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Showing 1 to 12 of 15 entries
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The Role of Chemotherapy in Management of Inoperable, Metastatic and/or Recurrent Melanotic Neuroectodermal Tumor of Infancy-Own Experience and Systematic Review.

Cancers

Styczewska M, Krawczyk MA, Brecht IB, Haug K, Iżycka-Świeszewska E, Godziński J, Raciborska A, Ussowicz M, Kukwa W, Cwalina N, Lundstrom E, Bień E.
PMID: 34359769
Cancers (Basel). 2021 Jul 31;13(15). doi: 10.3390/cancers13153872.

Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a very rare pediatric neoplasm of neural crest origin. In most cases, it develops in infants as a localized tumor of the maxilla, and surgery is usually curative. In less than 10%...

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance.

Cell death & disease

Mehlich D, Łomiak M, Sobiborowicz A, Mazan A, Dymerska D, Szewczyk ŁM, Mehlich A, Borowiec A, Prełowska MK, Gorczyński A, Jabłoński P, Iżycka-Świeszewska E, Nowis D, Marusiak AA.
PMID: 34839359
Cell Death Dis. 2021 Nov 27;12(12):1111. doi: 10.1038/s41419-021-04405-0.

Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the...

Central nervous system autopsy - a neuropathological procedure based on multidisciplinary pathoclinical cooperation.

Neurologia i neurochirurgia polska

Sejda A, Wierzba-Bobrowicz T, Adamek D, Gulczyński J, Michalak S, Grajkowska W, Iżycka-Świeszewska E.
PMID: 34913473
Neurol Neurochir Pol. 2021 Dec 16; doi: 10.5603/PJNNS.a2021.0088. Epub 2021 Dec 16.

INTRODUCTION: Neuropathological brain and spinal cord post mortem examination is a distinct procedure that still plays an important role in modern medicine. In front of increasing amounts of clinical and genetic data, together with important developments in the field...

Peripheral and Intestinal T-regulatory Cells are Upregulated in Children with Inflammatory Bowel Disease at Onset of Disease.

Immunological investigations

Sznurkowska K, Żawrocki A, Sznurkowski J, Zieliński M, Landowski P, Plata-Nazar K, Iżycka-Świeszewska E, Trzonkowski P, Szlagatys-Sidorkiewicz A, Kamińska B.
PMID: 27759462
Immunol Invest. 2016 Nov;45(8):787-796. doi: 10.1080/08820139.2016.1214961. Epub 2016 Oct 19.

BACKGROUND/AIMS: To determine the proportion of T-regulatory cells (CD4MATERIAL AND METHODS: 24 patients newly diagnosed for IBD were included in the study: ulcerative colitis (UC; n = 13) and Crohn's disease (CD; n = 11). Seventeen healthy controls (HC)...

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance.

Cell death & disease

Mehlich D, Łomiak M, Sobiborowicz A, Mazan A, Dymerska D, Szewczyk ŁM, Mehlich A, Borowiec A, Prełowska MK, Gorczyński A, Jabłoński P, Iżycka-Świeszewska E, Nowis D, Marusiak AA.
PMID: 34839359
Cell Death Dis. 2021 Nov 27;12(12):1111. doi: 10.1038/s41419-021-04405-0.

Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the...

Bilateral Ovarian Germ Cell Tumor in a 46,XX Female with Nijmegen Breakage Syndrome and hypergonadotropic hypogonadism.

Journal of clinical research in pediatric endocrinology

Krawczyk MA, Styczewska M, Birkholz-Walerzak D, Iliszko M, Lipska-Zietkiewicz BS, Kosiak W, Irga-Jaworska N, Izycka-Swieszewska E, Bien E.
PMID: 34544220
J Clin Res Pediatr Endocrinol. 2021 Sep 21; doi: 10.4274/jcrpe.galenos.2021.2021.0151. Epub 2021 Sep 21.

Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disease, affecting mainly patients of Slavic origin. It is caused by a defect in NBN gene, resulting in defective nibrin protein formation. This leads to chromosomal instability, which predisposes to...

Comparative genomic analysis of intracranial germ cell tumors - the preliminary study focused on Sonic Hedgehog signaling pathway.

Contemporary oncology (Poznan, Poland)

Kuleszo D, Koczkowska M, Lipska-Ziętkiewicz BS, Grajkowska W, Adamkiewicz-Drożyńska E, Dembowska-Bagińska B, Ciołkowski M, Iżycka-Świeszewska E.
PMID: 29416433
Contemp Oncol (Pozn). 2017;21(4):279-284. doi: 10.5114/wo.2017.72390. Epub 2017 Dec 30.

AIM OF THE STUDY: Examination of copy number changes in a group of intracranial germ cell tumors (GCTs) with particular focus on putative aberrations of the main genes coding SHh pathway proteins.MATERIAL AND METHODS: The study was performed on...

Platelet 12-lipoxygenase and stem cells in Barrett's esophagus.

Oncology letters

Jaœkiewicz K, Iżycka-Œwieszewska E, Janiak M, Lysiak-Szydłowska W, Adrych K, Reinartz J, Jankun J, Skrzypczak-Jankun E.
PMID: 22966380
Oncol Lett. 2010 Sep;1(5):789-791. doi: 10.3892/ol_00000137. Epub 2010 Sep 01.

Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis...

Case Report: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Application in Intraperitoneally Disseminated Inflammatory Myofibroblastic Tumor and in the Youngest Patient in the World: New Indication and Modification of Technique.

Frontiers in surgery

Garnier H, Murawski M, Jastrzebski T, Pawinska-Wasikowska K, Balwierz W, Sinacka K, Gorecki W, Izycka-Swieszewska E, Czauderna P.
PMID: 34712693
Front Surg. 2021 Oct 12;8:746700. doi: 10.3389/fsurg.2021.746700. eCollection 2021.

No abstract available.

High Expression of Solute Carrier Family 2 Member 1 (SLC2A1) in Cancer Cells Is an Independent Unfavorable Prognostic Factor in Pediatric Malignant Peripheral Nerve Sheath Tumor.

Diagnostics (Basel, Switzerland)

Krawczyk MA, Kunc M, Styczewska M, Gabrych A, Karpinsky G, Izycka-Swieszewska E, Bien E.
PMID: 33810575
Diagnostics (Basel). 2021 Mar 26;11(4). doi: 10.3390/diagnostics11040598.

Malignant peripheral nerve sheath tumor (MPNST) in children is a rare mesenchymal malignancy developing predominantly in the setting of neurofibromatosis type 1. The prognosis in advanced MPNST is poor therefore new prognostic markers are highly needed for optimal therapeutic...

On the significance of germline cytogenetic rearrangements at MYCN locus in neuroblastoma.

Molecular cytogenetics

Lipska BS, Koczkowska M, Wierzba J, Ploszynska A, Iliszko M, Izycka-Swieszewska E, Adamkiewicz-Drozynska E, Limon J.
PMID: 24131700
Mol Cytogenet. 2013 Oct 16;6(1):43. doi: 10.1186/1755-8166-6-43.

BACKGROUND: MYCN oncogene amplification is the most important prognostic factor in neuroblastoma. 25% neuroblastoma tumors have somatic amplifications at this locus but little is known about its constitutional aberrations and their potential role in carcinogenesis. Here, we have performed...

microRNA Expression Profile in Single Hormone Receptor-Positive Breast Cancers is Mainly Dependent on HER2 Status-A Pilot Study.

Diagnostics (Basel, Switzerland)

Kunc M, Popęda M, Niemira M, Szałkowska A, Bieńkowski M, Pęksa R, Łacko A, Radecka BS, Braun M, Pikiel J, Litwiniuk M, Pogoda K, Iżycka-Świeszewska E, Krętowski A, Żaczek AJ, Biernat W, Senkus-Konefka E.
PMID: 32825530
Diagnostics (Basel). 2020 Aug 20;10(9). doi: 10.3390/diagnostics10090617.

Estrogen (ER) and progesterone (PgR) receptors and HER2 are crucial in the assessment of breast cancer specimens due to their prognostic and predictive significance. Single hormone receptor-positive breast cancers are less common and their clinical course is less favorable...

Showing 1 to 12 of 15 entries