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Showing 1 to 12 of 107 entries
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Sudden Onset of Brain Metastasis despite the Use of Vemurafenib for Another Metastatic Lesion in Malignant Melanoma Patients.

Case reports in oncology

Imafuku K, Yoshino K, Yamaguchi K, Tsuboi S, Ohara K, Hata H.
PMID: 28512412
Case Rep Oncol. 2017 Apr 04;10(1):290-295. doi: 10.1159/000461576. eCollection 2017.

Vemurafenib is an inhibitor of the BRAF mutation and has been approved by the Food and Drug Administration as a treatment option for patients with unresectable melanoma without brain metastasis. In the literature, vemurafenib has been reported to be...

Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events.

Case reports in oncology

Imafuku K, Yoshino K, Yamaguchi K, Tsuboi S, Ohara K, Hata H.
PMID: 28512413
Case Rep Oncol. 2017 Apr 04;10(1):296-300. doi: 10.1159/000463379. eCollection 2017.

Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis. Prednisolone can effectively treat irAEs. However, it is...

Heavy Element Effects in the Diagonal Born-Oppenheimer Correction within a Relativistic Spin-Free Hamiltonian.

The journal of physical chemistry. A

Imafuku Y, Abe M, Schmidt MW, Hada M.
PMID: 27003510
J Phys Chem A. 2016 Apr 07;120(13):2150-9. doi: 10.1021/acs.jpca.6b01507. Epub 2016 Mar 29.

Methodologies beyond the Born-Oppenheimer (BO) approximation are nowadays important to explain high precision spectroscopic measurements. Most previous evaluations of the BO correction are, however, focused on light-element molecules and based on a nonrelativistic Hamiltonian, so no information about the...

Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration.

Case reports in oncology

Imafuku K, Yoshino K, Yamaguchi K, Tsuboi S, Ohara K, Hata H.
PMID: 28559821
Case Rep Oncol. 2017 Apr 24;10(1):368-371. doi: 10.1159/000471480. eCollection 2017.

Immune checkpoint inhibitors have drastically changed in the treatment of many kinds of malignancies, especially malignant melanoma. The focus of the recent experiments has not only been on their efficacy but also immune-related adverse events (irAEs). We report a...

Synthesis of poly(6-azulenylethynyl)benzene derivatives as a multielectron redox system with liquid crystalline behavior.

Journal of the American Chemical Society

Ito S, Inabe H, Morita N, Ohta K, Kitamura T, Imafuku K.
PMID: 12568629
J Am Chem Soc. 2003 Feb 12;125(6):1669-80. doi: 10.1021/ja0209262.

A series of poly(6-azulenylethynyl)benzenes substituted with n-hexyloxycarbonyl chains at 1,3-positions in azulene rings, i.e., hexakis-, 1,2,4,5-tetrakis-, 1,3,5-tris-, and 1,4-bis(6-azulenylethynyl)benzene derivatives 1, 2, 3, and 4b, have been prepared by a simple one-pot reaction involving repeated Pd-catalyzed alkynylation of halogenated...

Synthesis and redox behavior of azulene-substituted benzene derivatives and (eta(5)-cyclopentadienyl)[tetra- and di(6-azulenyl)cyclobutadiene]cobalt complexes.

The Journal of organic chemistry

Ito S, Inabe H, Okujima T, Morita N, Watanabe M, Harada N, Imafuku K.
PMID: 11597235
J Org Chem. 2001 Oct 19;66(21):7090-101. doi: 10.1021/jo010540u.

1,2-Di(6-azulenyl)tetraphenylbenzenes and (6-azulenyl)pentaphenylbenzenes were synthesized by Diels-Alder reactions of di(6-azulenyl)acetylenes and 6-(phenylethynyl)azulenes with tetraphenylcyclopentadienone. Cobalt-mediated cyclooligomerization of mono- and di(6-azulenyl)acetylenes afforded 1,3,5- and 1,2,4-tri(6-azulenyl)benzene derivatives together with (eta(5)-cyclopentadienyl)[tetra- and di(6-azulenyl)cyclobutadiene]cobalt complexes. The redox behavior of these novel (6-azulenyl)benzene derivatives...

New transmission-type X-ray filters consisting of amorphous multilayer films.

Journal of synchrotron radiation

Takagi Y, Imafuku M.
PMID: 15263592
J Synchrotron Radiat. 1998 May 01;5:603-5. doi: 10.1107/S0909049598001496. Epub 1998 May 01.

New transmission-type X-ray filters have been developed. The filters consist of X-ray-amorphous metal (less than 30 A)/metalloid ( approximately 10 A) multilayer films sputter-deposited on X-ray-transparent polymer substrates. Such metal/metalloid multilayer films show only very broad diffraction peaks, since...

Effect of contrast material (Levovist) infusion on peak systolic velocity in middle cerebral artery using transcranial color-coded duplex sonography.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Hamaguchi H, Kanda F, Imafuku I, Kunimoto M, Chihara K.
PMID: 17903986
J Stroke Cerebrovasc Dis. 2004 Nov-Dec;13(6):267-70. doi: 10.1016/j.jstrokecerebrovasdis.2004.07.005.

It is of crucial importance to predict the presence of stenosis in cerebral artery before occurrence of a stroke. To determine stenosis in the middle cerebral artery (MCA), we examined the effect of contrast agent (Levovist) infusion on transcranial...

Observation of a large reaction cross section in the drip-line nucleus 22C.

Physical review letters

Tanaka K, Yamaguchi T, Suzuki T, Ohtsubo T, Fukuda M, Nishimura D, Takechi M, Ogata K, Ozawa A, Izumikawa T, Aiba T, Aoi N, Baba H, Hashizume Y, Inafuku K, Iwasa N, Kobayashi K, Komuro M, Kondo Y, Kubo T, Kurokawa M, Matsuyama T, Michimasa S, Motobayashi T, Nakabayashi T, Nakajima S, Nakamura T, Sakurai H, Shinoda R, Shinohara M, Suzuki H, Takeshita E, Takeuchi S, Togano Y, Yamada K, Yasuno T, Yoshitake M.
PMID: 20366816
Phys Rev Lett. 2010 Feb 12;104(6):062701. doi: 10.1103/PhysRevLett.104.062701. Epub 2010 Feb 08.

Reaction cross sections (sigma(R)) for 19C, 20C and the drip-line nucleus 22C on a liquid hydrogen target have been measured at around 40A MeV by a transmission method. A large enhancement of sigma(R) for 22C compared to those for...

Evaluation of the local environment for nanoscale quasicrystal formation in Zr(80)Pt(20) glassy alloy using Voronoi analysis.

Journal of physics. Condensed matter : an Institute of Physics journal

Saida J, Itoh K, Sato S, Imafuku M, Sanada T, Inoue A.
PMID: 21832335
J Phys Condens Matter. 2009 Sep 16;21(37):375104. doi: 10.1088/0953-8984/21/37/375104. Epub 2009 Aug 11.

The local atomic structure of nano-quasicrystal-forming Zr(80)Pt(20) binary glassy alloy was investigated by reverse Monte Carlo modeling based on the results of x-ray diffraction. A prepeak at Q∼17 nm(-1) originating from the unique bonding between the Pt-Pt pair is...

Serum levels of soluble CD163 and CXCL5 may be predictive markers for immune-related adverse events in patients with advanced melanoma treated with nivolumab: a pilot study.

Oncotarget

Fujimura T, Sato Y, Tanita K, Kambayashi Y, Otsuka A, Fujisawa Y, Yoshino K, Matsushita S, Funakoshi T, Hata H, Yamamoto Y, Uchi H, Nonomura Y, Tanaka R, Aoki M, Imafuku K, Okuhira H, Furudate S, Hidaka T, Aiba S.
PMID: 29643991
Oncotarget. 2018 Feb 15;9(21):15542-15551. doi: 10.18632/oncotarget.24509. eCollection 2018 Mar 20.

Antibodies against PD-1, such as nivolumab and pembrolizumab, are widely used in the treatment of various cancers including advanced melanoma. The anti-PD-1 Ab significantly prolongs survival in patients with metastatic melanoma, and its administration in combination with local or...

Serum Level of Soluble CD163 May Be a Predictive Marker of the Effectiveness of Nivolumab in Patients With Advanced Cutaneous Melanoma.

Frontiers in oncology

Fujimura T, Sato Y, Tanita K, Kambayashi Y, Otsuka A, Fujisawa Y, Yoshino K, Matsushita S, Funakoshi T, Hata H, Yamamoto Y, Uchi H, Nonomura Y, Tanaka R, Aoki M, Imafuku K, Okuhira H, Wada N, Irie H, Hidaka T, Hashimoto A, Aiba S.
PMID: 30510916
Front Oncol. 2018 Nov 19;8:530. doi: 10.3389/fonc.2018.00530. eCollection 2018.

Antibodies against programmed cell death protein 1, such as nivolumab and pembrolizumab, are widely used for treating various cancers, including advanced melanoma. Nivolumab significantly prolongs survival in patients with metastatic melanoma, and sequential administration with lipilimumab may improve outcomes...

Showing 1 to 12 of 107 entries