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Showing 1 to 12 of 34 entries
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A new problem-solving curriculum.

Academic medicine : journal of the Association of American Medical Colleges

Iatridis PG.
PMID: 1497780
Acad Med. 1992 Aug;67(8):520. doi: 10.1097/00001888-199208000-00007.

No abstract available.

Trends in Bone Morphogenetic Protein Usage since the U.S. Food and Drug Administration Advisory in 2008: What Happens to Physician Practices When the Food and Drug Administration Issues an Advisory?.

Global spine journal

Mckie J, Qureshi S, Iatridis J, Egorova N, Cho S, Hecht A.
PMID: 25072000
Global Spine J. 2014 Jun;4(2):71-6. doi: 10.1055/s-0033-1363515. Epub 2013 Dec 19.

Study Design Retrospective cross-sectional study of spinal procedures from 2002 to 2010 using the Nationwide Inpatient Sample database. Objective To determine the patterns of bone morphogenetic protein (BMP) usage in fusion surgery before and after the U.S. Food and...

Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model.

JOR spine

Long RG, Ferguson SJ, Benneker LM, Sakai D, Li Z, Pandit A, Grijpma DW, Eglin D, Zeiter S, Schmid T, Eberli U, Nehrbass D, Di Pauli von Treuheim T, Alini M, Iatridis JC, Grad S.
PMID: 32211587
JOR Spine. 2019 Dec 21;3(1):e1074. doi: 10.1002/jsp2.1074. eCollection 2020 Mar.

Tissue engineering repair of annulus fibrosus (AF) defects has the potential to prevent disability and pain from intervertebral disc (IVD) herniation and its progression to degeneration. Clinical translation of AF repair methods requires assessment in long-term large animal models....

High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE-KO mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

D'Erminio DN, Krishnamoorthy D, Lai A, Hoy RC, Natelson DM, Poeran J, Torres A, Laudier DM, Nasser P, Vashishth D, Illien-Jünger S, Iatridis JC.
PMID: 34676612
J Orthop Res. 2021 Oct 21; doi: 10.1002/jor.25191. Epub 2021 Oct 21.

Back pain and spinal pathologies are associated with obesity in juveniles and adults, yet studies identifying causal relationships are lacking and none investigate sex differences. This study determined if high fat (HF) diet causes structural and functional changes to...

Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice.

European cells & materials

Levillain A, Ahmed S, Kaimaki DM, Schuler S, Barros S, Labonte D, Iatridis JC, Nowlan NC.
PMID: 34021906
Eur Cell Mater. 2021 May 22;41:558-575. doi: 10.22203/eCM.v041a36.

Embryonic muscle forces are necessary for normal vertebral development and spinal curvature, but their involvement in intervertebral disc (IVD) development remains unclear. The aim of the current study was to determine how muscle contractions affect (1) notochord involution and...

Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of .

NPJ Regenerative medicine

Torre OM, Mroz V, Benitez ARM, Huang AH, Iatridis JC.
PMID: 31885875
NPJ Regen Med. 2019 Dec 20;4:23. doi: 10.1038/s41536-019-0085-4. eCollection 2019.

Intervertebral disc (IVD) injuries are a cause of degenerative changes in adults which can lead to back pain, a leading cause of disability. We developed a model of neonatal IVD regeneration with full functional restoration and investigate the cellular...

Cartilage

Di Pauli von Treuheim T, Torre OM, Ferreri ED, Nasser P, Abbondandolo A, Delgado Caceres M, Lin D, Docheva D, Iatridis JC.
PMID: 34486420
Cartilage. 2021 Dec;13(2):604S-614S. doi: 10.1177/19476035211029696. Epub 2021 Sep 04.

OBJECTIVE: The underlying mechanisms and molecular factors influencing intervertebral disc (IVD) homeostasis and degeneration remain clinically relevant. Tenomodulin (Tnmd) and chondromodulin (Chm1) are antiangiogenic transmembrane glycoproteins, with cleavable C-terminus, expressed by IVD cells that are implicated in the onset...

Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations.

Advanced healthcare materials

DiStefano TJ, Vaso K, Danias G, Chionuma HN, Weiser JR, Iatridis JC.
PMID: 34297485
Adv Healthc Mater. 2021 Jul 23;e2100596. doi: 10.1002/adhm.202100596. Epub 2021 Jul 23.

Emergent approaches in regenerative medicine look toward the use of extracellular vesicles (EVs) as a next-generation treatment strategy for intervertebral disc (IVD) degeneration (IVDD) because of their ability to attenuate chronic inflammation, reduce apoptosis, and stimulate proliferation in a...

3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.

Additive manufacturing

Borrello J, Nasser P, Iatridis J, Costa KD.
PMID: 31106119
Addit Manuf. 2018 Oct;23:374-380. doi: 10.1016/j.addma.2018.08.019. Epub 2018 Aug 18.

Multi-material 3D printing with several mechanically distinct materials at once has expanded the potential applications for additive manufacturing technology. Fewer material options exist, however, for additive systems that employ vat photopolymerization (such as stereolithography, SLA, and digital light projection,...

Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.

Bone research

Lyu FJ, Cui H, Pan H, Mc Cheung K, Cao X, Iatridis JC, Zheng Z.
PMID: 33514693
Bone Res. 2021 Jan 29;9(1):7. doi: 10.1038/s41413-020-00125-x.

Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and...

A perspective on the .

JOR spine

Dahia CL, Engiles JB, Gullbrand SE, Iatridis JC, Lai A, Le Maitre CL, Lotz JC, Masuda K, Séguin CA, Tryfonidou MA.
PMID: 34337339
JOR Spine. 2021 Jul 26;4(2):e1165. doi: 10.1002/jsp2.1165. eCollection 2021 Jun.

This perspective summarizes the genesis, development, and potential future directions of the multispecies

Does the neutral zone quantification method matter? Efficacy of evaluating neutral zone during destabilization and restabilization in human spine implant testing.

Journal of biomechanics

Di Pauli von Treuheim T, Zengerle L, Hecht AC, Iatridis JC, Wilke HJ.
PMID: 34619461
J Biomech. 2021 Dec 02;129:110756. doi: 10.1016/j.jbiomech.2021.110756. Epub 2021 Sep 21.

Neutral zone (NZ) is an important biomechanical parameter when evaluating spinal instability following destabilizing and restabilizing events, with particular relevance for implant efficacy testing. It remains unclear what NZ calculation methods are most sensitive at capturing NZ changes across...

Showing 1 to 12 of 34 entries