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CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.

mBio

Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S.
PMID: 27677791
mBio. 2016 Sep 27;7(5). doi: 10.1128/mBio.01367-16.

Proteins containing polyglutamine (polyQ) regions are found in almost all eukaryotes, albeit with various frequencies. In humans, proteins such as huntingtin (Htt) with abnormally expanded polyQ regions cause neurodegenerative diseases such as Huntington's disease (HD). To study how the...

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Zurawel AA, Kabeche R, DiGregorio SE, et al. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. mBio. 2016;7(5)doi: 10.1128/mBio.01367-16.
Zurawel, A. A., Kabeche, R., DiGregorio, S. E., Deng, L., Menon, K. M., Opalko, H., Duennwald, M. L., Moseley, J. B., & Supattapone, S. (2016). CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. mBio, 7(5), . https://doi.org/10.1128/mBio.01367-16
Zurawel, Ashley A, et al. "CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins." mBio vol. 7,5 (2016). doi: https://doi.org/10.1128/mBio.01367-16
Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. mBio. 2016 Sep 27;7(5). doi: 10.1128/mBio.01367-16. PMID: 27677791; PMCID: PMC5040113.
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Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial.

Diabetologia

Nowotny B, Zahiragic L, Bierwagen A, Kabisch S, Groener JB, Nowotny PJ, Fleitmann AK, Firouzi P, Herder C, Pacini G, Erlund I, Landberg R, Haering HU, Pfeiffer AF, Nawroth PP, Roden M.
PMID: 26961504
Diabetologia. 2016 Jun;59(6):1329. doi: 10.1007/s00125-016-3918-3.

No abstract available.

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Nowotny B, Zahiragic L, Bierwagen A, et al. Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial. Diabetologia. 2016;59(6):1329doi: 10.1007/s00125-016-3918-3.
Nowotny, B., Zahiragic, L., Bierwagen, A., Kabisch, S., Groener, J. B., Nowotny, P. J., Fleitmann, A. K., Firouzi, P., Herder, C., Pacini, G., Erlund, I., Landberg, R., Haering, H. U., Pfeiffer, A. F., Nawroth, P. P., & Roden, M. (2016). Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial. Diabetologia, 59(6), 1329. https://doi.org/10.1007/s00125-016-3918-3
Nowotny, Bettina, et al. "Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial." Diabetologia vol. 59,6 (2016): 1329. doi: https://doi.org/10.1007/s00125-016-3918-3
Nowotny B, Zahiragic L, Bierwagen A, Kabisch S, Groener JB, Nowotny PJ, Fleitmann AK, Firouzi P, Herder C, Pacini G, Erlund I, Landberg R, Haering HU, Pfeiffer AF, Nawroth PP, Roden M. Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial. Diabetologia. 2016 Jun;59(6):1329. doi: 10.1007/s00125-016-3918-3. PMID: 26961504.
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Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms.

Journal of analytical methods in chemistry

Kombath S, Balde IB, Carret S, Kabiche S, Cisternino S, Fontan JE, Schlatter J.
PMID: 26605105
J Anal Methods Chem. 2015;2015:835986. doi: 10.1155/2015/835986. Epub 2015 Oct 29.

A stability-indicating method was validated for the determination in pharmaceutical forms of idebenone a coenzyme Q10-like compound. The assay was achieved by liquid chromatography analysis using a reversed-phase C18 column and a detector set at 480 nm. The optimized...

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Kombath S, Balde IB, Carret S, et al. Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms. J Anal Methods Chem. 2015;2015:835986doi: 10.1155/2015/835986.
Kombath, S., Balde, I. B., Carret, S., Kabiche, S., Cisternino, S., Fontan, J. E., & Schlatter, J. (2015). Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms. Journal of analytical methods in chemistry, 2015835986. https://doi.org/10.1155/2015/835986
Kombath, Sonoube, et al. "Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms." Journal of analytical methods in chemistry vol. 2015 (2015): 835986. doi: https://doi.org/10.1155/2015/835986
Kombath S, Balde IB, Carret S, Kabiche S, Cisternino S, Fontan JE, Schlatter J. Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms. J Anal Methods Chem. 2015;2015:835986. doi: 10.1155/2015/835986. Epub 2015 Oct 29. PMID: 26605105; PMCID: PMC4641926.
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Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry.

Proteomics

Aiche S, Sachsenberg T, Kenar E, Walzer M, Wiswedel B, Kristl T, Boyles M, Duschl A, Huber CG, Berthold MR, Reinert K, Kohlbacher O.
PMID: 25604327
Proteomics. 2015 Apr;15(8):1443-7. doi: 10.1002/pmic.201400391. Epub 2015 Feb 14.

MS-based proteomics and metabolomics are rapidly evolving research fields driven by the development of novel instruments, experimental approaches, and analysis methods. Monolithic analysis tools perform well on single tasks but lack the flexibility to cope with the constantly changing...

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Aiche S, Sachsenberg T, Kenar E, et al. Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry. Proteomics. 2015;15(8):1443-7doi: 10.1002/pmic.201400391.
Aiche, S., Sachsenberg, T., Kenar, E., Walzer, M., Wiswedel, B., Kristl, T., Boyles, M., Duschl, A., Huber, C. G., Berthold, M. R., Reinert, K., & Kohlbacher, O. (2015). Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry. Proteomics, 15(8), 1443-7. https://doi.org/10.1002/pmic.201400391
Aiche, Stephan, et al. "Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry." Proteomics vol. 15,8 (2015): 1443-7. doi: https://doi.org/10.1002/pmic.201400391
Aiche S, Sachsenberg T, Kenar E, Walzer M, Wiswedel B, Kristl T, Boyles M, Duschl A, Huber CG, Berthold MR, Reinert K, Kohlbacher O. Workflows for automated downstream data analysis and visualization in large-scale computational mass spectrometry. Proteomics. 2015 Apr;15(8):1443-7. doi: 10.1002/pmic.201400391. Epub 2015 Feb 14. PMID: 25604327; PMCID: PMC4415483.
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[In order to perform clinical trials efficiently in Japan--important issues regarding monitoring by sponsors].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

Kaichi S, Oda T, Goto K, Sato K.
PMID: 18051783
Nihon Kokyuki Gakkai Zasshi. 2007 Nov;45(11):829-35.

The guideline for Good Clinical Practice (GCP) of new drugs was enforced as Ministerial Ordinance No. 28, dated March 27, by the Ministry of Health, Labor and Welfare. In Article 21 of the guideline, a sponsor shall prepare the...

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Kaichi S, Oda T, Goto K, et al. [In order to perform clinical trials efficiently in Japan--important issues regarding monitoring by sponsors]. Nihon Kokyuki Gakkai Zasshi. 2007;45(11):829-35
Kaichi, S., Oda, T., Goto, K., & Sato, K. (2007). [In order to perform clinical trials efficiently in Japan--important issues regarding monitoring by sponsors]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 45(11), 829-35.
Kaichi, Satsuki, et al. "[In order to perform clinical trials efficiently in Japan--important issues regarding monitoring by sponsors]." Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society vol. 45,11 (2007): 829-35.
Kaichi S, Oda T, Goto K, Sato K. [In order to perform clinical trials efficiently in Japan--important issues regarding monitoring by sponsors]. Nihon Kokyuki Gakkai Zasshi. 2007 Nov;45(11):829-35. Japanese. PMID: 18051783.
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1n and 2n transfer with the Borromean nucleus 6He near the Coulomb barrier.

Physical review letters

Chatterjee A, Navin A, Shrivastava A, Bhattacharyya S, Rejmund M, Keeley N, Nanal V, Nyberg J, Pillay RG, Ramachandran K, Stefan I, Bazin D, Beaumel D, Blumenfeld Y, de France G, Gupta D, Labiche M, Lemasson A, Lemmon R, Raabe R, Scarpaci JA, Simenel C, Timis C.
PMID: 18764247
Phys Rev Lett. 2008 Jul 18;101(3):032701. doi: 10.1103/PhysRevLett.101.032701. Epub 2008 Jul 16.

Angular distributions for 1n and 2n transfer are reported for the 6He+65Cu system at E_{lab}=22.6 MeV. For the first time, triple coincidences between alpha particles, neutrons, and characteristic gamma rays from the targetlike residues were used to separate the...

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Chatterjee A, Navin A, Shrivastava A, et al. 1n and 2n transfer with the Borromean nucleus 6He near the Coulomb barrier. Phys Rev Lett. 2008;101(3):032701doi: 10.1103/PhysRevLett.101.032701.
Chatterjee, A., Navin, A., Shrivastava, A., Bhattacharyya, S., Rejmund, M., Keeley, N., Nanal, V., Nyberg, J., Pillay, R. G., Ramachandran, K., Stefan, I., Bazin, D., Beaumel, D., Blumenfeld, Y., de France, G., Gupta, D., Labiche, M., Lemasson, A., Lemmon, R., Raabe, R., Scarpaci, J. A., Simenel, C., & Timis, C. (2008). 1n and 2n transfer with the Borromean nucleus 6He near the Coulomb barrier. Physical review letters, 101(3), 032701. https://doi.org/10.1103/PhysRevLett.101.032701
Chatterjee, A, et al. "1n and 2n transfer with the Borromean nucleus 6He near the Coulomb barrier." Physical review letters vol. 101,3 (2008): 032701. doi: https://doi.org/10.1103/PhysRevLett.101.032701
Chatterjee A, Navin A, Shrivastava A, Bhattacharyya S, Rejmund M, Keeley N, Nanal V, Nyberg J, Pillay RG, Ramachandran K, Stefan I, Bazin D, Beaumel D, Blumenfeld Y, de France G, Gupta D, Labiche M, Lemasson A, Lemmon R, Raabe R, Scarpaci JA, Simenel C, Timis C. 1n and 2n transfer with the Borromean nucleus 6He near the Coulomb barrier. Phys Rev Lett. 2008 Jul 18;101(3):032701. doi: 10.1103/PhysRevLett.101.032701. Epub 2008 Jul 16. PMID: 18764247.
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2-Amino-5-nitro-pyridinium hydrogen selenate.

Acta crystallographica. Section E, Structure reports online

Akriche S, Rzaigui M.
PMID: 21578747
Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 07;65:o3009-10. doi: 10.1107/S1600536809042354.

There are two cations and two anions in the asymmetric unit of the title compound, C(5)H(6)N(3)O(2) (+)·HSeO(4) (-). In the crystal, there are two independent chains of HSeO(4) (-) anions running along the a axis, linked by O-H⋯O hydrogen...

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Akriche S, Rzaigui M. 2-Amino-5-nitro-pyridinium hydrogen selenate. Acta Crystallogr Sect E Struct Rep Online. 2009;65:o3009-10doi: 10.1107/S1600536809042354.
Akriche, S., & Rzaigui, M. (2009). 2-Amino-5-nitro-pyridinium hydrogen selenate. Acta crystallographica. Section E, Structure reports online, 65o3009-10. https://doi.org/10.1107/S1600536809042354
Akriche, Samah, and Rzaigui, Mohamed. "2-Amino-5-nitro-pyridinium hydrogen selenate." Acta crystallographica. Section E, Structure reports online vol. 65 (2009): o3009-10. doi: https://doi.org/10.1107/S1600536809042354
Akriche S, Rzaigui M. 2-Amino-5-nitro-pyridinium hydrogen selenate. Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 07;65:o3009-10. doi: 10.1107/S1600536809042354. PMID: 21578747; PMCID: PMC2971877.
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Bis(2-amino-3-nitro-pyridinium) dichromate(VI).

Acta crystallographica. Section E, Structure reports online

Akriche S, Rzaigui M.
PMID: 21581487
Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 20;65:m123. doi: 10.1107/S1600536808043018.

The title compound, (C(5)H(6)N(3)O(2))(2)[Cr(2)O(7)], consists of 2-amino-3-nitro-pyridinium cations and discrete dichromate anions linked together by N-H⋯O and C-H⋯O hydrogen bonds, forming thick layers parallel to (101). Layer cohesion is ensured by N-H⋯O hydrogen bonding in addition to electrostatic and...

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Akriche S, Rzaigui M. Bis(2-amino-3-nitro-pyridinium) dichromate(VI). Acta Crystallogr Sect E Struct Rep Online. 2008;65:m123doi: 10.1107/S1600536808043018.
Akriche, S., & Rzaigui, M. (2008). Bis(2-amino-3-nitro-pyridinium) dichromate(VI). Acta crystallographica. Section E, Structure reports online, 65m123. https://doi.org/10.1107/S1600536808043018
Akriche, Samah, and Rzaigui, Mohamed. "Bis(2-amino-3-nitro-pyridinium) dichromate(VI)." Acta crystallographica. Section E, Structure reports online vol. 65 (2008): m123. doi: https://doi.org/10.1107/S1600536808043018
Akriche S, Rzaigui M. Bis(2-amino-3-nitro-pyridinium) dichromate(VI). Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 20;65:m123. doi: 10.1107/S1600536808043018. PMID: 21581487; PMCID: PMC2968023.
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4-Ammonio-2,2,6,6-tetra-methyl-piperidinium bis-(dihydrogen phosphate) monohydrate.

Acta crystallographica. Section E, Structure reports online

Mrad ML, Akriche S, Rzaigui M, Ben Nasr C.
PMID: 21582488
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 14;65:o757-8. doi: 10.1107/S1600536809008563.

In the crystal structure of the title compound, C(9)H(22)N(2) (2+)·2H(2)PO(4) (-)·H(2)O, the H(2)PO(4) (-) anions are hydrogen bonded to each other, forming a ribbon parallel to the b axis. The water mol-ecules connect these ribbons via O-H⋯O hydrogen bonds....

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Mrad ML, Akriche S, Rzaigui M, et al. 4-Ammonio-2,2,6,6-tetra-methyl-piperidinium bis-(dihydrogen phosphate) monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2009;65:o757-8doi: 10.1107/S1600536809008563.
Mrad, M. L., Akriche, S., Rzaigui, M., & Ben Nasr, C. (2009). 4-Ammonio-2,2,6,6-tetra-methyl-piperidinium bis-(dihydrogen phosphate) monohydrate. Acta crystallographica. Section E, Structure reports online, 65o757-8. https://doi.org/10.1107/S1600536809008563
Mrad, Mohamed Lahbib, et al. "4-Ammonio-2,2,6,6-tetra-methyl-piperidinium bis-(dihydrogen phosphate) monohydrate." Acta crystallographica. Section E, Structure reports online vol. 65 (2009): o757-8. doi: https://doi.org/10.1107/S1600536809008563
Mrad ML, Akriche S, Rzaigui M, Ben Nasr C. 4-Ammonio-2,2,6,6-tetra-methyl-piperidinium bis-(dihydrogen phosphate) monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 14;65:o757-8. doi: 10.1107/S1600536809008563. PMID: 21582488; PMCID: PMC2968974.
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Migration of nuclear shell gaps studied in the d(24Ne,pγ)25Ne reaction.

Physical review letters

Catford WN, Timis CN, Lemmon RC, Labiche M, Orr NA, Fernández-Domínguez B, Chapman R, Freer M, Chartier M, Savajols H, Rejmund M, Achouri NL, Amzal N, Ashwood NI, Baldwin TD, Burns M, Caballero L, Casadjian JM, Curtis N, de France G, Gelletly W, Liang X, Pain SD, Pucknell VP, Rubio B, Sorlin O, Spohr K, Theisen Ch, Warner DD.
PMID: 20866960
Phys Rev Lett. 2010 May 14;104(19):192501. doi: 10.1103/PhysRevLett.104.192501. Epub 2010 May 10.

The transfer of neutrons onto 24Ne has been measured using a reaccelerated radioactive beam of 24Ne to study the (d,p) reaction in inverse kinematics. The unusual raising of the first 3/2+ level in 25Ne and its significance in terms...

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Catford WN, Timis CN, Lemmon RC, et al. Migration of nuclear shell gaps studied in the d(24Ne,pγ)25Ne reaction. Phys Rev Lett. 2010;104(19):192501doi: 10.1103/PhysRevLett.104.192501.
Catford, W. N., Timis, C. N., Lemmon, R. C., Labiche, M., Orr, N. A., Fernández-Domínguez, B., Chapman, R., Freer, M., Chartier, M., Savajols, H., Rejmund, M., Achouri, N. L., Amzal, N., Ashwood, N. I., Baldwin, T. D., Burns, M., Caballero, L., Casadjian, J. M., Curtis, N., de France, G., Gelletly, W., Liang, X., Pain, S. D., Pucknell, V. P., Rubio, B., Sorlin, O., Spohr, K., Theisen, C. h., & Warner, D. D. (2010). Migration of nuclear shell gaps studied in the d(24Ne,pγ)25Ne reaction. Physical review letters, 104(19), 192501. https://doi.org/10.1103/PhysRevLett.104.192501
Catford, W N, et al. "Migration of nuclear shell gaps studied in the d(24Ne,pγ)25Ne reaction." Physical review letters vol. 104,19 (2010): 192501. doi: https://doi.org/10.1103/PhysRevLett.104.192501
Catford WN, Timis CN, Lemmon RC, Labiche M, Orr NA, Fernández-Domínguez B, Chapman R, Freer M, Chartier M, Savajols H, Rejmund M, Achouri NL, Amzal N, Ashwood NI, Baldwin TD, Burns M, Caballero L, Casadjian JM, Curtis N, de France G, Gelletly W, Liang X, Pain SD, Pucknell VP, Rubio B, Sorlin O, Spohr K, Theisen Ch, Warner DD. Migration of nuclear shell gaps studied in the d(24Ne,pγ)25Ne reaction. Phys Rev Lett. 2010 May 14;104(19):192501. doi: 10.1103/PhysRevLett.104.192501. Epub 2010 May 10. PMID: 20866960.
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Technique of Gene Expression Profiles Extraction Based on the Complex Use of Clustering and Classification Methods.

Diagnostics (Basel, Switzerland)

Babichev S, Škvor J.
PMID: 32806785
Diagnostics (Basel). 2020 Aug 12;10(8). doi: 10.3390/diagnostics10080584.

In this paper, we present the results of the research concerning extraction of informative gene expression profiles from high-dimensional array of gene expressions considering the state of patients' health using clustering method, ML-based binary classifiers and fuzzy inference system....

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Babichev S, Škvor J. Technique of Gene Expression Profiles Extraction Based on the Complex Use of Clustering and Classification Methods. Diagnostics (Basel). 2020;10(8)doi: 10.3390/diagnostics10080584.
Babichev, S., & Škvor, J. (2020). Technique of Gene Expression Profiles Extraction Based on the Complex Use of Clustering and Classification Methods. Diagnostics (Basel, Switzerland), 10(8), . https://doi.org/10.3390/diagnostics10080584
Babichev, Sergii, and Škvor, Jiří. "Technique of Gene Expression Profiles Extraction Based on the Complex Use of Clustering and Classification Methods." Diagnostics (Basel, Switzerland) vol. 10,8 (2020). doi: https://doi.org/10.3390/diagnostics10080584
Babichev S, Škvor J. Technique of Gene Expression Profiles Extraction Based on the Complex Use of Clustering and Classification Methods. Diagnostics (Basel). 2020 Aug 12;10(8). doi: 10.3390/diagnostics10080584. PMID: 32806785; PMCID: PMC7460566.
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Women, healthcare leadership and societal culture: a qualitative study.

Journal of healthcare leadership

Kalaitzi S, Czabanowska K, Azzopardi-Muscat N, Cuschieri L, Petelos E, Papadakaki M, Babich S.
PMID: 31043802
J Healthc Leadersh. 2019 Apr 12;11:43-59. doi: 10.2147/JHL.S194733. eCollection 2019.

PURPOSE: Women leaders encounter societal and cultural challenges that define and diminish their career potential. This occurs across several professions including healthcare. Scant attention has been drawn to the discursive dynamics among gender, healthcare leadership and societal culture. The...

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Kalaitzi S, Czabanowska K, Azzopardi-Muscat N, et al. Women, healthcare leadership and societal culture: a qualitative study. J Healthc Leadersh. 2019;11:43-59doi: 10.2147/JHL.S194733.
Kalaitzi, S., Czabanowska, K., Azzopardi-Muscat, N., Cuschieri, L., Petelos, E., Papadakaki, M., & Babich, S. (2019). Women, healthcare leadership and societal culture: a qualitative study. Journal of healthcare leadership, 1143-59. https://doi.org/10.2147/JHL.S194733
Kalaitzi, Stavroula, et al. "Women, healthcare leadership and societal culture: a qualitative study." Journal of healthcare leadership vol. 11 (2019): 43-59. doi: https://doi.org/10.2147/JHL.S194733
Kalaitzi S, Czabanowska K, Azzopardi-Muscat N, Cuschieri L, Petelos E, Papadakaki M, Babich S. Women, healthcare leadership and societal culture: a qualitative study. J Healthc Leadersh. 2019 Apr 12;11:43-59. doi: 10.2147/JHL.S194733. eCollection 2019. PMID: 31043802; PMCID: PMC6469472.
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