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Showing 1 to 12 of 26 entries
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Baseline subjective memory complaints associate with increased risk of incident dementia: the PREADVISE trial.

The journal of prevention of Alzheimer's disease

Abner EL, Kryscio RJ, Caban-Holt AM, Schmitt FA.
PMID: 26180776
J Prev Alzheimers Dis. 2015 Mar;2(1):11-16. doi: 10.14283/jpad.2015.37.

BACKGROUND: Subjective memory complaints reflect patient-identified deficits in memory and have been linked to increased risk of future dementia in nondemented (including cognitively intact) older adults.OBJECTIVES: To assess the risk of incident dementia during follow-up for participants in the...

Self-Reported Memory Complaints: A Comparison of Demented and Unimpaired Outcomes.

The journal of prevention of Alzheimer's disease

Kryscio RJ, Abner EL, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Lou W, Fardo DW, Cooper GE, Schmitt FA.
PMID: 27019842
J Prev Alzheimers Dis. 2016 Mar;3(1):13-19. doi: 10.14283/jpad.2015.74.

BACKGROUND: Subjective memory complaints are common in aged persons, indicating an increased, but incompletely understood, risk for dementia.OBJECTIVE: To compare cognitive trajectories and autopsy results of individuals with subjective complaints after stratifying by whether a subsequent clinical dementia occurred.DESIGN:...

Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer.

Journal of oncology

Hoff J, Baldwin L, Lefringhouse J, Pavlik E, Miller R, DeSimone C, Ueland F, Tucker T, Kryscio R, van Nagell JR.
PMID: 25254047
J Oncol. 2014;2014:312193. doi: 10.1155/2014/312193. Epub 2014 Sep 01.

Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and...

Letter to the Editor: Authors' Response.

Journal of periodontology

Frodge BD, Ebersole JL, Kryscio RJ, Thomas MV, Miller CS.
PMID: 29539177
J Periodontol. 2009 Oct;80(10):1566-1567. doi: 10.1902/jop.2009.090299.

No abstract available.

Estimation of Multi-state Models with Missing Covariate Values Based on Observed Data Likelihood.

Communications in statistics: theory and methods

Lou W, Abner EL, Wan L, Fardo DW, Lipton R, Katz M, Kryscio RJ.
PMID: 31649416
Commun Stat Theory Methods. 2019;48(23):5733-5747. doi: 10.1080/03610926.2018.1520884. Epub 2018 Dec 29.

Continuous-time multi-state models are commonly used to study diseases with multiple stages. Potential risk factors associated with the disease are added to the transition intensities of the model as covariates, but missing covariate measurements arise frequently in practice. We...

Brain structure changes over time in normal and mildly impaired aged persons.

AIMS neuroscience

Smith CD, Van Eldik LJ, Jicha GA, Schmitt FA, Nelson PT, Abner EL, Kryscio RJ, Murphy RR, Andersen AH.
PMID: 32607416
AIMS Neurosci. 2020 May 20;7(2):120-135. doi: 10.3934/Neuroscience.2020009. eCollection 2020.

Structural brain changes in aging are known to occur even in the absence of dementia, but the magnitudes and regions involved vary between studies. To further characterize these changes, we analyzed paired MRI images acquired with identical protocols and...

The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.

The journal of prevention of Alzheimer's disease

Kryscio RJ, Abner EL, Nelson PT, Bennett D, Schneider J, Yu L, Hemmy LS, Lim KO, Masaki K, Cairns N, Xiong C, Woltjer R, Dodge HH, Tyas S, Fardo DW, Lou W, Wan L, Schmitt FA.
PMID: 27709107
J Prev Alzheimers Dis. 2016 Jun;3(2):85-91. doi: 10.14283/jpad.2016.95.

BACKGROUND: Cerebral vascular pathology may contribute to cognitive decline experienced by some elderly near death. Given evidence for mixed neuropathologies in advanced age, preventing or reducing cerebrovascular burden in late life may be beneficial.OBJECTIVE: To correlate measures of cerebral...

Tau is reduced in AD plasma and validation of employed ELISA methods.

American journal of neurodegenerative disease

Sparks DL, Kryscio RJ, Sabbagh MN, Ziolkowski C, Lin Y, Sparks LM, Liebsack C, Johnson-Traver S.
PMID: 23383382
Am J Neurodegener Dis. 2012;1(1):99-106. Epub 2012 May 15.

OBJECTIVE: Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (MCI) and/or Alzheimer's disease...

Molecular docking simulations for macromolecularly imprinted polymers.

Industrial & engineering chemistry research

Kryscio DR, Shi Y, Ren P, Peppas NA.
PMID: 22287827
Ind Eng Chem Res. 2011 Oct 31;50(24):13877-13884. doi: 10.1021/ie201858n.

Molecularly imprinted polymers are fully synthetic antibody mimics prepared via the crosslinking of organic monomers in the presence of an analyte. This general procedure is now well developed for small molecule templates; however, attempts to extend the same techniques...

Mild cognitive impairment: statistical models of transition using longitudinal clinical data.

International journal of Alzheimer's disease

Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA.
PMID: 22536535
Int J Alzheimers Dis. 2012;2012:291920. doi: 10.1155/2012/291920. Epub 2012 Mar 25.

Mild cognitive impairment (MCI) refers to the clinical state between normal cognition and probable Alzheimer's disease (AD), but persons diagnosed with MCI may progress to non-AD forms of dementia, remain MCI until death, or recover to normal cognition. Risk...

Early age-related progression of AD-like neuropathology in Down's syndrome.

American journal of neurodegenerative disease

Sparks LD, Kryscio RJ, Hunsaker JC.
PMID: 23844336
Am J Neurodegener Dis. 2013 Jun 21;2(2):121-8. Print 2013.

We have previously reported that increased numbers of Alz-50-reactive (apoptotic) neurons occurred in young DS subjects compared to controls, but increased in density with increasing age, and in advance of identifiable senile plaques (SP) in DS. The purpose of...

Markov chains and semi-Markov models in time-to-event analysis.

Journal of biometrics & biostatistics

Abner EL, Charnigo RJ, Kryscio RJ.
PMID: 24818062
J Biom Biostat. 2013 Oct 25;19522. doi: 10.4172/2155-6180.S1-e001.

A variety of statistical methods are available to investigators for analysis of time-to-event data, often referred to as survival analysis. Kaplan-Meier estimation and Cox proportional hazards regression are commonly employed tools but are not appropriate for all studies, particularly...

Showing 1 to 12 of 26 entries