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Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?.

Infectious diseases in obstetrics and gynecology

Watson WJ, Awadallah S, Jaqua MJ.
PMID: 18476025
Infect Dis Obstet Gynecol. 1995;3(2):79-81. doi: 10.1155/S1064744995000366.

BACKGROUND: Although maternal infections with coxsackievirus during pregnancy are relatively common, fetal infections are quite rare. Coxsackievirus infection in utero has been associated with myocarditis, but has not been proven a teratogen.CASE: A patient whose fetus had structural cardiac...

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Watson WJ, Awadallah S, Jaqua MJ. Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?. Infect Dis Obstet Gynecol. 1995;3(2):79-81doi: 10.1155/S1064744995000366.
Watson, W. J., Awadallah, S., & Jaqua, M. J. (1995). Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?. Infectious diseases in obstetrics and gynecology, 3(2), 79-81. https://doi.org/10.1155/S1064744995000366
Watson, W J, et al. "Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?." Infectious diseases in obstetrics and gynecology vol. 3,2 (1995): 79-81. doi: https://doi.org/10.1155/S1064744995000366
Watson WJ, Awadallah S, Jaqua MJ. Intrauterine infection with coxsackievirus: is it a cause of congenital cardiac malformations?. Infect Dis Obstet Gynecol. 1995;3(2):79-81. doi: 10.1155/S1064744995000366. PMID: 18476025; PMCID: PMC2364419.
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Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma.

The journal of allergy and clinical immunology. In practice

Porsbjerg CM, Menzies-Gow AN, Tran TN, Murray RB, Unni B, Audrey Ang SL, Alacqua M, Al-Ahmad M, Al-Lehebi R, Altraja A, Belevskiy AS, Björnsdóttir US, Bourdin A, Busby J, Canonica GW, Christoff GC, Cosio BG, Costello RW, FitzGerald JM, Fonseca JA, Hansen S, Heaney LG, Heffler E, Hew M, Iwanaga T, Jackson DJ, Kocks JWH, Kallieri M, Bruce Ko HK, Koh MS, Larenas-Linnemann D, Lehtimäki LA, Loukides S, Lugogo N, Maspero J, Papaioannou AI, Perez-de-Llano L, Pitrez PM, Popov TA, Rasmussen LM, Rhee CK, Sadatsafavi M, Schmid J, Siddiqui S, Taillé C, Taube C, Torres-Duque CA, Ulrik C, Upham JW, Wang E, Wechsler ME, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, Hosseini N, Rowlands MA, Price D, van Boven JF.
PMID: 34990866
J Allergy Clin Immunol Pract. 2022 Jan 03; doi: 10.1016/j.jaip.2021.12.027. Epub 2022 Jan 03.

BACKGROUND: Regulatory bodies have approved five biologics for severe asthma. However, regional differences in accessibility may limit the global potential for personalized medicine.OBJECTIVE: To compare global differences in ease-of-access to biologics.METHODS: In April 2021, national prescription criteria for omalizumab,...

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Porsbjerg CM, Menzies-Gow AN, Tran TN, et al. Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma. J Allergy Clin Immunol Pract. 2022;doi: 10.1016/j.jaip.2021.12.027.
Porsbjerg, C. M., Menzies-Gow, A. N., Tran, T. N., Murray, R. B., Unni, B., Audrey Ang, S. L., Alacqua, M., Al-Ahmad, M., Al-Lehebi, R., Altraja, A., Belevskiy, A. S., Björnsdóttir, U. S., Bourdin, A., Busby, J., Canonica, G. W., Christoff, G. C., Cosio, B. G., Costello, R. W., FitzGerald, J. M., Fonseca, J. A., Hansen, S., Heaney, L. G., Heffler, E., Hew, M., Iwanaga, T., Jackson, D. J., Kocks, J. W. H., Kallieri, M., Bruce Ko, H. K., Koh, M. S., Larenas-Linnemann, D., Lehtimäki, L. A., Loukides, S., Lugogo, N., Maspero, J., Papaioannou, A. I., Perez-de-Llano, L., Pitrez, P. M., Popov, T. A., Rasmussen, L. M., Rhee, C. K., Sadatsafavi, M., Schmid, J., Siddiqui, S., Taillé, C., Taube, C., Torres-Duque, C. A., Ulrik, C., Upham, J. W., Wang, E., Wechsler, M. E., Bulathsinhala, L., Carter, V., Chaudhry, I., Eleangovan, N., Hosseini, N., Rowlands, M. A., Price, D., & van Boven, J. F. (2022). Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma. The journal of allergy and clinical immunology. In practice, . https://doi.org/10.1016/j.jaip.2021.12.027
Porsbjerg, Celeste M, et al. "Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma." The journal of allergy and clinical immunology. In practice vol. (2022). doi: https://doi.org/10.1016/j.jaip.2021.12.027
Porsbjerg CM, Menzies-Gow AN, Tran TN, Murray RB, Unni B, Audrey Ang SL, Alacqua M, Al-Ahmad M, Al-Lehebi R, Altraja A, Belevskiy AS, Björnsdóttir US, Bourdin A, Busby J, Canonica GW, Christoff GC, Cosio BG, Costello RW, FitzGerald JM, Fonseca JA, Hansen S, Heaney LG, Heffler E, Hew M, Iwanaga T, Jackson DJ, Kocks JWH, Kallieri M, Bruce Ko HK, Koh MS, Larenas-Linnemann D, Lehtimäki LA, Loukides S, Lugogo N, Maspero J, Papaioannou AI, Perez-de-Llano L, Pitrez PM, Popov TA, Rasmussen LM, Rhee CK, Sadatsafavi M, Schmid J, Siddiqui S, Taillé C, Taube C, Torres-Duque CA, Ulrik C, Upham JW, Wang E, Wechsler ME, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, Hosseini N, Rowlands MA, Price D, van Boven JF. Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma. J Allergy Clin Immunol Pract. 2022 Jan 03; doi: 10.1016/j.jaip.2021.12.027. Epub 2022 Jan 03. PMID: 34990866.
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Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort.

Chest

Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Koh MS, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB.
PMID: 33887242
Chest. 2021 Sep;160(3):814-830. doi: 10.1016/j.chest.2021.04.013. Epub 2021 Apr 19.

BACKGROUND: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts.RESEARCH QUESTION: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these...

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Heaney LG, Perez de Llano L, Al-Ahmad M, et al. Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest. 2021;160(3):814-830doi: 10.1016/j.chest.2021.04.013.
Heaney, L. G., Perez de Llano, L., Al-Ahmad, M., Backer, V., Busby, J., Canonica, G. W., Christoff, G. C., Cosio, B. G., FitzGerald, J. M., Heffler, E., Iwanaga, T., Jackson, D. J., Menzies-Gow, A. N., Papadopoulos, N. G., Papaioannou, A. I., Pfeffer, P. E., Popov, T. A., Porsbjerg, C. M., Rhee, C. K., Sadatsafavi, M., Tohda, Y., Wang, E., Wechsler, M. E., Alacqua, M., Altraja, A., Bjermer, L., Björnsdóttir, U. S., Bourdin, A., Brusselle, G. G., Buhl, R., Costello, R. W., Hew, M., Koh, M. S., Lehmann, S., Lehtimäki, L., Peters, M., Taillé, C., Taube, C., Tran, T. N., Zangrilli, J., Bulathsinhala, L., Carter, V. A., Chaudhry, I., Eleangovan, N., Hosseini, N., Kerkhof, M., Murray, R. B., Price, C. A., & Price, D. B. (2021). Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest, 160(3), 814-830. https://doi.org/10.1016/j.chest.2021.04.013
Heaney, Liam G, et al. "Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort." Chest vol. 160,3 (2021): 814-830. doi: https://doi.org/10.1016/j.chest.2021.04.013
Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Koh MS, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB. Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest. 2021 Sep;160(3):814-830. doi: 10.1016/j.chest.2021.04.013. Epub 2021 Apr 19. PMID: 33887242.
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Effect of surface stress on the stiffness of cantilever plates.

Physical review letters

Lachut MJ, Sader JE.
PMID: 18233163
Phys Rev Lett. 2007 Nov 16;99(20):206102. doi: 10.1103/PhysRevLett.99.206102. Epub 2007 Nov 15.

Measurements over the past 30 years have indicated that surface stress can significantly affect the stiffness of microcantilever plates. Several one-dimensional models based on beam theory have been proposed to explain this phenomenon, but are found to be in...

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Lachut MJ, Sader JE. Effect of surface stress on the stiffness of cantilever plates. Phys Rev Lett. 2007;99(20):206102doi: 10.1103/PhysRevLett.99.206102.
Lachut, M. J., & Sader, J. E. (2007). Effect of surface stress on the stiffness of cantilever plates. Physical review letters, 99(20), 206102. https://doi.org/10.1103/PhysRevLett.99.206102
Lachut, Michael J, and Sader, John E. "Effect of surface stress on the stiffness of cantilever plates." Physical review letters vol. 99,20 (2007): 206102. doi: https://doi.org/10.1103/PhysRevLett.99.206102
Lachut MJ, Sader JE. Effect of surface stress on the stiffness of cantilever plates. Phys Rev Lett. 2007 Nov 16;99(20):206102. doi: 10.1103/PhysRevLett.99.206102. Epub 2007 Nov 15. PMID: 18233163.
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Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD.

ERJ open research

Karlsson N, Atkinson MJ, Müllerová H, Alacqua M, Keen C, Hughes R, Janson C, Make B, Price D, Reddel HK.
PMID: 33569501
ERJ Open Res. 2021 Feb 01;7(1). doi: 10.1183/23120541.00828-2020. eCollection 2021 Jan.

BACKGROUND: The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in...

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Karlsson N, Atkinson MJ, Müllerová H, et al. Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD. ERJ Open Res. 2021;7(1)doi: 10.1183/23120541.00828-2020.
Karlsson, N., Atkinson, M. J., Müllerová, H., Alacqua, M., Keen, C., Hughes, R., Janson, C., Make, B., Price, D., & Reddel, H. K. (2021). Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD. ERJ open research, 7(1), . https://doi.org/10.1183/23120541.00828-2020
Karlsson, Niklas, et al. "Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD." ERJ open research vol. 7,1 (2021). doi: https://doi.org/10.1183/23120541.00828-2020
Karlsson N, Atkinson MJ, Müllerová H, Alacqua M, Keen C, Hughes R, Janson C, Make B, Price D, Reddel HK. Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD. ERJ Open Res. 2021 Feb 01;7(1). doi: 10.1183/23120541.00828-2020. eCollection 2021 Jan. PMID: 33569501; PMCID: PMC7861031.
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Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators.

Frontiers in molecular neuroscience

Holford M, Auer S, Laqua M, Ibañez-Tallon I.
PMID: 19915728
Front Mol Neurosci. 2009 Oct 30;2:21. doi: 10.3389/neuro.02.021.2009. eCollection 2009.

Neuronal circuits depend on the precise regulation of cell-surface receptors and ion channels. An ongoing challenge in neuroscience research is deciphering the functional contribution of specific receptors and ion channels using engineered modulators. A novel strategy, termed "tethered toxins",...

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Holford M, Auer S, Laqua M, et al. Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Front Mol Neurosci. 2009;2:21doi: 10.3389/neuro.02.021.2009.
Holford, M., Auer, S., Laqua, M., & Ibañez-Tallon, I. (2009). Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Frontiers in molecular neuroscience, 221. https://doi.org/10.3389/neuro.02.021.2009
Holford, Mandë, et al. "Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators." Frontiers in molecular neuroscience vol. 2 (2009): 21. doi: https://doi.org/10.3389/neuro.02.021.2009
Holford M, Auer S, Laqua M, Ibañez-Tallon I. Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Front Mol Neurosci. 2009 Oct 30;2:21. doi: 10.3389/neuro.02.021.2009. eCollection 2009. PMID: 19915728; PMCID: PMC2776481.
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Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort.

Chest

Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Koh MS, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB.
PMID: 33887242
Chest. 2021 Sep;160(3):814-830. doi: 10.1016/j.chest.2021.04.013. Epub 2021 Apr 19.

BACKGROUND: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts.RESEARCH QUESTION: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these...

Cite
Heaney LG, Perez de Llano L, Al-Ahmad M, et al. Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest. 2021;160(3):814-830doi: 10.1016/j.chest.2021.04.013.
Heaney, L. G., Perez de Llano, L., Al-Ahmad, M., Backer, V., Busby, J., Canonica, G. W., Christoff, G. C., Cosio, B. G., FitzGerald, J. M., Heffler, E., Iwanaga, T., Jackson, D. J., Menzies-Gow, A. N., Papadopoulos, N. G., Papaioannou, A. I., Pfeffer, P. E., Popov, T. A., Porsbjerg, C. M., Rhee, C. K., Sadatsafavi, M., Tohda, Y., Wang, E., Wechsler, M. E., Alacqua, M., Altraja, A., Bjermer, L., Björnsdóttir, U. S., Bourdin, A., Brusselle, G. G., Buhl, R., Costello, R. W., Hew, M., Koh, M. S., Lehmann, S., Lehtimäki, L., Peters, M., Taillé, C., Taube, C., Tran, T. N., Zangrilli, J., Bulathsinhala, L., Carter, V. A., Chaudhry, I., Eleangovan, N., Hosseini, N., Kerkhof, M., Murray, R. B., Price, C. A., & Price, D. B. (2021). Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest, 160(3), 814-830. https://doi.org/10.1016/j.chest.2021.04.013
Heaney, Liam G, et al. "Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort." Chest vol. 160,3 (2021): 814-830. doi: https://doi.org/10.1016/j.chest.2021.04.013
Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Koh MS, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB. Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort. Chest. 2021 Sep;160(3):814-830. doi: 10.1016/j.chest.2021.04.013. Epub 2021 Apr 19. PMID: 33887242.
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DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution.

Genome research

Elacqua JJ, Ranu N, DiIorio SE, Blainey PC.
PMID: 33355294
Genome Res. 2021 Jan;31(1):75-87. doi: 10.1101/gr.265223.120. Epub 2020 Dec 21.

DNA single-strand breaks (SSBs), or "nicks," are the most common form of DNA damage. Oxidative stress, endogenous enzyme activities, and other processes cause tens of thousands of nicks per cell per day. Accumulation of nicks, caused by high rates...

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Elacqua JJ, Ranu N, DiIorio SE, et al. DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution. Genome Res. 2020;31(1):75-87doi: 10.1101/gr.265223.120.
Elacqua, J. J., Ranu, N., DiIorio, S. E., & Blainey, P. C. (2021). DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution. Genome research, 31(1), 75-87. https://doi.org/10.1101/gr.265223.120
Elacqua, Joshua J, et al. "DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution." Genome research vol. 31,1 (2021): 75-87. doi: https://doi.org/10.1101/gr.265223.120
Elacqua JJ, Ranu N, DiIorio SE, Blainey PC. DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution. Genome Res. 2021 Jan;31(1):75-87. doi: 10.1101/gr.265223.120. Epub 2020 Dec 21. PMID: 33355294; PMCID: PMC7849381.
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Blood eosinophil count predicts treatment failure and hospital readmission for COPD.

ERJ open research

Kerkhof M, Chaudhry I, Pavord ID, Miravitlles M, Kook Rhee C, Halpin DMG, Usmani OS, Jones R, Kocks J, Alacqua M, Morris T, Kaplan A, Price DB.
PMID: 33693048
ERJ Open Res. 2020 Nov 10;6(4). doi: 10.1183/23120541.00188-2020. eCollection 2020 Oct.

We examined associations between blood eosinophil counts (BEC) and risk of treatment failure or hospital readmission following acute oral corticosteroid (OCS)-treated COPD exacerbations. We conducted studies from the Optimum Patient Care Research Database (OPCRD) (www.optimumpatientcare.org/opcrd) and Clinical Practice Research...

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Kerkhof M, Chaudhry I, Pavord ID, et al. Blood eosinophil count predicts treatment failure and hospital readmission for COPD. ERJ Open Res. 2020;6(4)doi: 10.1183/23120541.00188-2020.
Kerkhof, M., Chaudhry, I., Pavord, I. D., Miravitlles, M., Kook Rhee, C., Halpin, D. M. G., Usmani, O. S., Jones, R., Kocks, J., Alacqua, M., Morris, T., Kaplan, A., & Price, D. B. (2020). Blood eosinophil count predicts treatment failure and hospital readmission for COPD. ERJ open research, 6(4), . https://doi.org/10.1183/23120541.00188-2020
Kerkhof, Marjan, et al. "Blood eosinophil count predicts treatment failure and hospital readmission for COPD." ERJ open research vol. 6,4 (2020). doi: https://doi.org/10.1183/23120541.00188-2020
Kerkhof M, Chaudhry I, Pavord ID, Miravitlles M, Kook Rhee C, Halpin DMG, Usmani OS, Jones R, Kocks J, Alacqua M, Morris T, Kaplan A, Price DB. Blood eosinophil count predicts treatment failure and hospital readmission for COPD. ERJ Open Res. 2020 Nov 10;6(4). doi: 10.1183/23120541.00188-2020. eCollection 2020 Oct. PMID: 33693048; PMCID: PMC7927786.
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