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Showing 1 to 12 of 30 entries
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Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Molecular medicine (Cambridge, Mass.)

Folkersen L, Brynedal B, Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Westerlind H, Sundström Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Rönnblom L, Brunak S, Malmström V, Catrina A, Moerch UG, Klareskog L, Padyukov L, Berg L.
PMID: 27532898
Mol Med. 2016 Sep;22:322-328. doi: 10.2119/molmed.2016.00078. Epub 2016 Aug 15.

OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful replications. Our objective was to build a biobank with DNA,...

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study.

Modern rheumatology

Yahya A, Bengtsson C, Larsson P, Too CL, Mustafa AN, Abdullah NA, Muhamad NA, Klareskog L, Murad S, Alfredsson L.
PMID: 23615838
Mod Rheumatol. 2013 Apr 25; doi: 10.1007/s10165-013-0890-3. Epub 2013 Apr 25.

OBJECTIVES: Silica exposure has been associated with an increased risk of developing rheumatoid arthritis (RA), especially among smokers. In this study, we aimed at examining the association between silica exposure (and its interaction with smoking) and the risk of...

Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X.

BMC clinical pathology

Haraldsson S, Klarskov L, Nilbert M, Bernstein I, Bonde J, Holck S.
PMID: 28824332
BMC Clin Pathol. 2017 Aug 17;17:11. doi: 10.1186/s12907-017-0052-1. eCollection 2017.

BACKGROUND: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than...

Relationship between shift work and the onset of rheumatoid arthritis.

RMD open

Hedström AK, Åkerstedt T, Klareskog L, Alfredsson L.
PMID: 29225920
RMD Open. 2017 Aug 29;3(2):e000475. doi: 10.1136/rmdopen-2017-000475. eCollection 2017.

BACKGROUND: Environmental factors play a prominent role in rheumatoid arthritis (RA) aetiologyMETHODS: The present report is based on a population-based, case-control study with incident cases of RA (1951 cases and 2225 controls matched by age, gender and residential area)....

Working in cold environment and risk of developing rheumatoid arthritis: results from the Swedish EIRA case-control study.

RMD open

Zeng P, Bengtsson C, Klareskog L, Alfredsson L.
PMID: 28879055
RMD Open. 2017 Aug 16;3(2):e000488. doi: 10.1136/rmdopen-2017-000488. eCollection 2017.

OBJECTIVES: To investigate (1) whether working in cold environment (WCE) is associated with an increased risk of developing rheumatoid arthritis (RA) (overall), anticitrullinated protein antibody (ACPA)-positive RA and ACPA-negative RA and (2) whether WCE interacts with occupational physical workload...

Reply.

Arthritis & rheumatology (Hoboken, N.J.)

Tang B, Alfredsson L, Klareskog L, Padyukov L, Shi H, Jiang X.
PMID: 33881221
Arthritis Rheumatol. 2021 Oct;73(10):1944-1945. doi: 10.1002/art.41769. Epub 2021 Aug 24.

No abstract available.

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis.

Scientific reports

Sharma RK, Boddul SV, Yoosuf N, Turcinov S, Dubnovitsky A, Kozhukh G, Wermeling F, Kwok WW, Klareskog L, Malmström V.
PMID: 34972837
Sci Rep. 2021 Dec 31;11(1):24512. doi: 10.1038/s41598-021-04291-8.

We aimed to search for common features in the autoreactive T cell receptor (TCR) repertoire in patients with rheumatoid arthritis (RA), focusing on the newly identified candidate antigen citrullinated Tenascin C (cit-TNC). Mononuclear cells from peripheral blood or synovial...

Understanding and Prevention of the Evolution Toward Autoimmune Rheumatoid Arthritis: The New Challenge.

Clinical therapeutics

Klareskog L.
PMID: 31196654
Clin Ther. 2019 Jul;41(7):1232-1234. doi: 10.1016/j.clinthera.2019.04.034. Epub 2019 Jun 10.

No abstract available.

Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision.

RMD open

Bower H, Frisell T, di Giuseppe D, Delcoigne B, Ahlenius GM, Baecklund E, Chatzidionysiou K, Feltelius N, Forsblad-d'Elia H, Kastbom A, Klareskog L, Lindqvist E, Lindström U, Turesson C, Sjowall C, Askling J.
PMID: 34880127
RMD Open. 2021 Dec;7(3). doi: 10.1136/rmdopen-2021-001987.

OBJECTIVES: To compare risks for COVID-19-related outcomes in inflammatory joint diseases (IJDs) and across disease-modifying antirheumatic drugs (DMARDs) during the first two waves of the pandemic and to assess effects of the pandemic on rheumatology care provision.METHODS: Through nationwide...

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis.

Journal of clinical medicine

Eriksson K, Fei G, Lundmark A, Benchimol D, Lee L, Hu YOO, Kats A, Saevarsdottir S, Catrina AI, Klinge B, Andersson AF, Klareskog L, Lundberg K, Jansson L, Yucel-Lindberg T.
PMID: 31072030
J Clin Med. 2019 May 08;8(5). doi: 10.3390/jcm8050630.

This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection...

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.

The Journal of experimental medicine

Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, Engström M, Snir O, Israelsson L, Catrina AI, Wardemann H, Corti D, Meffre E, Klareskog L, Malmström V.
PMID: 30567717
J Exp Med. 2019 Jan 07;216(1):245. doi: 10.1084/jem.2012148612112018r. Epub 2018 Dec 19.

No abstract available.

Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case-control study.

RMD open

Zeng P, Klareskog L, Alfredsson L, Bengtsson C.
PMID: 28326188
RMD Open. 2017 Mar 14;3(1):e000324. doi: 10.1136/rmdopen-2016-000324. eCollection 2017.

OBJECTIVES: This study investigated: (1) the association of physical workload (PW) and risk of rheumatoid arthritis (RA); (2) the potential interactions between PW and the genes in the human leucocyte antigen (HLA) region.METHODS: A population-based case-control study involving incident...

Showing 1 to 12 of 30 entries