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Showing 1 to 12 of 56 entries
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Weight loss maintenance in women 3 years after following a 12-week structured weight loss program.

Obesity research & clinical practice

Cleanthous X, Noakes M, Keogh JB, Mohr P, Clifton PM.
PMID: 24351546
Obes Res Clin Pract. 2007 Oct;1(3):I-II. doi: 10.1016/j.orcp.2007.07.002.

SUMMARY: Structured weight loss programs such as those using meal replacements are associated with both short-term and long-term weight loss, but the effectiveness of structured weight loss programs using whole foods has not been established. The primary aim of...

Prospects for treatment of Porphyromonas gingivalis-mediated disease - immune-based therapy.

Journal of oral microbiology

Reynolds EC, O'Brien-Simpson N, Rowe T, Nash A, McCluskey J, Vingadassalom D, Kleanthous H.
PMID: 26387645
J Oral Microbiol. 2015 Sep 18;7:29125. doi: 10.3402/jom.v7.29125. eCollection 2015.

Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth associated with a polymicrobial biofilm (subgingival plaque) accreted to the tooth which results in destruction of the tooth's supporting tissues. A characteristic feature of the disease-associated...

Clinical and microbiological parameters of naturally occurring periodontitis in the non-human primate .

Journal of oral microbiology

Colombo APV, Paster BJ, Grimaldi G, Lourenço TGB, Teva A, Campos-Neto A, McCluskey J, Kleanthous H, Van Dyke TE, Stashenko P.
PMID: 29805776
J Oral Microbiol. 2017 Nov 25;9(1):1403843. doi: 10.1080/20002297.2017.1403843. eCollection 2017.

No abstract available.

The quantitative basis for the redistribution of immobile bacterial lipoproteins to division septa.

PLoS computational biology

Connolley L, Szczepaniak J, Kleanthous C, Murray SM.
PMID: 34965245
PLoS Comput Biol. 2021 Dec 29;17(12):e1009756. doi: 10.1371/journal.pcbi.1009756. eCollection 2021 Dec.

The spatial localisation of proteins is critical for most cellular function. In bacteria, this is typically achieved through capture by established landmark proteins. However, this requires that the protein is diffusive on the appropriate timescale. It is therefore unknown...

Phase separation in the outer membrane of .

Proceedings of the National Academy of Sciences of the United States of America

Benn G, Mikheyeva IV, Inns PG, Forster JC, Ojkic N, Bortolini C, Ryadnov MG, Kleanthous C, Silhavy TJ, Hoogenboom BW.
PMID: 34716276
Proc Natl Acad Sci U S A. 2021 Nov 02;118(44). doi: 10.1073/pnas.2112237118.

Gram-negative bacteria are surrounded by a protective outer membrane (OM) with phospholipids in its inner leaflet and lipopolysaccharides (LPS) in its outer leaflet. The OM is also populated with many β-barrel outer-membrane proteins (OMPs), some of which have been...

Proteomic Studies for the Investigation of γ-Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures.

Journal of clinical medicine

Theodorou A, Phylactides M, Katsantoni E, Vougas K, Garbis SD, Fanis P, Sitarou M, Thein SL, Kleanthous M.
PMID: 31947809
J Clin Med. 2020 Jan 03;9(1). doi: 10.3390/jcm9010134.

Reactivation of γ-globin is considered a promising approach for the treatment of β-thalassemia and sickle cell disease. Therapeutic induction of γ-globin expression, however, is fraught with lack of suitable therapeutic targets. The aim of this study was to investigate...

Colicin-Mediated Transport of DNA through the Iron Transporter FepA.

mBio

Cohen-Khait R, Harmalkar A, Pham P, Webby MN, Housden NG, Elliston E, Hopper JTS, Mohammed S, Robinson CV, Gray JJ, Kleanthous C.
PMID: 34544275
mBio. 2021 Oct 26;12(5):e0178721. doi: 10.1128/mBio.01787-21. Epub 2021 Sep 21.

Colicins are protein antibiotics deployed by Escherichia coli to eliminate competing strains. Colicins frequently exploit outer membrane (OM) nutrient transporters to penetrate the selectively permeable bacterial cell envelope. Here, by applying live-cell fluorescence imaging, we were able to monitor...

Adapting the ACMG/AMP variant classification framework: A perspective from the ClinGen Hemoglobinopathy Variant Curation Expert Panel.

Human mutation

Kountouris P, Stephanou C, Lederer CW, Traeger-Synodinos J, Bento C, Harteveld CL, Fylaktou E, Koopmann TT, Halim-Fikri H, Michailidou K, Nfonsam LE, Waye JS, Zilfalil BA, Kleanthous M, Variant Curation Expert Panel OBOCH.
PMID: 34510646
Hum Mutat. 2021 Sep 12; doi: 10.1002/humu.24280. Epub 2021 Sep 12.

Accurate and consistent interpretation of sequence variants is integral to the delivery of safe and reliable diagnostic genetic services. To standardize the interpretation process, in 2015, the American College of Medical Genetics and Genomics (ACMG) and the Association for...

Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF.

The EMBO journal

Francis MR, Webby MN, Housden NG, Kaminska R, Elliston E, Chinthammit B, Lukoyanova N, Kleanthous C.
PMID: 34515361
EMBO J. 2021 Nov 02;40(21):e108610. doi: 10.15252/embj.2021108610. Epub 2021 Sep 13.

Bacteria deploy weapons to kill their neighbours during competition for resources and to aid survival within microbiomes. Colicins were the first such antibacterial system identified, yet how these bacteriocins cross the outer membrane (OM) of Escherichia coli is unknown....

Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs.

NPJ vaccines

Job ER, Ysenbaert T, Smet A, Christopoulou I, Strugnell T, Oloo EO, Oomen RP, Kleanthous H, Vogel TU, Saelens X.
PMID: 30510776
NPJ Vaccines. 2018 Nov 29;3:55. doi: 10.1038/s41541-018-0093-1. eCollection 2018.

Split inactivated influenza vaccines remain one of the primary preventative strategies against severe influenza disease in the population. However, current vaccines are only effective against a limited number of matched strains. The need for broadly protective vaccines is acute...

Reliability and psychometric properties of the Greek translation of the State-Trait Anxiety Inventory form Y: preliminary data.

Annals of general psychiatry

Fountoulakis KN, Papadopoulou M, Kleanthous S, Papadopoulou A, Bizeli V, Nimatoudis I, Iacovides A, Kaprinis GS.
PMID: 16448554
Ann Gen Psychiatry. 2006 Jan 31;5:2. doi: 10.1186/1744-859X-5-2.

BACKGROUND: The State-Trait Anxiety Inventory form Y is a brief self-rating scale for the assessment of state and trait anxiety. The aim of the current preliminary study was to assess the psychometric properties of its Greek translation.MATERIALS AND METHODS:...

Asymptomatic bladder neurofibroma in neurofibromatosis type I.

Minerva pediatrica

Kleanthous K, Alexopoulou E, Papadopoulos I, Mazioti A, Tsipi M, Attilakos A, Dinopoulos A.
PMID: 32241104
Minerva Pediatr. 2020 Apr 02; doi: 10.23736/S0026-4946.20.05648-0. Epub 2020 Apr 02.

No abstract available.

Showing 1 to 12 of 56 entries