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Showing 1 to 12 of 32 entries
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Overexpression of KIR inhibitory ligands (HLA-I) determines that immunosurveillance of myeloma depends on diverse and strong NK cell licensing.

Oncoimmunology

Martínez-Sánchez MV, Periago A, Legaz I, Gimeno L, Mrowiec A, Montes-Barqueros NR, Campillo JA, Bolarin JM, Bernardo MV, López-Álvarez MR, González C, García-Garay MC, Muro M, Cabañas-Perianes V, Fuster JL, García-Alonso AM, Moraleda JM, Álvarez-Lopez MR, Minguela A.
PMID: 27141379
Oncoimmunology. 2015 Oct 29;5(4):e1093721. doi: 10.1080/2162402X.2015.1093721. eCollection 2016 Apr.

Missing self recognition makes cancer sensitive to natural killer cell (NKc) reactivity. However, this model disregards the NKc licensing effect, which highly increases NKc reactivity through interactions of inhibitory killer cell immunoglobulin-like receptors (iKIR) with their cognate HLA-I ligands....

Using a trichromatic CCD camera for spectral skylight estimation.

Applied optics

López-Alvarez MA, Hernández-Andrés J, Romero J, Olmo FJ, Cazorla A, Alados-Arboledas L.
PMID: 19037348
Appl Opt. 2008 Dec 01;47(34):H31-8. doi: 10.1364/ao.47.000h31.

In a previous work [J. Opt. Soc. Am. A 24, 942-956 (2007)] we showed how to design an optimum multispectral system aimed at spectral recovery of skylight. Since high-resolution multispectral images of skylight could be interesting for many scientific...

NKG2D Polymorphism in Melanoma Patients from Southeastern Spain.

Cancers

Gimeno L, Martínez-Banaclocha H, Bernardo MV, Bolarin JM, Marín L, López-Hernández R, López-Alvarez MR, Moya-Quiles MR, Muro M, Frias-Iniesta JF, Martínez-Escribano J, Alvarez-López MR, Minguela A, Campillo JA.
PMID: 30925758
Cancers (Basel). 2019 Mar 28;11(4). doi: 10.3390/cancers11040438.

BACKGROUND: Natural killer (NK) and CD8+ T cells are involved in the immune response against melanoma. C-Type lectin-like NK cell receptors are located in the Natural Killer Complex (NKC) region 12p13.2-p12.3 and play a critical role in regulating the...

Frailty Assessment in a Cohort of Elderly Patients with Severe Symptomatic Aortic Stenosis: Insights from the FRailty Evaluation in Severe Aortic Stenosis (FRESAS) Registry.

Journal of clinical medicine

Solla-Suárez P, Avanzas P, Pascual I, Bermúdez-Menéndez De La Granda M, Almendarez M, Arche-Coto JM, Hernández-Vaquero D, Lorca R, López-Álvarez E, Álvarez-Velasco R, Moreno-Planillo C, Morís de la Tassa C, Gutiérrez-Rodríguez J.
PMID: 34071871
J Clin Med. 2021 May 27;10(11). doi: 10.3390/jcm10112345.

BACKGROUND: Precise evaluation of the degree of frailty is a fundamental part of the global geriatric assessment that helps to avoid therapies that could be futile. Our main objective was to determine the prevalence of frailty in a specific...

CHROME Criteria and Quality of Life: A Pilot Study from Maria Wolff-Albertia.

Journal of Alzheimer's disease reports

Muñiz R, López-Álvarez J, Perea L, Rivera S, González L, Olazarán J.
PMID: 34632299
J Alzheimers Dis Rep. 2021 Aug 06;5(1):613-624. doi: 10.3233/ADR-210015. eCollection 2021.

BACKGROUND: Over- and potentially inappropriate prescribing of psychotropic medications is a major public health concern among people with dementia.OBJECTIVE: Describe the METHODS: Observational, prospective, two-wave study conducted in two nursing homes. A multicomponent program to eliminate chemical restraints and...

Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats.

Biology open

López-Álvarez GS, Wojdacz TK, García-Cuellar CM, Monroy-Ramírez HC, Rodríguez-Segura MA, Pacheco-Rivera RA, Valencia-Antúnez CA, Cervantes-Anaya N, Soto-Reyes E, Vásquez-Garzón VR, Sánchez-Pérez Y, Villa-Treviño S.
PMID: 27895046
Biol Open. 2017 Jan 15;6(1):59-70. doi: 10.1242/bio.020370.

The association between the downregulation of genes and DNA methylation in their CpG islands has been extensively studied as a mechanism that favors carcinogenesis. The objective of this study was to analyze the methylation of a set of genes...

The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease.

Frontiers in aging neuroscience

Olazarán J, Valentí M, Frades B, Zea-Sevilla MA, Ávila-Villanueva M, Fernández-Blázquez MÁ, Calero M, Dobato JL, Hernández-Tamames JA, León-Salas B, Agüera-Ortiz L, López-Álvarez J, Larrañaga P, Bielza C, Álvarez-Linera J, Martínez-Martín P.
PMID: 26483681
Front Aging Neurosci. 2015 Sep 30;7:181. doi: 10.3389/fnagi.2015.00181. eCollection 2015.

INTRODUCTION: Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms of late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations of variables from several domains (i.e.,...

Depression in the Elderly. Consensus Statement of the Spanish Psychogeriatric Association.

Frontiers in psychiatry

Agüera-Ortiz L, Claver-Martín MD, Franco-Fernández MD, López-Álvarez J, Martín-Carrasco M, Ramos-García MI, Sánchez-Pérez M.
PMID: 32508684
Front Psychiatry. 2020 May 20;11:380. doi: 10.3389/fpsyt.2020.00380. eCollection 2020.

INTRODUCTION: Present knowledge about depression in the elderly is still scarce and often controversial, despite its high frequency and impact. This article reports the results and most relevant conclusions of a Delphi-based consensus on geriatric depression promoted by the...

The Immunity Gap Challenge: Protection against a Recent Florida Clade 2 Equine Influenza Strain.

Vaccines

Paillot R, Garrett D, Lopez-Alvarez MR, Birand I, Montesso F, Horspool L.
PMID: 30004410
Vaccines (Basel). 2018 Jul 02;6(3). doi: 10.3390/vaccines6030038.

Vaccination is one of the most effective tools for limiting the impact of equine influenza (EI). The humoral immunity established following a primary vaccination course can decrease significantly between the second (V2) and third immunisations (V3), leaving some horses...

Ultrasound-guided pediatric vascular cannulation by inexperienced operators: outcomes in a training model.

Journal of ultrasound

López-Álvarez JM, Pérez-Quevedo O, Naya-Esteban J, Ramirez-Lorenzo T, Falcón-González JC, Lorenzo-Villegas DL.
PMID: 33948886
J Ultrasound. 2021 May 04; doi: 10.1007/s40477-021-00585-9. Epub 2021 May 04.

OBJECTIVE: To present the results of an ultrasound vascular cannulation (UGVC) training program for inexperienced operators using a training model.METHOD: This was a descriptive observational study developed in the paediatric intensive care unit (PICU) of a third-level hospital. Operators...

[Medical consultation: problems and solutions].

Medicina clinica

Montero Ruiz E, López-Álvarez J.
PMID: 19767026
Med Clin (Barc). 2011 Apr 23;136(11):488-90. doi: 10.1016/j.medcli.2009.06.039. Epub 2009 Sep 20.

No abstract available.

Early-Onset Dementia Associated with a Heterozygous, Nonsense, and de novo Variant in the MBD5 Gene.

Journal of Alzheimer's disease : JAD

González-Ortega G, Llamas-Velasco S, Arteche-López A, Quesada-Espinosa JF, Puertas-Martín V, Gómez-Grande A, López-Álvarez J, Saiz Díaz RA, Lezana-Rosales JM, Villarejo-Galende A, González de la Aleja J.
PMID: 34459404
J Alzheimers Dis. 2021;84(1):73-78. doi: 10.3233/JAD-210648.

The haploinsufficiency of the methyl-binding domain protein 5 (MBD5) gene has been identified as the determinant cause of the neuropsychiatric disorders grouped under the name MBD5-neurodevelopment disorders (MAND). MAND includes patients with intellectual disability, behavioral problems, and seizures with...

Showing 1 to 12 of 32 entries