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Showing 1 to 12 of 92 entries
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Plant derived substances with anti-cancer activity: from folklore to practice.

Frontiers in plant science

Fridlender M, Kapulnik Y, Koltai H.
PMID: 26483815
Front Plant Sci. 2015 Oct 01;6:799. doi: 10.3389/fpls.2015.00799. eCollection 2015.

Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that 70-95% of the...

Preparing local strain patterns in graphene by atomic force microscope based indentation.

Scientific reports

Nemes-Incze P, Kukucska G, Koltai J, Kürti J, Hwang C, Tapasztó L, Biró LP.
PMID: 28596579
Sci Rep. 2017 Jun 08;7(1):3035. doi: 10.1038/s41598-017-03332-5.

Patterning graphene into various mesoscopic devices such as nanoribbons, quantum dots, etc. by lithographic techniques has enabled the guiding and manipulation of graphene's Dirac-type charge carriers. Graphene, with well-defined strain patterns, holds promise of similarly rich physics while avoiding...

Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity.

F1000Research

Koltai T.
PMID: 26097685
F1000Res. 2015 Jan 12;4:9. doi: 10.12688/f1000research.5827.2. eCollection 2015.

OBJECTIVE: To review the mechanisms of anti-cancer activity of nelfinavir and other protease inhibitors (PIs) based on evidences reported in the published literature.METHODS: We extensively reviewed the literature concerning nelfinavir (NFV) as an off target anti-cancer drug and other...

An unusual erupted complex composite odontoma: a rare case.

Case reports in dentistry

Ali Azhar D, Kota MZ, El-Nagdy S.
PMID: 23346425
Case Rep Dent. 2013;2013:106019. doi: 10.1155/2013/106019. Epub 2013 Jan 03.

Odontomas are malformations of the dental tissues and may interfere with the eruption of the associated tooth. Complex composite odontoma (CO) was described as a distinct entity for the first time by Broca in 1866. This lesion takes place...

End-of-life decision making by family caregivers of persons with advanced dementia: A literature review of decision aids.

SAGE open medicine

Xie B, Berkley AS, Kwak J, Fleischmann KR, Champion JD, Koltai KS.
PMID: 29844911
SAGE Open Med. 2018 May 21;6:2050312118777517. doi: 10.1177/2050312118777517. eCollection 2018.

OBJECTIVES: To investigate existing knowledge in the literature about end-of-life decision making by family caregivers of persons with dementia, focusing on decision aids for caregivers of persons with advanced dementia, and to identify gaps in the literature that can...

Transition Manifolds of Complex Metastable Systems: Theory and Data-Driven Computation of Effective Dynamics.

Journal of nonlinear science

Bittracher A, Koltai P, Klus S, Banisch R, Dellnitz M, Schütte C.
PMID: 29527099
J Nonlinear Sci. 2018;28(2):471-512. doi: 10.1007/s00332-017-9415-0. Epub 2017 Oct 12.

We consider complex dynamical systems showing metastable behavior, but no local separation of fast and slow time scales. The article raises the question of whether such systems exhibit a low-dimensional manifold supporting its effective dynamics. For answering this question,...

Repeated Administration of Cocaine Alters Dopamine Uptake and Release in the Striatum Nucleus Accumbens.

Annals of the New York Academy of Sciences

Clay LH, Mazzio EA, Kolta MG, Soliman KFA.
PMID: 29090828
Ann N Y Acad Sci. 1998 May;844(1):346-355. doi: 10.1111/j.1749-6632.1998.tb08249.x.

Male Sprague-Dawley rats were administered 25 mg/kg, intraperitoneally (i.p.) cocaine-HCl twice daily for 14 consecutive days (total of 50 mg/kg), while control animals received an equivalent volume of 0.9% saline. After three days of withdrawal, the animals were sacrificed...

Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

Circulation

Reynolds HR, Shaw LJ, Min JK, Page CB, Berman DS, Chaitman BR, Picard MH, Kwong RY, O'Brien SM, Huang Z, Mark DB, Nath RK, Dwivedi SK, Smanio PEP, Stone PH, Held C, Keltai M, Bangalore S, Newman JD, Spertus JA, Stone GW, Maron DJ, Hochman JS.
PMID: 34496632
Circulation. 2021 Sep 28;144(13):1024-1038. doi: 10.1161/CIRCULATIONAHA.120.049755. Epub 2021 Sep 09.

BACKGROUND: The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity...

Votes, populism, and pandemics.

International journal of public health

Gugushvili A, Koltai J, Stuckler D, McKee M.
PMID: 32740685
Int J Public Health. 2020 Jul;65(6):721-722. doi: 10.1007/s00038-020-01450-y. Epub 2020 Aug 01.

No abstract available.

Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial.

European heart journal. Cardiovascular pharmacotherapy

De Caterina R, Patti G, Westerbergh J, Horowitz J, Ezekowitz JA, Lewis BS, Lopes RD, McMurray JJV, Atar D, Bahit MC, Keltai M, López-Sendón JL, Ruzyllo W, Granger CB, Alexander JH, Wallentin L.
PMID: 33367487
Eur Heart J Cardiovasc Pharmacother. 2020 Dec 28; doi: 10.1093/ehjcvp/pvaa140. Epub 2020 Dec 28.

AIMS: Whether diabetes without insulin therapy is an independent cardiovascular (CV) risk factor in atrial fibrillation (AF) has recently been questioned. We investigated the prognostic relevance of diabetes with or without insulin treatment in patients in the ARISTOTLE trial.METHODS...

Signature of Large-Gap Quantum Spin Hall State in the Layered Mineral Jacutingaite.

Nano letters

Kandrai K, Vancsó P, Kukucska G, Koltai J, Baranka G, Ákos Hoffmann, Áron Pekker, Kamarás K, Horváth ZE, Vymazalová A, Tapasztó L, Nemes-Incze P.
PMID: 32551708
Nano Lett. 2020 Jul 08;20(7):5207-5213. doi: 10.1021/acs.nanolett.0c01499. Epub 2020 Jun 24.

Quantum spin Hall (QSH) insulators host edge states, where the helical locking of spin and momentum suppresses backscattering of charge carriers, promising applications from low-power electronics to quantum computing. A major challenge for applications is the identification of large...

Cancer: fundamentals behind pH targeting and the double-edged approach.

OncoTargets and therapy

Koltai T.
PMID: 27799782
Onco Targets Ther. 2016 Oct 17;9:6343-6360. doi: 10.2147/OTT.S115438. eCollection 2016.

The highly regulated pH of cells and the less-regulated pH of the surrounding extracellular matrix (ECM) is the result of a delicate balance between metabolic processes and proton production, proton transportation, chemical buffering, and vascular removal of waste products....

Showing 1 to 12 of 92 entries