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Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.

The journal of pathology. Clinical research

Howat WJ, Blows FM, Provenzano E, Brook MN, Morris L, Gazinska P, Johnson N, McDuffus LA, Miller J, Sawyer EJ, Pinder S, van Deurzen CH, Jones L, Sironen R, Visscher D, Caldas C, Daley F, Coulson P, Broeks A, Sanders J, Wesseling J, Nevanlinna H, Fagerholm R, Blomqvist C, Heikkilä P, Ali HR, Dawson SJ, Figueroa J, Lissowska J, Brinton L, Mannermaa A, Kataja V, Kosma VM, Cox A, Brock IW, Cross SS, Reed MW, Couch FJ, Olson JE, Devillee P, Mesker WE, Seyaneve CM, Hollestelle A, Benitez J, Perez JI, Menéndez P, Bolla MK, Easton DF, Schmidt MK, Pharoah PD, Sherman ME, García-Closas M.
PMID: 27499890
J Pathol Clin Res. 2014 Dec 04;1(1):18-32. doi: 10.1002/cjp2.3. eCollection 2015 Jan.

Breast cancer risk factors and clinical outcomes vary by tumour marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need for high throughput, standardized scoring methods. To...

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Howat WJ, Blows FM, Provenzano E, et al. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium. J Pathol Clin Res. 2014;1(1):18-32doi: 10.1002/cjp2.3.
Howat, W. J., Blows, F. M., Provenzano, E., Brook, M. N., Morris, L., Gazinska, P., Johnson, N., McDuffus, L. A., Miller, J., Sawyer, E. J., Pinder, S., van Deurzen, C. H., Jones, L., Sironen, R., Visscher, D., Caldas, C., Daley, F., Coulson, P., Broeks, A., Sanders, J., Wesseling, J., Nevanlinna, H., Fagerholm, R., Blomqvist, C., Heikkilä, P., Ali, H. R., Dawson, S. J., Figueroa, J., Lissowska, J., Brinton, L., Mannermaa, A., Kataja, V., Kosma, V. M., Cox, A., Brock, I. W., Cross, S. S., Reed, M. W., Couch, F. J., Olson, J. E., Devillee, P., Mesker, W. E., Seyaneve, C. M., Hollestelle, A., Benitez, J., Perez, J. I., Menéndez, P., Bolla, M. K., Easton, D. F., Schmidt, M. K., Pharoah, P. D., Sherman, M. E., & García-Closas, M. (2015). Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium. The journal of pathology. Clinical research, 1(1), 18-32. https://doi.org/10.1002/cjp2.3
Howat, William J, et al. "Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium." The journal of pathology. Clinical research vol. 1,1 (2015): 18-32. doi: https://doi.org/10.1002/cjp2.3
Howat WJ, Blows FM, Provenzano E, Brook MN, Morris L, Gazinska P, Johnson N, McDuffus LA, Miller J, Sawyer EJ, Pinder S, van Deurzen CH, Jones L, Sironen R, Visscher D, Caldas C, Daley F, Coulson P, Broeks A, Sanders J, Wesseling J, Nevanlinna H, Fagerholm R, Blomqvist C, Heikkilä P, Ali HR, Dawson SJ, Figueroa J, Lissowska J, Brinton L, Mannermaa A, Kataja V, Kosma VM, Cox A, Brock IW, Cross SS, Reed MW, Couch FJ, Olson JE, Devillee P, Mesker WE, Seyaneve CM, Hollestelle A, Benitez J, Perez JI, Menéndez P, Bolla MK, Easton DF, Schmidt MK, Pharoah PD, Sherman ME, García-Closas M. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium. J Pathol Clin Res. 2014 Dec 04;1(1):18-32. doi: 10.1002/cjp2.3. eCollection 2015 Jan. PMID: 27499890; PMCID: PMC4858117.
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Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases.

Meta gene

Tsipi M, Tzetis M, Kosma K, Moschos M, Braoudaki M, Poulou M, Kanavakis E, Kitsiou-Tzeli S.
PMID: 27014590
Meta Gene. 2016 Feb 16;8:37-43. doi: 10.1016/j.mgene.2016.02.002. eCollection 2016 Jun.

BACKGROUND: Retinal dystrophies are a clinically and genetically heterogeneous group of disorders which affect more than two million people worldwide. The present study focused on the role of the ABCA4 gene in the pathogenesis of hereditary retinal dystrophies (autosomal...

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Tsipi M, Tzetis M, Kosma K, et al. Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases. Meta Gene. 2016;8:37-43doi: 10.1016/j.mgene.2016.02.002.
Tsipi, M., Tzetis, M., Kosma, K., Moschos, M., Braoudaki, M., Poulou, M., Kanavakis, E., & Kitsiou-Tzeli, S. (2016). Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases. Meta gene, 837-43. https://doi.org/10.1016/j.mgene.2016.02.002
Tsipi, Maria, et al. "Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases." Meta gene vol. 8 (2016): 37-43. doi: https://doi.org/10.1016/j.mgene.2016.02.002
Tsipi M, Tzetis M, Kosma K, Moschos M, Braoudaki M, Poulou M, Kanavakis E, Kitsiou-Tzeli S. Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases. Meta Gene. 2016 Feb 16;8:37-43. doi: 10.1016/j.mgene.2016.02.002. eCollection 2016 Jun. PMID: 27014590; PMCID: PMC4792891.
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Efficient Chemical Synthesis of the Two Anomers of ADP-L-glycero- and D-glycero-D-manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases This work was supported by grants from FWF (grant nos. P11449-MOB and P13843-CHE).

Angewandte Chemie (International ed. in English)

Zamyatina A, Gronow S, Oertelt C, Puchberger M, Brade H, Kosma P.
PMID: 11093236
Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4150-4153. doi: 10.1002/1521-3773(20001117)39:22<4150::aid-anie4150>3.0.co;2-a.

No abstract available.

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Zamyatina A, Gronow S, Oertelt C, et al. Efficient Chemical Synthesis of the Two Anomers of ADP-L-glycero- and D-glycero-D-manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases This work was supported by grants from FWF (grant nos. P11449-MOB and P13843-CHE). Angew Chem Int Ed Engl. 2000;39(22):4150-4153doi: 10.1002/1521-3773(20001117)39:22<4150::aid-anie4150>3.0.co;2-a.
Zamyatina, A., Gronow, S., Oertelt, C., Puchberger, M., Brade, H., & Kosma, P. (2000). Efficient Chemical Synthesis of the Two Anomers of ADP-L-glycero- and D-glycero-D-manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases This work was supported by grants from FWF (grant nos. P11449-MOB and P13843-CHE). Angewandte Chemie (International ed. in English), 39(22), 4150-4153. https://doi.org/10.1002/1521-3773(20001117)39:22<4150::aid-anie4150>3.0.co;2-a
Zamyatina, et al. "Efficient Chemical Synthesis of the Two Anomers of ADP-L-glycero- and D-glycero-D-manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases This work was supported by grants from FWF (grant nos. P11449-MOB and P13843-CHE)." Angewandte Chemie (International ed. in English) vol. 39,22 (2000): 4150-4153. doi: https://doi.org/10.1002/1521-3773(20001117)39:22<4150::aid-anie4150>3.0.co;2-a
Zamyatina A, Gronow S, Oertelt C, Puchberger M, Brade H, Kosma P. Efficient Chemical Synthesis of the Two Anomers of ADP-L-glycero- and D-glycero-D-manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases This work was supported by grants from FWF (grant nos. P11449-MOB and P13843-CHE). Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4150-4153. doi: 10.1002/1521-3773(20001117)39:22<4150::aid-anie4150>3.0.co;2-a. PMID: 11093236.
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Sub-10-fs supercontinuum radiation generated by filamentation of few-cycle 800 nm pulses in argon.

Optics letters

Trushin SA, Kosma K, Fuss W, Schmid WE.
PMID: 17700809
Opt Lett. 2007 Aug 15;32(16):2432-4. doi: 10.1364/ol.32.002432.

Focusing 12 fs pulses of 800 nm with moderate energy (0.35 mJ) into atmospheric-pressure argon (Ar) gives rise to filamentation (self-focusing) and a supercontinuum with a very broad pedestal, extending to 250 nm. According to the present understanding, the...

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Trushin SA, Kosma K, Fuss W, et al. Sub-10-fs supercontinuum radiation generated by filamentation of few-cycle 800 nm pulses in argon. Opt Lett. 2007;32(16):2432-4doi: 10.1364/ol.32.002432.
Trushin, S. A., Kosma, K., Fuss, W., & Schmid, W. E. (2007). Sub-10-fs supercontinuum radiation generated by filamentation of few-cycle 800 nm pulses in argon. Optics letters, 32(16), 2432-4. https://doi.org/10.1364/ol.32.002432
Trushin, Sergei A, et al. "Sub-10-fs supercontinuum radiation generated by filamentation of few-cycle 800 nm pulses in argon." Optics letters vol. 32,16 (2007): 2432-4. doi: https://doi.org/10.1364/ol.32.002432
Trushin SA, Kosma K, Fuss W, Schmid WE. Sub-10-fs supercontinuum radiation generated by filamentation of few-cycle 800 nm pulses in argon. Opt Lett. 2007 Aug 15;32(16):2432-4. doi: 10.1364/ol.32.002432. PMID: 17700809.
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Ab initio characterization of (CH3IO3) isomers and the CH3O2 + IO reaction pathways.

The journal of physical chemistry. A

Drougas E, Kosmas AM.
PMID: 17419596
J Phys Chem A. 2007 May 03;111(17):3402-8. doi: 10.1021/jp068348p. Epub 2007 Apr 10.

The geometries, harmonic vibrational frequencies, relative energetics, and enthalpies of formation of (CH(3)IO(3)) isomers and the reaction CH(3)O(2) + IO have been investigated using quantum mechanical methods. Optimization has been performed at the MP2 level of theory, using all...

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Drougas E, Kosmas AM. Ab initio characterization of (CH3IO3) isomers and the CH3O2 + IO reaction pathways. J Phys Chem A. 2007;111(17):3402-8doi: 10.1021/jp068348p.
Drougas, E., & Kosmas, A. M. (2007). Ab initio characterization of (CH3IO3) isomers and the CH3O2 + IO reaction pathways. The journal of physical chemistry. A, 111(17), 3402-8. https://doi.org/10.1021/jp068348p
Drougas, Evangelos, and Kosmas, Agnie M. "Ab initio characterization of (CH3IO3) isomers and the CH3O2 + IO reaction pathways." The journal of physical chemistry. A vol. 111,17 (2007): 3402-8. doi: https://doi.org/10.1021/jp068348p
Drougas E, Kosmas AM. Ab initio characterization of (CH3IO3) isomers and the CH3O2 + IO reaction pathways. J Phys Chem A. 2007 May 03;111(17):3402-8. doi: 10.1021/jp068348p. Epub 2007 Apr 10. PMID: 17419596.
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The Democratic Party's National Platform on Health Care.

Managed care interface

Kozma CM.
PMID: 17274483
Manag Care Interface. 2006 Dec;19(12):52, 55.

No abstract available.

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Kozma CM. The Democratic Party's National Platform on Health Care. Manag Care Interface. 2006;19(12):52, 55
Kozma, C. M. (2006). The Democratic Party's National Platform on Health Care. Managed care interface, 19(12), 52, 55.
Kozma, Chris M. "The Democratic Party's National Platform on Health Care." Managed care interface vol. 19,12 (2006): 52, 55.
Kozma CM. The Democratic Party's National Platform on Health Care. Manag Care Interface. 2006 Dec;19(12):52, 55. PMID: 17274483.
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Cyclohexadiene ring opening observed with 13 fs resolution: coherent oscillations confirm the reaction path.

Physical chemistry chemical physics : PCCP

Kosma K, Trushin SA, Fuss W, Schmid WE.
PMID: 19081921
Phys Chem Chem Phys. 2009 Jan 07;11(1):172-81. doi: 10.1039/b814201g. Epub 2008 Nov 06.

The third harmonic (270 nm, 11 fs), produced in a short argon cell from Ti-sapphire laser pulses (810 nm, 12 fs), was used to excite 1,3-cyclohexadiene to its lowest pipi* state (1B). Probing was done by transient ionization by...

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Kosma K, Trushin SA, Fuss W, et al. Cyclohexadiene ring opening observed with 13 fs resolution: coherent oscillations confirm the reaction path. Phys Chem Chem Phys. 2008;11(1):172-81doi: 10.1039/b814201g.
Kosma, K., Trushin, S. A., Fuss, W., & Schmid, W. E. (2009). Cyclohexadiene ring opening observed with 13 fs resolution: coherent oscillations confirm the reaction path. Physical chemistry chemical physics : PCCP, 11(1), 172-81. https://doi.org/10.1039/b814201g
Kosma, K, et al. "Cyclohexadiene ring opening observed with 13 fs resolution: coherent oscillations confirm the reaction path." Physical chemistry chemical physics : PCCP vol. 11,1 (2009): 172-81. doi: https://doi.org/10.1039/b814201g
Kosma K, Trushin SA, Fuss W, Schmid WE. Cyclohexadiene ring opening observed with 13 fs resolution: coherent oscillations confirm the reaction path. Phys Chem Chem Phys. 2009 Jan 07;11(1):172-81. doi: 10.1039/b814201g. Epub 2008 Nov 06. PMID: 19081921.
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Photodissociation of group-6 hexacarbonyls: observation of coherent oscillations in an antisymmetric (pseudorotation) vibration in Mo(CO)(5) and W(CO)(5).

Physical chemistry chemical physics : PCCP

Kosma K, Trushin SA, Fuss W, Schmid WE, Schneider BM.
PMID: 20820586
Phys Chem Chem Phys. 2010 Oct 28;12(40):13197-214. doi: 10.1039/c0cp00731e. Epub 2010 Aug 31.

On dissociation of M(CO)(6), M = Cr, Mo and W, by a femtosecond UV laser (

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Kosma K, Trushin SA, Fuss W, et al. Photodissociation of group-6 hexacarbonyls: observation of coherent oscillations in an antisymmetric (pseudorotation) vibration in Mo(CO)(5) and W(CO)(5). Phys Chem Chem Phys. 2010;12(40):13197-214doi: 10.1039/c0cp00731e.
Kosma, K., Trushin, S. A., Fuss, W., Schmid, W. E., & Schneider, B. M. (2010). Photodissociation of group-6 hexacarbonyls: observation of coherent oscillations in an antisymmetric (pseudorotation) vibration in Mo(CO)(5) and W(CO)(5). Physical chemistry chemical physics : PCCP, 12(40), 13197-214. https://doi.org/10.1039/c0cp00731e
Kosma, Kyriaki, et al. "Photodissociation of group-6 hexacarbonyls: observation of coherent oscillations in an antisymmetric (pseudorotation) vibration in Mo(CO)(5) and W(CO)(5)." Physical chemistry chemical physics : PCCP vol. 12,40 (2010): 13197-214. doi: https://doi.org/10.1039/c0cp00731e
Kosma K, Trushin SA, Fuss W, Schmid WE, Schneider BM. Photodissociation of group-6 hexacarbonyls: observation of coherent oscillations in an antisymmetric (pseudorotation) vibration in Mo(CO)(5) and W(CO)(5). Phys Chem Chem Phys. 2010 Oct 28;12(40):13197-214. doi: 10.1039/c0cp00731e. Epub 2010 Aug 31. PMID: 20820586.
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Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs.

Environmental toxicology and pharmacology

Jussila J, Komulainen H, Kosma VM, Pelkonen J, Hirvonen MR.
PMID: 21782633
Environ Toxicol Pharmacol. 2002 Oct;12(3):137-45. doi: 10.1016/s1382-6689(02)00018-2.

Excess moisture and microbial growth have been associated with adverse health effects, especially in the airways, of the inhabitants of moisture-damaged buildings. The spores of Penicillium spp. are commonly present in the indoor air, both in moisture-damaged and in...

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Jussila J, Komulainen H, Kosma VM, et al. Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs. Environ Toxicol Pharmacol. 2002;12(3):137-45doi: 10.1016/s1382-6689(02)00018-2.
Jussila, J., Komulainen, H., Kosma, V. M., Pelkonen, J., & Hirvonen, M. R. (2002). Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs. Environmental toxicology and pharmacology, 12(3), 137-45. https://doi.org/10.1016/s1382-6689(02)00018-2
Jussila, Juha, et al. "Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs." Environmental toxicology and pharmacology vol. 12,3 (2002): 137-45. doi: https://doi.org/10.1016/s1382-6689(02)00018-2
Jussila J, Komulainen H, Kosma VM, Pelkonen J, Hirvonen MR. Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs. Environ Toxicol Pharmacol. 2002 Oct;12(3):137-45. doi: 10.1016/s1382-6689(02)00018-2. PMID: 21782633.
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4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate.

Acta crystallographica. Section E, Structure reports online

Kosma P, Selzer E, Mereiter K.
PMID: 23476238
Acta Crystallogr Sect E Struct Rep Online. 2012 Dec 01;68:o3417-8. doi: 10.1107/S1600536812047307. Epub 2012 Nov 24.

The mol-ecular structure of the title compound, C20H18N2O5S·C3H7NO, represents an essentially planar 5-benzyl-idene-thia-zolidine moiety (r.m.s. deviation from planarity without ring substituents = 0.095 Å) to which the 4-amino-benzoic acid fragment is inclined at 76.23 (1)°. In the crystal, the...

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Kosma P, Selzer E, Mereiter K. 4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012;68:o3417-8doi: 10.1107/S1600536812047307.
Kosma, P., Selzer, E., & Mereiter, K. (2012). 4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate. Acta crystallographica. Section E, Structure reports online, 68o3417-8. https://doi.org/10.1107/S1600536812047307
Kosma, Paul, et al. "4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate." Acta crystallographica. Section E, Structure reports online vol. 68 (2012): o3417-8. doi: https://doi.org/10.1107/S1600536812047307
Kosma P, Selzer E, Mereiter K. 4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 Dec 01;68:o3417-8. doi: 10.1107/S1600536812047307. Epub 2012 Nov 24. PMID: 23476238; PMCID: PMC3589002.
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[Neuroleptic Malignant Syndrome after whithdrawal of anticholinergic agents].

Psychiatrike = Psychiatriki

Kosma K, Roumbos B, Mamali M, Xipas K, Kolovou K, Kalogiratos G, Fortos A.
PMID: 22218008
Psychiatriki. 2008 Jul;19(3):245-7.

Neuroleptic Malignant Syndrome (NMS) is a rare but a potential lethal condition therefore it always represents a neurological emergency. Although NMS is considered mainly as idiosyncratic complication of antipsychotic medication, isolated reports show that the syndrome can rarely occur...

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Kosma K, Roumbos B, Mamali M, et al. [Neuroleptic Malignant Syndrome after whithdrawal of anticholinergic agents]. Psychiatriki. 2008;19(3):245-7
Kosma, K., Roumbos, B., Mamali, M., Xipas, K., Kolovou, K., Kalogiratos, G., & Fortos, A. (2008). [Neuroleptic Malignant Syndrome after whithdrawal of anticholinergic agents]. Psychiatrike = Psychiatriki, 19(3), 245-7.
Kosma, K, et al. "[Neuroleptic Malignant Syndrome after whithdrawal of anticholinergic agents]." Psychiatrike = Psychiatriki vol. 19,3 (2008): 245-7.
Kosma K, Roumbos B, Mamali M, Xipas K, Kolovou K, Kalogiratos G, Fortos A. [Neuroleptic Malignant Syndrome after whithdrawal of anticholinergic agents]. Psychiatriki. 2008 Jul;19(3):245-7. Greek, Modern. PMID: 22218008.
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Whispering gallery mode microsphere resonator integrated inside a microstructured optical fiber.

Optics letters

Kosma K, Zito G, Schuster K, Pissadakis S.
PMID: 23595465
Opt Lett. 2013 Apr 15;38(8):1301-3. doi: 10.1364/OL.38.001301.

A compact and robust scheme for broadband excitation of whispering gallery mode (WGM) resonances into a microsphere is demonstrated. A polymer microsphere (10 μm) is encapsulated into the capillary of a microstructured optical fiber, in direct contact with the...

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Kosma K, Zito G, Schuster K, et al. Whispering gallery mode microsphere resonator integrated inside a microstructured optical fiber. Opt Lett. 2013;38(8):1301-3doi: 10.1364/OL.38.001301.
Kosma, K., Zito, G., Schuster, K., & Pissadakis, S. (2013). Whispering gallery mode microsphere resonator integrated inside a microstructured optical fiber. Optics letters, 38(8), 1301-3. https://doi.org/10.1364/OL.38.001301
Kosma, Kyriaki, et al. "Whispering gallery mode microsphere resonator integrated inside a microstructured optical fiber." Optics letters vol. 38,8 (2013): 1301-3. doi: https://doi.org/10.1364/OL.38.001301
Kosma K, Zito G, Schuster K, Pissadakis S. Whispering gallery mode microsphere resonator integrated inside a microstructured optical fiber. Opt Lett. 2013 Apr 15;38(8):1301-3. doi: 10.1364/OL.38.001301. PMID: 23595465.
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