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Uncertainty transformation via Hopf bifurcation in fast-slow systems.

Proceedings. Mathematical, physical, and engineering sciences

Kuehn C.
PMID: 28484318
Proc Math Phys Eng Sci. 2017 Apr;473(2200):20160346. doi: 10.1098/rspa.2016.0346. Epub 2017 Apr 12.

Propagation of uncertainty in dynamical systems is a significant challenge. Here we focus on random multiscale ordinary differential equation models. In particular, we study Hopf bifurcation in the fast subsystem for random initial conditions. We show that a random...

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Kuehn C. Uncertainty transformation via Hopf bifurcation in fast-slow systems. Proc Math Phys Eng Sci. 2017;473(2200):20160346doi: 10.1098/rspa.2016.0346.
Kuehn, C. (2017). Uncertainty transformation via Hopf bifurcation in fast-slow systems. Proceedings. Mathematical, physical, and engineering sciences, 473(2200), 20160346. https://doi.org/10.1098/rspa.2016.0346
Kuehn, Christian. "Uncertainty transformation via Hopf bifurcation in fast-slow systems." Proceedings. Mathematical, physical, and engineering sciences vol. 473,2200 (2017): 20160346. doi: https://doi.org/10.1098/rspa.2016.0346
Kuehn C. Uncertainty transformation via Hopf bifurcation in fast-slow systems. Proc Math Phys Eng Sci. 2017 Apr;473(2200):20160346. doi: 10.1098/rspa.2016.0346. Epub 2017 Apr 12. PMID: 28484318; PMCID: PMC5415678.
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Breastfeeding, lung volumes and alveolar size at school-age.

BMJ open respiratory research

Dogaru CM, Narayanan M, Spycher BD, Pescatore AM, Owers-Bradley J, Beardsmore CS, Silverman M, Kuehni CE.
PMID: 26180638
BMJ Open Respir Res. 2015 Jul 06;2(1):e000081. doi: 10.1136/bmjresp-2015-000081. eCollection 2015.

BACKGROUND: Previous studies found larger lung volumes at school-age in formerly breastfed children, with some studies suggesting an effect modification by maternal asthma. We wanted to explore this further in children who had undergone extensive lung function testing. The...

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Dogaru CM, Narayanan M, Spycher BD, et al. Breastfeeding, lung volumes and alveolar size at school-age. BMJ Open Respir Res. 2015;2(1):e000081doi: 10.1136/bmjresp-2015-000081.
Dogaru, C. M., Narayanan, M., Spycher, B. D., Pescatore, A. M., Owers-Bradley, J., Beardsmore, C. S., Silverman, M., & Kuehni, C. E. (2015). Breastfeeding, lung volumes and alveolar size at school-age. BMJ open respiratory research, 2(1), e000081. https://doi.org/10.1136/bmjresp-2015-000081
Dogaru, Cristian M, et al. "Breastfeeding, lung volumes and alveolar size at school-age." BMJ open respiratory research vol. 2,1 (2015): e000081. doi: https://doi.org/10.1136/bmjresp-2015-000081
Dogaru CM, Narayanan M, Spycher BD, Pescatore AM, Owers-Bradley J, Beardsmore CS, Silverman M, Kuehni CE. Breastfeeding, lung volumes and alveolar size at school-age. BMJ Open Respir Res. 2015 Jul 06;2(1):e000081. doi: 10.1136/bmjresp-2015-000081. eCollection 2015. PMID: 26180638; PMCID: PMC4499711.
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Syntheses of Strychnan- and Aspidospermatan-Type Alkaloids. 9.(1) The Enantioselective Generation of Tetracyclic ABCE Intermediates by a Tandem Condensation, [3,3]-Sigmatropic Rearrangement, and Cyclization Sequence.

The Journal of organic chemistry

Kuehne ME, Xu F.
PMID: 11671897
J Org Chem. 1997 Nov 14;62(23):7950-7960. doi: 10.1021/jo970207j.

Reactions of substituted acroleins with the tryptophan-derived benzyl 2-(benzylamino)-3-[3-[2-[(methoxycarbonyl)methyl]indolyl]]propionate gave tetracyclic hexahydro-1H-pyrrolo[2,3-d] intermediates with stereoselective placement of substituents for cyclization to pentacyclic Strychnos alkaloids. The benzyl ester moiety was readily removed by formation of a corresponding nitrile and reduction,...

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Kuehne ME, Xu F. Syntheses of Strychnan- and Aspidospermatan-Type Alkaloids. 9.(1) The Enantioselective Generation of Tetracyclic ABCE Intermediates by a Tandem Condensation, [3,3]-Sigmatropic Rearrangement, and Cyclization Sequence. J Org Chem. 1997;62(23):7950-7960doi: 10.1021/jo970207j.
Kuehne, M. E., & Xu, F. (1997). Syntheses of Strychnan- and Aspidospermatan-Type Alkaloids. 9.(1) The Enantioselective Generation of Tetracyclic ABCE Intermediates by a Tandem Condensation, [3,3]-Sigmatropic Rearrangement, and Cyclization Sequence. The Journal of organic chemistry, 62(23), 7950-7960. https://doi.org/10.1021/jo970207j
Kuehne, Martin E., and Xu, Feng. "Syntheses of Strychnan- and Aspidospermatan-Type Alkaloids. 9.(1) The Enantioselective Generation of Tetracyclic ABCE Intermediates by a Tandem Condensation, [3,3]-Sigmatropic Rearrangement, and Cyclization Sequence." The Journal of organic chemistry vol. 62,23 (1997): 7950-7960. doi: https://doi.org/10.1021/jo970207j
Kuehne ME, Xu F. Syntheses of Strychnan- and Aspidospermatan-Type Alkaloids. 9.(1) The Enantioselective Generation of Tetracyclic ABCE Intermediates by a Tandem Condensation, [3,3]-Sigmatropic Rearrangement, and Cyclization Sequence. J Org Chem. 1997 Nov 14;62(23):7950-7960. doi: 10.1021/jo970207j. PMID: 11671897.
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A Biomimetic Synthesis of the Pauciflorine A and B Skeleton.

Organic letters

Kuehne ME, Li YL.
PMID: 10814255
Org Lett. 2000 Jan 13;2(1):97. doi: 10.1021/ol991235m.

No abstract available.

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Kuehne ME, Li YL. A Biomimetic Synthesis of the Pauciflorine A and B Skeleton. Org Lett. 2000;2(1):97doi: 10.1021/ol991235m.
Kuehne, M. E., & Li, Y. L. (2000). A Biomimetic Synthesis of the Pauciflorine A and B Skeleton. Organic letters, 2(1), 97. https://doi.org/10.1021/ol991235m
Kuehne, and Li. "A Biomimetic Synthesis of the Pauciflorine A and B Skeleton." Organic letters vol. 2,1 (2000): 97. doi: https://doi.org/10.1021/ol991235m
Kuehne ME, Li YL. A Biomimetic Synthesis of the Pauciflorine A and B Skeleton. Org Lett. 2000 Jan 13;2(1):97. doi: 10.1021/ol991235m. PMID: 10814255.
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NURSING FORUM.

The Journal of burn care & rehabilitation

Carrougher GJ, Kuehn CN.
PMID: 11773762
J Burn Care Rehabil. 2001 May-Jun;22(3):249. doi: 10.1097/00004630-200105000-00013.

No abstract available.

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Carrougher GJ, Kuehn CN. NURSING FORUM. J Burn Care Rehabil. 2001;22(3):249doi: 10.1097/00004630-200105000-00013.
Carrougher, G. J., & Kuehn, C. N. (2001). NURSING FORUM. The Journal of burn care & rehabilitation, 22(3), 249. https://doi.org/10.1097/00004630-200105000-00013
Carrougher, Gretchen J., and Kuehn, Candyce N.. "NURSING FORUM." The Journal of burn care & rehabilitation vol. 22,3 (2001): 249. doi: https://doi.org/10.1097/00004630-200105000-00013
Carrougher GJ, Kuehn CN. NURSING FORUM. J Burn Care Rehabil. 2001 May-Jun;22(3):249. doi: 10.1097/00004630-200105000-00013. PMID: 11773762.
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Syntheses of Strychnos and Aspidospermatan-Type Alkaloids. 8. Selective Total Syntheses of Mossambine and 14-epi-Mossambine by a Radical Cyclization Reaction(1).

The Journal of organic chemistry

Kuehne ME, Wang T, Seraphin D.
PMID: 11667746
J Org Chem. 1996 Nov 01;61(22):7873-7881. doi: 10.1021/jo961023s.

Mossambine (6) was obtained by a six-step reaction sequence from the indoloazepine ester 7. Radical cyclization of the tetracyclic vinyl iodide 12a provided a racemic pentacyclic ketone 16E, which could be converted to either enantiomer by condensation with (S...

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Kuehne ME, Wang T, Seraphin D. Syntheses of Strychnos and Aspidospermatan-Type Alkaloids. 8. Selective Total Syntheses of Mossambine and 14-epi-Mossambine by a Radical Cyclization Reaction(1). J Org Chem. 1996;61(22):7873-7881doi: 10.1021/jo961023s.
Kuehne, M. E., Wang, T., & Seraphin, D. (1996). Syntheses of Strychnos and Aspidospermatan-Type Alkaloids. 8. Selective Total Syntheses of Mossambine and 14-epi-Mossambine by a Radical Cyclization Reaction(1). The Journal of organic chemistry, 61(22), 7873-7881. https://doi.org/10.1021/jo961023s
Kuehne, Martin E., et al. "Syntheses of Strychnos and Aspidospermatan-Type Alkaloids. 8. Selective Total Syntheses of Mossambine and 14-epi-Mossambine by a Radical Cyclization Reaction(1)." The Journal of organic chemistry vol. 61,22 (1996): 7873-7881. doi: https://doi.org/10.1021/jo961023s
Kuehne ME, Wang T, Seraphin D. Syntheses of Strychnos and Aspidospermatan-Type Alkaloids. 8. Selective Total Syntheses of Mossambine and 14-epi-Mossambine by a Radical Cyclization Reaction(1). J Org Chem. 1996 Nov 01;61(22):7873-7881. doi: 10.1021/jo961023s. PMID: 11667746.
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How well are color components of samples of the Natural Color System estimated?.

Journal of the Optical Society of America. A, Optics, image science, and vision

Shamey R, Shepherd S, Abed M, Chargualaf M, Garner N, Dippel N, Weisner N, Kuehni RG.
PMID: 21979500
J Opt Soc Am A Opt Image Sci Vis. 2011 Oct 01;28(10):1962-9. doi: 10.1364/JOSAA.28.001962.

The aim of this study was to determine how accurately color-normal subjects that have received basic information about, but do not have practical experience with, the Natural Color System (NCS) can estimate the Heringian components of a representative selection...

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Shamey R, Shepherd S, Abed M, et al. How well are color components of samples of the Natural Color System estimated?. J Opt Soc Am A Opt Image Sci Vis. 2011;28(10):1962-9doi: 10.1364/JOSAA.28.001962.
Shamey, R., Shepherd, S., Abed, M., Chargualaf, M., Garner, N., Dippel, N., Weisner, N., & Kuehni, R. G. (2011). How well are color components of samples of the Natural Color System estimated?. Journal of the Optical Society of America. A, Optics, image science, and vision, 28(10), 1962-9. https://doi.org/10.1364/JOSAA.28.001962
Shamey, Renzo, et al. "How well are color components of samples of the Natural Color System estimated?." Journal of the Optical Society of America. A, Optics, image science, and vision vol. 28,10 (2011): 1962-9. doi: https://doi.org/10.1364/JOSAA.28.001962
Shamey R, Shepherd S, Abed M, Chargualaf M, Garner N, Dippel N, Weisner N, Kuehni RG. How well are color components of samples of the Natural Color System estimated?. J Opt Soc Am A Opt Image Sci Vis. 2011 Oct 01;28(10):1962-9. doi: 10.1364/JOSAA.28.001962. PMID: 21979500.
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Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study.

The Lancet. Child & adolescent health

Agyeman PKA, Schlapbach LJ, Giannoni E, Stocker M, Posfay-Barbe KM, Heininger U, Schindler M, Korten I, Konetzny G, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Baer W, Kuehni CE, Aebi C, Berger C.
PMID: 30169202
Lancet Child Adolesc Health. 2017 Oct;1(2):124-133. doi: 10.1016/S2352-4642(17)30010-X. Epub 2017 Jul 21.

BACKGROUND: Sepsis is a leading cause of childhood mortality worldwide. We assessed population-based incidence and outcomes of blood culture-proven bacterial sepsis in children in Switzerland.METHODS: We did a multicentre, prospective, cohort study at ten paediatric hospitals in Switzerland. We...

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Agyeman PKA, Schlapbach LJ, Giannoni E, et al. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Health. 2017;1(2):124-133doi: 10.1016/S2352-4642(17)30010-X.
Agyeman, P. K. A., Schlapbach, L. J., Giannoni, E., Stocker, M., Posfay-Barbe, K. M., Heininger, U., Schindler, M., Korten, I., Konetzny, G., Niederer-Loher, A., Kahlert, C. R., Donas, A., Leone, A., Hasters, P., Relly, C., Baer, W., Kuehni, C. E., Aebi, C., Berger, C. (2017). Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. The Lancet. Child & adolescent health, 1(2), 124-133. https://doi.org/10.1016/S2352-4642(17)30010-X
Agyeman, Philipp K A, et al. "Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study." The Lancet. Child & adolescent health vol. 1,2 (2017): 124-133. doi: https://doi.org/10.1016/S2352-4642(17)30010-X
Agyeman PKA, Schlapbach LJ, Giannoni E, Stocker M, Posfay-Barbe KM, Heininger U, Schindler M, Korten I, Konetzny G, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Baer W, Kuehni CE, Aebi C, Berger C. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Health. 2017 Oct;1(2):124-133. doi: 10.1016/S2352-4642(17)30010-X. Epub 2017 Jul 21. PMID: 30169202.
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Proceedings of the 4.

BMC proceedings

Gardner LE, Horton KL, Shoemark A, Lucas JS, Nielsen KG, Kobbernagel H, Rubbo B, Hirst RA, Kouis P, Ullmann N, Reula A, Rumman N, Mitchison HM, Pinto A, Richardson C, Schmidt A, Thompson J, Gaupmann R, Dabrowski M, Mill P, Carr SB, Norris DP, Kuehni CE, Goutaki M, Hogg C.
PMID: 32577127
BMC Proc. 2020 Jun 19;14:7. doi: 10.1186/s12919-020-00191-3. eCollection 2020.

Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and

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Gardner LE, Horton KL, Shoemark A, et al. Proceedings of the 4. BMC Proc. 2020;14:7doi: 10.1186/s12919-020-00191-3.
Gardner, L. E., Horton, K. L., Shoemark, A., Lucas, J. S., Nielsen, K. G., Kobbernagel, H., Rubbo, B., Hirst, R. A., Kouis, P., Ullmann, N., Reula, A., Rumman, N., Mitchison, H. M., Pinto, A., Richardson, C., Schmidt, A., Thompson, J., Gaupmann, R., Dabrowski, M., Mill, P., Carr, S. B., Norris, D. P., Kuehni, C. E., Goutaki, M., & Hogg, C. (2020). Proceedings of the 4. BMC proceedings, 147. https://doi.org/10.1186/s12919-020-00191-3
Gardner, Laura E, et al. "Proceedings of the 4." BMC proceedings vol. 14 (2020): 7. doi: https://doi.org/10.1186/s12919-020-00191-3
Gardner LE, Horton KL, Shoemark A, Lucas JS, Nielsen KG, Kobbernagel H, Rubbo B, Hirst RA, Kouis P, Ullmann N, Reula A, Rumman N, Mitchison HM, Pinto A, Richardson C, Schmidt A, Thompson J, Gaupmann R, Dabrowski M, Mill P, Carr SB, Norris DP, Kuehni CE, Goutaki M, Hogg C. Proceedings of the 4. BMC Proc. 2020 Jun 19;14:7. doi: 10.1186/s12919-020-00191-3. eCollection 2020. PMID: 32577127; PMCID: PMC7304082.
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Dynamics of respiratory symptoms during infancy and associations with wheezing at school age.

ERJ open research

Usemann J, Xu B, Delgado-Eckert E, Korten I, Anagnostopoulou P, Gorlanova O, Kuehni C, Röösli M, Latzin P, Frey U.
PMID: 30474038
ERJ Open Res. 2018 Nov 20;4(4). doi: 10.1183/23120541.00037-2018. eCollection 2018 Oct.

Children with frequent respiratory symptoms in infancy have an increased risk for later wheezing, but the association with symptom dynamics is unknown. We developed an observer-independent method to characterise symptom dynamics and tested their association with subsequent respiratory morbidity....

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Usemann J, Xu B, Delgado-Eckert E, et al. Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ Open Res. 2018;4(4)doi: 10.1183/23120541.00037-2018.
Usemann, J., Xu, B., Delgado-Eckert, E., Korten, I., Anagnostopoulou, P., Gorlanova, O., Kuehni, C., Röösli, M., Latzin, P., & Frey, U. (2018). Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ open research, 4(4), . https://doi.org/10.1183/23120541.00037-2018
Usemann, Jakob, et al. "Dynamics of respiratory symptoms during infancy and associations with wheezing at school age." ERJ open research vol. 4,4 (2018). doi: https://doi.org/10.1183/23120541.00037-2018
Usemann J, Xu B, Delgado-Eckert E, Korten I, Anagnostopoulou P, Gorlanova O, Kuehni C, Röösli M, Latzin P, Frey U. Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ Open Res. 2018 Nov 20;4(4). doi: 10.1183/23120541.00037-2018. eCollection 2018 Oct. PMID: 30474038; PMCID: PMC6243079.
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Responsive Contrast Agents: Synthesis and Characterization of a Tunable Series of pH-Sensitive Near-Infrared Pentamethines.

ACS omega

Wycisk V, Achazi K, Hillmann P, Hirsch O, Kuehne C, Dernedde J, Haag R, Licha K.
PMID: 30023492
ACS Omega. 2016 Nov 30;1(5):808-817. doi: 10.1021/acsomega.6b00182. Epub 2016 Nov 04.

The demand for responsive dyes in optical imaging is high to achieve a better signal-to-noise ratio and, more specifically, to visualize acidic compartments of the endocytic pathway. Herein, we present a new synthetic route, with a step-by-step synthesis of...

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Wycisk V, Achazi K, Hillmann P, et al. Responsive Contrast Agents: Synthesis and Characterization of a Tunable Series of pH-Sensitive Near-Infrared Pentamethines. ACS Omega. 2016;1(5):808-817doi: 10.1021/acsomega.6b00182.
Wycisk, V., Achazi, K., Hillmann, P., Hirsch, O., Kuehne, C., Dernedde, J., Haag, R., & Licha, K. (2016). Responsive Contrast Agents: Synthesis and Characterization of a Tunable Series of pH-Sensitive Near-Infrared Pentamethines. ACS omega, 1(5), 808-817. https://doi.org/10.1021/acsomega.6b00182
Wycisk, Virginia, et al. "Responsive Contrast Agents: Synthesis and Characterization of a Tunable Series of pH-Sensitive Near-Infrared Pentamethines." ACS omega vol. 1,5 (2016): 808-817. doi: https://doi.org/10.1021/acsomega.6b00182
Wycisk V, Achazi K, Hillmann P, Hirsch O, Kuehne C, Dernedde J, Haag R, Licha K. Responsive Contrast Agents: Synthesis and Characterization of a Tunable Series of pH-Sensitive Near-Infrared Pentamethines. ACS Omega. 2016 Nov 30;1(5):808-817. doi: 10.1021/acsomega.6b00182. Epub 2016 Nov 04. PMID: 30023492; PMCID: PMC6044694.
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Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome.

Critical care medicine

Seeliger B, Doebler M, Hofmaenner DA, Wendel-Garcia PD, Schuepbach RA, Schmidt JJ, Welte T, Hoeper MM, Gillmann HJ, Kuehn C, Ehrentraut SF, Schewe JC, Putensen C, Stahl K, Bode C, David S.
PMID: 35020672
Crit Care Med. 2022 Jan 12; doi: 10.1097/CCM.0000000000005441. Epub 2022 Jan 12.

OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) is a potentially lifesaving procedure in acute respiratory distress syndrome (ARDS) due to COVID-19. Previous studies have shown a high prevalence of clinically silent cerebral microbleeds in patients with COVID-19. Based on this fact,...

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Seeliger B, Doebler M, Hofmaenner DA, et al. Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome. Crit Care Med. 2022;doi: 10.1097/CCM.0000000000005441.
Seeliger, B., Doebler, M., Hofmaenner, D. A., Wendel-Garcia, P. D., Schuepbach, R. A., Schmidt, J. J., Welte, T., Hoeper, M. M., Gillmann, H. J., Kuehn, C., Ehrentraut, S. F., Schewe, J. C., Putensen, C., Stahl, K., Bode, C., & David, S. (2022). Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome. Critical care medicine, . https://doi.org/10.1097/CCM.0000000000005441
Seeliger, Benjamin, et al. "Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome." Critical care medicine vol. (2022). doi: https://doi.org/10.1097/CCM.0000000000005441
Seeliger B, Doebler M, Hofmaenner DA, Wendel-Garcia PD, Schuepbach RA, Schmidt JJ, Welte T, Hoeper MM, Gillmann HJ, Kuehn C, Ehrentraut SF, Schewe JC, Putensen C, Stahl K, Bode C, David S. Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome. Crit Care Med. 2022 Jan 12; doi: 10.1097/CCM.0000000000005441. Epub 2022 Jan 12. PMID: 35020672.
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