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Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler.

BMC bioinformatics

Verbist B, Adriaensen E, Keersmaekers V, Putri D, Crabbe M, Derks M, Bagdziunas R, Laenen G, De Wolf H.
PMID: 31286864
BMC Bioinformatics. 2019 Jul 08;20(1):378. doi: 10.1186/s12859-019-2975-2.

BACKGROUND: The QuantiGene® Plex 2.0 platform (ThermoFisher Scientific) combines bDNA with the Luminex/xMAP magnetic bead capturing technology to assess differential gene expression in a compound exposure setting. This technology allows multiplexing in a single well of a 96 or...

Cite
Verbist B, Adriaensen E, Keersmaekers V, et al. Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler. BMC Bioinformatics. 2019;20(1):378doi: 10.1186/s12859-019-2975-2.
Verbist, B., Adriaensen, E., Keersmaekers, V., Putri, D., Crabbe, M., Derks, M., Bagdziunas, R., Laenen, G., & De Wolf, H. (2019). Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler. BMC bioinformatics, 20(1), 378. https://doi.org/10.1186/s12859-019-2975-2
Verbist, Bie, et al. "Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler." BMC bioinformatics vol. 20,1 (2019): 378. doi: https://doi.org/10.1186/s12859-019-2975-2
Verbist B, Adriaensen E, Keersmaekers V, Putri D, Crabbe M, Derks M, Bagdziunas R, Laenen G, De Wolf H. Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler. BMC Bioinformatics. 2019 Jul 08;20(1):378. doi: 10.1186/s12859-019-2975-2. PMID: 31286864; PMCID: PMC6615108.
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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.

Molecular cancer therapeutics

Brehmer D, Beke L, Wu T, Millar HJ, Moy C, Sun W, Mannens G, Pande V, Boeckx A, van Heerde E, Nys T, Gustin EM, Verbist B, Zhou L, Fan Y, Bhargava V, Safabakhsh P, Vinken P, Verhulst T, Gilbert A, Rai S, Graubert TA, Pastore F, Fiore D, Gu J, Johnson A, Philippar U, Morschhäuser B, Walker D, De Lange D, Keersmaekers V, Viellevoye M, Diels G, Schepens W, Thuring JW, Meerpoel L, Packman K, Lorenzi MV, Laquerre S.
PMID: 34583982
Mol Cancer Ther. 2021 Dec;20(12):2317-2328. doi: 10.1158/1535-7163.MCT-21-0367. Epub 2021 Sep 28.

The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular proliferation. Dysregulation of PRMT5 is associated with...

Cite
Brehmer D, Beke L, Wu T, et al. Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity. Mol Cancer Ther. 2021;20(12):2317-2328doi: 10.1158/1535-7163.MCT-21-0367.
Brehmer, D., Beke, L., Wu, T., Millar, H. J., Moy, C., Sun, W., Mannens, G., Pande, V., Boeckx, A., van Heerde, E., Nys, T., Gustin, E. M., Verbist, B., Zhou, L., Fan, Y., Bhargava, V., Safabakhsh, P., Vinken, P., Verhulst, T., Gilbert, A., Rai, S., Graubert, T. A., Pastore, F., Fiore, D., Gu, J., Johnson, A., Philippar, U., Morschhäuser, B., Walker, D., De Lange, D., Keersmaekers, V., Viellevoye, M., Diels, G., Schepens, W., Thuring, J. W., Meerpoel, L., Packman, K., Lorenzi, M. V., & Laquerre, S. (2021). Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity. Molecular cancer therapeutics, 20(12), 2317-2328. https://doi.org/10.1158/1535-7163.MCT-21-0367
Brehmer, Dirk, et al. "Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity." Molecular cancer therapeutics vol. 20,12 (2021): 2317-2328. doi: https://doi.org/10.1158/1535-7163.MCT-21-0367
Brehmer D, Beke L, Wu T, Millar HJ, Moy C, Sun W, Mannens G, Pande V, Boeckx A, van Heerde E, Nys T, Gustin EM, Verbist B, Zhou L, Fan Y, Bhargava V, Safabakhsh P, Vinken P, Verhulst T, Gilbert A, Rai S, Graubert TA, Pastore F, Fiore D, Gu J, Johnson A, Philippar U, Morschhäuser B, Walker D, De Lange D, Keersmaekers V, Viellevoye M, Diels G, Schepens W, Thuring JW, Meerpoel L, Packman K, Lorenzi MV, Laquerre S. Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity. Mol Cancer Ther. 2021 Dec;20(12):2317-2328. doi: 10.1158/1535-7163.MCT-21-0367. Epub 2021 Sep 28. PMID: 34583982.
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