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Showing 1 to 12 of 448 entries
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Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.

Frontiers in immunology

Basner-Tschakarjan E, Mingozzi F.
PMID: 25101090
Front Immunol. 2014 Jul 23;5:350. doi: 10.3389/fimmu.2014.00350. eCollection 2014.

Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene...

[GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines].

Gaceta sanitaria

Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, Treweek S, Mustafa RA, Vandvik PO, Meerpohl J, Guyatt GH, Schünemann HJ.
PMID: 28917831
Gac Sanit. 2018 Mar - Apr;32(2):167.e1-167.e10. doi: 10.1016/j.gaceta.2017.03.008. Epub 2017 Sep 13.

Clinicians do not have the time or resources to consider the underlying evidence for the myriad decisions they must make each day and, as a consequence, rely on recommendations from clinical practice guidelines. Guideline panels should consider all the...

Shaping of light beams by 3D direct laser writing on facets of nonlinear crystals.

Optics letters

Lightman S, Gvishi R, Hurvitz G, Arie A.
PMID: 26421556
Opt Lett. 2015 Oct 01;40(19):4460-3. doi: 10.1364/OL.40.004460.

We demonstrate experimentally spatial-mode conversions of light beams generated in a quadratic nonlinear process by micron-scale structures placed on the facets of nonlinear crystals. These structures were printed on the crystal facets using a three-dimensional (3D) direct laser writing...

Identification of glypican-3-derived long peptides activating both CD8.

Oncoimmunology

Sayem MA, Tomita Y, Yuno A, Hirayama M, Irie A, Tsukamoto H, Senju S, Yuba E, Yoshikawa T, Kono K, Nakatsura T, Nishimura Y.
PMID: 26942076
Oncoimmunology. 2015 Aug 31;5(1):e1062209. doi: 10.1080/2162402X.2015.1062209. eCollection 2016.

In a recent phase I clinical trial, a vaccine consisting of glypican-3 (GPC3)-derived CTL epitopes was found to be safe and induced measurable immune and clinical responses in patients with hepatocellular carcinoma (HCC). The aim of this study was...

Unveiling the orbital angular momentum and acceleration of electron beams.

Physical review letters

Shiloh R, Tsur Y, Remez R, Lereah Y, Malomed BA, Shvedov V, Hnatovsky C, Krolikowski W, Arie A.
PMID: 25793830
Phys Rev Lett. 2015 Mar 06;114(9):096102. doi: 10.1103/PhysRevLett.114.096102. Epub 2015 Mar 04.

New forms of electron beams have been intensively investigated recently, including vortex beams carrying orbital angular momentum, as well as Airy beams propagating along a parabolic trajectory. Their traits may be harnessed for applications in materials science, electron microscopy,...

[A heterogeneous spleen].

La Revue de medecine interne

Atig A, Bouker A, Ghannouchi N, Bahri F.
PMID: 27087563
Rev Med Interne. 2017 Aug;38(8):564-565. doi: 10.1016/j.revmed.2016.03.004. Epub 2016 Apr 14.

No abstract available.

Plasma membranes modified by plasma treatment or deposition as solid electrolytes for potential application in solid alkaline fuel cells.

Membranes

Reinholdt M, Ilie A, Roualdès S, Frugier J, Schieda M, Coutanceau C, Martemianov S, Flaud V, Beche E, Durand J.
PMID: 24958295
Membranes (Basel). 2012 Jul 30;2(3):529-52. doi: 10.3390/membranes2030529.

In the highly competitive market of fuel cells, solid alkaline fuel cells using liquid fuel (such as cheap, non-toxic and non-valorized glycerol) and not requiring noble metal as catalyst seem quite promising. One of the main hurdles for emergence...

Comments on Brown Tumor of Cervical Spines.

Asian spine journal

Ozyurek S, Atik A.
PMID: 26097670
Asian Spine J. 2015 Jun;9(3):493-4. doi: 10.4184/asj.2015.9.3.493. Epub 2015 Jun 08.

No abstract available.

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes.

Molecular therapy. Methods & clinical development

Hui DJ, Edmonson SC, Podsakoff GM, Pien GC, Ivanciu L, Camire RM, Ertl H, Mingozzi F, High KA, Basner-Tschakarjan E.
PMID: 26445723
Mol Ther Methods Clin Dev. 2015 Sep 30;2:15029. doi: 10.1038/mtm.2015.29. eCollection 2015.

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe....

Assessment of Immunization to Hepatitis B Vaccine among Children under Five Years in Rural Areas of Taiz, Yemen.

Hepatitis research and treatment

Alssamei FA, Al-Sonboli NA, Alkumaim FA, Alsayaad NS, Al-Ahdal MS, Higazi TB, Elagib AA.
PMID: 28367327
Hepat Res Treat. 2017;2017:2131627. doi: 10.1155/2017/2131627. Epub 2017 Mar 06.

No abstract available.

High conversion efficiency in resonant four-wave mixing processes.

Optics express

Lee CY, Wu BH, Wang G, Chen YF, Chen YC, Yu IA.
PMID: 26832483
Opt Express. 2016 Jan 25;24(2):1008-16. doi: 10.1364/OE.24.001008.

We propose a new scheme of the resonant four-wave mixing (FWM) for the frequency up or down conversion, which is more efficient than the commonly-used scheme of the non-resonant FWM. In this new scheme, two control fields are spatially...

Multiple nonlinear optical interactions with arbitrary wave vector differences.

Physical review letters

Fradkin-Kashi K, Arie A, Urenski P, Rosenman G.
PMID: 11801015
Phys Rev Lett. 2002 Jan 14;88(2):023903. doi: 10.1103/PhysRevLett.88.023903. Epub 2001 Dec 26.

We present a novel method for simultaneously phase matching several nonlinear optical interactions within a single crystal. Quasiperiodic modulation of the nonlinear coefficient enables one to achieve high frequency mixing efficiencies for interactions with arbitrary wave vector differences. Doubling...

Showing 1 to 12 of 448 entries