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Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors.

Beilstein journal of organic chemistry

Cortes-Pacheco A, Jiménez-Arellanes MA, Palacios-Can FJ, Valcarcel-Gamiño JA, Razo-Hernández RS, Juárez-Vázquez MDC, López-Torres A, Ramírez-Marroquín OA.
PMID: 32566030
Beilstein J Org Chem. 2020 Jun 08;16:1277-1287. doi: 10.3762/bjoc.16.108. eCollection 2020.

Bisphosphonic acids (or bisphosphonates) have been successfully used in the clinic treatment of bone diseases for over decades. Additionally, the antiinflammatory activity of these compounds has been gaining attention. In our previous work, we synthesized and in vivo evaluated...

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Cortes-Pacheco A, Jiménez-Arellanes MA, Palacios-Can FJ, et al. Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors. Beilstein J Org Chem. 2020;16:1277-1287doi: 10.3762/bjoc.16.108.
Cortes-Pacheco, A., Jiménez-Arellanes, M. A., Palacios-Can, F. J., Valcarcel-Gamiño, J. A., Razo-Hernández, R. S., Juárez-Vázquez, M. D. C., López-Torres, A., & Ramírez-Marroquín, O. A. (2020). Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors. Beilstein journal of organic chemistry, 161277-1287. https://doi.org/10.3762/bjoc.16.108
Cortes-Pacheco, Abimelek, et al. "Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors." Beilstein journal of organic chemistry vol. 16 (2020): 1277-1287. doi: https://doi.org/10.3762/bjoc.16.108
Cortes-Pacheco A, Jiménez-Arellanes MA, Palacios-Can FJ, Valcarcel-Gamiño JA, Razo-Hernández RS, Juárez-Vázquez MDC, López-Torres A, Ramírez-Marroquín OA. Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors. Beilstein J Org Chem. 2020 Jun 08;16:1277-1287. doi: 10.3762/bjoc.16.108. eCollection 2020. PMID: 32566030; PMCID: PMC7296197.
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Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes.

Evidence-based complementary and alternative medicine : eCAM

Jiménez-Arellanes A, León-Díaz R, Meckes M, Tapia A, Molina-Salinas GM, Luna-Herrera J, Yépez-Mulia L.
PMID: 22454670
Evid Based Complement Alternat Med. 2012;2012:593403. doi: 10.1155/2012/593403. Epub 2012 Feb 16.

We analyzed the antimycobacterial activity of the hexane extract of rhizomes from Aristolochia elegans. Some compounds of this extract were purified and tested against a group of drug-resistant Mycobacterium tuberculosis strains. We also evaluated their antiprotozoal activities. The hexane...

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Jiménez-Arellanes A, León-Díaz R, Meckes M, et al. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evid Based Complement Alternat Med. 2012;2012:593403doi: 10.1155/2012/593403.
Jiménez-Arellanes, A., León-Díaz, R., Meckes, M., Tapia, A., Molina-Salinas, G. M., Luna-Herrera, J., & Yépez-Mulia, L. (2012). Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evidence-based complementary and alternative medicine : eCAM, 2012593403. https://doi.org/10.1155/2012/593403
Jiménez-Arellanes, Adelina, et al. "Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 593403. doi: https://doi.org/10.1155/2012/593403
Jiménez-Arellanes A, León-Díaz R, Meckes M, Tapia A, Molina-Salinas GM, Luna-Herrera J, Yépez-Mulia L. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evid Based Complement Alternat Med. 2012;2012:593403. doi: 10.1155/2012/593403. Epub 2012 Feb 16. PMID: 22454670; PMCID: PMC3292206.
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Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes.

Evidence-based complementary and alternative medicine : eCAM

Jiménez-Arellanes A, León-Díaz R, Meckes M, Tapia A, Molina-Salinas GM, Luna-Herrera J, Yépez-Mulia L.
PMID: 22454670
Evid Based Complement Alternat Med. 2012;2012:593403. doi: 10.1155/2012/593403. Epub 2012 Feb 16.

We analyzed the antimycobacterial activity of the hexane extract of rhizomes from Aristolochia elegans. Some compounds of this extract were purified and tested against a group of drug-resistant Mycobacterium tuberculosis strains. We also evaluated their antiprotozoal activities. The hexane...

Cite
Jiménez-Arellanes A, León-Díaz R, Meckes M, et al. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evid Based Complement Alternat Med. 2012;2012:593403doi: 10.1155/2012/593403.
Jiménez-Arellanes, A., León-Díaz, R., Meckes, M., Tapia, A., Molina-Salinas, G. M., Luna-Herrera, J., & Yépez-Mulia, L. (2012). Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evidence-based complementary and alternative medicine : eCAM, 2012593403. https://doi.org/10.1155/2012/593403
Jiménez-Arellanes, Adelina, et al. "Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 593403. doi: https://doi.org/10.1155/2012/593403
Jiménez-Arellanes A, León-Díaz R, Meckes M, Tapia A, Molina-Salinas GM, Luna-Herrera J, Yépez-Mulia L. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evid Based Complement Alternat Med. 2012;2012:593403. doi: 10.1155/2012/593403. Epub 2012 Feb 16. PMID: 22454670; PMCID: PMC3292206.
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Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update.

Asian Pacific journal of tropical medicine

Gutiérrez-Rebolledo GA, Drier-Jonas S, Jiménez-Arellanes MA.
PMID: 29268964
Asian Pac J Trop Med. 2017 Dec;10(12):1105-1110. doi: 10.1016/j.apjtm.2017.10.016. Epub 2017 Nov 07.

Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceral-type leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous...

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Gutiérrez-Rebolledo GA, Drier-Jonas S, Jiménez-Arellanes MA. Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update. Asian Pac J Trop Med. 2017;10(12):1105-1110doi: 10.1016/j.apjtm.2017.10.016.
Gutiérrez-Rebolledo, G. A., Drier-Jonas, S., & Jiménez-Arellanes, M. A. (2017). Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update. Asian Pacific journal of tropical medicine, 10(12), 1105-1110. https://doi.org/10.1016/j.apjtm.2017.10.016
Gutiérrez-Rebolledo, Gabriel Alfonso, et al. "Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update." Asian Pacific journal of tropical medicine vol. 10,12 (2017): 1105-1110. doi: https://doi.org/10.1016/j.apjtm.2017.10.016
Gutiérrez-Rebolledo GA, Drier-Jonas S, Jiménez-Arellanes MA. Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update. Asian Pac J Trop Med. 2017 Dec;10(12):1105-1110. doi: 10.1016/j.apjtm.2017.10.016. Epub 2017 Nov 07. PMID: 29268964.
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Hepatoprotective and Anti-Inflammatory Activities of the .

Evidence-based complementary and alternative medicine : eCAM

Pérez-González MZ, Siordia-Reyes AG, Damián-Nava P, Hernández-Ortega S, Macías-Rubalcava ML, Jiménez-Arellanes MA.
PMID: 30147729
Evid Based Complement Alternat Med. 2018 Jul 25;2018:3896517. doi: 10.1155/2018/3896517. eCollection 2018.

Previous report described that CHCl

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Pérez-González MZ, Siordia-Reyes AG, Damián-Nava P, et al. Hepatoprotective and Anti-Inflammatory Activities of the . Evid Based Complement Alternat Med. 2018;2018:3896517doi: 10.1155/2018/3896517.
Pérez-González, M. Z., Siordia-Reyes, A. G., Damián-Nava, P., Hernández-Ortega, S., Macías-Rubalcava, M. L., & Jiménez-Arellanes, M. A. (2018). Hepatoprotective and Anti-Inflammatory Activities of the . Evidence-based complementary and alternative medicine : eCAM, 20183896517. https://doi.org/10.1155/2018/3896517
Pérez-González, Mariana Z, et al. "Hepatoprotective and Anti-Inflammatory Activities of the ." Evidence-based complementary and alternative medicine : eCAM vol. 2018 (2018): 3896517. doi: https://doi.org/10.1155/2018/3896517
Pérez-González MZ, Siordia-Reyes AG, Damián-Nava P, Hernández-Ortega S, Macías-Rubalcava ML, Jiménez-Arellanes MA. Hepatoprotective and Anti-Inflammatory Activities of the . Evid Based Complement Alternat Med. 2018 Jul 25;2018:3896517. doi: 10.1155/2018/3896517. eCollection 2018. PMID: 30147729; PMCID: PMC6083640.
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Microbiological and Pharmacological Evaluation of the Micropropagated Rubus liebmannii Medicinal Plant.

Evidence-based complementary and alternative medicine : eCAM

Jiménez-Arellanes A, Cornejo-Garrido J, Rojas-Bribiesca G, Nicasio-Torres Mdel P, Said-Fernández S, Mata-Cárdenas BD, Molina-Salinas GM, Tortoriello J, Meckes-Fischer M.
PMID: 22966243
Evid Based Complement Alternat Med. 2012;2012:503031. doi: 10.1155/2012/503031. Epub 2012 Aug 26.

Rubus liebmannii is an endemic species from Mexico used in traditional medicine primarily to treat dysentery and cough. The in vitro activity against Giardia lamblia and Entamoeba histolytica that produces the ethanolic extract of the aerial parts of the...

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Jiménez-Arellanes A, Cornejo-Garrido J, Rojas-Bribiesca G, et al. Microbiological and Pharmacological Evaluation of the Micropropagated Rubus liebmannii Medicinal Plant. Evid Based Complement Alternat Med. 2012;2012:503031doi: 10.1155/2012/503031.
Jiménez-Arellanes, A., Cornejo-Garrido, J., Rojas-Bribiesca, G., Nicasio-Torres, M. d. e. l. . P., Said-Fernández, S., Mata-Cárdenas, B. D., Molina-Salinas, G. M., Tortoriello, J., & Meckes-Fischer, M. (2012). Microbiological and Pharmacological Evaluation of the Micropropagated Rubus liebmannii Medicinal Plant. Evidence-based complementary and alternative medicine : eCAM, 2012503031. https://doi.org/10.1155/2012/503031
Jiménez-Arellanes, Adelina, et al. "Microbiological and Pharmacological Evaluation of the Micropropagated Rubus liebmannii Medicinal Plant." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 503031. doi: https://doi.org/10.1155/2012/503031
Jiménez-Arellanes A, Cornejo-Garrido J, Rojas-Bribiesca G, Nicasio-Torres Mdel P, Said-Fernández S, Mata-Cárdenas BD, Molina-Salinas GM, Tortoriello J, Meckes-Fischer M. Microbiological and Pharmacological Evaluation of the Micropropagated Rubus liebmannii Medicinal Plant. Evid Based Complement Alternat Med. 2012;2012:503031. doi: 10.1155/2012/503031. Epub 2012 Aug 26. PMID: 22966243; PMCID: PMC3433153.
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Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana.

Asian Pacific journal of tropical medicine

Gutiérrez-Rebolledo GA, Pérez-González MZ, Zamilpa A, Jiménez-Arellanes MA.
PMID: 28237478
Asian Pac J Trop Med. 2017 Feb;10(2):141-147. doi: 10.1016/j.apjtm.2017.01.008. Epub 2017 Jan 21.

OBJECTIVE: To identify the anti-inflammatory activity through two murine models and in the median Lethal Dose (LDMETHODS: The anti-inflammatory activity of three dietary supplements (Cicatrisan/GastricusRESULTS: For the TPA model, Cicatrisan/GastricusCONCLUSIONS: Of the three food supplements containing M. deppeana, only...

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Gutiérrez-Rebolledo GA, Pérez-González MZ, Zamilpa A, et al. Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana. Asian Pac J Trop Med. 2017;10(2):141-147doi: 10.1016/j.apjtm.2017.01.008.
Gutiérrez-Rebolledo, G. A., Pérez-González, M. Z., Zamilpa, A., & Jiménez-Arellanes, M. A. (2017). Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana. Asian Pacific journal of tropical medicine, 10(2), 141-147. https://doi.org/10.1016/j.apjtm.2017.01.008
Gutiérrez-Rebolledo, Gabriel Alfonso, et al. "Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana." Asian Pacific journal of tropical medicine vol. 10,2 (2017): 141-147. doi: https://doi.org/10.1016/j.apjtm.2017.01.008
Gutiérrez-Rebolledo GA, Pérez-González MZ, Zamilpa A, Jiménez-Arellanes MA. Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana. Asian Pac J Trop Med. 2017 Feb;10(2):141-147. doi: 10.1016/j.apjtm.2017.01.008. Epub 2017 Jan 21. PMID: 28237478.
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Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage.

Asian Pacific journal of tropical medicine

Gutiérrez-Rebolledo GA, Siordia-Reyes AG, Meckes-Fischer M, Jiménez-Arellanes A.
PMID: 27393091
Asian Pac J Trop Med. 2016 Jul;9(7):644-51. doi: 10.1016/j.apjtm.2016.05.015. Epub 2016 May 31.

OBJECTIVE: To estimate to what extent the mixture of ursolic acid and oleanolic acid, in addition to the antitubercular standard regime, affects the hepatotoxicity profile.METHODS: Liver injury was induced in male BALB/c mice by administering, per os and daily...

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Gutiérrez-Rebolledo GA, Siordia-Reyes AG, Meckes-Fischer M, et al. Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage. Asian Pac J Trop Med. 2016;9(7):644-51doi: 10.1016/j.apjtm.2016.05.015.
Gutiérrez-Rebolledo, G. A., Siordia-Reyes, A. G., Meckes-Fischer, M., & Jiménez-Arellanes, A. (2016). Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage. Asian Pacific journal of tropical medicine, 9(7), 644-51. https://doi.org/10.1016/j.apjtm.2016.05.015
Gutiérrez-Rebolledo, Gabriel A, et al. "Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage." Asian Pacific journal of tropical medicine vol. 9,7 (2016): 644-51. doi: https://doi.org/10.1016/j.apjtm.2016.05.015
Gutiérrez-Rebolledo GA, Siordia-Reyes AG, Meckes-Fischer M, Jiménez-Arellanes A. Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage. Asian Pac J Trop Med. 2016 Jul;9(7):644-51. doi: 10.1016/j.apjtm.2016.05.015. Epub 2016 May 31. PMID: 27393091.
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Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review.

Asian Pacific journal of tropical medicine

Jiménez-Arellanes MA, Gutiérrez-Rebolledo GA, Meckes-Fischer M, León-Díaz R.
PMID: 27955741
Asian Pac J Trop Med. 2016 Dec;9(12):1141-1149. doi: 10.1016/j.apjtm.2016.10.010. Epub 2016 Nov 09.

Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of...

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Jiménez-Arellanes MA, Gutiérrez-Rebolledo GA, Meckes-Fischer M, et al. Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review. Asian Pac J Trop Med. 2016;9(12):1141-1149doi: 10.1016/j.apjtm.2016.10.010.
Jiménez-Arellanes, M. A., Gutiérrez-Rebolledo, G. A., Meckes-Fischer, M., & León-Díaz, R. (2016). Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review. Asian Pacific journal of tropical medicine, 9(12), 1141-1149. https://doi.org/10.1016/j.apjtm.2016.10.010
Jiménez-Arellanes, María Adelina, et al. "Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review." Asian Pacific journal of tropical medicine vol. 9,12 (2016): 1141-1149. doi: https://doi.org/10.1016/j.apjtm.2016.10.010
Jiménez-Arellanes MA, Gutiérrez-Rebolledo GA, Meckes-Fischer M, León-Díaz R. Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review. Asian Pac J Trop Med. 2016 Dec;9(12):1141-1149. doi: 10.1016/j.apjtm.2016.10.010. Epub 2016 Nov 09. PMID: 27955741.
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