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Showing 1 to 12 of 15 entries
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Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease.

Journal of Parkinson's disease

Picillo M, LaFontant DE, Bressman S, Caspell-Garcia C, Coffey C, Cho HR, Burghardt EL, Dahodwala N, Sanders-Pullman R, Tanner CM, Amara AW.
PMID: 34744052
J Parkinsons Dis. 2021 Nov 04; doi: 10.3233/JPD-212892. Epub 2021 Nov 04.

BACKGROUND: Investigation of sex-related motor and non-motor differences and biological markers in Parkinson's disease (PD) may improve precision medicine approach.OBJECTIVE: To examine sex-related longitudinal changes in motor and non-motor features and biologic biomarkers in early PD.METHODS: We compared 5-year...

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease: A Randomized Clinical Trial.

JAMA neurology

Simuni T, Fiske B, Merchant K, Coffey CS, Klingner E, Caspell-Garcia C, Lafontant DE, Matthews H, Wyse RK, Brundin P, Simon DK, Schwarzschild M, Weiner D, Adams J, Venuto C, Dawson TM, Baker L, Kostrzebski M, Ward T, Rafaloff G.
PMID: 33315105
JAMA Neurol. 2021 Mar 01;78(3):312-320. doi: 10.1001/jamaneurol.2020.4725.

IMPORTANCE: There is a critical need for careful and independent validation of reported symptomatic efficacy and dopaminergic biomarker changes induced by nilotinib in Parkinson disease (PD).OBJECTIVES: To assess safety and tolerability of nilotinib in participants with moderately advanced PD....

Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease.

Journal of Parkinson's disease

Picillo M, LaFontant DE, Bressman S, Caspell-Garcia C, Coffey C, Cho HR, Burghardt EL, Dahodwala N, Sanders-Pullman R, Tanner CM, Amara AW.
PMID: 34744052
J Parkinsons Dis. 2021 Nov 04; doi: 10.3233/JPD-212892. Epub 2021 Nov 04.

BACKGROUND: Investigation of sex-related motor and non-motor differences and biological markers in Parkinson's disease (PD) may improve precision medicine approach.OBJECTIVE: To examine sex-related longitudinal changes in motor and non-motor features and biologic biomarkers in early PD.METHODS: We compared 5-year...

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease: A Randomized Clinical Trial.

JAMA neurology

Simuni T, Fiske B, Merchant K, Coffey CS, Klingner E, Caspell-Garcia C, Lafontant DE, Matthews H, Wyse RK, Brundin P, Simon DK, Schwarzschild M, Weiner D, Adams J, Venuto C, Dawson TM, Baker L, Kostrzebski M, Ward T, Rafaloff G.
PMID: 33315105
JAMA Neurol. 2021 Mar 01;78(3):312-320. doi: 10.1001/jamaneurol.2020.4725.

IMPORTANCE: There is a critical need for careful and independent validation of reported symptomatic efficacy and dopaminergic biomarker changes induced by nilotinib in Parkinson disease (PD).OBJECTIVES: To assess safety and tolerability of nilotinib in participants with moderately advanced PD....

Spatial clustering of filarial transmission before and after a Mass Drug Administration in a setting of low infection prevalence.

Filaria journal

Washington CH, Radday J, Streit TG, Boyd HA, Beach MJ, Addiss DG, Lovince R, Lovegrove MC, Lafontant JG, Lammie PJ, Hightower AW.
PMID: 15128461
Filaria J. 2004 May 05;3(1):3. doi: 10.1186/1475-2883-3-3.

BACKGROUND: In the global program for the elimination of lymphatic filariasis (LF) longitudinal assessment of the prevalence of microfilaremia and antigenemia is recommended to monitor the effect of mass treatment on transmission. Additional monitoring tools such as entomologic and...

Far upstream activating promoter regions are responsible for expression of the BnC1 cruciferin gene from Brassica napus.

Plant cell reports

Bilodeau P, Lafontaine JG, Bellemare G.
PMID: 24192879
Plant Cell Rep. 1994 Dec;14(2):125-30. doi: 10.1007/BF00233775.

Cruciferin is the major seed storage protein in Brassica napus. As much as 1.9 kbp of the BnC1 cruciferin gene promoter have been sequenced and analyzed. Promoter fragments with 5' deletions from -2500 to -v202 were fused with the...

Low soluble amyloid-β 42 is associated with smaller brain volume in Parkinson's disease.

Parkinsonism & related disorders

Espay AJ, Lafontant DE, Poston KL, Caspell-Garcia C, Marsili L, Cho HR, McDaniel C, Kim N, Coffey CS, Mahajan A, Ezzat K, Sturchio A.
PMID: 34656902
Parkinsonism Relat Disord. 2021 Nov;92:15-21. doi: 10.1016/j.parkreldis.2021.10.010. Epub 2021 Oct 13.

INTRODUCTION: We sought to examine whether levels of soluble alpha-synuclein (α-syn), amyloid-beta (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau), as measured in cerebrospinal fluid (CSF), are associated with changes in brain volume in Parkinson's disease.METHODS: We assessed the...

Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart.

Journal of cardiovascular development and disease

Dyck PKV, Hockaden N, Nelson EC, Koch AR, Hester KL, Pillai N, Coffing GC, Burns AR, Lafontant PJ.
PMID: 33022937
J Cardiovasc Dev Dis. 2020 Oct 03;7(4). doi: 10.3390/jcdd7040041.

In the last two decades, the zebrafish has emerged as an important model species for heart regeneration studies. Various approaches to model loss of cardiac myocytes and myocardial infarction in the zebrafish have been devised, and have included resection,...

Corrigendum to "Low doses of arsenic, via perturbing p53, promotes tumorigenesis" [Toxicol. Appl. Pharmacol. (2016) 98-104].

Toxicology and applied pharmacology

Ganapathy S, Li P, Fagman J, Yu T, Lafontant J, Zhang G, Chen C.
PMID: 27851896
Toxicol Appl Pharmacol. 2017 Jan 01;314:118. doi: 10.1016/j.taap.2016.11.005. Epub 2016 Nov 13.

No abstract available.

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.

Acta neuropathologica communications

Russo MJ, Orru CD, Concha-Marambio L, Giaisi S, Groveman BR, Farris CM, Holguin B, Hughson AG, LaFontant DE, Caspell-Garcia C, Coffey CS, Mollon J, Hutten SJ, Merchant K, Heym RG, Soto C, Caughey B, Kang UJ.
PMID: 34742348
Acta Neuropathol Commun. 2021 Nov 06;9(1):179. doi: 10.1186/s40478-021-01282-8.

Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson's disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and other synucleinopathy patient...

Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (.

Journal of developmental biology

Shifatu O, Glasshagel-Chilson S, Nelson HM, Patel P, Tomamichel W, Higginbotham C, Evans PK, Lafontant GS, Burns AR, Lafontant PJ.
PMID: 30037066
J Dev Biol. 2018 Jul 21;6(3). doi: 10.3390/jdb6030019.

Giant danios (genus

Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.

CellR4-- repair, replacement, regeneration, & reprogramming

, Ansite J, Balamurugan AN, Barbaro B, Battle J, Brandhorst D, Cano J, Chen X, Deng S, Feddersen D, Friberg A, Gilmore T, Goldstein JS, Holbrook E, Khan A, Kin T, Lei J, Linetsky E, Liu C, Luo X, McElvaney K, Min Z, Moreno J, O'Gorman D, Papas KK, Putz G, Ricordi C, Szot G, Templeton T, Wang L, Wilhelm JJ, Willits J, Wilson T, Zhang X, Avila J, Begley B, Cano J, Carpentier S, Holbrook E, Hutchinson J, Larsen CP, Moreno J, Sears M, Turgeon NA, Webster D, Deng S, Lei J, Markmann JF, Bridges ND, Czarniecki CW, Goldstein JS, Putz G, Templeton T, Wilson T, Eggerman TL, Al-Saden P, Battle J, Chen X, Hecyk A, Kissler H, Luo X, Molitch M, Monson N, Stuart E, Wallia A, Wang L, Wang S, Zhang X, Bigam D, Campbell P, Dinyari P, Kin T, Kneteman N, Lyon J, Malcolm A, O'Gorman D, Onderka C, Owen R, Pawlick R, Richer B, Rosichuk S, Sarman D, Schroeder A, Senior PA, Shapiro AMJ, Toth L, Toth V, Zhai W, Johnson K, McElroy J, Posselt AM, Ramos M, Rojas T, Stock PG, Szot G, Barbaro B, Martellotto J, Oberholzer J, Qi M, Wang Y, Bayman L, Chaloner K, Clarke W, Dillon JS, Diltz C, Doelle GC, Ecklund D, Feddersen D, Foster E, Hunsicker LG, Jasperson C, Lafontant DE, McElvaney K, Neill-Hudson T, Nollen D, Qidwai J, Riss H, Schwieger T, Willits J, Yankey J, Alejandro R, Corrales AC, Faradji R, Froud T, Garcia AA, Herrada E, Ichii H, Inverardi L, Kenyon N, Khan A, Linetsky E, Montelongo J, Peixoto E, Peterson K, Ricordi C, Szust J, Wang X, Abdulla MH, Ansite J, Balamurugan AN, Bellin MD, Brandenburg M, Gilmore T, Harmon JV, Hering BJ, Kandaswamy R, Loganathan G, Mueller K, Papas KK, Pedersen J, Wilhelm JJ, Witson J, Dalton-Bakes C, Fu H, Kamoun M, Kearns J, Li Y, Liu C, Luning-Prak E, Luo Y, Markmann E, Min Z, Naji A, Palanjian M, Rickels M, Shlansky-Goldberg R, Vivek K, Ziaie AS, Fernandez L, Kaufman DB, Zitur L, Brandhorst D, Friberg A, Korsgren O.
PMID: 30613755
CellR4 Repair Replace Regen Reprogram. 2017;5(3). Epub 2017 May 26.

No abstract available.

Showing 1 to 12 of 15 entries