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Showing 1 to 8 of 8 entries
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Population-based estimation of renal function in healthy young Indian adults based on body mass index and sex correlating renal volume, serum creatinine, and cystatin C.

International journal of nephrology and renovascular disease

Rajagopalan P, Abraham G, Reddy YN, Lakshmanasami R, Prakash ML, Reddy YN.
PMID: 27729810
Int J Nephrol Renovasc Dis. 2016 Sep 27;9:243-247. doi: 10.2147/IJNRD.S104983. eCollection 2016.

This population-based prospective study was undertaken in Mahatma Gandhi Medical College to estimate the renal function in young healthy Indian adults. A young healthy heterogeneous Indian cohort comprising 978 individuals, predominantly medical students, was assessed by a detailed questionnaire,...

Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast Cancer.

Cancers

J Sedano M, I Ramos E, Choudhari R, L Harrison A, Subramani R, Lakshmanaswamy R, Zilaie M, Gadad SS.
PMID: 32532008
Cancers (Basel). 2020 Jun 10;12(6). doi: 10.3390/cancers12061522.

Hypoxanthine phosphoribosyl transferase 1 (

FOXC1 plays a crucial role in the growth of pancreatic cancer.

Oncogenesis

Subramani R, Camacho FA, Levin CI, Flores K, Clift A, Galvez A, Terres M, Rivera S, Kolli SN, Dodderer J, Miranda M, Rodriguez A, Pedroza DA, Chatterjee A, Lakshmanaswamy R.
PMID: 29976975
Oncogenesis. 2018 Jul 06;7(7):52. doi: 10.1038/s41389-018-0061-7.

IGF-1R signaling controls various vital cellular functions and this signaling is deregulated in many cancers, including pancreatic cancer. Several efforts have mainly focused on inhibiting the IGF-1R signaling cascade. The outcomes of these focused preclinical studies have been positive,...

Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide.

Molecular therapy oncolytics

Arumugam A, Subramani R, Lakshmanaswamy R.
PMID: 33768141
Mol Ther Oncolytics. 2021 Feb 24;20:596-606. doi: 10.1016/j.omto.2021.02.014. eCollection 2021 Mar 26.

Triple-negative breast cancers (TNBCs) are aggressive cancers, which currently do not have effective treatment options. Migration and establishment of metastatic colonies require dynamic cytoskeletal modifications characterized by polymerization and depolymerization of actin. Studies have demonstrated a direct molecular link...

miRNome and Functional Network Analysis of PGRMC1 Regulated miRNA Target Genes Identify Pathways and Biological Functions Associated With Triple Negative Breast Cancer.

Frontiers in oncology

Pedroza DA, Ramirez M, Rajamanickam V, Subramani R, Margolis V, Gurbuz T, Estrada A, Lakshmanaswamy R.
PMID: 34350123
Front Oncol. 2021 Jul 19;11:710337. doi: 10.3389/fonc.2021.710337. eCollection 2021.

BACKGROUND: Increased expression of the progesterone receptor membrane component 1, a heme and progesterone binding protein, is frequently found in triple negative breast cancer tissue. The basis for the expression of PGRMC1 and its regulation on cellular signaling mechanisms...

Pregnancy Inhibits Mammary Carcinogenesis by Persistently Altering the Hypothalamic-Pituitary Axis.

Cancers

Subramani R, Estrada A, Dixon M, Parada M, Rodriguez S, Pedroza DA, Ramirez MD, Clift A, Garcia L, Lakshmanaswamy R.
PMID: 34206988
Cancers (Basel). 2021 Jun 26;13(13). doi: 10.3390/cancers13133207.

Early full-term pregnancy is known to reduce the lifetime risk of breast cancer. Although the phenomenon of parity-induced protection is well-established, the physiological mechanisms involved in this protection are not clear. Earlier reports have shown that pregnancy results in...

Design of wide-core planar waveguides by an inverse scattering method.

Optics letters

Lakshmanasamy S, Jordan AK.
PMID: 19749937
Opt Lett. 1989 Apr 15;14(8):411-3. doi: 10.1364/ol.14.000411.

An inverse scattering method is used to design single-mode planar optical waveguides. Waveguides with wider cores compared with those designed by direct scattering methods are obtained, and a numerical example is given.

Classical and Non-Classical Progesterone Signaling in Breast Cancers.

Cancers

Pedroza DA, Subramani R, Lakshmanaswamy R.
PMID: 32867363
Cancers (Basel). 2020 Aug 27;12(9). doi: 10.3390/cancers12092440.

Much emphasis is placed on estrogen (E2) and estrogen receptor (ER) signaling as most research is focused on understanding E2 and ER's ability to enhance proliferative signals in breast cancers. Progesterone (P4) is important for normal mammary gland development,...

Showing 1 to 8 of 8 entries