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Showing 1 to 12 of 64 entries
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Role and rationale for the use of milnacipran in the management of fibromyalgia.

Neuropsychiatric disease and treatment

Kranzler JD, Gendreau RM.
PMID: 20520784
Neuropsychiatr Dis Treat. 2010 May 25;6:197-208. doi: 10.2147/ndt.s9622.

Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread musculoskeletal pain which is often accompanied by multiple other symptoms, including fatigue, sleep disturbances, decreased physical functioning, and dyscognition. Due to these multiple symptoms, as well as high rates...

Variation in Mu-Opioid Receptor Gene .

Journal of alcoholism and drug dependence

Chen AC, Morgenstern J, Davis CM, Kuerbis AN, Covault J, Kranzler HR.
PMID: 24729984
J Alcohol Drug Depend. 2013 Jan 01;1(1):101. doi: 10.4172/2329-6488.1000101.

BACKGROUND: It is well known that naltrexone, an FDA-approved medication for treatment of alcohol dependence, is effective for only a subset of individuals. Recent studies have examined the utility of a functional A118G single nucleotide polymorphism (SNP) of the...

Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

Nature communications

Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J.
PMID: 31481659
Nat Commun. 2019 Sep 03;10(1):4050. doi: 10.1038/s41467-019-11916-0.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A Comparative Study of Iron Uptake Rates and Mechanisms amongst Marine and Fresh Water Cyanobacteria: Prevalence of Reductive Iron Uptake.

Life (Basel, Switzerland)

Lis H, Kranzler C, Keren N, Shaked Y.
PMID: 25768677
Life (Basel). 2015 Mar 11;5(1):841-60. doi: 10.3390/life5010841.

In this contribution, we address the question of iron bioavailability to cyanobacteria by measuring Fe uptake rates and probing for a reductive uptake pathway in diverse cyanobacterial species. We examined three Fe-substrates: dissolved inorganic iron (Fe') and the Fe-siderophores...

Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.

Neurobiology of stress

Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R.
PMID: 33665242
Neurobiol Stress. 2021 Feb 18;14:100309. doi: 10.1016/j.ynstr.2021.100309. eCollection 2021 May.

Epidemiologic studies recognize that trauma and posttraumatic stress are associated with heightened suicidal behavior severity, yet examination of these associations from a genetic perspective is limited. We performed a multivariate gene-by-environment genome-wide interaction study (GEWIS) of suicidality in 123,633...

Genome-Wide Association Study of Opioid Cessation.

Journal of clinical medicine

Cox JW, Sherva RM, Lunetta KL, Johnson EC, Martin NG, Degenhardt L, Agrawal A, Nelson EC, Kranzler HR, Gelernter J, Farrer LA.
PMID: 31936517
J Clin Med. 2020 Jan 09;9(1). doi: 10.3390/jcm9010180.

The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-related deaths. However, the genetic basis for the ability to discontinue opioid use has not been investigated. We performed a genome-wide association study (GWAS) of opioid...

Accuracy of Consumer-marketed smartphone-paired alcohol breath testing devices: A laboratory validation study.

Alcoholism, clinical and experimental research

Delgado MK, Shofer F, Wetherill R, Curtis B, Hemmons J, Spencer E, Branas C, Wiebe DJ, Kranzler HR.
PMID: 33966283
Alcohol Clin Exp Res. 2021 May;45(5):1091-1099. doi: 10.1111/acer.14597. Epub 2021 May 09.

BACKGROUND: Although alcohol breath testing devices that pair with smartphones are promoted for the prevention of alcohol-impaired driving, their accuracy has not been established.METHODS: In a within-subjects laboratory study, we administered weight-based doses of ethanol to two groups of...

Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals.

Addiction biology

Hartwell EE, Merikangas AK, Verma SS, Ritchie MD, Kranzler HR, Kember RL.
PMID: 34611967
Addict Biol. 2021 Oct 05;e13099. doi: 10.1111/adb.13099. Epub 2021 Oct 05.

Polygenic risk scores (PRS) represent an individual's summed genetic risk for a trait and can serve as biomarkers for disease. Less is known about the utility of PRS as a means to quantify genetic risk for substance use disorders...

Do Longitudinal Trends in Tobacco 21-Related Media Coverage Correlate with Policy Support? an Exploratory Analysis Using Supervised and Unsupervised Machine Learning Methods.

Health communication

Siegel LN, Levin AV, Kranzler EC, Gibson LA.
PMID: 32900231
Health Commun. 2022 Jan;37(1):29-38. doi: 10.1080/10410236.2020.1816282. Epub 2020 Sep 08.

Media coverage can impact support for health policies and, ultimately, compliance with those policies. Prior research found consistent, high support for Tobacco 21 policies, which raise the minimum legal age of tobacco purchase to 21, among adults and nonsmoking...

Predictors of Treatment Referral after AUDIT-C Screening for Heavy Drinking.

Addictive disorders & their treatment

Naps MS, Maass D, Kranzler HR, Smith RV, Ingram E, Oslin DW.
PMID: 30271280
Addict Disord Their Treat. 2018 Sep;17(3):124-133. doi: 10.1097/ADT.0000000000000134.

OBJECTIVES: The Veterans Health Administration has implemented annual screening for heavy drinking during primary care encounters using the 3-item Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) questionnaire and made specialized services available to patients with alcohol use disorders...

An Interpersonal Model of Addiction Relapse.

Addictive disorders & their treatment

Leach D, Kranzler HR.
PMID: 24489485
Addict Disord Their Treat. 2013 Dec;12(4):183-192. doi: 10.1097/ADT.0b013e31826ac408.

In this article, we review the literature on interpersonal stress and rejection sensitivity and examine how these factors increase the risk of relapse in individuals with alcohol or drug dependence. We begin by considering the constructs of social pain...

How Should Addiction-Related Research at the National Institutes of Health be Reorganized?.

Frontiers in psychiatry

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD.
PMID: 21629835
Front Psychiatry. 2011 May 03;2:2. doi: 10.3389/fpsyt.2011.00002. eCollection 2011.

No abstract available.

Showing 1 to 12 of 64 entries