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Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives.

Scientia pharmaceutica

Nosulenko IS, Voskoboynik OY, Berest GG, Safronyuk SL, Kovalenko SI, Kamyshnyi OM, Polishchuk NM, Sinyak RS, Katsev AV.
PMID: 25853063
Sci Pharm. 2014 Mar 24;82(3):483-500. doi: 10.3797/scipharm.1402-10. Print 2014.

Potassium 8-R(1)-9-R(2)-10-R(3)-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-thiolates 2.1-2.26 were synthesized via cyclocondensation of 6-R-3-(3-R(1)-4-R(2)-5-R(3)-aminophenyl)-1,2,4-triazin-5-ones 1.1-1.26 with carbon disulfide, potassium hydroxide, and ethanol or with potassium O-ethyl dithiocarbonate in 2-propanol. The corresponding thiones 3.1-3.26 were obtained by treatment of 2.1-2.26 with hydrochloric acid. It was...

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Nosulenko IS, Voskoboynik OY, Berest GG, et al. Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives. Sci Pharm. 2014;82(3):483-500doi: 10.3797/scipharm.1402-10.
Nosulenko, I. S., Voskoboynik, O. Y., Berest, G. G., Safronyuk, S. L., Kovalenko, S. I., Kamyshnyi, O. M., Polishchuk, N. M., Sinyak, R. S., & Katsev, A. V. (2014). Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives. Scientia pharmaceutica, 82(3), 483-500. https://doi.org/10.3797/scipharm.1402-10
Nosulenko, Inna S, et al. "Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives." Scientia pharmaceutica vol. 82,3 (2014): 483-500. doi: https://doi.org/10.3797/scipharm.1402-10
Nosulenko IS, Voskoboynik OY, Berest GG, Safronyuk SL, Kovalenko SI, Kamyshnyi OM, Polishchuk NM, Sinyak RS, Katsev AV. Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives. Sci Pharm. 2014 Mar 24;82(3):483-500. doi: 10.3797/scipharm.1402-10. Print 2014. PMID: 25853063; PMCID: PMC4318151.
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The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with .

Iranian journal of microbiology

Bukina Y, Thyhonovska M, Koval M, Marushchak M, Krynytska I, Kamyshnyi A.
PMID: 32685120
Iran J Microbiol. 2020 Jun;12(3):231-241.

BACKGROUND AND OBJECTIVES: Intestinal microbiota is involved in the development and maintenance of immune homeostasis. This study was conducted to investigate the levels of key immunoregulatory bacteria in the intestinal wall-associated microflora and its effect on the transcriptional activity...

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Bukina Y, Thyhonovska M, Koval M, et al. The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with . Iran J Microbiol. 2020;12(3):231-241
Bukina, Y., Thyhonovska, M., Koval, M., Marushchak, M., Krynytska, I., & Kamyshnyi, A. (2020). The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with . Iranian journal of microbiology, 12(3), 231-241.
Bukina, Yuliia, et al. "The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with ." Iranian journal of microbiology vol. 12,3 (2020): 231-241.
Bukina Y, Thyhonovska M, Koval M, Marushchak M, Krynytska I, Kamyshnyi A. The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with . Iran J Microbiol. 2020 Jun;12(3):231-241. PMID: 32685120; PMCID: PMC7340605.
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2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones and Their S-Substituted Derivatives: Synthesis, Spectroscopic Data, and Biological Activity.

ChemPlusChem

Bilyi AK, Antypenko LM, Ivchuk VV, Kamyshnyi OM, Polishchuk NM, Kovalenko SI.
PMID: 31973251
Chempluschem. 2015 Jun;80(6):980-989. doi: 10.1002/cplu.201500051. Epub 2015 Mar 04.

In the continuing search for novel, biologically effective heterocyclic agents, several methods for the synthesis of 2-heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones have been developed: thiolation of oxo derivatives, [5+1] cyclocondensation of [2-(3-heteroaryl-[1,2,4]triazol-5-yl)phenyl]amines with carbon disulfide, potassium ethyl xanthogenate, or aryl isothiocyanates, and...

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Bilyi AK, Antypenko LM, Ivchuk VV, et al. 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones and Their S-Substituted Derivatives: Synthesis, Spectroscopic Data, and Biological Activity. Chempluschem. 2015;80(6):980-989doi: 10.1002/cplu.201500051.
Bilyi, A. K., Antypenko, L. M., Ivchuk, V. V., Kamyshnyi, O. M., Polishchuk, N. M., & Kovalenko, S. I. (2015). 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones and Their S-Substituted Derivatives: Synthesis, Spectroscopic Data, and Biological Activity. ChemPlusChem, 80(6), 980-989. https://doi.org/10.1002/cplu.201500051
Bilyi, Andrii K, et al. "2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones and Their S-Substituted Derivatives: Synthesis, Spectroscopic Data, and Biological Activity." ChemPlusChem vol. 80,6 (2015): 980-989. doi: https://doi.org/10.1002/cplu.201500051
Bilyi AK, Antypenko LM, Ivchuk VV, Kamyshnyi OM, Polishchuk NM, Kovalenko SI. 2-Heteroaryl-[1,2,4]triazolo[1,5-c]quinazoline-5(6 H)-thiones and Their S-Substituted Derivatives: Synthesis, Spectroscopic Data, and Biological Activity. Chempluschem. 2015 Jun;80(6):980-989. doi: 10.1002/cplu.201500051. Epub 2015 Mar 04. PMID: 31973251.
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Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility.

Central-European journal of immunology

Koval HD, Chopyak VV, Kamyshnyi OM, Kurpisz MK.
PMID: 29736151
Cent Eur J Immunol. 2018;43(1):90-96. doi: 10.5114/ceji.2018.74878. Epub 2018 Mar 30.

Endometriosis is a disease of epidemiological gravity of unknown primary reason. A complex of constitutional factors including the immune system has been considered as its background. The aim of the study was to identify Th1 and Th2 cells as...

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Koval HD, Chopyak VV, Kamyshnyi OM, et al. Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility. Cent Eur J Immunol. 2018;43(1):90-96doi: 10.5114/ceji.2018.74878.
Koval, H. D., Chopyak, V. V., Kamyshnyi, O. M., & Kurpisz, M. K. (2018). Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility. Central-European journal of immunology, 43(1), 90-96. https://doi.org/10.5114/ceji.2018.74878
Koval, Halyna D, et al. "Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility." Central-European journal of immunology vol. 43,1 (2018): 90-96. doi: https://doi.org/10.5114/ceji.2018.74878
Koval HD, Chopyak VV, Kamyshnyi OM, Kurpisz MK. Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility. Cent Eur J Immunol. 2018;43(1):90-96. doi: 10.5114/ceji.2018.74878. Epub 2018 Mar 30. PMID: 29736151; PMCID: PMC5927178.
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Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology.

International journal of hypertension

Kamyshnyi A, Krynytska I, Matskevych V, Marushchak M, Lushchak O.
PMID: 33489355
Int J Hypertens. 2020 Dec 04;2020:8019360. doi: 10.1155/2020/8019360. eCollection 2020.

Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is an ongoing global public health challenge. Current clinical data suggest that, in COVID-19 patients, arterial hypertension (AH) is one of the most common cardiovascular...

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Kamyshnyi A, Krynytska I, Matskevych V, et al. Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. Int J Hypertens. 2020;2020:8019360doi: 10.1155/2020/8019360.
Kamyshnyi, A., Krynytska, I., Matskevych, V., Marushchak, M., & Lushchak, O. (2020). Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. International journal of hypertension, 20208019360. https://doi.org/10.1155/2020/8019360
Kamyshnyi, Alexander, et al. "Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology." International journal of hypertension vol. 2020 (2020): 8019360. doi: https://doi.org/10.1155/2020/8019360
Kamyshnyi A, Krynytska I, Matskevych V, Marushchak M, Lushchak O. Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. Int J Hypertens. 2020 Dec 04;2020:8019360. doi: 10.1155/2020/8019360. eCollection 2020. PMID: 33489355; PMCID: PMC7803108.
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BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population.

Endocrine regulations

Kamyshna II, Pavlovych LB, Sydorchuk LP, Malyk IV, Kamyshnyi AM.
PMID: 34879183
Endocr Regul. 2021 Dec 07;55(4):193-203. doi: 10.2478/enr-2021-0021.

No abstract available.

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Kamyshna II, Pavlovych LB, Sydorchuk LP, et al. BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population. Endocr Regul. 2021;55(4):193-203doi: 10.2478/enr-2021-0021.
Kamyshna, I. I., Pavlovych, L. B., Sydorchuk, L. P., Malyk, I. V., & Kamyshnyi, A. M. (2021). BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population. Endocrine regulations, 55(4), 193-203. https://doi.org/10.2478/enr-2021-0021
Kamyshna, Iryna I, et al. "BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population." Endocrine regulations vol. 55,4 (2021): 193-203. doi: https://doi.org/10.2478/enr-2021-0021
Kamyshna II, Pavlovych LB, Sydorchuk LP, Malyk IV, Kamyshnyi AM. BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population. Endocr Regul. 2021 Dec 07;55(4):193-203. doi: 10.2478/enr-2021-0021. PMID: 34879183.
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Showing 1 to 6 of 6 entries