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Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.

Physiological reports

Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD.
PMID: 25602015
Physiol Rep. 2015 Jan 19;3(1). doi: 10.14814/phy2.12257. Print 2015 Jan 01.

Preeclampsia is a cardiovascular disorder of late pregnancy that is, commonly characterized by hypertension, renal structural damage and dysfunction, and fetal growth restriction. Prevailing etiologic models of this disorder include T-cell dysfunction as an initiating cause of preeclampsia. Indoleamine...

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