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Death receptor-mediated suicide: a novel target of autoimmune disease treatment.

Expert opinion on investigational drugs

Brunner T, Arnold D, Wasem C, Laissue JA, Mueller C.
PMID: 15992154
Expert Opin Investig Drugs. 1999 Sep;8(9):1359-72. doi: 10.1517/13543784.8.9.1359.

In the thymus, based on the reactivity of their T-cell receptor with self-MHC and antigenic peptides, developing immature T-cells undergo positive and negative selection. Cells recognising self-peptides and MHC with high affinity are considered autoreactive, and thus potentially harmful,...

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Brunner T, Arnold D, Wasem C, et al. Death receptor-mediated suicide: a novel target of autoimmune disease treatment. Expert Opin Investig Drugs. 1999;8(9):1359-72doi: 10.1517/13543784.8.9.1359.
Brunner, T., Arnold, D., Wasem, C., Laissue, J. A., & Mueller, C. (1999). Death receptor-mediated suicide: a novel target of autoimmune disease treatment. Expert opinion on investigational drugs, 8(9), 1359-72. https://doi.org/10.1517/13543784.8.9.1359
Brunner, T, et al. "Death receptor-mediated suicide: a novel target of autoimmune disease treatment." Expert opinion on investigational drugs vol. 8,9 (1999): 1359-72. doi: https://doi.org/10.1517/13543784.8.9.1359
Brunner T, Arnold D, Wasem C, Laissue JA, Mueller C. Death receptor-mediated suicide: a novel target of autoimmune disease treatment. Expert Opin Investig Drugs. 1999 Sep;8(9):1359-72. doi: 10.1517/13543784.8.9.1359. PMID: 15992154.
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Mouse models for identifying genes modulating fertility parameters.

Animal : an international journal of animal bioscience

Laissue P, L'hôte D, Serres C, Vaiman D.
PMID: 22444172
Animal. 2009 Jan;3(1):55-71. doi: 10.1017/S1751731108003315.

Fertility can be defined as the natural capability of giving life. It is an important factor both for human medicine, where ~10% of the couples call for the services of assisted reproductive technologies, and for species of economic interest....

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Laissue P, L'hôte D, Serres C, et al. Mouse models for identifying genes modulating fertility parameters. Animal. 2009;3(1):55-71doi: 10.1017/S1751731108003315.
Laissue, P., L'hôte, D., Serres, C., & Vaiman, D. (2009). Mouse models for identifying genes modulating fertility parameters. Animal : an international journal of animal bioscience, 3(1), 55-71. https://doi.org/10.1017/S1751731108003315
Laissue, P, et al. "Mouse models for identifying genes modulating fertility parameters." Animal : an international journal of animal bioscience vol. 3,1 (2009): 55-71. doi: https://doi.org/10.1017/S1751731108003315
Laissue P, L'hôte D, Serres C, Vaiman D. Mouse models for identifying genes modulating fertility parameters. Animal. 2009 Jan;3(1):55-71. doi: 10.1017/S1751731108003315. PMID: 22444172.
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Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches.

Reproductive sciences (Thousand Oaks, Calif.)

Quintero-Ronderos P, Laissue P.
PMID: 30879428
Reprod Sci. 2019 Mar 17;1933719119831769. doi: 10.1177/1933719119831769. Epub 2019 Mar 17.

Recurrent pregnancy loss (RPL) affects up to 5% of couples. It is believed that genetic factors contribute to the disease's etiology and pathophysiology. Hundreds of genes represent coherent RPL candidates due to mammalian implantation's inherent complexity. Sanger sequencing (direct...

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Quintero-Ronderos P, Laissue P. Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches. Reprod Sci. 2019;1933719119831769doi: 10.1177/1933719119831769.
Quintero-Ronderos, P., & Laissue, P. (2019). Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches. Reproductive sciences (Thousand Oaks, Calif.), 1933719119831769. https://doi.org/10.1177/1933719119831769
Quintero-Ronderos, Paula, and Laissue, Paul. "Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches." Reproductive sciences (Thousand Oaks, Calif.) vol. (2019): 1933719119831769. doi: https://doi.org/10.1177/1933719119831769
Quintero-Ronderos P, Laissue P. Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches. Reprod Sci. 2019 Mar 17;1933719119831769. doi: 10.1177/1933719119831769. Epub 2019 Mar 17. PMID: 30879428.
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FLASH radiotherapy with photon beams.

Medical physics

Montay-Gruel P, Corde S, Laissue JA, Bazalova-Carter M.
PMID: 34519042
Med Phys. 2021 Sep 14; doi: 10.1002/mp.15222. Epub 2021 Sep 14.

Ultra-high-dose rate "FLASH" radiotherapy (FLASH-RT) has been shown to drastically reduce normal tissue toxicities while being as efficacious as conventional dose rate radiotherapy to treat tumors. A large number of preclinical studies describing this so-called FLASH effect have led...

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Montay-Gruel P, Corde S, Laissue JA, et al. FLASH radiotherapy with photon beams. Med Phys. 2021;doi: 10.1002/mp.15222.
Montay-Gruel, P., Corde, S., Laissue, J. A., & Bazalova-Carter, M. (2021). FLASH radiotherapy with photon beams. Medical physics, . https://doi.org/10.1002/mp.15222
Montay-Gruel, Pierre, et al. "FLASH radiotherapy with photon beams." Medical physics vol. (2021). doi: https://doi.org/10.1002/mp.15222
Montay-Gruel P, Corde S, Laissue JA, Bazalova-Carter M. FLASH radiotherapy with photon beams. Med Phys. 2021 Sep 14; doi: 10.1002/mp.15222. Epub 2021 Sep 14. PMID: 34519042.
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Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms.

iScience

Ducat A, Couderc B, Bouter A, Biquard L, Aouache R, Passet B, Doridot L, Cohen MB, Ribaux P, Apicella C, Gaillard I, Palfray S, Chen Y, Vargas A, Julé A, Frelin L, Cocquet J, San Martin CR, Jacques S, Busato F, Tost J, Méhats C, Laissue P, Vilotte JL, Miralles F, Vaiman D.
PMID: 32371375
iScience. 2020 May 22;23(5):101086. doi: 10.1016/j.isci.2020.101086. Epub 2020 Apr 21.

STOX1 is a transcription factor involved in preeclampsia and Alzheimer disease. We show that the knock-down of the gene induces rather mild effect on gene expression in trophoblast cell lines (BeWo). We identified binding sites of STOX1 shared by...

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Ducat A, Couderc B, Bouter A, et al. Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms. iScience. 2020;23(5):101086doi: 10.1016/j.isci.2020.101086.
Ducat, A., Couderc, B., Bouter, A., Biquard, L., Aouache, R., Passet, B., Doridot, L., Cohen, M. B., Ribaux, P., Apicella, C., Gaillard, I., Palfray, S., Chen, Y., Vargas, A., Julé, A., Frelin, L., Cocquet, J., San Martin, C. R., Jacques, S., Busato, F., Tost, J., Méhats, C., Laissue, P., Vilotte, J. L., Miralles, F., & Vaiman, D. (2020). Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms. iScience, 23(5), 101086. https://doi.org/10.1016/j.isci.2020.101086
Ducat, Aurélien, et al. "Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms." iScience vol. 23,5 (2020): 101086. doi: https://doi.org/10.1016/j.isci.2020.101086
Ducat A, Couderc B, Bouter A, Biquard L, Aouache R, Passet B, Doridot L, Cohen MB, Ribaux P, Apicella C, Gaillard I, Palfray S, Chen Y, Vargas A, Julé A, Frelin L, Cocquet J, San Martin CR, Jacques S, Busato F, Tost J, Méhats C, Laissue P, Vilotte JL, Miralles F, Vaiman D. Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms. iScience. 2020 May 22;23(5):101086. doi: 10.1016/j.isci.2020.101086. Epub 2020 Apr 21. PMID: 32371375; PMCID: PMC7200942.
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Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors.

Cancers

Eling L, Bouchet A, Ocadiz A, Adam JF, Kershmiri S, Elleaume H, Krisch M, Verry C, Laissue JA, Balosso J, Serduc R.
PMID: 33668110
Cancers (Basel). 2021 Feb 24;13(5). doi: 10.3390/cancers13050936.

Delivery of high-radiation doses to brain tumors via multiple arrays of synchrotron X-ray microbeams permits huge therapeutic advantages. Brain tumor (9LGS)-bearing and normal rats were irradiated using a conventional, homogeneous Broad Beam (BB), or Microbeam Radiation Therapy (MRT), then...

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Eling L, Bouchet A, Ocadiz A, et al. Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors. Cancers (Basel). 2021;13(5)doi: 10.3390/cancers13050936.
Eling, L., Bouchet, A., Ocadiz, A., Adam, J. F., Kershmiri, S., Elleaume, H., Krisch, M., Verry, C., Laissue, J. A., Balosso, J., & Serduc, R. (2021). Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors. Cancers, 13(5), . https://doi.org/10.3390/cancers13050936
Eling, Laura, et al. "Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors." Cancers vol. 13,5 (2021). doi: https://doi.org/10.3390/cancers13050936
Eling L, Bouchet A, Ocadiz A, Adam JF, Kershmiri S, Elleaume H, Krisch M, Verry C, Laissue JA, Balosso J, Serduc R. Unexpected Benefits of Multiport Synchrotron Microbeam Radiation Therapy for Brain Tumors. Cancers (Basel). 2021 Feb 24;13(5). doi: 10.3390/cancers13050936. PMID: 33668110; PMCID: PMC7956531.
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A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions.

Pharmacogenomics and personalized medicine

Calderon-Ospina CA, Hernández-Sómerson M, García AM, Mejia A, Tamayo-Agudelo C, Laissue P, Fonseca Mendoza DJ.
PMID: 32184647
Pharmgenomics Pers Med. 2020 Mar 02;13:59-70. doi: 10.2147/PGPM.S228709. eCollection 2020.

Rosuvastatin, is a widely-used statin for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Although rosuvastatin is well tolerated, about 3/10.000 patients can suffer severe myopathy. Rhabdomyolysis is a severe medical condition that causes injury to the...

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Calderon-Ospina CA, Hernández-Sómerson M, García AM, et al. A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions. Pharmgenomics Pers Med. 2020;13:59-70doi: 10.2147/PGPM.S228709.
Calderon-Ospina, C. A., Hernández-Sómerson, M., García, A. M., Mejia, A., Tamayo-Agudelo, C., Laissue, P., & Fonseca Mendoza, D. J. (2020). A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions. Pharmacogenomics and personalized medicine, 1359-70. https://doi.org/10.2147/PGPM.S228709
Calderon-Ospina, Carlos Alberto, et al. "A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions." Pharmacogenomics and personalized medicine vol. 13 (2020): 59-70. doi: https://doi.org/10.2147/PGPM.S228709
Calderon-Ospina CA, Hernández-Sómerson M, García AM, Mejia A, Tamayo-Agudelo C, Laissue P, Fonseca Mendoza DJ. A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions. Pharmgenomics Pers Med. 2020 Mar 02;13:59-70. doi: 10.2147/PGPM.S228709. eCollection 2020. PMID: 32184647; PMCID: PMC7060025.
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Improving the evaluation of milestones for students completing a clinical genetics elective.

Genetics in medicine : official journal of the American College of Medical Genetics

Laissue P, Restrepo CM, Ortiz AM.
PMID: 28492531
Genet Med. 2017 Dec;19(12). doi: 10.1038/gim.2017.62. Epub 2017 May 11.

No abstract available.

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Laissue P, Restrepo CM, Ortiz AM. Improving the evaluation of milestones for students completing a clinical genetics elective. Genet Med. 2017;19(12)doi: 10.1038/gim.2017.62.
Laissue, P., Restrepo, C. M., & Ortiz, A. M. (2017). Improving the evaluation of milestones for students completing a clinical genetics elective. Genetics in medicine : official journal of the American College of Medical Genetics, 19(12), . https://doi.org/10.1038/gim.2017.62
Laissue, Paul, et al. "Improving the evaluation of milestones for students completing a clinical genetics elective." Genetics in medicine : official journal of the American College of Medical Genetics vol. 19,12 (2017). doi: https://doi.org/10.1038/gim.2017.62
Laissue P, Restrepo CM, Ortiz AM. Improving the evaluation of milestones for students completing a clinical genetics elective. Genet Med. 2017 Dec;19(12). doi: 10.1038/gim.2017.62. Epub 2017 May 11. PMID: 28492531.
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Identification and Functional Characterization of GAA Mutations in Colombian Patients Affected by Pompe Disease.

JIMD reports

Niño MY, Mateus HE, Fonseca DJ, Kroos MA, Ospina SY, Mejía JF, Uribe JA, Reuser AJ, Laissue P.
PMID: 23430493
JIMD Rep. 2013;7:39-48. doi: 10.1007/8904_2012_138. Epub 2012 Apr 19.

Pompe disease (PD) is a recessive metabolic disorder characterized by acid α-glucosidase (GAA) deficiency, which results in lysosomal accumulation of glycogen in all tissues, especially in skeletal muscles. PD clinical course is mainly determined by the nature of the...

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Niño MY, Mateus HE, Fonseca DJ, et al. Identification and Functional Characterization of GAA Mutations in Colombian Patients Affected by Pompe Disease. JIMD Rep. 2012;7:39-48doi: 10.1007/8904_2012_138.
Niño, M. Y., Mateus, H. E., Fonseca, D. J., Kroos, M. A., Ospina, S. Y., Mejía, J. F., Uribe, J. A., Reuser, A. J., & Laissue, P. (2013). Identification and Functional Characterization of GAA Mutations in Colombian Patients Affected by Pompe Disease. JIMD reports, 739-48. https://doi.org/10.1007/8904_2012_138
Niño, Mónica Yasmín, et al. "Identification and Functional Characterization of GAA Mutations in Colombian Patients Affected by Pompe Disease." JIMD reports vol. 7 (2013): 39-48. doi: https://doi.org/10.1007/8904_2012_138
Niño MY, Mateus HE, Fonseca DJ, Kroos MA, Ospina SY, Mejía JF, Uribe JA, Reuser AJ, Laissue P. Identification and Functional Characterization of GAA Mutations in Colombian Patients Affected by Pompe Disease. JIMD Rep. 2013;7:39-48. doi: 10.1007/8904_2012_138. Epub 2012 Apr 19. PMID: 23430493; PMCID: PMC3575054.
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Mouse models for identifying genes modulating fertility parameters.

Animal : an international journal of animal bioscience

Laissue P, L'hôte D, Serres C, Vaiman D.
PMID: 22444172
Animal. 2009 Jan;3(1):55-71. doi: 10.1017/S1751731108003315.

Fertility can be defined as the natural capability of giving life. It is an important factor both for human medicine, where ~10% of the couples call for the services of assisted reproductive technologies, and for species of economic interest....

Cite
Laissue P, L'hôte D, Serres C, et al. Mouse models for identifying genes modulating fertility parameters. Animal. 2009;3(1):55-71doi: 10.1017/S1751731108003315.
Laissue, P., L'hôte, D., Serres, C., & Vaiman, D. (2009). Mouse models for identifying genes modulating fertility parameters. Animal : an international journal of animal bioscience, 3(1), 55-71. https://doi.org/10.1017/S1751731108003315
Laissue, P, et al. "Mouse models for identifying genes modulating fertility parameters." Animal : an international journal of animal bioscience vol. 3,1 (2009): 55-71. doi: https://doi.org/10.1017/S1751731108003315
Laissue P, L'hôte D, Serres C, Vaiman D. Mouse models for identifying genes modulating fertility parameters. Animal. 2009 Jan;3(1):55-71. doi: 10.1017/S1751731108003315. PMID: 22444172.
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A Pharmacogenetic Study of .

Journal of personalized medicine

Angulo-Aguado M, Panche K, Tamayo-Agudelo CA, Ruiz-Torres DA, Sambracos-Parrado S, Niño-Orrego MJ, Páez N, Piñeros-Hernandez LB, Castillo-León LF, Pardo-Oviedo JM, Abaunza KP, Laissue P, Contreras N, Calderón-Ospina CA, Fonseca-Mendoza DJ.
PMID: 34065778
J Pers Med. 2021 May 12;11(5). doi: 10.3390/jpm11050400.

Clopidogrel, an oral platelet P2Y

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Angulo-Aguado M, Panche K, Tamayo-Agudelo CA, et al. A Pharmacogenetic Study of . J Pers Med. 2021;11(5)doi: 10.3390/jpm11050400.
Angulo-Aguado, M., Panche, K., Tamayo-Agudelo, C. A., Ruiz-Torres, D. A., Sambracos-Parrado, S., Niño-Orrego, M. J., Páez, N., Piñeros-Hernandez, L. B., Castillo-León, L. F., Pardo-Oviedo, J. M., Abaunza, K. P., Laissue, P., Contreras, N., Calderón-Ospina, C. A., & Fonseca-Mendoza, D. J. (2021). A Pharmacogenetic Study of . Journal of personalized medicine, 11(5), . https://doi.org/10.3390/jpm11050400
Angulo-Aguado, Mariana, et al. "A Pharmacogenetic Study of ." Journal of personalized medicine vol. 11,5 (2021). doi: https://doi.org/10.3390/jpm11050400
Angulo-Aguado M, Panche K, Tamayo-Agudelo CA, Ruiz-Torres DA, Sambracos-Parrado S, Niño-Orrego MJ, Páez N, Piñeros-Hernandez LB, Castillo-León LF, Pardo-Oviedo JM, Abaunza KP, Laissue P, Contreras N, Calderón-Ospina CA, Fonseca-Mendoza DJ. A Pharmacogenetic Study of . J Pers Med. 2021 May 12;11(5). doi: 10.3390/jpm11050400. PMID: 34065778; PMCID: PMC8150782.
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Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation.

Cancers

Sabatasso S, Fernandez-Palomo C, Hlushchuk R, Fazzari J, Tschanz S, Pellicioli P, Krisch M, Laissue JA, Djonov V.
PMID: 33925455
Cancers (Basel). 2021 Apr 27;13(9). doi: 10.3390/cancers13092103.

BACKGROUND: Microbeam Radiation Therapy (MRT) induces a transient vascular permeability window, which offers a novel drug-delivery system for the preferential accumulation of therapeutic compounds in tumors. MRT is a preclinical cancer treatment modality that spatially fractionates synchrotron X-rays into...

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Sabatasso S, Fernandez-Palomo C, Hlushchuk R, et al. Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation. Cancers (Basel). 2021;13(9)doi: 10.3390/cancers13092103.
Sabatasso, S., Fernandez-Palomo, C., Hlushchuk, R., Fazzari, J., Tschanz, S., Pellicioli, P., Krisch, M., Laissue, J. A., & Djonov, V. (2021). Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation. Cancers, 13(9), . https://doi.org/10.3390/cancers13092103
Sabatasso, Sara, et al. "Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation." Cancers vol. 13,9 (2021). doi: https://doi.org/10.3390/cancers13092103
Sabatasso S, Fernandez-Palomo C, Hlushchuk R, Fazzari J, Tschanz S, Pellicioli P, Krisch M, Laissue JA, Djonov V. Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation. Cancers (Basel). 2021 Apr 27;13(9). doi: 10.3390/cancers13092103. PMID: 33925455; PMCID: PMC8123803.
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Showing 1 to 12 of 35 entries