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Showing 1 to 12 of 19 entries
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Standard PREanalytical Code Version 3.0.

Biopreservation and biobanking

Betsou F, Bilbao R, Case J, Chuaqui R, Clements JA, De Souza Y, De Wilde A, Geiger J, Grizzle W, Guadagni F, Gunter E, Heil S, Kiehntopf M, Koppandi I, Lehmann S, Linsen L, Mackenzie-Dodds J, Quesada RA, Tebbakha R, Selander T, Shea K, Sobel M, Somiari S, Spyropoulos D, Stone M, Tybring G, Valyi-Nagy K, Wadhwa L.
PMID: 29377712
Biopreserv Biobank. 2018 Feb;16(1):9-12. doi: 10.1089/bio.2017.0109. Epub 2018 Jan 29.

No abstract available.

Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease.

Frontiers in immunology

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM.
PMID: 29988557
Front Immunol. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459. eCollection 2018.

Diarrhea-positive hemolytic-uremic syndrome (HUS) is a renal disorder that results from infections with Shiga-toxin (Stx)-producing

Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis.

Critical care explorations

Ramoji A, Thomas-Rüddel D, Ryabchykov O, Bauer M, Arend N, Giamarellos-Bourboulis EJ, Eugen-Olsen J, Kiehntopf M, Bocklitz T, Popp J, Bloos F, Neugebauer U.
PMID: 34079942
Crit Care Explor. 2021 May 12;3(5):e0394. doi: 10.1097/CCE.0000000000000394. eCollection 2021 May.

OBJECTIVES: Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis. This study aims to use the Raman spectroscopic fingerprints of blood-derived leukocytes to differentiate inflammation, infection,...

Limited comparability of creatinine assays in patients with liver cirrhosis and their impact on the MELD score.

Practical laboratory medicine

Kaiser T, Kinny-Köster B, Gnewuch C, Karailieva D, Kiehntopf M, Kessler A, Ritter-Sket C, Schmidt M, Brand K, Thiery J, Lichtinghagen R.
PMID: 28856226
Pract Lab Med. 2017 Apr 14;8:41-48. doi: 10.1016/j.plabm.2017.04.002. eCollection 2017 Aug.

BACKGROUND & AIM: Patients with end-stage liver disease require valid estimations of mortality for organ allocation and risk stratification. The model of end-stage liver disease (MELD) score is used for this purpose in most countries and incorporates bilirubin, International...

LacaScore: a novel plasma sample quality control tool based on ascorbic acid and lactic acid levels.

Metabolomics : Official journal of the Metabolomic Society

Trezzi JP, Bulla A, Bellora C, Rose M, Lescuyer P, Kiehntopf M, Hiller K, Betsou F.
PMID: 27199628
Metabolomics. 2016;12:96. doi: 10.1007/s11306-016-1038-1. Epub 2016 Apr 27.

INTRODUCTION: Metabolome analysis is complicated by the continuous dynamic changes of metabolites in vivo and ex vivo. One of the main challenges in metabolomics is the robustness and reproducibility of results, partially driven by pre-analytical variations.OBJECTIVES: The objective of...

Optimized Identification of Advanced Chronic Kidney Disease and Absence of Kidney Disease by Combining Different Electronic Health Data Resources and by Applying Machine Learning Strategies.

Journal of clinical medicine

Weber C, Röschke L, Modersohn L, Lohr C, Kolditz T, Hahn U, Ammon D, Betz B, Kiehntopf M.
PMID: 32932685
J Clin Med. 2020 Sep 12;9(9). doi: 10.3390/jcm9092955.

Automated identification of advanced chronic kidney disease (CKD ≥ III) and of no known kidney disease (NKD) can support both clinicians and researchers. We hypothesized that identification of CKD and NKD can be improved, by combining information from different...

Prospective surveillance study in a 1,400-bed university hospital: COVID-19 exposure at home was the main risk factor for SARS-CoV-2 point seroprevalence among hospital staff.

Transboundary and emerging diseases

Bahrs C, Kimmig A, Weis S, Ankert J, Hagel S, Maschmann J, Stallmach A, Steiner A, Bauer M, Behringer W, Baier M, Kesselmeier M, Richert C, Zepf F, Walter M, Scherag A, Kiehntopf M, Löffler B, Pletz MW.
PMID: 33605549
Transbound Emerg Dis. 2021 Feb 19; doi: 10.1111/tbed.14041. Epub 2021 Feb 19.

The Co-HCW study is a prospective cohort study among hospital staff, including healthcare workers (HCWs) and administration staff, at the Jena University Hospital (JUH), Germany. The objectives of this study were to assess SARS-CoV-2 IgG seroprevalence, individual exposure risk...

Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors.

Computational and structural biotechnology journal

Khaliq W, Großmann P, Neugebauer S, Kleyman A, Domizi R, Calcinaro S, Brealey D, Gräler M, Kiehntopf M, Schäuble S, Singer M, Panagiotou G, Bauer M.
PMID: 33304464
Comput Struct Biotechnol J. 2020 Nov 21;18:3678-3691. doi: 10.1016/j.csbj.2020.11.009. eCollection 2020.

Sepsis remains a major cause of death despite advances in medical care. Metabolic deregulation is an important component of the survival process. Metabolomic analysis allows profiling of critical metabolic functions with the potential to classify patient outcome. Our prospective...

Biomarkers of Cholestasis and Liver Injury in the Early Phase of Acute Respiratory Distress Syndrome and Their Pathophysiological Value.

Diagnostics (Basel, Switzerland)

Harnisch LO, Baumann S, Mihaylov D, Kiehntopf M, Bauer M, Moerer O, Quintel M.
PMID: 34943592
Diagnostics (Basel). 2021 Dec 14;11(12). doi: 10.3390/diagnostics11122356.

BACKGROUND: Impaired liver function and cholestasis are frequent findings in critically ill patients and are associated with poor outcomes. We tested the hypothesis that hypoxic liver injury and hypoxic cholangiocyte injury are detectable very early in patients with ARDS,...

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction.

Cellular and molecular gastroenterology and hepatology

Leonhardt J, Haider RS, Sponholz C, Leonhardt S, Drube J, Spengler K, Mihaylov D, Neugebauer S, Kiehntopf M, Lambert NA, Kortgen A, Bruns T, Tacke F, Hoffmann C, Bauer M, Heller R.
PMID: 33545429
Cell Mol Gastroenterol Hepatol. 2021;12(1):25-40. doi: 10.1016/j.jcmgh.2021.01.011. Epub 2021 Feb 02.

BACKGROUND & AIMS: Retention of bile acids in the blood is a hallmark of liver failure. Recent studies have shown that increased serum bile acid levels correlate with bacterial infection and increased mortality. However, the mechanisms by which circulating...

Alpha-fetoprotein and its value for predicting pregnancy outcomes - a re-evaluation.

Journal of prenatal medicine

Darouich AA, Liehr T, Weise A, Schlembach D, Schleußner E, Kiehntopf M, Schreyer I.
PMID: 27358693
J Prenat Med. 2015 Jul-Dec;9(3):18-23. doi: 10.11138/jpm/2015.9.3.018.

INTRODUCTION: Alpha-fetoprotein (AFP) concentrations can be determined framing others from invasively acquired amnion fluid (AF-AFP). While the biological role of AFP remains unclear it is well known that AFP-levels can be altered in connection with specific clinical and/or genetic...

Prognostic impact of standard laboratory values on outcome in patients with sudden sensorineural hearing loss.

BMC ear, nose, and throat disorders

Wittig J, Wittekindt C, Kiehntopf M, Guntinas-Lichius O.
PMID: 25028570
BMC Ear Nose Throat Disord. 2014 Jul 09;14:6. doi: 10.1186/1472-6815-14-6. eCollection 2014.

BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after idiopathic sudden sensorineural hearing loss (SSNHL).METHODS: Using a retrospective review, 173 patients were included presenting between 2006 and 2009...

Showing 1 to 12 of 19 entries