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Showing 1 to 12 of 29 entries
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Growing the path to the patient: an editorial outlook for Alternative therapies.

Alternative therapies in health and medicine

Krucoff MW.
PMID: 10895511
Altern Ther Health Med. 2000 Jul;6(4):36-7.

No abstract available.

Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms.

Therapeutic innovation & regulatory science

Sabol ME, Finkle J, Krucoff M, Stockbridge N, Parkhill N, Shinagawa K, Mahaffey K, Tcheng J, Lenihan D, Melloni C, Todaro T, Michelson E, Munley J, Zander J, Oh R.
PMID: 30222439
Ther Innov Regul Sci. 2015 Jul;49(4):511-513. doi: 10.1177/2168479014567319.

Detection of off-target cardiovascular (CV) effects remains a significant challenge to drug development. Documentation of CV events in non-CV trials is often inadequate to interpret imbalances between treatment arms, which may lead to concerns about potential CV safety "signals."...

Definitions and Clinical Trial Design Principles for Coronary Artery Chronic Total Occlusion Therapies: CTO-ARC Consensus Recommendations.

Circulation

Ybarra LF, Rinfret S, Brilakis ES, Karmpaliotis D, Azzalini L, Grantham JA, Kandzari DE, Mashayekhi K, Spratt JC, Wijeysundera HC, Ali ZA, Buller CE, Carlino M, Cohen DJ, Cutlip DE, De Martini T, Di Mario C, Farb A, Finn AV, Galassi AR, Gibson CM, Hanratty C, Hill JM, Jaffer FA, Krucoff MW, Lombardi WL, Maehara A, Magee PFA, Mehran R, Moses JW, Nicholson WJ, Onuma Y, Sianos G, Sumitsuji S, Tsuchikane E, Virmani R, Walsh SJ, Werner GS, Yamane M, Stone GW, Rinfret S, Stone GW.
PMID: 33523728
Circulation. 2021 Feb 02;143(5):479-500. doi: 10.1161/CIRCULATIONAHA.120.046754. Epub 2021 Feb 01.

Over the past 2 decades, chronic total occlusion (CTO) percutaneous coronary intervention has developed into its own subspecialty of interventional cardiology. Dedicated terminology, techniques, devices, courses, and training programs have enabled progressive advancements. However, only a few randomized trials...

Understanding Variable Motor Responses to Direct Electrical Stimulation of the Human Motor Cortex During Brain Surgery.

Frontiers in surgery

Aaronson DM, Martinez Del Campo E, Boerger TF, Conway B, Cornell S, Tate M, Mueller WM, Chang EF, Krucoff MO.
PMID: 34660677
Front Surg. 2021 Oct 01;8:730367. doi: 10.3389/fsurg.2021.730367. eCollection 2021.

Direct electrical stimulation of the brain is the gold standard technique used to define functional-anatomical relationships during neurosurgical procedures. Areas that respond to stimulation are considered "critical nodes" of circuits that must remain intact for the subject to maintain...

Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention: TWILIGHT-HBR.

European heart journal

Escaned J, Cao D, Baber U, Nicolas J, Sartori S, Zhang Z, Dangas G, Angiolillo DJ, Briguori C, Cohen DJ, Collier T, Dudek D, Gibson M, Gil R, Huber K, Kaul U, Kornowski R, Krucoff MW, Kunadian V, Mehta S, Moliterno DJ, Ohman EM, Oldroyd KG, Sardella G, Sharma SK, Shlofmitz R, Weisz G, Witzenbichler B, Pocock S, Mehran R.
PMID: 34662382
Eur Heart J. 2021 Dec 01;42(45):4624-4634. doi: 10.1093/eurheartj/ehab702.

AIMS: Patients at high bleeding risk (HBR) represent a prevalent subgroup among those undergoing percutaneous coronary intervention (PCI). Early aspirin discontinuation after a short course of dual antiplatelet therapy (DAPT) has emerged as a bleeding avoidance strategy. The aim...

Ticagrelor Monotherapy After PCI in High-Risk Patients With Prior MI: A Prespecified TWILIGHT Substudy.

JACC. Cardiovascular interventions

Chiarito M, Baber U, Cao D, Sharma SK, Dangas G, Angiolillo DJ, Briguori C, Cohen DJ, Dudek D, Džavík V, Escaned J, Gil R, Hamm CW, Henry T, Huber K, Kastrati A, Kaul U, Kornowski R, Krucoff M, Kunadian V, Mehta SR, Moliterno D, Ohman EM, Oldroyd K, Sardella G, Zhongjie Z, Sartori S, Stefanini G, Shlofmitz R, Steg PG, Weisz G, Witzenbichler B, Han YL, Pocock S, Gibson CM, Mehran R.
PMID: 35033468
JACC Cardiovasc Interv. 2022 Jan 05; doi: 10.1016/j.jcin.2021.11.005. Epub 2022 Jan 05.

OBJECTIVES: The aim of this study was to evaluate if patients with prior myocardial infarction (MI) could benefit from ticagrelor monotherapy in terms of bleeding reduction without any compromise in ischemic event prevention.BACKGROUND: Patients with history of MI who...

Does Realism Matter? A Randomized Controlled Trial Comparing Models for Medical Student Suture Education.

Plastic and reconstructive surgery. Global open

Blau JA, Shammas RL, Anolik RA, Avashia YJ, Krucoff KB, Zenn MR.
PMID: 32440409
Plast Reconstr Surg Glob Open. 2020 Apr 22;8(4):e2738. doi: 10.1097/GOX.0000000000002738. eCollection 2020 Apr.

BACKGROUND: We hypothesized that medical students trained in suturing using high-fidelity models (cadaveric tissue) would demonstrate greater proficiency when compared with those trained using low-fidelity models (synthetic tissue).METHODS: Forty-three medical students were randomized into 2 groups. Group 1 consisted...

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.

Frontiers in neuroscience

Krucoff MO, Rahimpour S, Slutzky MW, Edgerton VR, Turner DA.
PMID: 28082858
Front Neurosci. 2016 Dec 27;10:584. doi: 10.3389/fnins.2016.00584. eCollection 2016.

After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working...

Drug eluting stents and the critical path initiative: Evolving paradigms for safety evaluation.

Drug discovery today. Technologies

Sanhai WR, Stockbridge N, Fiorentino RP, Uchida T, Uhl K, Krucoff MW.
PMID: 24980839
Drug Discov Today Technol. 2007;4(2):43-6. doi: 10.1016/j.ddtec.2007.10.004.

Recent discussions between FDA and other stakeholders have focused on the benefits and risks associated with drug eluting stents (DES). A particular topic of focus is DES thrombosis, a rare, but serious, clinical event that may occur months to...

Assessing the Risks of Bleeding vs Thrombotic Events in Patients at High Bleeding Risk After Coronary Stent Implantation: The ARC-High Bleeding Risk Trade-off Model.

JAMA cardiology

Urban P, Gregson J, Owen R, Mehran R, Windecker S, Valgimigli M, Varenne O, Krucoff M, Saito S, Baber U, Chevalier B, Capodanno D, Morice MC, Pocock S.
PMID: 33404627
JAMA Cardiol. 2021 Apr 01;6(4):410-419. doi: 10.1001/jamacardio.2020.6814.

IMPORTANCE: Patients who are candidates for percutaneous coronary intervention (PCI) and are at high bleeding risk constitute a therapeutic challenge because they often also face an increased risk of thrombotic complications.OBJECTIVES: To develop and validate models to predict the...

Japan-USA orbital atherectomy for calcific coronary lesions: COAST study, Hharmonization by Doing proof-of-concept.

Cardiovascular revascularization medicine : including molecular interventions

Martinsen BJ, Kumar K, Saito S, Sharma SK, Ikeno F, Fearnot NE, Shlofmitz RA, Thatcher R, Krucoff MW.
PMID: 34607786
Cardiovasc Revasc Med. 2021 Aug 26; doi: 10.1016/j.carrev.2021.08.021. Epub 2021 Aug 26.

Effective treatment strategies and medical devices continue to be needed in Japan and the United States of America (US) to mitigate the growing burden of cardiovascular disease and coronary heart disease. Unfortunately, there can be a delay in gaining...

Safety and Efficacy of Ticagrelor Monotherapy According to Drug-Eluting Stent Type: The TWILIGHT-STENT Study.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Dangas G, Baber U, Sharma SK, Giustino G, Sartori S, Nicolas J, Goel R, Mehta SR, Cohen DJ, Angiolillo DJ, Zhang Z, Camaj A, Cao D, Briguori C, Dudek D, Escaned J, Huber K, Collier T, Kornowski R, Kunadian V, Moliterno DJ, Ohman EM, Weisz G, Gil RJ, Krucoff MW, Kaul U, Oldroyd KG, Sardella G, Shlofmitz RA, Witzenbichler B, Kastrati A, Han Y, Steg PG, Pocock SJ, Gibson CM, Mehran R.
PMID: 34881696
EuroIntervention. 2021 Aug 26; doi: 10.4244/EIJ-D-21-00721. Epub 2021 Aug 26.

BACKGROUND: In the TWILIGHT trial, ticagrelor monotherapy after a short course of dual antiplatelet therapy (DAPT) was shown to be a safe bleeding avoidance strategy in high-risk patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES).AIMS: To evaluate...

Showing 1 to 12 of 29 entries