec;98(12):1744. doi: 10.1094/PDIS-06-14-0630-PDN.

The mitosporic ascomycetes Dothistroma septosporum s.s. (Dorog.) Morelet and D. pini Hulbary are closely related species (1) causing red band needle blight on Pinus spp. D. septosporum (teleomorph Mycosphaerella pini Rostr.) is considered as a cosmopolitan species, whereas D....

Personalized medicine

Holdenrieder S.
PMID: 29758799
Per Med. 2014 Aug;11(6):565-568. doi: 10.2217/pme.14.47.

Dr Stefan Holdenrieder is senior physician at the Institute of Clinical Chemistry and Clinical Pharmacology of the University Hospital Bonn, Germany. He is an expert in the field of circulating tumor biomarkers and particularly circulating nucleosomes. He has conducted...

Frontiers in pharmacology

Schneider KL, Kunst M, Leuchs AK, Böhme M, Weckbecker K, Kastenmüller K, Bleckwenn M, Holdenrieder S, Coch C, Hartmann G, Stingl JC.
PMID: 32047440
Front Pharmacol. 2020 Jan 28;10:1620. doi: 10.3389/fphar.2019.01620. eCollection 2019.

BACKGROUND: Dose requirements of vitamin K antagonists are associated with METHODS: Aim was to scrutinize phenprocoumon dose requirements, dose stability and anticoagulation quality in association to RESULTS: Average weekly dose per patient was 14.4 ± 5.3 mg, 11.9 ±...

Epilepsia open

Nass RD, Zur B, Elger CE, Holdenrieder S, Surges R.
PMID: 31819916
Epilepsia Open. 2019 Oct 22;4(4):599-608. doi: 10.1002/epi4.12364. eCollection 2019 Dec.

OBJECTIVE: Tonic-clonic seizures (TCS) lead to metabolic stress and changes in related blood markers. Such markers may indicate harmful conditions but can also help to identify TCS as a cause of transient loss of consciousness. In this study, we...

Trends in ecology & evolution

Holdenrieder O, Pautasso M, Weisberg PJ, Lonsdale D.
PMID: 16701303
Trends Ecol Evol. 2004 Aug;19(8):446-52. doi: 10.1016/j.tree.2004.06.003.

Forest pathology inherently involves a landscape perspective, because tree pathogens propagate according to heterogeneous spatial patterns of flow and isolation. Landscape pathology is a field that is now emerging from the transdisciplinary cooperation of forest pathologists with landscape ecologists....

Diagnostics (Basel, Switzerland)

Pilzweger C, Holdenrieder S.
PMID: 26854151
Diagnostics (Basel). 2015 Jun 16;5(2):219-53. doi: 10.3390/diagnostics5020219.

High molecular group box 1 (HMGB1) is a highly conserved member of the HMG-box-family; abundantly expressed in almost all human cells and released in apoptosis; necrosis or by activated immune cells. Once in the extracellular space, HMGB1 can act...

Cell journal

Gezer U, Tiryakioglu D, Bilgin E, Dalay N, Holdenrieder S.
PMID: 25685739
Cell J. 2015;16(4):488-93. doi: 10.22074/cellj.2015.494. Epub 2015 Jan 13.

OBJECTIVE: Prostate cancer antigen 3 (PCA3) and microRNA-141 (miR-141) are emerging molecules in prostate cancer (PCa) pathogenesis and have been shown to be involved in androgen signaling. In this original research, we designed an experimental cell model with androgen-sensitive...

Cardiovascular diagnosis and therapy

Kornhuber KTI, Seidel H, Pujol C, Meierhofer C, Röschenthaler F, Pressler A, Stöckl A, Nagdyman N, Neidenbach RC, von Hundelshausen P, Halle M, Holdenrieder S, Ewert P, Kaemmerer H, Hauser M.
PMID: 31737529
Cardiovasc Diagn Ther. 2019 Oct;9:S209-S220. doi: 10.21037/cdt.2019.08.09.

BACKGROUND: Aortic root ectasia might induce hemostatic disorders in patients with Marfan syndrome (MFS) via altered blood flow and rheology. The aim of this study was to explore the hemostasis in patients with MFS compared with healthy controls.METHODS: In...

Frontiers in molecular biosciences

Cavalier E, Guiot J, Lechner K, Dutsch A, Eccleston M, Herzog M, Bygott T, Schomburg A, Kelly T, Holdenrieder S.
PMID: 33816549
Front Mol Biosci. 2021 Mar 18;8:600881. doi: 10.3389/fmolb.2021.600881. eCollection 2021.

The severity of coronavirus disease 2019 (COVID-19) varies significantly with cases spanning from asymptomatic to lethal with a subset of individuals developing Severe Acute Respiratory Syndrome (SARS) and death from respiratory failure. To determine whether global nucleosome and citrullinated...

Cell reports

Wagner KI, Mateyka LM, Jarosch S, Grass V, Weber S, Schober K, Hammel M, Burrell T, Kalali B, Poppert H, Beyer H, Schambeck S, Holdenrieder S, Strötges-Achatz A, Haselmann V, Neumaier M, Erber J, Priller A, Yazici S, Roggendorf H, Odendahl M, Tonn T, Dick A, Witter K, Mijočević H, Protzer U, Knolle PA, Pichlmair A, Crowell CS, Gerhard M, D'Ippolito E, Busch DH.
PMID: 34968416
Cell Rep. 2021 Dec 17;110214. doi: 10.1016/j.celrep.2021.110214. Epub 2021 Dec 17.

T cell immunity is crucial for control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been studied widely on a quantitative level. However, the quality of responses, in particular of CD8

Cancers

Mc Laughlin AM, Schmulenson E, Teplytska O, Zimmermann S, Opitz P, Groenland SL, Huitema ADR, Steeghs N, Müller L, Fuxius S, Illerhaus G, Joerger M, Mayer F, Fuhr U, Holdenrieder S, Hempel G, Scherf-Clavel O, Jaehde U, Kloft C, For The On-Target Study Consortium.
PMID: 34944899
Cancers (Basel). 2021 Dec 14;13(24). doi: 10.3390/cancers13246281.

Exposure-efficacy and/or exposure-toxicity relationships have been identified for up to 80% of oral anticancer drugs (OADs). Usually, OADs are administered at fixed doses despite their high interindividual pharmacokinetic variability resulting in large differences in drug exposure. Consequently, a substantial...