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Showing 1 to 12 of 46 entries
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Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria.

Iranian journal of pharmaceutical research : IJPR

Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H.
PMID: 26330870
Iran J Pharm Res. 2015;14(3):825-32.

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of...

Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment.

Clinical and experimental hepatology

Niknahad H, Jamshidzadeh A, Heidari R, Zarei M, Ommati MM.
PMID: 29062904
Clin Exp Hepatol. 2017 Sep;3(3):141-151. doi: 10.5114/ceh.2017.68833. Epub 2017 Jul 05.

INTRODUCTION: Ammonia-induced oxidative stress, mitochondrial dysfunction, and energy crisis are known as some the major mechanisms of brain injury in hepatic encephalopathy (HE). Hyperammonemia also affects the liver and hepatocytes. Therefore, targeting mitochondria seems to be a therapeutic point...

An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity.

Iranian journal of basic medical sciences

Jamshidzadeh A, Heidari R, Razmjou M, Karimi F, Moein MR, Farshad O, Akbarizadeh AR, Shayesteh MR.
PMID: 25825639
Iran J Basic Med Sci. 2015 Feb;18(2):205-11.

OBJECTIVES: Protective effects of different extracts and essential oil from Pimpinella anisum L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes...

The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics.

Naunyn-Schmiedeberg's archives of pharmacology

Ommati MM, Li H, Jamshidzadeh A, Khoshghadam F, Retana-Márquez S, Lu Y, Farshad O, Nategh Ahmadi MH, Gholami A, Heidari R.
PMID: 34994824
Naunyn Schmiedebergs Arch Pharmacol. 2022 Jan 07; doi: 10.1007/s00210-021-02177-0. Epub 2022 Jan 07.

Several studies have focused on the high potential effects of probiotics on the reproductive system. However, there is a paucity of information regarding the ameliorative intracellular roles of indigenous Iranian yogurt-extracted/cultured probiotics on animals' reproductive health suffering from obesity...

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.

Toxicology in vitro : an international journal published in association with BIBRA

Ghaffarian-Bahraman A, Arabnezhad MR, Keshavarzi M, Davani-Davari D, Jamshidzadeh A, Mohammadi-Bardbori A.
PMID: 34856342
Toxicol In Vitro. 2021 Nov 29;79:105282. doi: 10.1016/j.tiv.2021.105282. Epub 2021 Nov 29.

Many environmental pollutants, natural compounds, as well as endogenous chemicals exert their biological/toxicological effects by reacting with the aryl hydrocarbon receptor (AhR). Previous evidence shed new light on the role of AhR in skin physiology by regulating melanin production....

Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction.

Current research in pharmacology and drug discovery

Ommati MM, Farshad O, Niknahad H, Mousavi K, Moein M, Azarpira N, Mohammadi H, Jamshidzadeh A, Heidari R.
PMID: 34909638
Curr Res Pharmacol Drug Discov. 2020 Jun 16;1:10-18. doi: 10.1016/j.crphar.2020.06.001. eCollection 2020 Apr.

It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal injury in cirrhosis could lead to bacterial lipopolysaccharide (LPS) translocation to the systemic circulation. It has been found that high plasma LPS is connected with...

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.

Toxicology in vitro : an international journal published in association with BIBRA

Ghaffarian-Bahraman A, Arabnezhad MR, Keshavarzi M, Davani-Davari D, Jamshidzadeh A, Mohammadi-Bardbori A.
PMID: 34856342
Toxicol In Vitro. 2021 Nov 29;79:105282. doi: 10.1016/j.tiv.2021.105282. Epub 2021 Nov 29.

Many environmental pollutants, natural compounds, as well as endogenous chemicals exert their biological/toxicological effects by reacting with the aryl hydrocarbon receptor (AhR). Previous evidence shed new light on the role of AhR in skin physiology by regulating melanin production....

Anti-melanogenesis and anti-tyrosinase properties of aryl-substituted acetamides of phenoxy methyl triazole conjugated with thiosemicarbazide: Design, synthesis and biological evaluations.

Bioorganic chemistry

Hosseinpoor H, Moghadam Farid S, Iraji A, Askari S, Edraki N, Hosseini S, Jamshidzadeh A, Larijani B, Attarroshan M, Pirhadi S, Mahdavi M, Khoshneviszadeh M.
PMID: 34140181
Bioorg Chem. 2021 Sep;114:104979. doi: 10.1016/j.bioorg.2021.104979. Epub 2021 May 11.

A series of aryl phenoxy methyl triazole conjugated with thiosemicarbazides were designed, synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa and l-tyrosine as substrates. All the compounds showed tyrosinase inhibition in the sub-micromolar concentration....

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.

Toxicology in vitro : an international journal published in association with BIBRA

Ghaffarian-Bahraman A, Arabnezhad MR, Keshavarzi M, Davani-Davari D, Jamshidzadeh A, Mohammadi-Bardbori A.
PMID: 34856342
Toxicol In Vitro. 2021 Nov 29;79:105282. doi: 10.1016/j.tiv.2021.105282. Epub 2021 Nov 29.

Many environmental pollutants, natural compounds, as well as endogenous chemicals exert their biological/toxicological effects by reacting with the aryl hydrocarbon receptor (AhR). Previous evidence shed new light on the role of AhR in skin physiology by regulating melanin production....

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.

Toxicology in vitro : an international journal published in association with BIBRA

Ghaffarian-Bahraman A, Arabnezhad MR, Keshavarzi M, Davani-Davari D, Jamshidzadeh A, Mohammadi-Bardbori A.
PMID: 34856342
Toxicol In Vitro. 2021 Nov 29;79:105282. doi: 10.1016/j.tiv.2021.105282. Epub 2021 Nov 29.

Many environmental pollutants, natural compounds, as well as endogenous chemicals exert their biological/toxicological effects by reacting with the aryl hydrocarbon receptor (AhR). Previous evidence shed new light on the role of AhR in skin physiology by regulating melanin production....

Antioxidant Effects of Bone Marrow Mesenchymal Stem Cell against Carbon Tetrachloride-Induced Oxidative Damage in Rat Livers.

International journal of organ transplantation medicine

Ayatollahi M, Hesami Z, Jamshidzadeh A, Gramizadeh B.
PMID: 25426285
Int J Organ Transplant Med. 2014;5(4):166-73.

BACKGROUND: Liver fibrosis results from excessive accumulation of extracellular matrix, which affects liver function over time and leads to its failure. In the past, liver transplant was thought to be the only treatment for end-stage liver disease, but due...

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.

Toxicology in vitro : an international journal published in association with BIBRA

Ghaffarian-Bahraman A, Arabnezhad MR, Keshavarzi M, Davani-Davari D, Jamshidzadeh A, Mohammadi-Bardbori A.
PMID: 34856342
Toxicol In Vitro. 2021 Nov 29;79:105282. doi: 10.1016/j.tiv.2021.105282. Epub 2021 Nov 29.

Many environmental pollutants, natural compounds, as well as endogenous chemicals exert their biological/toxicological effects by reacting with the aryl hydrocarbon receptor (AhR). Previous evidence shed new light on the role of AhR in skin physiology by regulating melanin production....

Showing 1 to 12 of 46 entries