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Showing 1 to 8 of 8 entries
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Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore .

Metabolites

Hoppe A, Ilkavets I, Dooley S, Holzhütter HG.
PMID: 24957771
Metabolites. 2012 Nov 21;2(4):983-1003. doi: 10.3390/metabo2040983.

TGFb signaling plays a major role in the reorganization of liver tissue upon injury and is an important driver of chronic liver disease. This is achieved by a deep impact on a cohort of cellular functions. To comprehensively assess...

Temoporfin-in-Cyclodextrin-in-Liposome-A New Approach for Anticancer Drug Delivery: The Optimization of Composition.

Nanomaterials (Basel, Switzerland)

Yakavets I, Lassalle HP, Scheglmann D, Wiehe A, Zorin V, Bezdetnaya L.
PMID: 30340318
Nanomaterials (Basel). 2018 Oct 18;8(10). doi: 10.3390/nano8100847.

The main goal of this study was to use hybrid delivery system for effective transportation of temoporfin (

Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening.

Journal of clinical medicine

Yakavets I, Jenard S, Francois A, Maklygina Y, Loschenov V, Lassalle HP, Dolivet G, Bezdetnaya L.
PMID: 31618880
J Clin Med. 2019 Oct 15;8(10). doi: 10.3390/jcm8101686.

Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient...

mTHPC-Loaded Extracellular Vesicles Significantly Improve mTHPC Diffusion and Photodynamic Activity in Preclinical Models.

Pharmaceutics

Millard M, Posty S, Piffoux M, Jasniewski J, Lassalle HP, Yakavets I, Gazeau F, Wilhelm C, Silva AKA, Bezdetnaya L.
PMID: 32709026
Pharmaceutics. 2020 Jul 17;12(7). doi: 10.3390/pharmaceutics12070676.

Extracellular vesicles (EVs), derived from the cell, display a phospholipid bilayer membrane that protects the cargo molecules from degradation and contributes to increasing their stability in the bloodstream and tumor targeting. EVs are interesting in regard to the delivery...

Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids.

Cancers

Yakavets I, Millard M, Lamy L, Francois A, Scheglmann D, Wiehe A, Lassalle HP, Zorin V, Bezdetnaya L.
PMID: 31540319
Cancers (Basel). 2019 Sep 13;11(9). doi: 10.3390/cancers11091366.

The balance between the amount of drug delivered to tumor tissue and the homogeneity of its distribution is a challenge in the efficient delivery of photosensitizers (PSs) in photodynamic therapy (PDT) of cancer. To date, many efforts have been...

NIR Imaging of the Integrin-Rich Head and Neck Squamous Cell Carcinoma Using Ternary Copper Indium Selenide/Zinc Sulfide-Based Quantum Dots.

Cancers

Yakavets I, Francois A, Guiot M, Lequeux N, Fragola A, Pons T, Bezdetnaya L, Marchal F.
PMID: 33322532
Cancers (Basel). 2020 Dec 11;12(12). doi: 10.3390/cancers12123727.

The efficient intraoperative identification of cancers requires the development of the bright, minimally-toxic, tumor-specific near-infrared (NIR) probes as contrast agents. Luminescent semiconductor quantum dots (QDs) offer several unique advantages for in vivo cellular imaging by providing bright and photostable...

Fluorescent Nanoparticles for the Guided Surgery of Ovarian Peritoneal Carcinomatosis.

Nanomaterials (Basel, Switzerland)

Mangeolle T, Yakavets I, Marchal S, Debayle M, Pons T, Bezdetnaya L, Marchal F.
PMID: 30050022
Nanomaterials (Basel). 2018 Jul 26;8(8). doi: 10.3390/nano8080572.

Complete surgical resection is the ideal cure for ovarian peritoneal carcinomatosis, but remains challenging. Fluorescent guided surgery can be a promising approach for precise cytoreduction when appropriate fluorophore is used. In the presence paper, we review already developed near-...

Modulation of Temoporfin Distribution in Blood by β-Cyclodextrin Nanoshuttles.

Pharmaceutics

Yakavets I, Yankovsky I, Zorina T, Belevtsev M, Bezdetnaya L, Zorin V.
PMID: 34371745
Pharmaceutics. 2021 Jul 09;13(7). doi: 10.3390/pharmaceutics13071054.

Photodynamic therapy represents a more targeted and less invasive alternative cancer treatment to traditional modalities. Temoporfin, as with many photosensitizers, is given by injection into a vein, and its subsequent fate is largely determined by the binding to plasma...

Showing 1 to 8 of 8 entries