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Showing 1 to 12 of 360 entries
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[Health pedagogy].

Ugeskrift for laeger

Jørgensen K, Schnack K.
PMID: 483402
Ugeskr Laeger. 1979 Aug 13;141(33):2275-6.

No abstract available.

Asymmetric formation of bridged benzoxazocines through an organocatalytic multicomponent dienamine-mediated one-pot cascade.

Organic letters

Ransborg LK, Overgaard M, Hejmanowska J, Barfüsser S, Jørgensen KA, Albrecht Ł.
PMID: 25084456
Org Lett. 2014 Aug 15;16(16):4182-5. doi: 10.1021/ol501882x. Epub 2014 Aug 01.

An organocatalytic one-pot cascade leading to the stereoselective formation of novel bridged benzoxazocines is presented. The developed methodology is based on the first example of a γ-selective-Mannich-initiated cascade reaction and allows for direct annulation of the bridged benzoxazocines by...

Objectively measured physical activity level and sedentary behavior in Norwegian children during a week in preschool.

Preventive medicine reports

Andersen E, Borch-Jenssen J, Øvreås S, Ellingsen H, Jørgensen KA, Moser T.
PMID: 28660120
Prev Med Rep. 2017 Jun 09;7:130-135. doi: 10.1016/j.pmedr.2017.06.003. eCollection 2017 Sep.

Although many studies have reported on physical activity (PA) levels using accelerometers, a thorough description of the PA pattern in preschool children during their stay in the preschool, is lacking in the current literature. Furthermore, there remains a lack...

Model selection for Gaussian kernel PCA denoising.

IEEE transactions on neural networks and learning systems

Jørgensen KW, Hansen LK.
PMID: 24808465
IEEE Trans Neural Netw Learn Syst. 2012 Jan;23(1):163-8. doi: 10.1109/TNNLS.2011.2178325.

We propose kernel parallel analysis (kPA) for automatic kernel scale and model order selection in Gaussian kernel principal component analysis (KPCA). Parallel analysis is based on a permutation test for covariance and has previously been applied for model order...

Enantioselective Formal [4+2] Cycloadditions to 3-Nitroindoles by Trienamine Catalysis: Synthesis of Chiral Dihydrocarbazoles.

Angewandte Chemie (International ed. in English)

Li Y, Tur F, Nielsen RP, Jiang H, Jensen F, Jørgensen KA.
PMID: 26636665
Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1020-4. doi: 10.1002/anie.201509693. Epub 2015 Dec 04.

The first enantioselective formal [4+2] cycloadditions of 3-nitroindoles are presented. By using 3-nitroindoles in combination with an organocatalyst, chiral dihydrocarbazole scaffolds are formed in moderate to good yields (up to 87%) and enantioselectivities (up to 97% ee). The reaction...

Mechanistic Insights into the Mode of Action of Bifunctional Pyrrolidine-Squaramide-Derived Organocatalysts.

Chemistry (Weinheim an der Bergstrasse, Germany)

Roca-López D, Uria U, Reyes E, Carrillo L, Jørgensen KA, Vicario JL, Merino P.
PMID: 26612630
Chemistry. 2016 Jan 18;22(3):884-9. doi: 10.1002/chem.201504705. Epub 2015 Dec 11.

The catalytic modes of action of three squaramide-derived bifunctional organocatalysts have been investigated using DFT methods. The [5+2] cycloaddition between oxidopyrylium ylides and enals was used as the model reaction. Two primary modes were possible for the different catalysts...

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups.

Frontiers in physiology

Dahlmans D, Houzelle A, Jörgensen JA, Phielix E, Lindeboom L, Hesselink MKC, Schrauwen P, Hoeks J.
PMID: 28983252
Front Physiol. 2017 Sep 21;8:711. doi: 10.3389/fphys.2017.00711. eCollection 2017.

In recent years, several microRNAs (miRNAs)-post-transcriptional regulators of gene expression-have been linked to the regulation of peripheral insulin sensitivity. Many of these studies, however, have been conducted in cell or animal models and the few human studies available lack...

Organocatalytic stereoselective [8+2] and [6+4] cycloadditions.

Nature chemistry

Mose R, Preegel G, Larsen J, Jakobsen S, Iversen EH, Jørgensen KA.
PMID: 28430196
Nat Chem. 2017 May;9(5):487-492. doi: 10.1038/nchem.2682. Epub 2016 Dec 19.

Cycloadditions that involve more than six π electrons are termed higher-order cycloadditions and are an excellent tool for solving complex synthetic challenges, as they provide direct access to polycyclic scaffolds that contain medium-sized rings. They have interesting synthetic potential...

The stereoselective formation of highly substituted CF3-dihydropyrans as versatile building blocks.

Chemical communications (Cambridge, England)

Donslund BS, Monleón A, Larsen J, Ibsen L, Jørgensen KA.
PMID: 26225818
Chem Commun (Camb). 2015 Sep 14;51(71):13666-9. doi: 10.1039/c5cc04874e.

The highly enantioselective dienamine-mediated formation of 5-bromo-6-(trifluoromethyl)-3,4-dihydro-2H-pyrans from α,β-unsaturated aldehydes and α-bromo-(trifluoromethyl)-enones employing a C2-symmetric aminocatalyst is described. The products are demonstrated to be applicable in coupling reactions directly onto the ring, thereby granting access to a broad scope...

Asymmetric Brønsted Base Catalyzed and Directed [3+2] Cycloaddition of 2-Acyl Cycloheptatrienes with Azomethine Ylides.

Chemistry (Weinheim an der Bergstrasse, Germany)

Lauridsen VH, Ibsen L, Blom J, Jørgensen KA.
PMID: 26807826
Chemistry. 2016 Mar 01;22(10):3259-3263. doi: 10.1002/chem.201600255. Epub 2016 Feb 02.

Conjugated cyclic trienes have the potential for different types of cycloaddition reactions. In the present work, we will, in a novel asymmetric cycloaddition reaction, demonstrate that the organocatalytic reaction of 2-acyl cycloheptatrienes with azomethine ylides proceeds as a [3+2]...

Formal Asymmetric α-Alkenylation of Aldehydes and the Synthetic Application toward Forming α-exo-Methylene-γ-butyrolactones and Skipped Dienes.

Organic letters

Li Y, Ibsen L, Jørgensen KA.
PMID: 28230372
Org Lett. 2017 Mar 03;19(5):1200-1203. doi: 10.1021/acs.orglett.7b00254. Epub 2017 Feb 23.

A formal asymmetric α-alkenylation of aldehydes is reported based on the organocatalytic reaction of aldehydes with nitroacrylates. The reaction proceeds in a one-pot manner forming the products with up to 77% yield and up to >99% ee. This strategy...

Phytochrome control of RNA levels in developing pea and mung-bean leaves.

Planta

Thompson WF, Everett M, Polans NO, Jorgensen RA, Palmer JD.
PMID: 24264922
Planta. 1983 Aug;158(6):487-500. doi: 10.1007/BF00397240.

We have examined phytochrome effects on the abundance of transcripts from several nuclear and chloroplast genes in buds of dark-grown pea seedlings and primary leaves of dark-grown mung-bean seedlings. Probes for nuclear-coded RNAs were selected from a library of...

Showing 1 to 12 of 360 entries