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Showing 1 to 12 of 35 entries
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Medicines as a Service: A New Commercial Model for Big Pharma in the Postblockbuster World.

Rand health quarterly

Mattke S, Klautzer L, Mengistu T.
PMID: 28083254
Rand Health Q. 2012 Jun 01;2(2):13. eCollection 2012.

The past decade has not been kind to large pharmaceutical companies. Their share prices have been lagging the market after many years of outperforming it. Many had to undergo painful restructuring and workforce reductions because their traditional blockbuster model...

Improving Care for Chronic Conditions: Current Practices and Future Trends in Health Plan Programs.

Rand health quarterly

Mattke S, Mengistu T, Klautzer L, Sloss EM, Brook RH.
PMID: 28083379
Rand Health Q. 2015 Nov 30;5(2):3. eCollection 2015 Nov 30.

The need for better management of chronic conditions is urgent. About 141 million people in the United States were living with one or more chronic conditions in 2010, and this number is projected to increase to 171 million by...

Never the Twain…Introduction to the Special Issue Psychology of Religion: Dialogues Between Sociocultural and Cognitive Perspectives.

Integrative psychological & behavioral science

Kloetzer L, Clément F.
PMID: 30706202
Integr Psychol Behav Sci. 2019 Mar;53(1):86-92. doi: 10.1007/s12124-018-9469-z.

Bringing together perspectives is rarely an easy task. By assembling researchers from cognitive and cultural traditions to discuss their reciprocal research in the field of psychology of religion, we thought that we will end up with an ecumenical conclusion,...

Co-occurrence of severe PTSD, somatic symptoms and dissociation in a large sample of childhood trauma inpatients: a network analysis.

European archives of psychiatry and clinical neuroscience

Kratzer L, Knefel M, Haselgruber A, Heinz P, Schennach R, Karatzias T.
PMID: 34635928
Eur Arch Psychiatry Clin Neurosci. 2021 Oct 11; doi: 10.1007/s00406-021-01342-z. Epub 2021 Oct 11.

Co-occurrence of mental disorders including severe PTSD, somatic symptoms, and dissociation in the aftermath of trauma is common and sometimes associated with poor treatment outcomes. However, the interrelationships between these conditions at symptom level are not well understood. In...

Therapy-related transcriptional subtypes in matched primary and recurrent head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Weber P, Künstner A, Hess J, Unger K, Marschner S, Idel C, Ribbat-Idel J, Baumeister P, Gires O, Walz C, Rietzler S, Valeanu L, Herkommer T, Kreutzer L, Klymenko O, Drexler G, Kirchner T, Maihöfer C, Ganswindt U, Walch A, Sterr M, Lickert H, Canis M, Rades D, Perner S, Berriel Diaz M, Herzig S, Lauber K, Wollenberg B, Busch H, Belka C, Zitzelsberger H.
PMID: 34965946
Clin Cancer Res. 2021 Dec 29; doi: 10.1158/1078-0432.CCR-21-2244. Epub 2021 Dec 29.

PURPOSE: The genetic relatedness between primary and recurrent head and neck squamous cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of tumor subpopulations. Yet, current treatment of recurrent HNSCC ignores the molecular characteristics of therapy-resistant tumor...

Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice.

Frontiers in neurology

Zareba-Paslawska J, Patra K, Kluzer L, Revesz T, Svenningsson P.
PMID: 33519674
Front Neurol. 2021 Jan 15;11:589471. doi: 10.3389/fneur.2020.589471. eCollection 2020.

The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. They are further subclassified based on the preferential pathological aggregation of three carboxyl-terminal repeat domains (3R)...

The quality of screening colonoscopy in rural and underserved areas.

Surgical endoscopy

Brajcich BC, Yang AD, Keswani RN, Kreutzer L, Molt PL, Rossi MB, Bilimoria KY, Halverson AL.
PMID: 34741204
Surg Endosc. 2021 Nov 05; doi: 10.1007/s00464-021-08833-z. Epub 2021 Nov 05.

BACKGROUND: Screening colonoscopy effectiveness depends on procedure quality; however, knowledge about colonoscopy quality in rural and underserved areas is limited. This study aimed to describe the characteristics and quality of colonoscopy and to examine predictors of colonoscopy quality at...

Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing-Using Rifampicin as an Example.

Frontiers in pharmacology

Keutzer L, Simonsson USH.
PMID: 32536870
Front Pharmacol. 2020 May 27;11:794. doi: 10.3389/fphar.2020.00794. eCollection 2020.

Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitude of IOV...

Direct Extraction of Fumaric Acid from .

Biomolecules

Cascaval D, Galaction AI, Tucaliuc A, Kloetzer L.
PMID: 34827561
Biomolecules. 2021 Oct 21;11(11). doi: 10.3390/biom11111563.

Experimental studies on the reactive extraction of fumaric acid with Amberlite LA-2 from

Significant improvement of posttraumatic stress disorder and psychotic symptoms after inpatient Eye Movement Desensitization and Reprocessing treatment: A case report with 6-month follow-up.

Indian journal of psychiatry

Kratzer L, Heinz P, Schennach R.
PMID: 29085105
Indian J Psychiatry. 2017 Jul-Sep;59(3):389-390. doi: 10.4103/psychiatry.IndianJPsychiatry_318_16.

No abstract available.

Improving Access to Medicines for Non-Communicable Diseases in the Developing World.

Rand health quarterly

Mattke S, Haims MC, Ayivi-Guedehoussou N, Gillen EM, Hunter LE, Klautzer L, Mengistu T.
PMID: 28083188
Rand Health Q. 2011 Sep 01;1(3):1. eCollection 2011.

Non-communicable diseases (NCDs) now account for the majority of global morbidity and mortality and are increasingly affecting developing countries whose under-resourced health care systems also have to handle a high burden of infectious disease. To counter the global devastation...

First report of nodular skin lesions caused by .

JFMS open reports

Niederhäuser S, Klauser L, Bolliger J, Friedel U, Schmitt S, Ruetten M, Greene CE, Ghielmetti G.
PMID: 30186616
JFMS Open Rep. 2018 Aug 27;4(2):2055116918792685. doi: 10.1177/2055116918792685. eCollection 2018.

CASE SUMMARY: A 9-year-old cat was referred with multiple, raised, ulcerative skin nodules in the region of the neck and dorsal head. Histopathological findings of a biopsied nodule were granulomatous dermatitis and panniculitis without multinucleated giant cells or caseous...

Showing 1 to 12 of 35 entries