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Western blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodies.

Physiological reports

Bhattarai Y, Fernandes R, Kadrofske MM, Lockwood LR, Galligan JJ, Xu H.
PMID: 25355855
Physiol Rep. 2014 Oct 28;2(10). doi: 10.14814/phy2.12189. Print 2014 Oct 01.

Large conductance Ca(2+)-activated K(+) (BK) channels consist of pore-forming α- and accessory β-subunits. There are four β-subunit subtypes (β1-β4), BK β1-subunit is specific for smooth muscle cells (SMC). Reduced BK β1-subunit expression is associated with SMC dysfunction in animal...

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