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Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages.

Archives of toxicology

Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU.
PMID: 34642770
Arch Toxicol. 2022 Jan;96(1):121-134. doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13.

Few human data on exposure and toxicity are available on neonicotinoids and neonicotinoid-like compounds (NNIs), an important group of insecticides worldwide. Specifically, exposure assessment of humans by biomonitoring remains a challenge due to the lack of appropriate biomarkers. We...

Cite
Wrobel SA, Bury D, Hayen H, et al. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2021;96(1):121-134doi: 10.1007/s00204-021-03159-0.
Wrobel, S. A., Bury, D., Hayen, H., Koch, H. M., Brüning, T., & Käfferlein, H. U. (2022). Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Archives of toxicology, 96(1), 121-134. https://doi.org/10.1007/s00204-021-03159-0
Wrobel, Sonja A, et al. "Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages." Archives of toxicology vol. 96,1 (2022): 121-134. doi: https://doi.org/10.1007/s00204-021-03159-0
Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2022 Jan;96(1):121-134. doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13. PMID: 34642770.
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Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma.

Cancers

Gambichler T, Abu Rached N, Tannapfel A, Becker JC, Vogt M, Skrygan M, Wieland U, Silling S, Susok L, Stücker M, Meyer T, Stockfleth E, Junker K, Käfferlein HU, Brüning T, Lang K.
PMID: 34063983
Cancers (Basel). 2021 May 21;13(11). doi: 10.3390/cancers13112524.

We aimed to assess for the first time the mismatch repair (MMR) protein expression in Merkel cell carcinoma (MCC). Immunohistochemistry was performed for MLH1, MSH2, MSH6, and PMS2 on patients' tumor tissue (

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Gambichler T, Abu Rached N, Tannapfel A, et al. Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma. Cancers (Basel). 2021;13(11)doi: 10.3390/cancers13112524.
Gambichler, T., Abu Rached, N., Tannapfel, A., Becker, J. C., Vogt, M., Skrygan, M., Wieland, U., Silling, S., Susok, L., Stücker, M., Meyer, T., Stockfleth, E., Junker, K., Käfferlein, H. U., Brüning, T., & Lang, K. (2021). Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma. Cancers, 13(11), . https://doi.org/10.3390/cancers13112524
Gambichler, Thilo, et al. "Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma." Cancers vol. 13,11 (2021). doi: https://doi.org/10.3390/cancers13112524
Gambichler T, Abu Rached N, Tannapfel A, Becker JC, Vogt M, Skrygan M, Wieland U, Silling S, Susok L, Stücker M, Meyer T, Stockfleth E, Junker K, Käfferlein HU, Brüning T, Lang K. Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma. Cancers (Basel). 2021 May 21;13(11). doi: 10.3390/cancers13112524. PMID: 34063983; PMCID: PMC8196722.
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Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages.

Archives of toxicology

Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU.
PMID: 34642770
Arch Toxicol. 2021 Oct 13; doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13.

Few human data on exposure and toxicity are available on neonicotinoids and neonicotinoid-like compounds (NNIs), an important group of insecticides worldwide. Specifically, exposure assessment of humans by biomonitoring remains a challenge due to the lack of appropriate biomarkers. We...

Cite
Wrobel SA, Bury D, Hayen H, et al. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2021;doi: 10.1007/s00204-021-03159-0.
Wrobel, S. A., Bury, D., Hayen, H., Koch, H. M., Brüning, T., & Käfferlein, H. U. (2021). Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Archives of toxicology, . https://doi.org/10.1007/s00204-021-03159-0
Wrobel, Sonja A, et al. "Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages." Archives of toxicology vol. (2021). doi: https://doi.org/10.1007/s00204-021-03159-0
Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2021 Oct 13; doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13. PMID: 34642770.
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In-Vitro Identification and In-Vivo Confirmation of DNA Methylation Biomarkers for Urothelial Cancer.

Biomedicines

Köhler CU, Walter M, Lang K, Plöttner S, Roghmann F, Noldus J, Tannapfel A, Tam YC, Käfferlein HU, Brüning T.
PMID: 32707764
Biomedicines. 2020 Jul 22;8(8). doi: 10.3390/biomedicines8080233.

We identified DNA methylation targets specific for urothelial cancer (UC) by genome-wide methylation difference analysis of human urothelial (RT4, J82, 5637), prostate (LNCAP, DU-145, PC3) and renal (RCC-KP, CAKI-2, CAL-54) cancer cell lines with their respective primary epithelial cells....

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Köhler CU, Walter M, Lang K, et al. In-Vitro Identification and In-Vivo Confirmation of DNA Methylation Biomarkers for Urothelial Cancer. Biomedicines. 2020;8(8)doi: 10.3390/biomedicines8080233.
Köhler, C. U., Walter, M., Lang, K., Plöttner, S., Roghmann, F., Noldus, J., Tannapfel, A., Tam, Y. C., Käfferlein, H. U., & Brüning, T. (2020). In-Vitro Identification and In-Vivo Confirmation of DNA Methylation Biomarkers for Urothelial Cancer. Biomedicines, 8(8), . https://doi.org/10.3390/biomedicines8080233
Köhler, Christina U, et al. "In-Vitro Identification and In-Vivo Confirmation of DNA Methylation Biomarkers for Urothelial Cancer." Biomedicines vol. 8,8 (2020). doi: https://doi.org/10.3390/biomedicines8080233
Köhler CU, Walter M, Lang K, Plöttner S, Roghmann F, Noldus J, Tannapfel A, Tam YC, Käfferlein HU, Brüning T. In-Vitro Identification and In-Vivo Confirmation of DNA Methylation Biomarkers for Urothelial Cancer. Biomedicines. 2020 Jul 22;8(8). doi: 10.3390/biomedicines8080233. PMID: 32707764; PMCID: PMC7459535.
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Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions.

Archives of toxicology

Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T.
PMID: 29090345
Arch Toxicol. 2017 Nov;91(11):3597. doi: 10.1007/s00204-017-2095-6.

The article 'Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions' written by Heiko Udo Käfferlein, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 12th...

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Marek EM, Koslitz S, Weiss T, et al. Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Arch Toxicol. 2017;91(11):3597doi: 10.1007/s00204-017-2095-6.
Marek, E. M., Koslitz, S., Weiss, T., Fartasch, M., Schlüter, G., Käfferlein, H. U., & Brüning, T. (2017). Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Archives of toxicology, 91(11), 3597. https://doi.org/10.1007/s00204-017-2095-6
Marek, Eike Maximilian, et al. "Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions." Archives of toxicology vol. 91,11 (2017): 3597. doi: https://doi.org/10.1007/s00204-017-2095-6
Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Correction to: Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Arch Toxicol. 2017 Nov;91(11):3597. doi: 10.1007/s00204-017-2095-6. PMID: 29090345; PMCID: PMC5696494.
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Metabolism and elimination of N-ethyl-2-pyrrolidone (NEP) in human males after oral dosage.

Archives of toxicology

Koch HM, Bader M, Weiss T, Koslitz S, Schütze A, Käfferlein HU, Brüning T.
PMID: 24232175
Arch Toxicol. 2014 Apr;88(4):893-899. doi: 10.1007/s00204-013-1150-1. Epub 2013 Nov 14.

N-Ethyl-2-pyrrolidone (NEP) is an industrial solvent that has been increasingly used to substitute N-methyl-2-pyrrolidone. NEP is under scrutiny in scientific and regulatory committees because of developmental toxic and teratogenic effects in rodents. The two postulated NEP metabolites 5-hydroxy-N-ethyl-2-pyrrolidone (5-HNEP)...

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Koch HM, Bader M, Weiss T, et al. Metabolism and elimination of N-ethyl-2-pyrrolidone (NEP) in human males after oral dosage. Arch Toxicol. 2013;88(4):893-899doi: 10.1007/s00204-013-1150-1.
Koch, H. M., Bader, M., Weiss, T., Koslitz, S., Schütze, A., Käfferlein, H. U., & Brüning, T. (2014). Metabolism and elimination of N-ethyl-2-pyrrolidone (NEP) in human males after oral dosage. Archives of toxicology, 88(4), 893-899. https://doi.org/10.1007/s00204-013-1150-1
Koch, H M, et al. "Metabolism and elimination of N-ethyl-2-pyrrolidone (NEP) in human males after oral dosage." Archives of toxicology vol. 88,4 (2014): 893-899. doi: https://doi.org/10.1007/s00204-013-1150-1
Koch HM, Bader M, Weiss T, Koslitz S, Schütze A, Käfferlein HU, Brüning T. Metabolism and elimination of N-ethyl-2-pyrrolidone (NEP) in human males after oral dosage. Arch Toxicol. 2014 Apr;88(4):893-899. doi: 10.1007/s00204-013-1150-1. Epub 2013 Nov 14. PMID: 24232175.
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Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages.

Archives of toxicology

Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU.
PMID: 34642770
Arch Toxicol. 2022 Jan;96(1):121-134. doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13.

Few human data on exposure and toxicity are available on neonicotinoids and neonicotinoid-like compounds (NNIs), an important group of insecticides worldwide. Specifically, exposure assessment of humans by biomonitoring remains a challenge due to the lack of appropriate biomarkers. We...

Cite
Wrobel SA, Bury D, Hayen H, et al. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2021;96(1):121-134doi: 10.1007/s00204-021-03159-0.
Wrobel, S. A., Bury, D., Hayen, H., Koch, H. M., Brüning, T., & Käfferlein, H. U. (2022). Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Archives of toxicology, 96(1), 121-134. https://doi.org/10.1007/s00204-021-03159-0
Wrobel, Sonja A, et al. "Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages." Archives of toxicology vol. 96,1 (2022): 121-134. doi: https://doi.org/10.1007/s00204-021-03159-0
Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU. Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. Arch Toxicol. 2022 Jan;96(1):121-134. doi: 10.1007/s00204-021-03159-0. Epub 2021 Oct 13. PMID: 34642770.
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Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014.

International archives of occupational and environmental health

Ulrich N, Bury D, Koch HM, Rüther M, Weber T, Käfferlein HU, Weiss T, Brüning T, Kolossa-Gehring M.
PMID: 31853634
Int Arch Occup Environ Health. 2020 Jan;93(1):147. doi: 10.1007/s00420-019-01506-4.

The article Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014.

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Ulrich N, Bury D, Koch HM, et al. Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014. Int Arch Occup Environ Health. 2020;93(1):147doi: 10.1007/s00420-019-01506-4.
Ulrich, N., Bury, D., Koch, H. M., Rüther, M., Weber, T., Käfferlein, H. U., Weiss, T., Brüning, T., & Kolossa-Gehring, M. (2020). Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014. International archives of occupational and environmental health, 93(1), 147. https://doi.org/10.1007/s00420-019-01506-4
Ulrich, Nadin, et al. "Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014." International archives of occupational and environmental health vol. 93,1 (2020): 147. doi: https://doi.org/10.1007/s00420-019-01506-4
Ulrich N, Bury D, Koch HM, Rüther M, Weber T, Käfferlein HU, Weiss T, Brüning T, Kolossa-Gehring M. Correction to: Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014. Int Arch Occup Environ Health. 2020 Jan;93(1):147. doi: 10.1007/s00420-019-01506-4. PMID: 31853634; PMCID: PMC6989416.
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Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas.

Oncotarget

Lang K, Bonberg N, Robens S, Behrens T, Hovanec J, Deix T, Braun K, Roghmann F, Noldus J, Harth V, Jöckel KH, Erbel R, Tam YC, Tannapfel A, Käfferlein HU, Brüning T.
PMID: 29285224
Oncotarget. 2017 Sep 08;8(62):104946-104959. doi: 10.18632/oncotarget.20737. eCollection 2017 Dec 01.

Information on biomarkers of urothelial carcinomas (UC) for clinical decision-making is limited. Here, we newly identified and verified CXCL16 as a promising novel biomarker in urine for high grade and muscle invasive UC in a cross-sectional cohort of 308...

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Lang K, Bonberg N, Robens S, et al. Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. Oncotarget. 2017;8(62):104946-104959doi: 10.18632/oncotarget.20737.
Lang, K., Bonberg, N., Robens, S., Behrens, T., Hovanec, J., Deix, T., Braun, K., Roghmann, F., Noldus, J., Harth, V., Jöckel, K. H., Erbel, R., Tam, Y. C., Tannapfel, A., Käfferlein, H. U., & Brüning, T. (2017). Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. Oncotarget, 8(62), 104946-104959. https://doi.org/10.18632/oncotarget.20737
Lang, Kerstin, et al. "Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas." Oncotarget vol. 8,62 (2017): 104946-104959. doi: https://doi.org/10.18632/oncotarget.20737
Lang K, Bonberg N, Robens S, Behrens T, Hovanec J, Deix T, Braun K, Roghmann F, Noldus J, Harth V, Jöckel KH, Erbel R, Tam YC, Tannapfel A, Käfferlein HU, Brüning T. Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. Oncotarget. 2017 Sep 08;8(62):104946-104959. doi: 10.18632/oncotarget.20737. eCollection 2017 Dec 01. PMID: 29285224; PMCID: PMC5739611.
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Protein expression of prognostic genes in primary melanoma and benign nevi.

Journal of cancer research and clinical oncology

Gambichler T, Elfering J, Meyer T, Bruckmüller S, Stockfleth E, Skrygan M, Käfferlein HU, Brüning T, Lang K, Wagener D, Schröder S, Nick M, Susok L.
PMID: 34757537
J Cancer Res Clin Oncol. 2021 Nov 10; doi: 10.1007/s00432-021-03779-0. Epub 2021 Nov 10.

PURPOSE: To evaluate the protein expression characteristics of genes employed in a recently introduced prognostic gene expression assay for patients with cutaneous melanoma (CM).METHODS: We studied 37 patients with CM and 10 with benign (melanocytic) nevi (BN). Immunohistochemistry of...

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Gambichler T, Elfering J, Meyer T, et al. Protein expression of prognostic genes in primary melanoma and benign nevi. J Cancer Res Clin Oncol. 2021;doi: 10.1007/s00432-021-03779-0.
Gambichler, T., Elfering, J., Meyer, T., Bruckmüller, S., Stockfleth, E., Skrygan, M., Käfferlein, H. U., Brüning, T., Lang, K., Wagener, D., Schröder, S., Nick, M., & Susok, L. (2021). Protein expression of prognostic genes in primary melanoma and benign nevi. Journal of cancer research and clinical oncology, . https://doi.org/10.1007/s00432-021-03779-0
Gambichler, T, et al. "Protein expression of prognostic genes in primary melanoma and benign nevi." Journal of cancer research and clinical oncology vol. (2021). doi: https://doi.org/10.1007/s00432-021-03779-0
Gambichler T, Elfering J, Meyer T, Bruckmüller S, Stockfleth E, Skrygan M, Käfferlein HU, Brüning T, Lang K, Wagener D, Schröder S, Nick M, Susok L. Protein expression of prognostic genes in primary melanoma and benign nevi. J Cancer Res Clin Oncol. 2021 Nov 10; doi: 10.1007/s00432-021-03779-0. Epub 2021 Nov 10. PMID: 34757537.
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